Dimethyl Sulfoxide

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  • Identifiers

    CAS number
    67-68-5

    Molecular formula
    C2H6OS

    SMILES
    CS(=O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Oily 56.75%
    Garlic 55.45%
    Fatty 54.0%
    Sulfurous 53.88%
    Cheesy 52.97%
    Alliaceous 50.1%
    Onion 49.62%
    Pungent 48.47%
    Vegetable 43.24%
    Fishy 41.82%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.6

    Molecular weight
    78.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Melting point expt.

    • 65.3 °F (NTP, 1992)
    • 18.5 °C
    • 18.45 °C

    Boiling point

    • 372 °F at 760 mmHg (NTP, 1992)
    • 63 undefined
    • 189 °C
    • 189.00 to 190.00 °C. @ 760.00 mm Hg

    Flash point est.
    75.17 ˚C

    Flash point expt.

    • 203 °F (NTP, 1992)
    • 95 °C (203 °F) (Open cup)
    • 87 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • 1000000 mg/L
    • Soluble in water
    • Miscible with water
    • Soluble in ethanol, acetone, ether, carbon tetrachloride, ethyl acetate
    • Soluble in chloroform and benzene
    • 1000 mg/mL
    • Solubility in water: miscible
    • soluble in oil and alcohol; miscible with water

  • Synonyms

    • dimethyl sulfoxide
    • DMSO
    • 67-68-5
    • Methyl sulfoxide
    • Methylsulfinylmethane
    • Dimethyl sulphoxide
    • Dimethylsulfoxide
    • Methane, sulfinylbis-
    • Demasorb
    • Demsodrox
    • Demavet
    • Domoso
    • Infiltrina
    • Somipront
    • Dimexide
    • Dolicur
    • Dromisol
    • Durasorb
    • Syntexan
    • Deltan
    • Demeso
    • Hyadur
    • sulfinylbismethane
    • Dimethyl sulfur oxide
    • Doligur
    • Dipirartril-tropico
    • Gamasol 90
    • Sulfinylbis(methane)
    • Dermasorb
    • Kemsol
    • Dimethylsulfoxyde
    • Dimethylsulphoxide
    • Rimso-50
    • Topsym
    • Dimethylsulfoxid
    • Dimetil sulfoxido
    • SQ 9453
    • NSC-763
    • Rimso 50
    • Sulfinylbis-methane
    • Dimethyli sulfoxidum
    • Dimexidum
    • Caswell No. 381
    • (methylsulfinyl)methane
    • Dimetilsolfossido
    • (CH3)2SO
    • DMS-90
    • Sulfoxide, dimethyl
    • methanesulfinylmethane
    • A 10846
    • CCRIS 943
    • M 176
    • DMS 70
    • DMS 90
    • DMS-70
    • DTXSID2021735
    • NSC 763
    • Methyl sulphoxide
    • dimethyl-sulfoxide
    • S(O)Me2
    • MFCD00002089
    • EPA Pesticide Chemical Code 000177
    • SQ-9453
    • NSC763
    • YOW8V9698H
    • CHEBI:28262
    • AI3-26477
    • (methanesulfinyl)methane
    • (DMSO)
    • C2H6OS
    • CHEMBL504
    • Methane, 1,1'-sulfinylbis-
    • DTXCID401735
    • Dimethyl sulfoxide, HPLC Grade
    • Dimethylsulphinyl
    • Dimethyl sulfoxide, 99%
    • Topsym (rescinded)
    • Rimso-5
    • Dimethyl sulfoxide, cryoprotectant vitrification agent
    • Domoso (Veterinary)
    • DIMETHYL SULFOXIDE (II)
    • DIMETHYL SULFOXIDE [II]
    • methylsulfoxide
    • DIMETHYL SULFOXIDE (MART.)
    • DIMETHYL SULFOXIDE [MART.]
    • DIMETHYL SULFOXIDE (USP-RS)
    • DIMETHYL SULFOXIDE [USP-RS]
    • sulfinyldimethane
    • Dimetilsolfossido [DCIT]
    • Dimethyl sulpoxide
    • DIMETHYL SULFOXIDE (EP MONOGRAPH)
    • DIMETHYL SULFOXIDE [EP MONOGRAPH]
    • DIMETHYL SULFOXIDE (USP MONOGRAPH)
    • DIMETHYL SULFOXIDE [USP MONOGRAPH]
    • HSDB 80
    • Sulphoxide, Dimethyl
    • Dimethylsulfoxyde [INN-French]
    • Dimetil sulfoxido [INN-Spanish]
    • Dimethyli sulfoxidum [INN-Latin]
    • DMSO, sterile filtered
    • EINECS 200-664-3
    • UNII-YOW8V9698H
    • dimethysulfoxide
    • dimethlysulfoxide
    • dimethvlsulfoxide
    • dimethyisulfoxide
    • dimethylsulphoxid
    • Domoso Solution
    • dimethy sulfoxide
    • dimetyl sulfoxide
    • Domoso Gel
    • dimethyisulphoxide
    • dimethyl sulfoxyde
    • dimethyl-sulfoxyde
    • dimethyl suiphoxide
    • dimethyl-sulphoxide
    • dirnethyl sulfoxide
    • Dimethyl sulfoxixde
    • methylsulfmylmethane
    • DMSO (anydrous)
    • dimethyl sulf oxide
    • Dimethylis sulfoxidum
    • Zymso (TN)
    • DIMEHTYLSULFOXYDE
    • Dimethyl sulfoxide [USAN:USP:INN:BAN]
    • Methyl sulfoxide (8CI)
    • Rimso-50 (TN)
    • dimethyl sulfoxide (dmso)

  • Applications

    Methyl sulfoxide (dimethyl sulfoxide, DMSO, CAS 67-68-5) is a highly versatile polar aprotic solvent capable of dissolving a broad spectrum of organic and inorganic substances; it is therefore employed in organic synthesis (oxidations, rearrangements, Swern, Kornblum and other anion-mediated reactions), in pharmaceutical and veterinary formulations as a transdermal penetration enhancer, analgesic gel component and injectable excipient, and as the gold-standard cryoprotectant for cells, tissues, embryos and cord-blood stored in biobanks; in biotechnology and tissue culture it preserves membrane integrity during deep-freezing; in the polymer industry it serves as a spinning solvent for acrylic and polyurethane fibers and as a dispersing medium for inks, coatings and paint strippers; the microelectronics sector uses DMSO to strip photoresist, clean microchips and tune electrolyte conductivity in batteries; oil and gas operations apply it for desulfurization, demulsification and flow improvement, while analytical laboratories rely on it as a universal solvent for spectroscopy, NMR and toxicity assays, taking advantage of its high boiling point, low vapor pressure, thermal stability and complete miscibility with water and most organic solvents.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 305.82
    methanol 675.81
    isopropanol 186.23
    water 385.54
    ethyl acetate 81.61
    n-propanol 197.42
    acetone 245.27
    n-butanol 135.1
    acetonitrile 231.38
    DMF 382.82
    toluene 37.23
    isobutanol 120.66
    1,4-dioxane 196.22
    methyl acetate 128.97
    THF 211.36
    2-butanone 144.91
    n-pentanol 75.97
    sec-butanol 138.87
    n-hexane 35.67
    ethylene glycol 313.91
    NMP 319.52
    cyclohexane 49.7
    DMSO 227.53
    n-butyl acetate 55.91
    n-octanol 69.42
    chloroform 218.92
    n-propyl acetate 51.29
    acetic acid 363.64
    dichloromethane 160.98
    cyclohexanone 141.09
    propylene glycol 247.04
    isopropyl acetate 45.79
    DMAc 278.4
    2-ethoxyethanol 160.81
    isopentanol 75.21
    n-heptane 36.42
    ethyl formate 85.59
    1,2-dichloroethane 90.59
    n-hexanol 94.73
    2-methoxyethanol 341.72
    isobutyl acetate 33.19
    tetrachloromethane 75.74
    n-pentyl acetate 42.06
    transcutol 278.08
    n-heptanol 60.37
    ethylbenzene 22.77
    MIBK 43.5
    2-propoxyethanol 187.23
    tert-butanol 146.63
    MTBE 73.21
    2-butoxyethanol 108.67
    propionic acid 211.12
    o-xylene 39.86
    formic acid 340.71
    diethyl ether 108.72
    m-xylene 30.77
    p-xylene 32.66
    chlorobenzene 46.89
    dimethyl carbonate 57.3
    n-octane 14.19
    formamide 310.37
    cyclopentanone 195.24
    2-pentanone 88.73
    anisole 57.56
    cyclopentyl methyl ether 100.89
    gamma-butyrolactone 194.08
    1-methoxy-2-propanol 207.17
    pyridine 125.55
    3-pentanone 96.18
    furfural 179.86
    n-dodecane 10.78
    diethylene glycol 229.93
    diisopropyl ether 29.6
    tert-amyl alcohol 112.75
    acetylacetone 89.82
    n-hexadecane 11.06
    acetophenone 59.77
    methyl propionate 97.35
    isopentyl acetate 42.46
    trichloroethylene 146.27
    n-nonanol 59.39
    cyclohexanol 114.56
    benzyl alcohol 63.35
    2-ethylhexanol 52.92
    isooctanol 41.99
    dipropyl ether 71.9
    1,2-dichlorobenzene 48.86
    ethyl lactate 57.52
    propylene carbonate 89.0
    n-methylformamide 251.12
    2-pentanol 86.23
    n-pentane 41.35
    1-propoxy-2-propanol 126.35
    1-methoxy-2-propyl acetate 67.98
    2-(2-methoxypropoxy) propanol 101.05
    mesitylene 21.63
    ε-caprolactone 117.99
    p-cymene 27.58
    epichlorohydrin 131.81
    1,1,1-trichloroethane 98.81
    2-aminoethanol 317.31
    morpholine-4-carbaldehyde 265.89
    sulfolane 195.8
    2,2,4-trimethylpentane 13.83
    2-methyltetrahydrofuran 133.05
    n-hexyl acetate 66.95
    isooctane 9.0
    2-(2-butoxyethoxy)ethanol 129.83
    sec-butyl acetate 32.66
    tert-butyl acetate 45.12
    decalin 15.76
    glycerin 335.68
    diglyme 189.12
    acrylic acid 235.55
    isopropyl myristate 32.55
    n-butyric acid 134.27
    acetyl acetate 63.05
    di(2-ethylhexyl) phthalate 40.01
    ethyl propionate 55.58
    nitromethane 330.55
    1,2-diethoxyethane 73.0
    benzonitrile 62.28
    trioctyl phosphate 29.81
    1-bromopropane 61.19
    gamma-valerolactone 206.41
    n-decanol 46.17
    triethyl phosphate 34.78
    4-methyl-2-pentanol 39.5
    propionitrile 129.97
    vinylene carbonate 89.86
    1,1,2-trichlorotrifluoroethane 192.97
    DMS 64.11
    cumene 20.89
    2-octanol 41.8
    2-hexanone 62.42
    octyl acetate 46.06
    limonene 42.8
    1,2-dimethoxyethane 171.65
    ethyl orthosilicate 33.97
    tributyl phosphate 32.54
    diacetone alcohol 84.0
    N,N-dimethylaniline 52.66
    acrylonitrile 165.33
    aniline 82.41
    1,3-propanediol 222.45
    bromobenzene 36.1
    dibromomethane 114.87
    1,1,2,2-tetrachloroethane 137.14
    2-methyl-cyclohexyl acetate 47.75
    tetrabutyl urea 48.91
    diisobutyl methanol 32.27
    2-phenylethanol 63.91
    styrene 28.79
    dioctyl adipate 49.72
    dimethyl sulfate 80.42
    ethyl butyrate 48.75
    methyl lactate 108.35
    butyl lactate 56.38
    diethyl carbonate 37.07
    propanediol butyl ether 126.1
    triethyl orthoformate 40.77
    p-tert-butyltoluene 28.08
    methyl 4-tert-butylbenzoate 67.72
    morpholine 217.22
    tert-butylamine 109.03
    n-dodecanol 37.97
    dimethoxymethane 166.22
    ethylene carbonate 73.43
    cyrene 93.77
    2-ethoxyethyl acetate 59.55
    2-ethylhexyl acetate 36.56
    1,2,4-trichlorobenzene 64.47
    4-methylpyridine 94.29
    dibutyl ether 48.47
    2,6-dimethyl-4-heptanol 32.27
    DEF 120.15
    dimethyl isosorbide 112.76
    tetrachloroethylene 127.84
    eugenol 83.28
    triacetin 81.18
    span 80 109.22
    1,4-butanediol 106.94
    1,1-dichloroethane 100.89
    2-methyl-1-pentanol 49.86
    methyl formate 168.78
    2-methyl-1-butanol 89.19
    n-decane 17.08
    butyronitrile 85.51
    3,7-dimethyl-1-octanol 51.54
    1-chlorooctane 34.38
    1-chlorotetradecane 18.28
    n-nonane 17.79
    undecane 12.84
    tert-butylcyclohexane 15.34
    cyclooctane 17.69
    cyclopentanol 155.39
    tetrahydropyran 137.5
    tert-amyl methyl ether 61.82
    2,5,8-trioxanonane 152.24
    1-hexene 52.37
    2-isopropoxyethanol 95.36
    2,2,2-trifluoroethanol 218.68
    methyl butyrate 62.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Oenothera odorata flower headspace (China) Oenothera odorata Jacq., fam. Onagraceae 0.59%