Dihydrocurcumin

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  • Identifiers

    CAS number
    76474-56-1

    Molecular formula
    C21H22O6

    SMILES
    COC1=C(C=CC(=C1)CCC(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

    Safety labels

  • Odor profile

    Fragrance
    Vanilla 54.91%
    Spicy 52.15%
    Sweet 51.34%
    Balsamic 40.61%
    Creamy 35.42%
    Powdery 31.67%
    Savory 29.56%
    Warm 28.67%
    Milky 28.55%
    Woody 27.47%

     

    Flavor
    Odorless 35.79%
    Bitter 34.29%
    Mild 24.64%
    Bland 23.3%
    Sweet 22.93%
    Faint 22.51%
    Powdery 20.95%
    Ethyl benzoate 20.25%
    Parsley 19.76%
    Orange flower 19.7%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    10.56 (weak base)

    Molecular weight
    370.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    718°C

    Melting point expt.

    • 179 - 180 °C

    Flash point

    • 224.87 ˚C est.

  • Synonyms

    • LETESTUIANIN B
    • 4YU9OA673J
    • CHEBI:67262
    • (1E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione
    • (e)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione
    • 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3-one
    • (1E,4Z)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4-dien-3-one
    • 4,6-Heptadien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (Z,E)-
    • 4,6-Heptadien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (4Z,6E)-
    • RefChem:920210
    • DTXCID101011966
    • (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one
    • 76474-56-1
    • Dihydrocurcumin
    • DTXSID10873742
    • 1,2-Dihydrocurcumin
    • 943330-36-7
    • (1E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1-Heptene-3,5-dione;
    • UNII-4YU9OA673J
    • CHEMBL1254325
    • SCHEMBL12798130
    • SCHEMBL30230550
    • (E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hept-1-ene-3,5-dione
    • MSK164304
    • AKOS037514624
    • Q27135729
    • 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3-one, 9CI
    • 76474-56-1

  • Applications

    Dihydrocurcumin (CAS number: 76474-56-1) is commonly evaluated as an antioxidant and stabilizer in cosmetics and personal care formulations, where it can help protect sensitive ingredients from oxidation. In industrial manufacturing, it is used as an intermediate in the synthesis of curcuminoids and related derivatives. As an additive in polymers and coatings, it may act as an antioxidant/stabilizer to improve oxidative stability and longevity. In pharmaceutical and chemical research contexts, it is explored as a precursor for curcuminoid derivatives and related synthetic routes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.77
    methanol 16.78
    isopropanol 25.61
    water 0.01
    ethyl acetate 14.33
    n-propanol 29.18
    acetone 171.7
    n-butanol 9.33
    acetonitrile 15.07
    DMF 104.12
    toluene 3.25
    isobutanol 10.91
    1,4-dioxane 80.3
    methyl acetate 30.16
    THF 1409.06
    2-butanone 78.87
    n-pentanol 10.7
    sec-butanol 20.58
    n-hexane 0.31
    ethylene glycol 6.75
    NMP 39.21
    cyclohexane 0.42
    DMSO 2440.97
    n-butyl acetate 4.46
    n-octanol 4.31
    chloroform 21.93
    n-propyl acetate 8.27
    acetic acid 35.13
    dichloromethane 27.1
    cyclohexanone 61.56
    propylene glycol 15.33
    isopropyl acetate 7.4
    DMAc 153.23
    2-ethoxyethanol 51.37
    isopentanol 6.22
    n-heptane 0.34
    ethyl formate 11.21
    1,2-dichloroethane 25.3
    n-hexanol 5.23
    2-methoxyethanol 73.77
    isobutyl acetate 4.1
    tetrachloromethane 1.31
    n-pentyl acetate 5.21
    transcutol 51.72
    n-heptanol 3.97
    ethylbenzene 1.91
    MIBK 9.24
    2-propoxyethanol 30.91
    tert-butanol 27.31
    MTBE 11.73
    2-butoxyethanol 14.59
    propionic acid 18.19
    o-xylene 1.82
    formic acid 12.74
    diethyl ether 13.63
    m-xylene 1.12
    p-xylene 2.48
    chlorobenzene 4.02
    dimethyl carbonate 14.15
    n-octane 0.28
    formamide 33.36
    cyclopentanone 215.81
    2-pentanone 28.95
    anisole 10.06
    cyclopentyl methyl ether 26.61
    gamma-butyrolactone 122.92
    1-methoxy-2-propanol 47.32
    pyridine 34.56
    3-pentanone 20.31
    furfural 36.36
    n-dodecane 0.3
    diethylene glycol 25.86
    diisopropyl ether 1.64
    tert-amyl alcohol 16.85
    acetylacetone 46.13
    n-hexadecane 0.34
    acetophenone 10.93
    methyl propionate 20.14
    isopentyl acetate 5.06
    trichloroethylene 37.32
    n-nonanol 5.0
    cyclohexanol 11.07
    benzyl alcohol 10.57
    2-ethylhexanol 2.97
    isooctanol 3.55
    dipropyl ether 6.05
    1,2-dichlorobenzene 3.66
    ethyl lactate 8.22
    propylene carbonate 14.63
    n-methylformamide 35.91
    2-pentanol 5.88
    n-pentane 0.18
    1-propoxy-2-propanol 18.06
    1-methoxy-2-propyl acetate 12.48
    2-(2-methoxypropoxy) propanol 18.67
    mesitylene 0.69
    ε-caprolactone 27.35
    p-cymene 1.2
    epichlorohydrin 164.36
    1,1,1-trichloroethane 8.98
    2-aminoethanol 14.86
    morpholine-4-carbaldehyde 46.4
    sulfolane 201.45
    2,2,4-trimethylpentane 0.19
    2-methyltetrahydrofuran 94.5
    n-hexyl acetate 7.43
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 23.91
    sec-butyl acetate 4.5
    tert-butyl acetate 9.54
    decalin 0.31
    glycerin 20.95
    diglyme 48.22
    acrylic acid 16.73
    isopropyl myristate 3.79
    n-butyric acid 12.91
    acetyl acetate 9.07
    di(2-ethylhexyl) phthalate 4.63
    ethyl propionate 8.22
    nitromethane 112.58
    1,2-diethoxyethane 15.98
    benzonitrile 7.1
    trioctyl phosphate 3.34
    1-bromopropane 7.94
    gamma-valerolactone 118.11
    n-decanol 3.88
    triethyl phosphate 4.96
    4-methyl-2-pentanol 2.77
    propionitrile 14.52
    vinylene carbonate 12.45
    1,1,2-trichlorotrifluoroethane 47.09
    DMS 9.3
    cumene 1.24
    2-octanol 2.9
    2-hexanone 16.57
    octyl acetate 5.13
    limonene 1.9
    1,2-dimethoxyethane 77.87
    ethyl orthosilicate 4.63
    tributyl phosphate 4.12
    diacetone alcohol 21.57
    N,N-dimethylaniline 5.74
    acrylonitrile 18.33
    aniline 8.15
    1,3-propanediol 22.09
    bromobenzene 3.18
    dibromomethane 12.7
    1,1,2,2-tetrachloroethane 34.15
    2-methyl-cyclohexyl acetate 6.04
    tetrabutyl urea 7.44
    diisobutyl methanol 2.18
    2-phenylethanol 7.35
    styrene 2.55
    dioctyl adipate 7.82
    dimethyl sulfate 31.99
    ethyl butyrate 5.24
    methyl lactate 15.38
    butyl lactate 6.77
    diethyl carbonate 4.3
    propanediol butyl ether 12.57
    triethyl orthoformate 6.09
    p-tert-butyltoluene 1.11
    methyl 4-tert-butylbenzoate 10.71
    morpholine 112.87
    tert-butylamine 5.78
    n-dodecanol 2.97
    dimethoxymethane 83.45
    ethylene carbonate 11.1
    cyrene 21.1
    2-ethoxyethyl acetate 11.6
    2-ethylhexyl acetate 3.36
    1,2,4-trichlorobenzene 5.68
    4-methylpyridine 15.92
    dibutyl ether 6.48
    2,6-dimethyl-4-heptanol 2.18
    DEF 19.91
    dimethyl isosorbide 28.27
    tetrachloroethylene 14.54
    eugenol 11.25
    triacetin 11.88
    span 80 11.74
    1,4-butanediol 10.74
    1,1-dichloroethane 12.93
    2-methyl-1-pentanol 7.02
    methyl formate 29.75
    2-methyl-1-butanol 6.93
    n-decane 0.55
    butyronitrile 8.55
    3,7-dimethyl-1-octanol 3.8
    1-chlorooctane 2.51
    1-chlorotetradecane 1.06
    n-nonane 0.44
    undecane 0.39
    tert-butylcyclohexane 0.23
    cyclooctane 0.15
    cyclopentanol 32.91
    tetrahydropyran 79.95
    tert-amyl methyl ether 8.24
    2,5,8-trioxanonane 37.17
    1-hexene 1.98
    2-isopropoxyethanol 25.01
    2,2,2-trifluoroethanol 11.6
    methyl butyrate 10.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction