dihydronicotinamide-adenine dinucleotide, disodium salt

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  • Identifiers

    CAS number
    606-68-8

    Molecular formula
    C21H27N7Na2O14P2

    SMILES
    C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O.[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 86.63%
    Savory 22.69%
    Cooling 18.9%
    Cooked 15.65%
    Milky 15.58%
    Bitter 15.39%
    Sweet 15.05%
    Meaty 13.29%
    Clean 13.06%
    Alcoholic 12.91%

     

    Flavor
    Bitter 74.49%
    Odorless 49.46%
    Bland 32.87%
    Very mild 24.88%
    Sweet-like 23.68%
    Yeast 19.43%
    Nitrile 19.21%
    Mild 18.87%
    Cedarleaf 18.87%
    Scallion 18.4%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    4.14 (weak acid)

    Molecular weight
    709.4 g/mol

    Flash point

    • 436.2 ˚C est.

  • Synonyms

    • Dihydronicotinamide-adenine dinucleotide, disodium salt
    • RefChem:587765
    • 606-68-8
    • Disodium nicotinamide adenine dinucleotide
    • beta-Nicotinamide Adenine Dinucleotide Disodium Salt
    • NADH disodium salt
    • beta-NADH Disodium Salt
    • 8295030YNC
    • b-NADH Disodium Salt
    • MFCD00036200
    • disodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
    • NADH disodium salt hydrate
    • ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt
    • disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate
    • UNII-8295030YNC
    • NADH-Dinatriumsalz
    • EINECS 210-123-3
    • | cent-NADH
    • Cozymase Disodium Salt
    • NADH.2Na
    • Reduced beta-nicotinamide adenine dinucleotide disodium salt
    • Nicotinamide Impurity 2
    • beta-DPNH Disodium Salt
    • Coenzyme I Disodium Salt
    • orb1301924
    • Nicotinamide-adenine dinucleotide, reduced, disodium salt
    • SCHEMBL29352196
    • DTXSID901014657
    • AKOS024306766
    • AKOS030526168
    • EBC-616096
    • NN12622
    • AC-37029
    • Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide, disodium salt
    • AS-75103
    • D0920
    • beta-Diphosphopyridine Nucleotide Disodium Salt
    • C75833
    • NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM
    • Q27269326
    • DISODIUM NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED
    • NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM REDUCED
    • beta-Nicotinamide adenine dinucleotide reduced disodium salt
    • .BETA.-NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM SALT
    • b-Nicotinamide adenine dinucleotide reduced form, disodium salt
    • Adenosine 5'-(trihydrogen diphosphate), 5'->'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide, disodium salt
    • Adenosine 5'-(trihydrogen diphosphate), P'->5'-ester with 1,4-dihydro-1-beta-D-ribofuranosylnicotinamide, sodium salt (1:2)
    • disodium [(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate
    • 606-68-8

  • Applications

    dihydronicotinamide-adenine dinucleotide, disodium salt (NADH disodium salt) is a water-soluble redox cofactor widely used in NADH-dependent enzymatic reactions and biocatalysis in industrial manufacturing. In analytical biochemistry, NADH disodium salt serves as an electron donor in enzyme assays and for quantifying NADH/NAD+. It is employed in biosensors and electrochemical sensors for NADH detection. In pharmaceutical R&D and metabolic studies, it is used in in vitro enzyme systems and NADH regeneration schemes to study redox kinetics and optimize reactions. In cell-free systems and in vitro metabolic modeling, it supports biochemical pathways by supplying reducing equivalents for redox processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.87
    methanol 6.54
    isopropanol 0.58
    water 0.95
    ethyl acetate 0.36
    n-propanol 1.06
    acetone 2.76
    n-butanol 0.56
    acetonitrile 1.33
    DMF 21.36
    toluene 0.02
    isobutanol 0.32
    1,4-dioxane 1.14
    methyl acetate 1.13
    THF 2.96
    2-butanone 1.63
    n-pentanol 0.23
    sec-butanol 0.42
    n-hexane 0.0
    ethylene glycol 4.87
    NMP 25.21
    cyclohexane 0.01
    DMSO 24.0
    n-butyl acetate 0.23
    n-octanol 0.15
    chloroform 0.43
    n-propyl acetate 0.23
    acetic acid 13.51
    dichloromethane 0.49
    cyclohexanone 1.55
    propylene glycol 4.63
    isopropyl acetate 0.13
    DMAc 16.18
    2-ethoxyethanol 3.53
    isopentanol 0.2
    n-heptane 0.01
    ethyl formate 2.34
    1,2-dichloroethane 0.27
    n-hexanol 0.15
    2-methoxyethanol 13.57
    isobutyl acetate 0.06
    tetrachloromethane 0.08
    n-pentyl acetate 0.28
    transcutol 2.42
    n-heptanol 0.24
    ethylbenzene 0.01
    MIBK 0.15
    2-propoxyethanol 2.06
    tert-butanol 0.21
    MTBE 0.06
    2-butoxyethanol 2.03
    propionic acid 2.6
    o-xylene 0.02
    formic acid 50.42
    diethyl ether 0.13
    m-xylene 0.01
    p-xylene 0.02
    chlorobenzene 0.04
    dimethyl carbonate 1.06
    n-octane 0.0
    formamide 40.26
    cyclopentanone 4.74
    2-pentanone 0.61
    anisole 0.06
    cyclopentyl methyl ether 0.16
    gamma-butyrolactone 6.94
    1-methoxy-2-propanol 3.49
    pyridine 1.11
    3-pentanone 0.42
    furfural 8.21
    n-dodecane 0.0
    diethylene glycol 4.59
    diisopropyl ether 0.01
    tert-amyl alcohol 0.2
    acetylacetone 0.92
    n-hexadecane 0.0
    acetophenone 0.19
    methyl propionate 0.75
    isopentyl acetate 0.12
    trichloroethylene 0.7
    n-nonanol 0.16
    cyclohexanol 0.2
    benzyl alcohol 0.2
    2-ethylhexanol 0.05
    isooctanol 0.1
    dipropyl ether 0.08
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.67
    propylene carbonate 1.99
    n-methylformamide 17.21
    2-pentanol 0.14
    n-pentane 0.01
    1-propoxy-2-propanol 0.86
    1-methoxy-2-propyl acetate 0.4
    2-(2-methoxypropoxy) propanol 0.97
    mesitylene 0.01
    ε-caprolactone 1.48
    p-cymene 0.01
    epichlorohydrin 3.02
    1,1,1-trichloroethane 0.1
    2-aminoethanol 5.18
    morpholine-4-carbaldehyde 12.32
    sulfolane 13.39
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.52
    n-hexyl acetate 0.23
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.85
    sec-butyl acetate 0.07
    tert-butyl acetate 0.09
    decalin 0.0
    glycerin 14.81
    diglyme 3.13
    acrylic acid 5.38
    isopropyl myristate 0.05
    n-butyric acid 1.58
    acetyl acetate 0.28
    di(2-ethylhexyl) phthalate 0.16
    ethyl propionate 0.19
    nitromethane 26.56
    1,2-diethoxyethane 0.25
    benzonitrile 0.25
    trioctyl phosphate 0.13
    1-bromopropane 0.07
    gamma-valerolactone 14.57
    n-decanol 0.1
    triethyl phosphate 0.12
    4-methyl-2-pentanol 0.04
    propionitrile 0.58
    vinylene carbonate 2.07
    1,1,2-trichlorotrifluoroethane 10.03
    DMS 0.26
    cumene 0.01
    2-octanol 0.09
    2-hexanone 0.28
    octyl acetate 0.14
    limonene 0.02
    1,2-dimethoxyethane 2.76
    ethyl orthosilicate 0.08
    tributyl phosphate 0.12
    diacetone alcohol 0.59
    N,N-dimethylaniline 0.05
    acrylonitrile 1.57
    aniline 0.15
    1,3-propanediol 5.27
    bromobenzene 0.02
    dibromomethane 0.17
    1,1,2,2-tetrachloroethane 0.53
    2-methyl-cyclohexyl acetate 0.11
    tetrabutyl urea 0.34
    diisobutyl methanol 0.02
    2-phenylethanol 0.17
    styrene 0.01
    dioctyl adipate 0.14
    dimethyl sulfate 2.58
    ethyl butyrate 0.17
    methyl lactate 2.77
    butyl lactate 0.74
    diethyl carbonate 0.14
    propanediol butyl ether 2.23
    triethyl orthoformate 0.16
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.27
    morpholine 2.14
    tert-butylamine 0.05
    n-dodecanol 0.06
    dimethoxymethane 2.97
    ethylene carbonate 1.21
    cyrene 2.55
    2-ethoxyethyl acetate 0.61
    2-ethylhexyl acetate 0.09
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.43
    dibutyl ether 0.06
    2,6-dimethyl-4-heptanol 0.02
    DEF 1.31
    dimethyl isosorbide 1.28
    tetrachloroethylene 0.39
    eugenol 0.56
    triacetin 0.41
    span 80 0.86
    1,4-butanediol 1.48
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 0.1
    methyl formate 13.03
    2-methyl-1-butanol 0.25
    n-decane 0.01
    butyronitrile 0.39
    3,7-dimethyl-1-octanol 0.05
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.63
    tetrahydropyran 0.36
    tert-amyl methyl ether 0.06
    2,5,8-trioxanonane 1.99
    1-hexene 0.01
    2-isopropoxyethanol 0.73
    2,2,2-trifluoroethanol 9.25
    methyl butyrate 0.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
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Category 2
Products applied to the axillae
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Leave-on products applied to the hair with some hand contact
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Category 3
Products applied to the face/body using fingertips
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Products with significant anogenital exposure
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Category 4
Products related to fine fragrance
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Products with body and hand exposure, primarily rinse off
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Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
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Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
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