Dimethyl glutamic acid

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  • Identifiers

    CAS number
    6312-54-5

    Molecular formula
    C7H13NO4

    SMILES
    CN(C)[C@@H](CCC(=O)O)C(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 58.63%
    Savory 33.39%
    Sweet 32.15%
    Meaty 26.33%
    Milky 24.55%
    Cheesy 23.13%
    Sour 22.6%
    Creamy 19.57%
    Buttery 19.23%
    Cooked 18.15%

     

    Flavor
    Odorless 65.83%
    Mild 35.68%
    Bland 29.72%
    Sour 27.47%
    Very mild 27.27%
    Yeast 24.06%
    Acidic 22.11%
    Sweet-like 21.63%
    Stinky 20.88%
    Roquefort cheese 20.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.5

    pKa est.
    6.15 (neutral)

    Molecular weight
    175.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    341°C

    Flash point

    • 173.48 ˚C est.

  • Synonyms

    • n,n-dimethylglutamic acid
    • Dimethyl glutamic acid
    • 2E8WP6L8DL
    • L-Glutamic acid, N,N-dimethyl-
    • UNII-2E8WP6L8DL
    • Glutamic acid, N,N-dimethyl-, L-
    • NSC-40352
    • 6312-54-5
    • RefChem:200612
    • DIMETHYL GLUTAMIC ACID [INCI]
    • dimethylglutamic acid
    • (2S)-2-(dimethylamino)pentanedioic acid
    • N,N-Dimethyl-L-glutamic acid
    • SCHEMBL198528
    • DTXSID401021566
    • (S)-2-(dimethylamino)pentanedioic acid
    • EN300-7844608
    • Q27254619
    • 6312-54-5

  • Applications

    Dimethyl glutamic acid (CAS 6312-54-5) is primarily used as a protected amino acid derivative and versatile intermediate in organic synthesis. In pharmaceutical and fine chemical manufacturing it serves as a starting material for the preparation of amino acid esters, peptidomimetics, and other glutamate-derived compounds, and as a precursor to polymerizable derivatives for glutamate-based materials. It can also function as a building block in laboratory-scale method development and catalyst design, and is sometimes employed in industrial manufacturing as a feedstock for the synthesis of specialty chemicals. Overall, its role is that of a reactive intermediate, with applications governed by formulation constraints and local regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.97
    methanol 51.36
    isopropanol 4.31
    water 158.62
    ethyl acetate 3.14
    n-propanol 7.98
    acetone 2.69
    n-butanol 5.21
    acetonitrile 2.53
    DMF 115.14
    toluene 0.43
    isobutanol 4.17
    1,4-dioxane 20.07
    methyl acetate 2.71
    THF 23.95
    2-butanone 2.24
    n-pentanol 3.7
    sec-butanol 3.44
    n-hexane 0.25
    ethylene glycol 80.98
    NMP 427.56
    cyclohexane 0.3
    DMSO 129.56
    n-butyl acetate 3.1
    n-octanol 4.15
    chloroform 0.7
    n-propyl acetate 2.42
    acetic acid 84.2
    dichloromethane 2.21
    cyclohexanone 17.49
    propylene glycol 48.81
    isopropyl acetate 2.12
    DMAc 112.93
    2-ethoxyethanol 33.36
    isopentanol 3.19
    n-heptane 0.45
    ethyl formate 7.0
    1,2-dichloroethane 1.88
    n-hexanol 4.99
    2-methoxyethanol 103.78
    isobutyl acetate 1.43
    tetrachloromethane 0.29
    n-pentyl acetate 3.31
    transcutol 68.1
    n-heptanol 5.05
    ethylbenzene 0.54
    MIBK 1.92
    2-propoxyethanol 33.99
    tert-butanol 4.77
    MTBE 1.11
    2-butoxyethanol 22.29
    propionic acid 29.78
    o-xylene 1.2
    formic acid 379.73
    diethyl ether 1.23
    m-xylene 0.88
    p-xylene 0.93
    chlorobenzene 0.68
    dimethyl carbonate 7.03
    n-octane 0.24
    formamide 247.74
    cyclopentanone 27.31
    2-pentanone 2.39
    anisole 1.99
    cyclopentyl methyl ether 8.1
    gamma-butyrolactone 86.62
    1-methoxy-2-propanol 46.22
    pyridine 5.54
    3-pentanone 2.39
    furfural 75.15
    n-dodecane 0.17
    diethylene glycol 67.04
    diisopropyl ether 0.57
    tert-amyl alcohol 4.62
    acetylacetone 6.34
    n-hexadecane 0.18
    acetophenone 5.11
    methyl propionate 7.25
    isopentyl acetate 2.76
    trichloroethylene 2.58
    n-nonanol 4.04
    cyclohexanol 7.83
    benzyl alcohol 4.88
    2-ethylhexanol 2.84
    isooctanol 3.57
    dipropyl ether 2.46
    1,2-dichlorobenzene 1.51
    ethyl lactate 9.36
    propylene carbonate 29.8
    n-methylformamide 72.55
    2-pentanol 2.15
    n-pentane 0.19
    1-propoxy-2-propanol 17.42
    1-methoxy-2-propyl acetate 10.25
    2-(2-methoxypropoxy) propanol 23.87
    mesitylene 0.87
    ε-caprolactone 35.0
    p-cymene 1.13
    epichlorohydrin 24.04
    1,1,1-trichloroethane 0.51
    2-aminoethanol 87.51
    morpholine-4-carbaldehyde 243.59
    sulfolane 207.85
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 10.45
    n-hexyl acetate 5.4
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 37.94
    sec-butyl acetate 1.47
    tert-butyl acetate 3.11
    decalin 0.29
    glycerin 156.24
    diglyme 45.73
    acrylic acid 48.41
    isopropyl myristate 1.74
    n-butyric acid 18.82
    acetyl acetate 2.99
    di(2-ethylhexyl) phthalate 5.14
    ethyl propionate 3.34
    nitromethane 50.11
    1,2-diethoxyethane 4.41
    benzonitrile 3.15
    trioctyl phosphate 4.01
    1-bromopropane 0.54
    gamma-valerolactone 120.3
    n-decanol 2.91
    triethyl phosphate 4.27
    4-methyl-2-pentanol 1.5
    propionitrile 1.97
    vinylene carbonate 26.05
    1,1,2-trichlorotrifluoroethane 49.38
    DMS 8.25
    cumene 0.78
    2-octanol 2.55
    2-hexanone 1.81
    octyl acetate 3.18
    limonene 1.47
    1,2-dimethoxyethane 21.29
    ethyl orthosilicate 3.58
    tributyl phosphate 4.02
    diacetone alcohol 12.57
    N,N-dimethylaniline 3.85
    acrylonitrile 5.01
    aniline 2.56
    1,3-propanediol 55.82
    bromobenzene 0.44
    dibromomethane 0.93
    1,1,2,2-tetrachloroethane 2.71
    2-methyl-cyclohexyl acetate 4.45
    tetrabutyl urea 7.68
    diisobutyl methanol 1.78
    2-phenylethanol 5.23
    styrene 0.43
    dioctyl adipate 4.41
    dimethyl sulfate 31.9
    ethyl butyrate 3.11
    methyl lactate 28.16
    butyl lactate 10.13
    diethyl carbonate 2.43
    propanediol butyl ether 29.77
    triethyl orthoformate 3.91
    p-tert-butyltoluene 1.11
    methyl 4-tert-butylbenzoate 13.33
    morpholine 37.74
    tert-butylamine 1.66
    n-dodecanol 2.09
    dimethoxymethane 21.42
    ethylene carbonate 17.6
    cyrene 50.68
    2-ethoxyethyl acetate 6.77
    2-ethylhexyl acetate 2.32
    1,2,4-trichlorobenzene 2.57
    4-methylpyridine 4.75
    dibutyl ether 1.76
    2,6-dimethyl-4-heptanol 1.78
    DEF 19.76
    dimethyl isosorbide 43.23
    tetrachloroethylene 2.1
    eugenol 16.23
    triacetin 10.88
    span 80 25.25
    1,4-butanediol 20.02
    1,1-dichloroethane 0.5
    2-methyl-1-pentanol 2.83
    methyl formate 33.91
    2-methyl-1-butanol 3.8
    n-decane 0.28
    butyronitrile 2.03
    3,7-dimethyl-1-octanol 2.77
    1-chlorooctane 0.87
    1-chlorotetradecane 0.43
    n-nonane 0.26
    undecane 0.21
    tert-butylcyclohexane 0.25
    cyclooctane 0.23
    cyclopentanol 14.32
    tetrahydropyran 4.98
    tert-amyl methyl ether 1.89
    2,5,8-trioxanonane 39.7
    1-hexene 0.54
    2-isopropoxyethanol 12.68
    2,2,2-trifluoroethanol 41.55
    methyl butyrate 5.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction