Diisopropyl ether

Overview IFRA Request a quote

  • Identifiers

    CAS number
    108-20-3

    Molecular formula
    C6H14O

    SMILES
    CC(C)OC(C)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 77.94%
    Alcoholic 57.04%
    Fermented 53.38%
    Green 49.79%
    Fruity 49.15%
    Solvent 48.12%
    Pungent 43.52%
    Fresh 42.13%
    Cocoa 37.17%
    Malty 33.31%

     

    Flavor
    Ethereal 34.29%
    Fishy 25.9%
    Solvent 25.87%
    Oily 25.11%
    Fermented 24.99%
    Sulfurous 23.4%
    Green 23.22%
    Pungent 22.28%
    Glue 22.01%
    Yeasty 21.95%

     

    Odor impact est.
    High

    Odor threshold

    • Odor Threshold Low: 0.01 [mmHg]. Odor Threshold High: 0.05 [mmHg]. Detection odor threshold from AIHA (mean = 0.017 ppm)
    • WATER: 0.00080 MG/L; AIR: 0.017 UL/L; ODOR SAFETY CLASS A; A= MORE THAN 90% OF DISTRACTED PERSONS PERCEIVE WARNING OF TLV CONCN IN THE AIR.
    • 0.07 mg/cu m (odor low) 1260.00 mg/cu m (odor high).

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    8.94 (weak base)

    Molecular weight
    102.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -123 °F (USCG, 1999)
    • -86.8 °C
    • -60 °C
    • -123 °F
    • -76 °F

    Boiling point

    • 156 °F at 760 mmHg (USCG, 1999)
    • 68.5 °C
    • 69 °C
    • 154 °F

    Flash point

    • -25.88 ˚C est.
    • -18 °F (USCG, 1999)
    • -28 °C
    • -18 °F (-28 °C) (closed cup)
    • -18 °F

    Solubility expt.

    • 0.2 % (NIOSH, 2024)
    • Sol of commercial grade in water, 1.71% @ 19 °C; miscible with most organic solvents.
    • Sol in acetone; miscible in ethyl alcohol, ethyl ether
    • MISCIBLE WITH MOST ORG SOLVENTS
    • Water solubility = 8,800 mg/l @ 20 °C
    • Soluble in oxygenated solvents
    • Solubility in water: poor
    • 0.2%

  • Synonyms

    • Diisopropyl ether
    • ISOPROPYL ETHER
    • 108-20-3
    • Propane, 2,2'-oxybis-
    • 2-Isopropoxypropane
    • diisopropylether
    • Diisopropyl oxide
    • Isopropylether
    • 2,2'-oxydipropane
    • Ether, isopropyl
    • Bis(isopropyl) ether
    • 2,2'-Oxybis-propane
    • Izopropylowy eter
    • 2-propan-2-yloxypropane
    • di-iso-propylether
    • Di-isopropyl ether
    • Ether isopropylique
    • DIPE
    • 2,2'-Oxybispropane
    • HSDB 624
    • DIISOPROPYL-ETHER
    • Diiospropyl ether
    • 2-propyl ether
    • EINECS 203-560-6
    • UN1159
    • DTXSID4021890
    • UNII-DO7Y998826
    • AI3-24270
    • (iso-C3H7)2O
    • 1,1'-Dimethyldiethyl ether
    • ISOPROPYL ETHER [MI]
    • ISOPROPYL ETHER [HSDB]
    • DTXCID401890
    • EC 203-560-6
    • DO7Y998826
    • UN 1159
    • Isopropyl ether (stabilized with BHT)
    • Izopropylowy eter [Polish]
    • Ether isopropylique [French]
    • MFCD00008880
    • diisoproylether
    • diisopropyloxide
    • isopropy ether
    • i-propyl ether
    • di-isopropylether
    • diisoproply ether
    • iso-propyl ether
    • 2Isopropoxypropane
    • di-isopropyl-ether
    • Diisopropyl ether, contains either BHT or hydroquinone as stabilizer, ACS reagent, >=99.0%
    • Di Isopropyl Ether
    • 2,2'oxybispropane
    • di-iso-propyl ether
    • di-iso-propyl-ether
    • iPr2O
    • Di(2-propyl) ether
    • i-Pr2O
    • Propane, 2,2'oxybis
    • bis(1-methylethyl)ether
    • (i-Pr)2O
    • SCHEMBL1296
    • 2-(propan-2-yloxy)propane
    • Diisopropyl ether, LR, 98%
    • Isopropyl ether (ACGIH:OSHA)
    • CHEMBL3185565
    • Diisopropyl ether, LR, >=98%
    • Tox21_202551
    • STL280503
    • Diisopropyl ether, analytical standard
    • AKOS009031514
    • NCGC00166211-01
    • NCGC00260100-01
    • CAS-108-20-3
    • Diisopropyl ether, Stabilized, ACS Grade
    • I0172
    • I0917
    • NS00003939
    • Diisopropyl ether, SAJ first grade, >=99.0%
    • Diisopropyl ether, JIS special grade, >=99.0%
    • Diisopropyl ether [UN1159] [Flammable liquid]
    • Q418989
    • Diisopropyl ether, puriss. p.a., >=98.5% (GC)
    • F0001-0159
    • Diisopropyl ether, p.a., 99.0%, contains 0.0004-0.0007% BHT
    • Diisopropyl etheranhydrous, contains BHT (50-100 ppm) as stabilizer
    • Diisopropyl ether, anhydrous, 99%, contains either BHT or hydroquinone as stabilizer
    • Diisopropyl ether, ReagentPlus(R), 99%, contains either BHT or hydroquinone as stabilizer
    • Diisopropyl ether, UV HPLC spectroscopic, 99.8%, contains 0.0004-0.0007% BHT

  • Applications

    Diisopropyl ether (CAS 108-20-3) is a non-polar, low-boiling solvent commonly used as a solvent in organic synthesis and purification operations, for example as a medium for Grignard reactions and other liquid-phase processes. It is also used as a processing solvent in the manufacture of polymers and plastics, meeting requirements for solvent compatibility and solubility. In coatings, inks and adhesives, DIPE serves as a solvent medium to dissolve and disperse components. In the pharmaceutical sector, it is frequently employed as a solvent for extraction or purification and recrystallization. It is also used in industrial and laboratory cleaning due to its volatility and solvent properties. However, use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 625.89
    methanol 701.66
    isopropanol 460.04
    water 7.01
    ethyl acetate 490.71
    n-propanol 542.18
    acetone 435.3
    n-butanol 543.23
    acetonitrile 334.59
    DMF 336.23
    toluene 359.89
    isobutanol 394.8
    1,4-dioxane 783.99
    methyl acetate 463.95
    THF 1083.03
    2-butanone 452.36
    n-pentanol 316.65
    sec-butanol 546.74
    n-hexane 643.13
    ethylene glycol 163.94
    NMP 756.19
    cyclohexane 756.81
    DMSO 313.68
    n-butyl acetate 499.0
    n-octanol 382.44
    chloroform 1325.77
    n-propyl acetate 270.91
    acetic acid 603.05
    dichloromethane 981.84
    cyclohexanone 793.77
    propylene glycol 231.88
    isopropyl acetate 282.99
    DMAc 447.22
    2-ethoxyethanol 313.96
    isopentanol 377.92
    n-heptane 569.56
    ethyl formate 261.37
    1,2-dichloroethane 550.38
    n-hexanol 721.95
    2-methoxyethanol 556.87
    isobutyl acetate 199.79
    tetrachloromethane 511.24
    n-pentyl acetate 359.04
    transcutol 905.64
    n-heptanol 298.61
    ethylbenzene 211.62
    MIBK 215.49
    2-propoxyethanol 695.89
    tert-butanol 509.79
    MTBE 578.54
    2-butoxyethanol 332.78
    propionic acid 484.65
    o-xylene 264.54
    formic acid 202.43
    diethyl ether 734.75
    m-xylene 243.66
    p-xylene 259.38
    chlorobenzene 366.65
    dimethyl carbonate 111.7
    n-octane 166.99
    formamide 155.39
    cyclopentanone 676.9
    2-pentanone 363.97
    anisole 260.41
    cyclopentyl methyl ether 761.28
    gamma-butyrolactone 722.84
    1-methoxy-2-propanol 406.14
    pyridine 471.15
    3-pentanone 384.67
    furfural 493.93
    n-dodecane 102.06
    diethylene glycol 419.0
    diisopropyl ether 253.85
    tert-amyl alcohol 577.36
    acetylacetone 314.17
    n-hexadecane 110.56
    acetophenone 214.86
    methyl propionate 362.15
    isopentyl acetate 404.1
    trichloroethylene 833.4
    n-nonanol 325.67
    cyclohexanol 772.98
    benzyl alcohol 198.43
    2-ethylhexanol 491.54
    isooctanol 225.83
    dipropyl ether 638.1
    1,2-dichlorobenzene 339.33
    ethyl lactate 141.97
    propylene carbonate 426.46
    n-methylformamide 241.56
    2-pentanol 413.45
    n-pentane 454.38
    1-propoxy-2-propanol 584.27
    1-methoxy-2-propyl acetate 422.39
    2-(2-methoxypropoxy) propanol 308.9
    mesitylene 156.17
    ε-caprolactone 716.67
    p-cymene 213.42
    epichlorohydrin 623.65
    1,1,1-trichloroethane 752.99
    2-aminoethanol 285.0
    morpholine-4-carbaldehyde 603.44
    sulfolane 706.37
    2,2,4-trimethylpentane 180.29
    2-methyltetrahydrofuran 1109.75
    n-hexyl acetate 575.67
    isooctane 104.95
    2-(2-butoxyethoxy)ethanol 379.58
    sec-butyl acetate 218.87
    tert-butyl acetate 322.88
    decalin 229.74
    glycerin 259.81
    diglyme 588.91
    acrylic acid 350.02
    isopropyl myristate 241.1
    n-butyric acid 526.71
    acetyl acetate 313.64
    di(2-ethylhexyl) phthalate 179.15
    ethyl propionate 275.79
    nitromethane 429.09
    1,2-diethoxyethane 465.39
    benzonitrile 244.02
    trioctyl phosphate 146.73
    1-bromopropane 623.22
    gamma-valerolactone 699.86
    n-decanol 232.85
    triethyl phosphate 187.03
    4-methyl-2-pentanol 203.13
    propionitrile 343.09
    vinylene carbonate 337.71
    1,1,2-trichlorotrifluoroethane 544.03
    DMS 316.06
    cumene 162.03
    2-octanol 257.27
    2-hexanone 287.25
    octyl acetate 292.4
    limonene 425.49
    1,2-dimethoxyethane 515.81
    ethyl orthosilicate 200.74
    tributyl phosphate 185.66
    diacetone alcohol 288.88
    N,N-dimethylaniline 200.45
    acrylonitrile 282.46
    aniline 327.09
    1,3-propanediol 350.05
    bromobenzene 386.5
    dibromomethane 898.24
    1,1,2,2-tetrachloroethane 801.09
    2-methyl-cyclohexyl acetate 345.74
    tetrabutyl urea 228.92
    diisobutyl methanol 236.44
    2-phenylethanol 290.62
    styrene 224.53
    dioctyl adipate 282.61
    dimethyl sulfate 159.55
    ethyl butyrate 345.93
    methyl lactate 179.19
    butyl lactate 237.86
    diethyl carbonate 211.68
    propanediol butyl ether 293.43
    triethyl orthoformate 290.91
    p-tert-butyltoluene 214.42
    methyl 4-tert-butylbenzoate 299.08
    morpholine 827.53
    tert-butylamine 459.38
    n-dodecanol 185.91
    dimethoxymethane 305.42
    ethylene carbonate 318.83
    cyrene 230.04
    2-ethoxyethyl acetate 373.64
    2-ethylhexyl acetate 387.43
    1,2,4-trichlorobenzene 402.48
    4-methylpyridine 515.2
    dibutyl ether 487.52
    2,6-dimethyl-4-heptanol 236.44
    DEF 413.11
    dimethyl isosorbide 495.12
    tetrachloroethylene 659.34
    eugenol 221.2
    triacetin 406.91
    span 80 364.22
    1,4-butanediol 150.34
    1,1-dichloroethane 635.84
    2-methyl-1-pentanol 269.7
    methyl formate 194.28
    2-methyl-1-butanol 445.55
    n-decane 182.5
    butyronitrile 347.19
    3,7-dimethyl-1-octanol 349.75
    1-chlorooctane 383.95
    1-chlorotetradecane 159.53
    n-nonane 214.63
    undecane 127.26
    tert-butylcyclohexane 217.96
    cyclooctane 284.71
    cyclopentanol 680.28
    tetrahydropyran 1073.05
    tert-amyl methyl ether 558.78
    2,5,8-trioxanonane 420.13
    1-hexene 653.03
    2-isopropoxyethanol 260.29
    2,2,2-trifluoroethanol 205.42
    methyl butyrate 306.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction