Dihexyl Adipate

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  • Identifiers

    CAS number
    110-33-8

    Molecular formula
    C18H34O4

    SMILES
    CCCCCCOC(=O)CCCCC(=O)OCCCCCC

    Safety labels

  • Odor profile

    Fragrance
    Fruity 84.67%
    Oily 59.67%
    Winey 58.27%
    Green 50.2%
    Fatty 47.19%
    Sweet 39.87%
    Herbal 38.41%
    Cognac 36.41%
    Apple 35.1%
    Waxy 34.45%

     

    Flavor
    Fruity 84.71%
    Green 60.1%
    Waxy 56.49%
    Sweet 54.01%
    Apple 52.94%
    Pineapple 52.86%
    Tropical 46.23%
    Pear 46.01%
    Wine 44.15%
    Fruit 43.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.3

    pKa est.
    7.46 (neutral)

    Molecular weight
    314.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    354°C

    Flash point

    • 168.62 ˚C est.
    • 325 °F (USCG, 1999)

  • Synonyms

    • DIHEXYL ADIPATE
    • Dihexyl hexanedioate
    • 110-33-8
    • Hexanedioic acid, dihexyl ester
    • Di-n-hexyl adipate
    • Adipic acid, dihexyl ester
    • Plasticizer dihexyl adipate
    • EINECS 203-757-7
    • H16ECG10GB
    • BRN 1798668
    • DTXSID9026841
    • PLASTOMOLL DHA
    • AI3-07963
    • Hexanedioic acid, 1,6-dihexyl ester
    • DTXCID806841
    • EC 203-757-7
    • 203-757-7
    • RefChem:587637
    • DIHEXYL ADIPATE [INCI]
    • Hexanedioic acid,1,6-dihexyl ester
    • dihexyl hexane-1,6-dioate
    • Hexanedioic acid dihexyl ester
    • UNII-H16ECG10GB
    • Adimoll DH
    • Dihexyl hexanedioate #
    • dihexyl adipate, AldrichCPR
    • CBDivE_012758
    • SCHEMBL232603
    • CHEMBL3185271
    • Tox21_301005
    • MFCD00072253
    • MSK158613
    • SBB060690
    • AKOS024390878
    • NCGC00248250-01
    • NCGC00254907-01
    • CAS-110-33-8
    • NS00004304
    • ST51046822
    • F87650
    • Q27279475
    • 110-33-8

  • Applications

    Dihexyl adipate (CAS 110-33-8) is commonly used as a plasticizer for PVC and other polymers to increase flexibility and processability in plastics and rubber formulations; it also serves as a solvent and carrier in coatings, paints, and inks to aid processing and pigment dispersion. In cosmetics and personal care, it is typically used as an emollient and solvent in formulations, contributing a smooth, skin-friendly feel. In perfumery and fragrance applications, dihexyl adipate can function as a solvent for fragrances and as a carrier during fragrance blending. It is also employed as an additive in adhesives and coatings to improve flexibility and film-forming properties. Applications may vary with local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 106.79
    methanol 131.8
    isopropanol 120.57
    water 0.1
    ethyl acetate 377.57
    n-propanol 117.58
    acetone 522.71
    n-butanol 121.02
    acetonitrile 277.29
    DMF 604.5
    toluene 203.26
    isobutanol 115.65
    1,4-dioxane 441.22
    methyl acetate 318.65
    THF 915.81
    2-butanone 423.07
    n-pentanol 127.13
    sec-butanol 139.43
    n-hexane 33.97
    ethylene glycol 10.86
    NMP 858.86
    cyclohexane 118.08
    DMSO 883.34
    n-butyl acetate 326.87
    n-octanol 89.81
    chloroform 1423.5
    n-propyl acetate 368.95
    acetic acid 305.53
    dichloromethane 1528.48
    cyclohexanone 1076.03
    propylene glycol 26.46
    isopropyl acetate 317.91
    DMAc 886.93
    2-ethoxyethanol 215.94
    isopentanol 151.39
    n-heptane 16.71
    ethyl formate 212.98
    1,2-dichloroethane 1047.25
    n-hexanol 98.2
    2-methoxyethanol 228.84
    isobutyl acetate 234.29
    tetrachloromethane 225.11
    n-pentyl acetate 372.26
    transcutol 754.54
    n-heptanol 74.48
    ethylbenzene 128.36
    MIBK 312.56
    2-propoxyethanol 205.05
    tert-butanol 214.34
    MTBE 291.59
    2-butoxyethanol 196.08
    propionic acid 187.08
    o-xylene 168.14
    formic acid 62.13
    diethyl ether 235.66
    m-xylene 128.28
    p-xylene 203.34
    chlorobenzene 435.79
    dimethyl carbonate 109.82
    n-octane 12.68
    formamide 124.32
    cyclopentanone 958.55
    2-pentanone 400.57
    anisole 248.75
    cyclopentyl methyl ether 394.73
    gamma-butyrolactone 907.07
    1-methoxy-2-propanol 204.24
    pyridine 578.57
    3-pentanone 331.06
    furfural 731.97
    n-dodecane 9.83
    diethylene glycol 109.36
    diisopropyl ether 93.61
    tert-amyl alcohol 220.59
    acetylacetone 564.66
    n-hexadecane 11.89
    acetophenone 335.72
    methyl propionate 261.86
    isopentyl acetate 323.63
    trichloroethylene 1702.74
    n-nonanol 86.78
    cyclohexanol 257.85
    benzyl alcohol 184.41
    2-ethylhexanol 94.15
    isooctanol 77.86
    dipropyl ether 146.66
    1,2-dichlorobenzene 466.0
    ethyl lactate 126.32
    propylene carbonate 516.86
    n-methylformamide 217.52
    2-pentanol 98.44
    n-pentane 19.64
    1-propoxy-2-propanol 174.76
    1-methoxy-2-propyl acetate 289.14
    2-(2-methoxypropoxy) propanol 211.02
    mesitylene 96.74
    ε-caprolactone 792.99
    p-cymene 80.6
    epichlorohydrin 1009.37
    1,1,1-trichloroethane 996.88
    2-aminoethanol 43.06
    morpholine-4-carbaldehyde 603.32
    sulfolane 1209.13
    2,2,4-trimethylpentane 22.57
    2-methyltetrahydrofuran 650.29
    n-hexyl acetate 367.45
    isooctane 12.39
    2-(2-butoxyethoxy)ethanol 270.33
    sec-butyl acetate 257.8
    tert-butyl acetate 388.66
    decalin 48.35
    glycerin 48.56
    diglyme 648.33
    acrylic acid 151.31
    isopropyl myristate 124.23
    n-butyric acid 339.14
    acetyl acetate 316.44
    di(2-ethylhexyl) phthalate 124.18
    ethyl propionate 296.3
    nitromethane 640.48
    1,2-diethoxyethane 340.78
    benzonitrile 307.74
    trioctyl phosphate 86.2
    1-bromopropane 479.45
    gamma-valerolactone 1101.06
    n-decanol 58.72
    triethyl phosphate 156.04
    4-methyl-2-pentanol 77.86
    propionitrile 221.7
    vinylene carbonate 427.99
    1,1,2-trichlorotrifluoroethane 574.21
    DMS 244.49
    cumene 88.9
    2-octanol 75.48
    2-hexanone 353.18
    octyl acetate 157.96
    limonene 130.62
    1,2-dimethoxyethane 597.98
    ethyl orthosilicate 146.71
    tributyl phosphate 125.53
    diacetone alcohol 306.48
    N,N-dimethylaniline 175.28
    acrylonitrile 255.68
    aniline 188.53
    1,3-propanediol 85.95
    bromobenzene 517.28
    dibromomethane 963.0
    1,1,2,2-tetrachloroethane 1442.46
    2-methyl-cyclohexyl acetate 243.42
    tetrabutyl urea 174.37
    diisobutyl methanol 70.06
    2-phenylethanol 149.1
    styrene 175.98
    dioctyl adipate 222.69
    dimethyl sulfate 251.34
    ethyl butyrate 270.96
    methyl lactate 112.27
    butyl lactate 217.96
    diethyl carbonate 180.82
    propanediol butyl ether 162.97
    triethyl orthoformate 197.56
    p-tert-butyltoluene 74.79
    methyl 4-tert-butylbenzoate 291.15
    morpholine 556.05
    tert-butylamine 132.15
    n-dodecanol 43.32
    dimethoxymethane 285.52
    ethylene carbonate 384.21
    cyrene 250.86
    2-ethoxyethyl acetate 403.3
    2-ethylhexyl acetate 264.37
    1,2,4-trichlorobenzene 516.93
    4-methylpyridine 577.25
    dibutyl ether 195.26
    2,6-dimethyl-4-heptanol 70.06
    DEF 507.84
    dimethyl isosorbide 426.34
    tetrachloroethylene 906.57
    eugenol 234.11
    triacetin 373.21
    span 80 199.94
    1,4-butanediol 46.66
    1,1-dichloroethane 887.16
    2-methyl-1-pentanol 149.55
    methyl formate 163.31
    2-methyl-1-butanol 135.75
    n-decane 19.3
    butyronitrile 262.32
    3,7-dimethyl-1-octanol 97.98
    1-chlorooctane 105.3
    1-chlorotetradecane 36.51
    n-nonane 17.85
    undecane 12.89
    tert-butylcyclohexane 33.69
    cyclooctane 26.34
    cyclopentanol 255.99
    tetrahydropyran 582.19
    tert-amyl methyl ether 244.29
    2,5,8-trioxanonane 385.01
    1-hexene 117.82
    2-isopropoxyethanol 177.74
    2,2,2-trifluoroethanol 136.07
    methyl butyrate 452.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction