Dihydrocapsaicin

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  • Identifiers

    CAS number
    19408-84-5

    Molecular formula
    C18H29NO3

    SMILES
    CC(C)CCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Cooling 41.1%
    Odorless 38.64%
    Savory 38.17%
    Spicy 32.33%
    Meaty 31.01%
    Mint 29.77%
    Herbal 29.28%
    Animal 25.96%
    Burnt 20.9%
    Warm 20.68%

     

    Flavor
    Herbal 44.87%
    Bland 35.37%
    Odorless 35.32%
    Mild 32.63%
    Woody 24.25%
    Warm 23.55%
    Spicy 21.86%
    Bitter 20.72%
    Parsley 20.45%
    Lovage 20.32%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.4

    pKa est.
    10.08 (weak base)

    Molecular weight
    307.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    460°C

    Melting point expt.

    • 65.5 - 65.8 °C
    • 65.5-65.8 °F

    Flash point

    • 177.97 ˚C est.

  • Synonyms

    • Dihydrocapsaicin
    • 19408-84-5
    • 6,7-Dihydrocapsaicin
    • 8-Methyl-N-vanillylnonanamide
    • Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-
    • N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnonanamide
    • Nonanamide, 8-methyl-N-vanillyl-
    • W9BV32M08A
    • DTXSID4041864
    • CHEBI:46932
    • N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methylnonanamide
    • Nonanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-
    • N-[(4-Hydroxy-3-methoxy-phenyl)methyl]-8-methyl-nonanamide
    • N-((4-hydroxy-3-methoxy-phenyl)methyl)-8-methyl-nonanamide
    • RefChem:34595
    • DTXCID2021864
    • 606-308-7
    • N-(4-hydroxy-3-methoxybenzyl)-8-methylnonanamide
    • dihydro capsaicin
    • MFCD00057794
    • 8-methyl dihydrocapsaicin
    • 8-methyl-N-vanillyl-nonanamide
    • TNP00314
    • CCRIS 1589
    • SR-01000075976
    • BRN 2815150
    • UNII-W9BV32M08A
    • Dihydrocapsacine
    • Dihydrocapsaicin, Nonanamide, 8-methyl-N-vanillyl- (7CI,8CI); 6,7-Dihydrocapsaicin; Capsaicin, dihydro-; Dihydrocapsaicin
    • Lopac-M-1022
    • CAPSAICIN, DIHYDRO-
    • Dihydrocapsaicin (Standard)
    • Lopac0_000782
    • MLS002153458
    • Dihydro capsaicin - Synthetic
    • SCHEMBL119080
    • CHEMBL311158
    • orb1306267
    • SCHEMBL29819467
    • HY-N0361R
    • DIHYDROCAPSAICIN [USP-RS]
    • HMS2232L10
    • HMS3262M06
    • HMS3371M21
    • HMS3649N17
    • HMS5086N15
    • HMS6018K14
    • HY-N0361
    • MSK40113
    • Dihydrocapsaicin, analytical standard
    • Tox21_500782
    • BDBM50231198
    • STL570272
    • ZB1859
    • AKOS016009558
    • Dihydro capsaicin - Natural extraction
    • CCG-204867
    • EBC-615919
    • FD74977
    • LP00782
    • SDCCGSBI-0050760.P002
    • NCGC00015645-01
    • NCGC00015645-02
    • NCGC00015645-03
    • NCGC00015645-04
    • NCGC00015645-05
    • NCGC00015645-06
    • NCGC00015645-13
    • NCGC00094119-01
    • NCGC00094119-02
    • NCGC00094119-03
    • NCGC00261467-01
    • AC-23369
    • AS-77558
    • SMR001230817
    • ST057532
    • DB-044848
    • CS-0008911
    • EU-0100782
    • NS00015067
    • S9086
    • Dihydrocapsaicin, from Capsicum sp., >=85%
    • C16952
    • M 1022
    • 408D845
    • Q5276422
    • SR-01000075976-1
    • SR-01000075976-6
    • DIHYDROCAPSAICIN (CONSTITUENT OF CAPSICUM) [DSC]
    • N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-Nonanamide
    • Dihydrocapsaicin, United States Pharmacopeia (USP) Reference Standard
    • 8-methyl-N-vanillylnonenamide/N-(4-hydroxy-3-methoxybenzyl)-8-methylnonanamide
    • 19408-84-5

  • Applications

    Dihydrocapsaicin (CAS 19408-84-5), a capsaicinoid derived from chili peppers, is used as a spicy flavor component in food processing and seasoning formulations to deliver controlled heat. It is also employed as an irritant in pepper spray and related personal defense products, requiring careful handling and regulatory compliance. In industrial and pharmaceutical R&D, it can serve as a chemical intermediate and analytical reference for the synthesis and quality control of capsaicinoids, supporting structure–activity studies. Additionally, it is evaluated in topical formulations in cosmetic and pharmaceutical research for mild counterirritant or analgesic applications, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1034.16
    methanol 1676.54
    isopropanol 399.69
    water 0.21
    ethyl acetate 753.62
    n-propanol 435.54
    acetone 1176.22
    n-butanol 263.01
    acetonitrile 232.13
    DMF 479.04
    toluene 34.15
    isobutanol 199.82
    1,4-dioxane 463.64
    methyl acetate 390.46
    THF 791.64
    2-butanone 444.11
    n-pentanol 137.24
    sec-butanol 186.17
    n-hexane 0.4
    ethylene glycol 53.01
    NMP 192.06
    cyclohexane 2.15
    DMSO 1354.45
    n-butyl acetate 140.77
    n-octanol 34.75
    chloroform 352.83
    n-propyl acetate 195.58
    acetic acid 625.94
    dichloromethane 383.76
    cyclohexanone 432.17
    propylene glycol 149.78
    isopropyl acetate 283.46
    DMAc 486.88
    2-ethoxyethanol 456.74
    isopentanol 177.59
    n-heptane 0.6
    ethyl formate 253.59
    1,2-dichloroethane 309.99
    n-hexanol 82.85
    2-methoxyethanol 1010.03
    isobutyl acetate 114.59
    tetrachloromethane 27.01
    n-pentyl acetate 92.42
    transcutol 850.55
    n-heptanol 42.64
    ethylbenzene 17.97
    MIBK 168.7
    2-propoxyethanol 295.15
    tert-butanol 368.2
    MTBE 199.95
    2-butoxyethanol 148.11
    propionic acid 252.3
    o-xylene 26.48
    formic acid 187.65
    diethyl ether 105.05
    m-xylene 29.0
    p-xylene 26.78
    chlorobenzene 77.47
    dimethyl carbonate 87.98
    n-octane 0.83
    formamide 365.06
    cyclopentanone 543.8
    2-pentanone 378.77
    anisole 77.36
    cyclopentyl methyl ether 139.68
    gamma-butyrolactone 536.95
    1-methoxy-2-propanol 515.45
    pyridine 193.63
    3-pentanone 150.61
    furfural 326.31
    n-dodecane 1.23
    diethylene glycol 245.94
    diisopropyl ether 20.3
    tert-amyl alcohol 198.11
    acetylacetone 510.55
    n-hexadecane 1.4
    acetophenone 100.58
    methyl propionate 297.15
    isopentyl acetate 133.73
    trichloroethylene 492.39
    n-nonanol 33.25
    cyclohexanol 138.23
    benzyl alcohol 101.18
    2-ethylhexanol 34.99
    isooctanol 38.6
    dipropyl ether 23.94
    1,2-dichlorobenzene 74.99
    ethyl lactate 88.65
    propylene carbonate 239.01
    n-methylformamide 346.67
    2-pentanol 93.14
    n-pentane 0.33
    1-propoxy-2-propanol 158.71
    1-methoxy-2-propyl acetate 194.79
    2-(2-methoxypropoxy) propanol 121.19
    mesitylene 17.73
    ε-caprolactone 335.75
    p-cymene 15.01
    epichlorohydrin 641.88
    1,1,1-trichloroethane 179.38
    2-aminoethanol 209.19
    morpholine-4-carbaldehyde 319.09
    sulfolane 497.96
    2,2,4-trimethylpentane 1.9
    2-methyltetrahydrofuran 286.67
    n-hexyl acetate 100.73
    isooctane 1.38
    2-(2-butoxyethoxy)ethanol 202.8
    sec-butyl acetate 118.24
    tert-butyl acetate 237.22
    decalin 2.28
    glycerin 176.98
    diglyme 401.28
    acrylic acid 164.85
    isopropyl myristate 31.88
    n-butyric acid 532.12
    acetyl acetate 251.3
    di(2-ethylhexyl) phthalate 44.11
    ethyl propionate 129.75
    nitromethane 1041.38
    1,2-diethoxyethane 172.92
    benzonitrile 97.2
    trioctyl phosphate 29.65
    1-bromopropane 65.55
    gamma-valerolactone 737.76
    n-decanol 24.0
    triethyl phosphate 43.22
    4-methyl-2-pentanol 53.36
    propionitrile 124.88
    vinylene carbonate 178.84
    1,1,2-trichlorotrifluoroethane 357.76
    DMS 98.28
    cumene 14.77
    2-octanol 27.79
    2-hexanone 145.0
    octyl acetate 44.33
    limonene 19.64
    1,2-dimethoxyethane 478.99
    ethyl orthosilicate 41.25
    tributyl phosphate 37.18
    diacetone alcohol 290.47
    N,N-dimethylaniline 43.08
    acrylonitrile 166.37
    aniline 88.11
    1,3-propanediol 453.57
    bromobenzene 66.02
    dibromomethane 177.99
    1,1,2,2-tetrachloroethane 385.94
    2-methyl-cyclohexyl acetate 70.76
    tetrabutyl urea 47.52
    diisobutyl methanol 23.97
    2-phenylethanol 87.84
    styrene 23.27
    dioctyl adipate 59.81
    dimethyl sulfate 146.8
    ethyl butyrate 87.93
    methyl lactate 131.73
    butyl lactate 94.83
    diethyl carbonate 60.78
    propanediol butyl ether 144.04
    triethyl orthoformate 58.78
    p-tert-butyltoluene 14.84
    methyl 4-tert-butylbenzoate 95.49
    morpholine 653.76
    tert-butylamine 81.39
    n-dodecanol 17.61
    dimethoxymethane 409.8
    ethylene carbonate 180.5
    cyrene 120.11
    2-ethoxyethyl acetate 191.77
    2-ethylhexyl acetate 82.86
    1,2,4-trichlorobenzene 93.07
    4-methylpyridine 160.84
    dibutyl ether 34.32
    2,6-dimethyl-4-heptanol 23.97
    DEF 235.89
    dimethyl isosorbide 195.01
    tetrachloroethylene 213.52
    eugenol 102.41
    triacetin 135.13
    span 80 97.73
    1,4-butanediol 123.98
    1,1-dichloroethane 247.74
    2-methyl-1-pentanol 107.1
    methyl formate 247.62
    2-methyl-1-butanol 136.26
    n-decane 1.88
    butyronitrile 155.74
    3,7-dimethyl-1-octanol 40.11
    1-chlorooctane 15.31
    1-chlorotetradecane 5.83
    n-nonane 1.5
    undecane 1.47
    tert-butylcyclohexane 2.27
    cyclooctane 0.66
    cyclopentanol 145.54
    tetrahydropyran 318.53
    tert-amyl methyl ether 93.98
    2,5,8-trioxanonane 230.07
    1-hexene 4.88
    2-isopropoxyethanol 229.92
    2,2,2-trifluoroethanol 146.0
    methyl butyrate 203.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction