Dimethylaminoacetonitrile

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  • Identifiers

    CAS number
    926-64-7

    Molecular formula
    C4H8N2

    SMILES
    CN(C)CC#N

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 49.1%
    Cheesy 32.44%
    Sweet 29.12%
    Ripe 24.66%
    Floral 22.98%
    Odorless 22.51%
    Fresh 19.98%
    Oily 19.5%
    Animal 19.16%
    Citrus 18.48%

     

    Flavor
    Bitter 25.71%
    Odorless 22.94%
    Mild 19.79%
    Bland 19.38%
    Roasted 18.93%
    Nitrile 18.75%
    Glue 18.44%
    Bloody 18.42%
    Yeasty 18.21%
    Scallion 17.99%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    5.46 (weak acid)

    Molecular weight
    84.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    132°C

    Flash point

    • 40.23 ˚C est.

  • Synonyms

    • Dimethylaminoacetonitrile
    • 926-64-7
    • (Dimethylamino)acetonitrile
    • 2-(dimethylamino)acetonitrile
    • Acetonitrile, (dimethylamino)-
    • N-(Cyanomethyl)dimethylamine
    • 2-Dimethylaminoacetonitrile
    • Glycinonitrile, N,N-dimethyl-
    • N,N-Dimethylglycinonitrile
    • EINECS 213-140-4
    • NSC 148364
    • BRN 1735677
    • WU34F15N7C
    • AI3-22163
    • NSC-148364
    • DTXSID0073241
    • CHEBI:88381
    • PLXBWEPPAAQASG-UHFFFAOYSA-
    • MFCD00001890
    • UN2378
    • UNII-WU34F15N7C
    • dimethylamino-acetonitrile
    • Dimethylamino acetonitrile
    • Glycinonitrile,N-dimethyl-
    • (CH3)2NCH2CN
    • DIMETHYLCYANOMETHYLAMINE
    • (Dimethylamino)acetonitrile HCl
    • WLN: NC1N1&1
    • CHEMBL2448941
    • DTXCID9048805
    • (Dimethylamino)acetonitrile, 97%
    • methane, N-cyanomethylmethylamino-
    • EINECS 223-609-5
    • NSC148364
    • AKOS000179555
    • NSC 110567
    • UN 2378
    • (Dimethylamino)acetonitrile monohydrochloride
    • D1929
    • NS00039479
    • EN300-36240
    • Q27160226
    • 2-Dimethylaminoacetonitrile [UN2378] [Flammable liquid]
    • 213-140-4

  • Applications

    Dimethylaminoacetonitrile (CAS 926-64-7) is primarily used as a reactive intermediate in organic synthesis, providing both a dimethylamino functionality and a nitrile handle for subsequent transformations; it is commonly employed as a building block in the preparation of amine-containing intermediates and heterocyclic cores for pharmaceutical and agrochemical development; it can serve as a precursor to cyanomethyl or tertiary amine derivatives, enabling downstream functionalization such as alkylation, acylation, cyclization, or coupling reactions; in addition, it is used in specialty polymers, coatings, and dye/ink chemistries where nitrile and tertiary amine groups are advantageous; overall, its applications are centered on derivatization of complex molecules rather than bulk commodity use, with usage subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.33
    methanol 53.61
    isopropanol 3.6
    water 116.22
    ethyl acetate 3.86
    n-propanol 7.89
    acetone 4.91
    n-butanol 3.16
    acetonitrile 7.98
    DMF 20.12
    toluene 0.66
    isobutanol 3.54
    1,4-dioxane 8.65
    methyl acetate 9.56
    THF 7.61
    2-butanone 3.96
    n-pentanol 1.27
    sec-butanol 3.29
    n-hexane 0.24
    ethylene glycol 70.33
    NMP 60.22
    cyclohexane 0.75
    DMSO 11.86
    n-butyl acetate 6.73
    n-octanol 3.72
    chloroform 20.16
    n-propyl acetate 2.56
    acetic acid 201.96
    dichloromethane 13.92
    cyclohexanone 8.33
    propylene glycol 32.12
    isopropyl acetate 1.45
    DMAc 22.95
    2-ethoxyethanol 6.98
    isopentanol 1.24
    n-heptane 1.14
    ethyl formate 8.5
    1,2-dichloroethane 4.98
    n-hexanol 5.76
    2-methoxyethanol 23.67
    isobutyl acetate 1.82
    tetrachloromethane 6.01
    n-pentyl acetate 3.26
    transcutol 27.64
    n-heptanol 4.25
    ethylbenzene 0.5
    MIBK 0.7
    2-propoxyethanol 18.15
    tert-butanol 3.55
    MTBE 1.02
    2-butoxyethanol 10.86
    propionic acid 47.57
    o-xylene 1.14
    formic acid 236.46
    diethyl ether 1.1
    m-xylene 0.63
    p-xylene 0.85
    chlorobenzene 3.78
    dimethyl carbonate 5.97
    n-octane 0.33
    formamide 95.89
    cyclopentanone 13.17
    2-pentanone 1.29
    anisole 2.36
    cyclopentyl methyl ether 2.88
    gamma-butyrolactone 34.06
    1-methoxy-2-propanol 8.87
    pyridine 9.32
    3-pentanone 2.37
    furfural 45.07
    n-dodecane 0.43
    diethylene glycol 37.03
    diisopropyl ether 0.29
    tert-amyl alcohol 3.64
    acetylacetone 3.53
    n-hexadecane 0.43
    acetophenone 4.38
    methyl propionate 6.5
    isopentyl acetate 5.22
    trichloroethylene 18.09
    n-nonanol 3.55
    cyclohexanol 4.35
    benzyl alcohol 3.95
    2-ethylhexanol 4.35
    isooctanol 2.89
    dipropyl ether 2.92
    1,2-dichlorobenzene 6.39
    ethyl lactate 7.77
    propylene carbonate 21.48
    n-methylformamide 29.35
    2-pentanol 1.14
    n-pentane 0.26
    1-propoxy-2-propanol 12.39
    1-methoxy-2-propyl acetate 9.67
    2-(2-methoxypropoxy) propanol 19.59
    mesitylene 0.51
    ε-caprolactone 13.51
    p-cymene 2.61
    epichlorohydrin 12.17
    1,1,1-trichloroethane 6.35
    2-aminoethanol 43.89
    morpholine-4-carbaldehyde 32.97
    sulfolane 46.68
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 4.79
    n-hexyl acetate 5.54
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 17.06
    sec-butyl acetate 1.31
    tert-butyl acetate 1.86
    decalin 0.41
    glycerin 70.25
    diglyme 21.44
    acrylic acid 88.04
    isopropyl myristate 3.02
    n-butyric acid 16.9
    acetyl acetate 6.9
    di(2-ethylhexyl) phthalate 10.05
    ethyl propionate 2.7
    nitromethane 73.73
    1,2-diethoxyethane 2.82
    benzonitrile 5.17
    trioctyl phosphate 5.61
    1-bromopropane 1.38
    gamma-valerolactone 23.24
    n-decanol 2.95
    triethyl phosphate 7.19
    4-methyl-2-pentanol 0.58
    propionitrile 4.3
    vinylene carbonate 27.32
    1,1,2-trichlorotrifluoroethane 57.96
    DMS 11.77
    cumene 0.7
    2-octanol 1.81
    2-hexanone 1.15
    octyl acetate 5.22
    limonene 3.91
    1,2-dimethoxyethane 5.14
    ethyl orthosilicate 5.67
    tributyl phosphate 6.73
    diacetone alcohol 4.5
    N,N-dimethylaniline 2.35
    acrylonitrile 10.8
    aniline 4.77
    1,3-propanediol 18.4
    bromobenzene 2.48
    dibromomethane 6.95
    1,1,2,2-tetrachloroethane 13.46
    2-methyl-cyclohexyl acetate 9.16
    tetrabutyl urea 8.14
    diisobutyl methanol 1.97
    2-phenylethanol 8.38
    styrene 0.68
    dioctyl adipate 7.9
    dimethyl sulfate 14.9
    ethyl butyrate 5.18
    methyl lactate 15.66
    butyl lactate 8.65
    diethyl carbonate 6.37
    propanediol butyl ether 13.43
    triethyl orthoformate 5.52
    p-tert-butyltoluene 2.69
    methyl 4-tert-butylbenzoate 12.88
    morpholine 10.41
    tert-butylamine 2.07
    n-dodecanol 2.61
    dimethoxymethane 5.49
    ethylene carbonate 14.94
    cyrene 21.93
    2-ethoxyethyl acetate 6.95
    2-ethylhexyl acetate 4.79
    1,2,4-trichlorobenzene 11.53
    4-methylpyridine 3.96
    dibutyl ether 1.39
    2,6-dimethyl-4-heptanol 1.97
    DEF 4.29
    dimethyl isosorbide 29.18
    tetrachloroethylene 17.22
    eugenol 16.57
    triacetin 16.58
    span 80 21.61
    1,4-butanediol 6.55
    1,1-dichloroethane 3.43
    2-methyl-1-pentanol 0.87
    methyl formate 25.06
    2-methyl-1-butanol 2.11
    n-decane 0.48
    butyronitrile 1.84
    3,7-dimethyl-1-octanol 3.21
    1-chlorooctane 1.61
    1-chlorotetradecane 1.11
    n-nonane 0.42
    undecane 0.44
    tert-butylcyclohexane 0.41
    cyclooctane 0.26
    cyclopentanol 8.38
    tetrahydropyran 3.49
    tert-amyl methyl ether 1.23
    2,5,8-trioxanonane 23.78
    1-hexene 0.43
    2-isopropoxyethanol 3.52
    2,2,2-trifluoroethanol 114.76
    methyl butyrate 3.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction