Dimethylformamide dimethyl acetal

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  • Identifiers

    CAS number
    4637-24-5

    Molecular formula
    C5H13NO2

    SMILES
    CN(C)C(OC)OC

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 50.12%
    Ethereal 43.1%
    Alcoholic 34.95%
    Fermented 33.48%
    Fresh 27.91%
    Sweet 27.66%
    Odorless 27.61%
    Pungent 25.74%
    Malty 25.56%
    Green 24.55%

     

    Flavor
    Fruity 48.93%
    Green 37.84%
    Vegetable 25.54%
    Tropical 25.52%
    Oily 22.78%
    Sulfurous 22.48%
    Earthy 22.38%
    Fatty 22.15%
    Bitter 22.0%
    Grape skin 21.85%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    7.11 (neutral)

    Molecular weight
    119.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    107°C

    Flash point

    • 20.73 ˚C est.

  • Synonyms

    • N,N-Dimethylformamide dimethyl acetal
    • 4637-24-5
    • 1,1-dimethoxy-N,N-dimethylmethanamine
    • Methanamine, 1,1-dimethoxy-N,N-dimethyl-
    • DMF Dimethyl acetal
    • Dimethylformamide-dimethylacetal
    • DMFDMA
    • Dimethylformamide dimethyl acetal
    • DMF-DMA
    • Dimethoxy(dimethylamino)methane
    • DF7CTT5QPH
    • DTXSID3063540
    • CHEBI:85061
    • RefChem:134349
    • DTXCID8040488
    • 225-063-3
    • 1,1-Dimethoxytrimethylamine
    • (dimethoxymethyl)dimethylamine
    • dimethylformamide dimethylacetal
    • Trimethylamine, 1,1-dimethoxy-
    • Dimethoxy-N,N-dimethylmethanamine
    • N,N-Dimethylformamidedimethylacetal
    • MFCD00008482
    • 1,1-Dimethoxy-N,N-dimethylmethylamine
    • N-(Dimethoxymethyl)dimethylamine
    • N,N-Dimethylformamide dimethylacetal
    • N,N'-Dimethylformamide dimethyl acetal
    • 1,1-dimethoxy-N,N-dimethyl-methanamine
    • dimethylformamide-dimethyl acetal
    • N.N-dimethylformamide dimethyl acetal
    • n-(dimethoxymethyl)-n,n-dimethylamine
    • 1,1-dimethoxy-N,N-dimethyl methanamine
    • dimethoxymethyldimethylamine
    • Dimethylaminodimethoxymethane
    • DMF dimethylacetal
    • EINECS 225-063-3
    • (DIMETHYLAMINO)DIMETHOXYMETHANE
    • UNII-DF7CTT5QPH
    • (MeO)2CHNMe2
    • CH(OMe)2NMe2
    • Leflunomide Impurity 15
    • Me2NCH(OMe)2
    • METHYL-8
    • SCHEMBL978
    • EC 225-063-3
    • dimethoxymethyl-dimethylamine
    • (Me)2N-CH(OMe)2
    • (DIMETHYLAMINO)FORMALDEHYDE DIMETHYL ACETAL
    • dimethoxymethyl dimethyl-amine
    • dimethoxymethyl-dimethyl amine
    • dimethoxymethyl-dimethyl-amine
    • dimethyformamide dimethylacetal
    • dimethoxy-dimethylamino-methane
    • dimethyformamide dimethyl acetal
    • dimethylformamide dimetyl acetal
    • dimetylformamide dimethyl acetal
    • N-(Dimethoxymethyl)dimethylamin
    • dimethyl formamide dimethylacetal
    • dimethyl-formamide dimethylacetal
    • dimethyl-formamide-dimethylacetal
    • SCHEMBL28067613
    • dimethyl formamide dimethyl acetal
    • dimethyl formamide-dimethyl acetal
    • dimethyl-formamide dimethyl acetal
    • dimethoxy-N,N-dimethyl-methanamine
    • n,n-dimethylformamid dimethylacetal
    • n,n-dimethylformamid-dimethylacetal
    • (1,1-dimethoxymethyl)dimethylamine
    • N,N-dimethylformamide dimethlacetal
    • BB_SC-05862
    • EAA63724
    • n,n-dimethylformamide-dimethylacetal
    • n,n-dimethylformamidedimethyl acetal
    • n.n-dimethylformamide dimethylacetal
    • STR00254
    • Dimethoxy-N,N-dimethylmethanamine #
    • N,N-dimethyformamide dimethyl acetal
    • N,N-dimethylforamide dimethyl acetal
    • N,N-dimethylformamide dimethy acetal
    • N, N-dimethylformamide dimethylacetal
    • N,N dimethylformamide dimethyl acetal
    • n,n,-dimethylformamide dimethylacetal
    • N,N-dimethlyformamide dimethyl acetal
    • n,n-dimethyl formamide dimethylacetal
    • n,n-dimethyl-formamide dimethylacetal
    • N,N-dimethylformamide-dimethyl acetal
    • SBB056425
    • STK801436
    • AKOS000120005
    • N, N-dimethylformamide dimethyl acetal
    • N, N-dimethylformamide-dimethyl acetal
    • N,N dimethyl formamide dimethyl acetal
    • n,n,-dimethylformamide dimethyl acetal
    • N,N-dimethyl formamide dimethyl acetal
    • N,N-dimethyl-formamide dimethyl acetal
    • n,n-dimethyl-formamide dimethyl-acetal
    • 1,1-dimethyoxy-N,N-dimethylmethanamine
    • 1,1-Dimethoxy-N,N-dimethyl-methylamine
    • 1,1-Dimethoxy-N,N-dimethylmethaneamine
    • DIMETHOXY-N,N-DIMETHYLMETHYLAMINE
    • DIMETHYL DIMETHYLFORMAMIDE ACETAL
    • N, N-dimethyl formamide dimethyl acetal
    • BP-11395
    • N,N-DIMETHYL(DIMETHOXYMETHYL)AMINE
    • CS-0016065
    • D1293
    • D1332
    • D2071
    • N,N-DIMETHYLFORMAMIDO DIMETHYL ACETAL
    • NS00001669
    • EN300-19871
    • .ALPHA.,.ALPHA.-DIMETHOXYTRIMETHYLAMINE
    • F005030
    • F545282
    • N,N-DIMETHYL-1,1-BIS(METHYLOXY)METHANAMINE
    • Q27158310
    • F0001-1254
    • InChI=1/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H
    • N,N-Dimethylformamide dimethyl acetal, for GC derivatization
    • N,N-Dimethylformamide dimethyl acetal, technical grade, 94%
    • 4637-24-5

  • Applications

    Dimethylformamide dimethyl acetal (DMF-DMA) is primarily used as a carbonyl-protecting reagent in organic synthesis, converting aldehydes and ketones to their dimethyl acetal derivatives under acid catalysis to enable multi-step sequences. It is also employed as an intermediate in the synthesis of pharmaceutical and agrochemical products, where temporary protection of carbonyl groups is advantageous. In the broader field of fine chemicals and specialty chemicals manufacturing, DMF-DMA serves as a protecting-group reagent to enable complex sequences in process development and scale-up. Its use is typically governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5104.72
    methanol 8013.99
    isopropanol 3085.27
    water 1394.85
    ethyl acetate 1284.74
    n-propanol 3072.26
    acetone 1702.02
    n-butanol 2561.14
    acetonitrile 2666.44
    DMF 1800.27
    toluene 382.98
    isobutanol 2057.89
    1,4-dioxane 1884.29
    methyl acetate 1472.97
    THF 1897.73
    2-butanone 1222.27
    n-pentanol 1262.12
    sec-butanol 2473.98
    n-hexane 207.51
    ethylene glycol 2184.5
    NMP 1364.55
    cyclohexane 452.73
    DMSO 1696.17
    n-butyl acetate 670.32
    n-octanol 387.23
    chloroform 5234.07
    n-propyl acetate 612.09
    acetic acid 9742.31
    dichloromethane 4192.01
    cyclohexanone 1405.65
    propylene glycol 1803.32
    isopropyl acetate 625.55
    DMAc 1323.63
    2-ethoxyethanol 2199.09
    isopentanol 1458.12
    n-heptane 185.05
    ethyl formate 1662.06
    1,2-dichloroethane 1636.48
    n-hexanol 902.19
    2-methoxyethanol 4328.4
    isobutyl acetate 331.15
    tetrachloromethane 1995.58
    n-pentyl acetate 444.16
    transcutol 1289.66
    n-heptanol 494.8
    ethylbenzene 172.89
    MIBK 381.37
    2-propoxyethanol 1367.51
    tert-butanol 2623.59
    MTBE 1280.78
    2-butoxyethanol 931.88
    propionic acid 2633.63
    o-xylene 280.72
    formic acid 8462.15
    diethyl ether 1431.79
    m-xylene 222.58
    p-xylene 278.78
    chlorobenzene 645.14
    dimethyl carbonate 387.16
    n-octane 68.56
    formamide 5661.26
    cyclopentanone 1272.98
    2-pentanone 863.94
    anisole 361.9
    cyclopentyl methyl ether 950.82
    gamma-butyrolactone 1722.64
    1-methoxy-2-propanol 1949.62
    pyridine 1455.34
    3-pentanone 674.25
    furfural 1737.72
    n-dodecane 37.01
    diethylene glycol 1297.99
    diisopropyl ether 287.61
    tert-amyl alcohol 2131.46
    acetylacetone 665.7
    n-hexadecane 39.26
    acetophenone 360.98
    methyl propionate 870.27
    isopentyl acetate 508.29
    trichloroethylene 3540.14
    n-nonanol 309.11
    cyclohexanol 1834.7
    benzyl alcohol 521.76
    2-ethylhexanol 450.8
    isooctanol 362.21
    dipropyl ether 502.93
    1,2-dichlorobenzene 595.66
    ethyl lactate 350.18
    propylene carbonate 1036.86
    n-methylformamide 2527.04
    2-pentanol 1403.53
    n-pentane 340.03
    1-propoxy-2-propanol 863.21
    1-methoxy-2-propyl acetate 446.53
    2-(2-methoxypropoxy) propanol 310.05
    mesitylene 140.85
    ε-caprolactone 1285.5
    p-cymene 189.29
    epichlorohydrin 1799.27
    1,1,1-trichloroethane 2103.98
    2-aminoethanol 3023.95
    morpholine-4-carbaldehyde 1317.26
    sulfolane 1410.04
    2,2,4-trimethylpentane 162.79
    2-methyltetrahydrofuran 1737.62
    n-hexyl acetate 481.88
    isooctane 79.27
    2-(2-butoxyethoxy)ethanol 483.25
    sec-butyl acetate 365.28
    tert-butyl acetate 532.94
    decalin 102.48
    glycerin 2152.87
    diglyme 1073.86
    acrylic acid 2504.76
    isopropyl myristate 131.12
    n-butyric acid 3137.07
    acetyl acetate 832.03
    di(2-ethylhexyl) phthalate 157.56
    ethyl propionate 485.03
    nitromethane 5240.26
    1,2-diethoxyethane 551.67
    benzonitrile 651.97
    trioctyl phosphate 132.35
    1-bromopropane 1074.44
    gamma-valerolactone 1651.99
    n-decanol 200.7
    triethyl phosphate 249.38
    4-methyl-2-pentanol 503.51
    propionitrile 1479.4
    vinylene carbonate 1074.22
    1,1,2-trichlorotrifluoroethane 2586.59
    DMS 302.13
    cumene 139.03
    2-octanol 310.29
    2-hexanone 489.71
    octyl acetate 203.96
    limonene 301.78
    1,2-dimethoxyethane 1622.77
    ethyl orthosilicate 264.74
    tributyl phosphate 155.51
    diacetone alcohol 706.32
    N,N-dimethylaniline 268.98
    acrylonitrile 1658.21
    aniline 768.86
    1,3-propanediol 3605.19
    bromobenzene 562.09
    dibromomethane 2601.88
    1,1,2,2-tetrachloroethane 2627.82
    2-methyl-cyclohexyl acetate 303.14
    tetrabutyl urea 175.66
    diisobutyl methanol 259.21
    2-phenylethanol 435.44
    styrene 210.9
    dioctyl adipate 180.88
    dimethyl sulfate 525.84
    ethyl butyrate 519.8
    methyl lactate 556.64
    butyl lactate 357.29
    diethyl carbonate 367.71
    propanediol butyl ether 530.97
    triethyl orthoformate 396.41
    p-tert-butyltoluene 188.44
    methyl 4-tert-butylbenzoate 342.51
    morpholine 2396.53
    tert-butylamine 1720.07
    n-dodecanol 144.37
    dimethoxymethane 1150.47
    ethylene carbonate 916.57
    cyrene 347.34
    2-ethoxyethyl acetate 461.34
    2-ethylhexyl acetate 392.8
    1,2,4-trichlorobenzene 726.28
    4-methylpyridine 1089.27
    dibutyl ether 308.39
    2,6-dimethyl-4-heptanol 259.21
    DEF 1085.48
    dimethyl isosorbide 445.28
    tetrachloroethylene 2697.21
    eugenol 329.34
    triacetin 370.13
    span 80 327.12
    1,4-butanediol 1402.64
    1,1-dichloroethane 2018.08
    2-methyl-1-pentanol 822.15
    methyl formate 1951.86
    2-methyl-1-butanol 1643.5
    n-decane 71.59
    butyronitrile 1701.27
    3,7-dimethyl-1-octanol 319.33
    1-chlorooctane 217.99
    1-chlorotetradecane 73.65
    n-nonane 76.51
    undecane 47.05
    tert-butylcyclohexane 103.72
    cyclooctane 129.8
    cyclopentanol 1927.67
    tetrahydropyran 1742.05
    tert-amyl methyl ether 909.79
    2,5,8-trioxanonane 493.81
    1-hexene 435.76
    2-isopropoxyethanol 1067.17
    2,2,2-trifluoroethanol 3860.46
    methyl butyrate 771.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
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Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
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Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
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Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction