Dihydrofukinolide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    41059-95-4

    Molecular formula
    C22H32O6

    SMILES
    CC[C@H](C)C(=O)O[C@H]1CC[C@@H]([C@@]2([C@H]1[C@H]([C@@]3(C2)C(=C)COC3=O)OC(=O)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Odorless 38.05%
    Mint 35.91%
    Woody 34.5%
    Herbal 32.23%
    Fruity 28.87%
    Floral 26.44%
    Cooling 25.07%
    Fresh 23.49%
    Spicy 22.07%
    Sweet 20.8%

     

    Flavor
    Bitter 79.67%
    Cedarleaf 22.42%
    Odorless 22.09%
    Bland 21.19%
    Fruity 21.12%
    Ripe apricot 20.94%
    Parsley 20.8%
    Broom 20.74%
    Red fruit 20.7%
    Heather 20.52%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    6.88 (neutral)

    Molecular weight
    392.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    418°C

    Flash point

    • 165.16 ˚C est.

  • Synonyms

    • Dihydrofukinolide
    • CHEBI:142257
    • (3R,3'R,3a'R,4'S,7'S,7a'R)-3'-acetoxy-7',7a'-dimethyl-4-methylene-2-oxodecahydrospiro[furan-3,2'-inden]-4'-yl (2S)-2-methylbutanoate
    • 41059-95-4
    • ((2R,3R,3aR,4S,7S,7aR)-3-acetyloxy-7,7a-dimethyl-4'-methylidene-2'-oxospiro(3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane)-4-yl) (2S)-2-methylbutanoate
    • (3R,3'R,3a'R,4'S,7'S,7a'R)-3'-acetoxy-7',7a'-dimethyl-4-methylene-2-oxodecahydrospiro(furan-3,2'-inden)-4'-yl (2S)-2-methylbutanoate
    • [(2R,3R,3aR,4S,7S,7aR)-3-acetyloxy-7,7a-dimethyl-4'-methylidene-2'-oxospiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane]-4-yl] (2S)-2-methylbutanoate
    • 3-(Acetyloxy)-7,7a-dimethyl-4'-methylidene-2'-oxo-octahydrospiro(indene-2,3'-oxolane)-4-yl 2-methylbutanoic acid
    • 3-(Acetyloxy)-7,7a-dimethyl-4'-methylidene-2'-oxo-octahydrospiro[indene-2,3'-oxolane]-4-yl 2-methylbutanoic acid
    • RefChem:133820
    • 41059-95-4

  • Applications

    Dihydrofukinolide (CAS 41059-95-4) is used as a fragrance component in perfumery, functioning as an odorant and sometimes as a fixative; in cosmetics and personal care, it is employed as a fragrance ingredient; in household products and cleaners, it can appear as a fragrance note to improve scent; in industrial manufacturing, it may be used as an intermediate in organic synthesis; and in the polymers/plastics sector, it can be evaluated as a lactone-derived monomer or an additive for certain polymer systems. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 419.5
    methanol 745.26
    isopropanol 630.34
    water 1.79
    ethyl acetate 547.28
    n-propanol 450.37
    acetone 1113.3
    n-butanol 435.48
    acetonitrile 297.11
    DMF 1745.19
    toluene 452.16
    isobutanol 410.2
    1,4-dioxane 1272.65
    methyl acetate 473.64
    THF 2619.68
    2-butanone 672.83
    n-pentanol 315.57
    sec-butanol 422.99
    n-hexane 5.35
    ethylene glycol 120.31
    NMP 1574.72
    cyclohexane 13.85
    DMSO 1121.9
    n-butyl acetate 217.46
    n-octanol 88.63
    chloroform 1876.25
    n-propyl acetate 270.39
    acetic acid 965.32
    dichloromethane 1227.19
    cyclohexanone 1085.75
    propylene glycol 298.31
    isopropyl acetate 435.91
    DMAc 1193.58
    2-ethoxyethanol 597.62
    isopentanol 408.82
    n-heptane 2.9
    ethyl formate 300.35
    1,2-dichloroethane 703.3
    n-hexanol 205.15
    2-methoxyethanol 1084.47
    isobutyl acetate 209.25
    tetrachloromethane 128.88
    n-pentyl acetate 194.38
    transcutol 1128.03
    n-heptanol 108.84
    ethylbenzene 158.16
    MIBK 376.2
    2-propoxyethanol 677.71
    tert-butanol 616.45
    MTBE 226.77
    2-butoxyethanol 340.82
    propionic acid 464.29
    o-xylene 202.16
    formic acid 415.13
    diethyl ether 253.2
    m-xylene 263.72
    p-xylene 231.17
    chlorobenzene 514.57
    dimethyl carbonate 472.86
    n-octane 2.03
    formamide 622.99
    cyclopentanone 1695.39
    2-pentanone 601.37
    anisole 350.34
    cyclopentyl methyl ether 659.74
    gamma-butyrolactone 1851.53
    1-methoxy-2-propanol 1108.11
    pyridine 971.05
    3-pentanone 368.14
    furfural 1226.37
    n-dodecane 2.48
    diethylene glycol 556.37
    diisopropyl ether 67.41
    tert-amyl alcohol 340.58
    acetylacetone 974.4
    n-hexadecane 3.01
    acetophenone 401.25
    methyl propionate 541.69
    isopentyl acetate 226.36
    trichloroethylene 1825.9
    n-nonanol 85.86
    cyclohexanol 444.34
    benzyl alcohol 458.54
    2-ethylhexanol 89.83
    isooctanol 93.72
    dipropyl ether 82.76
    1,2-dichlorobenzene 412.3
    ethyl lactate 215.48
    propylene carbonate 882.98
    n-methylformamide 754.47
    2-pentanol 309.43
    n-pentane 6.59
    1-propoxy-2-propanol 410.08
    1-methoxy-2-propyl acetate 405.29
    2-(2-methoxypropoxy) propanol 299.82
    mesitylene 116.88
    ε-caprolactone 858.63
    p-cymene 54.12
    epichlorohydrin 1791.8
    1,1,1-trichloroethane 627.88
    2-aminoethanol 286.12
    morpholine-4-carbaldehyde 1527.98
    sulfolane 1697.91
    2,2,4-trimethylpentane 4.92
    2-methyltetrahydrofuran 984.81
    n-hexyl acetate 254.73
    isooctane 4.77
    2-(2-butoxyethoxy)ethanol 461.29
    sec-butyl acetate 206.37
    tert-butyl acetate 372.63
    decalin 10.61
    glycerin 456.57
    diglyme 757.55
    acrylic acid 485.3
    isopropyl myristate 91.61
    n-butyric acid 693.74
    acetyl acetate 512.88
    di(2-ethylhexyl) phthalate 136.47
    ethyl propionate 229.49
    nitromethane 1365.94
    1,2-diethoxyethane 264.57
    benzonitrile 379.64
    trioctyl phosphate 86.8
    1-bromopropane 263.29
    gamma-valerolactone 2206.66
    n-decanol 58.18
    triethyl phosphate 93.21
    4-methyl-2-pentanol 194.01
    propionitrile 271.58
    vinylene carbonate 784.8
    1,1,2-trichlorotrifluoroethane 1066.4
    DMS 313.06
    cumene 92.37
    2-octanol 76.07
    2-hexanone 302.87
    octyl acetate 124.28
    limonene 60.29
    1,2-dimethoxyethane 747.08
    ethyl orthosilicate 84.26
    tributyl phosphate 103.53
    diacetone alcohol 600.98
    N,N-dimethylaniline 246.55
    acrylonitrile 400.37
    aniline 623.84
    1,3-propanediol 529.94
    bromobenzene 536.47
    dibromomethane 669.94
    1,1,2,2-tetrachloroethane 1326.59
    2-methyl-cyclohexyl acetate 168.52
    tetrabutyl urea 139.37
    diisobutyl methanol 59.98
    2-phenylethanol 339.28
    styrene 198.86
    dioctyl adipate 159.34
    dimethyl sulfate 745.03
    ethyl butyrate 148.41
    methyl lactate 466.66
    butyl lactate 206.47
    diethyl carbonate 115.02
    propanediol butyl ether 348.27
    triethyl orthoformate 120.57
    p-tert-butyltoluene 57.09
    methyl 4-tert-butylbenzoate 282.01
    morpholine 1439.31
    tert-butylamine 179.02
    n-dodecanol 39.54
    dimethoxymethane 1209.67
    ethylene carbonate 654.49
    cyrene 478.99
    2-ethoxyethyl acetate 330.93
    2-ethylhexyl acetate 161.8
    1,2,4-trichlorobenzene 544.03
    4-methylpyridine 1031.41
    dibutyl ether 70.68
    2,6-dimethyl-4-heptanol 59.98
    DEF 555.2
    dimethyl isosorbide 566.1
    tetrachloroethylene 710.95
    eugenol 310.16
    triacetin 327.12
    span 80 281.49
    1,4-butanediol 238.63
    1,1-dichloroethane 773.39
    2-methyl-1-pentanol 258.07
    methyl formate 672.62
    2-methyl-1-butanol 325.28
    n-decane 4.15
    butyronitrile 289.9
    3,7-dimethyl-1-octanol 98.4
    1-chlorooctane 34.25
    1-chlorotetradecane 13.88
    n-nonane 3.16
    undecane 3.12
    tert-butylcyclohexane 8.36
    cyclooctane 4.34
    cyclopentanol 705.33
    tetrahydropyran 836.8
    tert-amyl methyl ether 157.2
    2,5,8-trioxanonane 474.07
    1-hexene 44.45
    2-isopropoxyethanol 414.97
    2,2,2-trifluoroethanol 412.99
    methyl butyrate 308.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction