Dimethyl Isosorbide

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  • Identifiers

    CAS number
    5306-85-4

    Molecular formula
    C8H14O4

    SMILES
    CO[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC

    Safety labels

  • Odor profile

    Fragrance
    Odorless 46.61%
    Alcoholic 26.2%
    Ethereal 24.54%
    Caramellic 21.91%
    Fruity 20.36%
    Sweet 19.74%
    Solvent 19.32%
    Buttery 19.18%
    Malty 18.61%
    Mint 17.66%

     

    Flavor
    Sweet 40.7%
    Bitter 34.88%
    Fatty 32.79%
    Vegetable 25.56%
    Cauliflower 23.83%
    Caramel 23.79%
    Roasted 23.18%
    Sweet-like 23.15%
    Oily 21.54%
    Alkaline 21.2%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    4.53 (weak acid)

    Molecular weight
    174.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    255°C

    Flash point

    • 95.81 ˚C est.

  • Synonyms

    • Isosorbide dimethyl ether
    • 5306-85-4
    • Dimethyl isosorbide
    • 2,5-Dimethylisosorbide
    • 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
    • SA6A6V432S
    • NSC-40727
    • NSC-44695
    • D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
    • DTXSID201019399
    • RefChem:134248
    • 2,5-O-dimethylisosorbide
    • DTXCID201477371
    • 226-159-8
    • Arlasolve DMI
    • (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan
    • MFCD00064828
    • (3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
    • 2,5-Di-O-methyl-1,4:3,6-dianhydro-D-glucitol
    • (3R,3aR,6S,6aR)-3,6-dimethoxy-hexahydrofuro[3,2-b]furan
    • 1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether
    • dimethyl isosorbide ether
    • dimethyl isosorbide, ResCo
    • UNII-SA6A6V432S
    • EINECS 226-159-8
    • Dimethyl isosorb ide
    • NSC 40727
    • NSC 44695
    • Isosorbide, dimethyl ether
    • Sorbitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
    • SCHEMBL301881
    • Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-, D-
    • DIMETHYL ISOSORBIDE [II]
    • Isosorbide dimethyl ether, 98%
    • NSC40727
    • NSC44695
    • AC8407
    • AKOS016010544
    • MD41783
    • AS-17682
    • SY038265
    • HY-134524
    • CS-0144267
    • I0390
    • NS00081463
    • ST50405701
    • F242921
    • D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl
    • Q5807233
    • (4S,1R,5R,8R)-4,8-dimethoxy-2,6-dioxabicyclo[3.3.0]octane
    • 5306-85-4

  • Applications

    Dimethyl Isosorbide (CAS 5306-85-4) is a polar, high-boiling solvent increasingly used as a formulation aid across multiple industries. In pharmaceuticals and biotech, it serves as a drug solubilizer and co-solvent to help dissolve poorly soluble actives for oral, topical or transdermal products, and as a processing excipient in various delivery systems. In cosmetics and personal care, it functions as a solvent to dissolve active ingredients and stabilize formulations. In perfumery and flavors, it is used as a solvent for aroma compounds, enabling consistent dispersion and release. In coatings, inks and adhesives, Dimethyl Isosorbide acts as a processing solvent/co-solvent to adjust viscosity and promote film formation. It is also employed in cleaning formulations as a specialty solvent for resins and oils. Usage is formulation-driven and subject to local regulations and limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 330.05
    methanol 754.71
    isopropanol 179.07
    water 704.28
    ethyl acetate 342.74
    n-propanol 219.29
    acetone 371.97
    n-butanol 169.35
    acetonitrile 435.63
    DMF 672.06
    toluene 41.05
    isobutanol 142.71
    1,4-dioxane 425.76
    methyl acetate 342.73
    THF 429.56
    2-butanone 174.86
    n-pentanol 89.28
    sec-butanol 129.63
    n-hexane 3.34
    ethylene glycol 515.93
    NMP 416.52
    cyclohexane 15.79
    DMSO 557.6
    n-butyl acetate 102.89
    n-octanol 52.18
    chloroform 1163.97
    n-propyl acetate 135.12
    acetic acid 1837.17
    dichloromethane 1059.49
    cyclohexanone 261.91
    propylene glycol 211.79
    isopropyl acetate 170.01
    DMAc 416.48
    2-ethoxyethanol 449.2
    isopentanol 117.83
    n-heptane 6.0
    ethyl formate 428.03
    1,2-dichloroethane 432.18
    n-hexanol 71.54
    2-methoxyethanol 918.83
    isobutyl acetate 74.49
    tetrachloromethane 216.42
    n-pentyl acetate 75.31
    transcutol 470.83
    n-heptanol 58.72
    ethylbenzene 23.23
    MIBK 86.71
    2-propoxyethanol 292.02
    tert-butanol 169.39
    MTBE 79.8
    2-butoxyethanol 203.1
    propionic acid 491.98
    o-xylene 40.35
    formic acid 2130.48
    diethyl ether 110.44
    m-xylene 36.11
    p-xylene 38.28
    chlorobenzene 145.41
    dimethyl carbonate 208.66
    n-octane 3.85
    formamide 2023.12
    cyclopentanone 353.23
    2-pentanone 142.04
    anisole 88.72
    cyclopentyl methyl ether 153.75
    gamma-butyrolactone 738.47
    1-methoxy-2-propanol 428.95
    pyridine 311.83
    3-pentanone 113.33
    furfural 853.27
    n-dodecane 4.36
    diethylene glycol 445.77
    diisopropyl ether 30.81
    tert-amyl alcohol 121.38
    acetylacetone 294.87
    n-hexadecane 4.89
    acetophenone 123.48
    methyl propionate 271.1
    isopentyl acetate 85.25
    trichloroethylene 1029.73
    n-nonanol 47.15
    cyclohexanol 156.52
    benzyl alcohol 139.26
    2-ethylhexanol 44.11
    isooctanol 47.25
    dipropyl ether 50.22
    1,2-dichlorobenzene 173.8
    ethyl lactate 141.37
    propylene carbonate 434.81
    n-methylformamide 779.3
    2-pentanol 91.6
    n-pentane 6.04
    1-propoxy-2-propanol 148.21
    1-methoxy-2-propyl acetate 152.26
    2-(2-methoxypropoxy) propanol 130.8
    mesitylene 27.0
    ε-caprolactone 346.14
    p-cymene 27.08
    epichlorohydrin 601.73
    1,1,1-trichloroethane 369.24
    2-aminoethanol 424.92
    morpholine-4-carbaldehyde 594.83
    sulfolane 551.87
    2,2,4-trimethylpentane 6.79
    2-methyltetrahydrofuran 222.93
    n-hexyl acetate 97.74
    isooctane 4.14
    2-(2-butoxyethoxy)ethanol 168.6
    sec-butyl acetate 85.78
    tert-butyl acetate 127.04
    decalin 8.35
    glycerin 604.6
    diglyme 419.48
    acrylic acid 675.03
    isopropyl myristate 38.75
    n-butyric acid 547.74
    acetyl acetate 365.3
    di(2-ethylhexyl) phthalate 48.84
    ethyl propionate 140.83
    nitromethane 2124.74
    1,2-diethoxyethane 108.01
    benzonitrile 175.38
    trioctyl phosphate 36.61
    1-bromopropane 97.68
    gamma-valerolactone 616.84
    n-decanol 33.47
    triethyl phosphate 76.33
    4-methyl-2-pentanol 54.12
    propionitrile 197.25
    vinylene carbonate 528.99
    1,1,2-trichlorotrifluoroethane 866.69
    DMS 128.94
    cumene 23.68
    2-octanol 34.57
    2-hexanone 66.85
    octyl acetate 51.64
    limonene 36.75
    1,2-dimethoxyethane 381.05
    ethyl orthosilicate 66.76
    tributyl phosphate 45.09
    diacetone alcohol 166.12
    N,N-dimethylaniline 63.7
    acrylonitrile 392.45
    aniline 131.67
    1,3-propanediol 548.07
    bromobenzene 122.74
    dibromomethane 437.5
    1,1,2,2-tetrachloroethane 640.19
    2-methyl-cyclohexyl acetate 78.11
    tetrabutyl urea 54.01
    diisobutyl methanol 31.73
    2-phenylethanol 103.63
    styrene 30.54
    dioctyl adipate 68.61
    dimethyl sulfate 335.58
    ethyl butyrate 102.75
    methyl lactate 259.99
    butyl lactate 82.66
    diethyl carbonate 94.56
    propanediol butyl ether 131.06
    triethyl orthoformate 88.42
    p-tert-butyltoluene 27.57
    methyl 4-tert-butylbenzoate 118.05
    morpholine 435.61
    tert-butylamine 85.4
    n-dodecanol 25.61
    dimethoxymethane 392.76
    ethylene carbonate 390.06
    cyrene 176.21
    2-ethoxyethyl acetate 129.33
    2-ethylhexyl acetate 62.64
    1,2,4-trichlorobenzene 211.81
    4-methylpyridine 188.63
    dibutyl ether 38.04
    2,6-dimethyl-4-heptanol 31.73
    DEF 255.0
    dimethyl isosorbide 208.9
    tetrachloroethylene 608.09
    eugenol 129.65
    triacetin 154.63
    span 80 100.85
    1,4-butanediol 187.67
    1,1-dichloroethane 345.85
    2-methyl-1-pentanol 69.42
    methyl formate 729.65
    2-methyl-1-butanol 115.09
    n-decane 6.56
    butyronitrile 164.35
    3,7-dimethyl-1-octanol 43.77
    1-chlorooctane 28.36
    1-chlorotetradecane 13.09
    n-nonane 5.78
    undecane 5.13
    tert-butylcyclohexane 6.91
    cyclooctane 5.93
    cyclopentanol 214.45
    tetrahydropyran 192.64
    tert-amyl methyl ether 66.74
    2,5,8-trioxanonane 245.22
    1-hexene 12.63
    2-isopropoxyethanol 218.44
    2,2,2-trifluoroethanol 1291.8
    methyl butyrate 185.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction