Difurfuryl ether

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  • Identifiers

    CAS number
    4437-22-3

    Molecular formula
    C10H10O3

    SMILES
    C1=COC(=C1)COCC2=CC=CO2

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Coffee 62.63%
    Earthy 58.42%
    Burnt 55.12%
    Nutty 53.66%
    Roasted 49.89%
    Mushroom 38.77%
    Caramellic 38.23%
    Green 37.42%
    Woody 35.13%
    Musty 34.55%

    Scent© AI

  • Properties

    XLogP3-AA
    1.3

    Molecular weight
    178.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point

    • 101.00 °C. @ 2.00 mm Hg

    Flash point est.
    94.37 ˚C

    Solubility expt.

    • Insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • Difurfuryl ether
    • 2,2'-(Oxybis(methylene))difuran
    • 4437-22-3
    • Furfuryl ether
    • 2,2'-Difurfuryl ether
    • 2-(furan-2-ylmethoxymethyl)furan
    • Furan, 2,2'-(oxydimethylene)di-
    • Furan, 2,2'-[oxybis(methylene)]bis-
    • 2,2'-(Oxydimethylene)difuran
    • FEMA No. 3337
    • Furan, 2,2'-(oxybis(methylene))bis-
    • 2,2'-(Oxybis(methylene))bisfuran
    • Di-alpha-furfuryl ether
    • NSC 97234
    • BRN 0156726
    • 55L57OC81G
    • 2,2'-[Oxybis(methylene)]bisfuran
    • Difurfuryl ether (7CI)
    • NSC-97234
    • DIFURFURYL ETHER [FHFI]
    • DTXSID8063464
    • 2-{[(furan-2-yl)methoxy]methyl}furan
    • FURAN, 2,2'-OXYDIMETHYLENEBIS-
    • 5,5'-OXYDIMETHYLENE-BIS-(2-FURFURAL)
    • 2,2'-(Oxybis(methylene))bis-Furan
    • 2,2'-[Oxybis(methylene)]bis-Furan
    • UNII-55L57OC81G
    • 2-[(furan-2-ylmethoxy)methyl]furan
    • Di-a-furfuryl ether
    • MFCD01725820
    • Bis(2-furylmethyl) ether
    • Furan, 2,2'-(oxydimethylene)di- (6CI,8CI)
    • SCHEMBL891457
    • Furan,2'-(oxydimethylene)di-
    • 2,2'-(Oxydimethylene)di-Furan
    • 2-(uran-2-ylmethoxymethyl)uran
    • DTXCID7040316
    • FEMA 3337
    • 2-[(2-Furylmethoxy)methyl]furan
    • CHEBI:193974
    • Furan,2'-[oxybis(methylene)]bis-
    • NSC97234
    • 2,2\'-(Oxybis(methylene))difuran
    • 2-[(2-Furylmethoxy)methyl]furan #
    • AKOS006278742
    • SB61017
    • BS-53000
    • CS-0199135
    • NS00126877
    • Furan, 2,2'-(oxydimethylene)di-(6CI,8CI)
    • E76163
    • Q27261318
    • 630-432-0

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.7
    methanol 53.2
    isopropanol 34.76
    water 0.7
    ethyl acetate 70.11
    n-propanol 40.31
    acetone 139.48
    n-butanol 35.64
    acetonitrile 104.66
    DMF 161.59
    toluene 42.49
    isobutanol 36.9
    1,4-dioxane 155.26
    methyl acetate 98.49
    THF 243.92
    2-butanone 114.75
    n-pentanol 36.48
    sec-butanol 45.5
    n-hexane 5.59
    ethylene glycol 32.34
    NMP 161.28
    cyclohexane 14.24
    DMSO 462.1
    n-butyl acetate 43.76
    n-octanol 23.25
    chloroform 330.46
    n-propyl acetate 56.58
    acetic acid 137.21
    dichloromethane 372.66
    cyclohexanone 117.77
    propylene glycol 46.57
    isopropyl acetate 45.52
    DMAc 258.79
    2-ethoxyethanol 115.12
    isopentanol 43.52
    n-heptane 8.47
    ethyl formate 44.55
    1,2-dichloroethane 197.39
    n-hexanol 29.77
    2-methoxyethanol 133.28
    isobutyl acetate 42.39
    tetrachloromethane 25.53
    n-pentyl acetate 27.7
    transcutol 400.24
    n-heptanol 17.96
    ethylbenzene 25.65
    MIBK 55.55
    2-propoxyethanol 79.17
    tert-butanol 64.75
    MTBE 70.75
    2-butoxyethanol 49.29
    propionic acid 76.19
    o-xylene 37.02
    formic acid 65.34
    diethyl ether 68.52
    m-xylene 29.15
    p-xylene 37.41
    chlorobenzene 68.22
    dimethyl carbonate 55.56
    n-octane 3.55
    formamide 114.41
    cyclopentanone 166.01
    2-pentanone 66.43
    anisole 85.25
    cyclopentyl methyl ether 90.59
    gamma-butyrolactone 180.67
    1-methoxy-2-propanol 108.44
    pyridine 153.51
    3-pentanone 75.35
    furfural 183.18
    n-dodecane 3.71
    diethylene glycol 83.26
    diisopropyl ether 23.41
    tert-amyl alcohol 68.04
    acetylacetone 104.08
    n-hexadecane 4.23
    acetophenone 81.23
    methyl propionate 75.55
    isopentyl acetate 48.85
    trichloroethylene 355.62
    n-nonanol 23.94
    cyclohexanol 55.81
    benzyl alcohol 64.31
    2-ethylhexanol 28.54
    isooctanol 19.0
    dipropyl ether 46.7
    1,2-dichlorobenzene 70.19
    ethyl lactate 50.49
    propylene carbonate 88.06
    n-methylformamide 74.04
    2-pentanol 31.68
    n-pentane 5.44
    1-propoxy-2-propanol 62.69
    1-methoxy-2-propyl acetate 70.54
    2-(2-methoxypropoxy) propanol 100.13
    mesitylene 20.75
    ε-caprolactone 95.09
    p-cymene 23.42
    epichlorohydrin 229.78
    1,1,1-trichloroethane 124.19
    2-aminoethanol 50.66
    morpholine-4-carbaldehyde 193.07
    sulfolane 248.68
    2,2,4-trimethylpentane 7.72
    2-methyltetrahydrofuran 129.45
    n-hexyl acetate 44.7
    isooctane 4.17
    2-(2-butoxyethoxy)ethanol 107.45
    sec-butyl acetate 43.46
    tert-butyl acetate 58.75
    decalin 9.48
    glycerin 83.28
    diglyme 216.07
    acrylic acid 95.05
    isopropyl myristate 26.38
    n-butyric acid 66.81
    acetyl acetate 57.33
    di(2-ethylhexyl) phthalate 28.58
    ethyl propionate 55.69
    nitromethane 241.34
    1,2-diethoxyethane 88.34
    benzonitrile 64.55
    trioctyl phosphate 17.41
    1-bromopropane 81.03
    gamma-valerolactone 169.44
    n-decanol 19.13
    triethyl phosphate 43.72
    4-methyl-2-pentanol 26.52
    propionitrile 62.73
    vinylene carbonate 87.67
    1,1,2-trichlorotrifluoroethane 195.78
    DMS 65.4
    cumene 22.18
    2-octanol 13.97
    2-hexanone 60.11
    octyl acetate 28.91
    limonene 35.25
    1,2-dimethoxyethane 171.13
    ethyl orthosilicate 40.2
    tributyl phosphate 26.22
    diacetone alcohol 78.22
    N,N-dimethylaniline 64.51
    acrylonitrile 98.32
    aniline 68.56
    1,3-propanediol 53.78
    bromobenzene 70.17
    dibromomethane 202.38
    1,1,2,2-tetrachloroethane 263.38
    2-methyl-cyclohexyl acetate 54.17
    tetrabutyl urea 36.1
    diisobutyl methanol 24.08
    2-phenylethanol 45.32
    styrene 35.6
    dioctyl adipate 47.38
    dimethyl sulfate 113.99
    ethyl butyrate 52.89
    methyl lactate 68.21
    butyl lactate 34.61
    diethyl carbonate 47.42
    propanediol butyl ether 57.8
    triethyl orthoformate 49.75
    p-tert-butyltoluene 22.15
    methyl 4-tert-butylbenzoate 71.57
    morpholine 160.77
    tert-butylamine 42.26
    n-dodecanol 15.72
    dimethoxymethane 112.91
    ethylene carbonate 64.58
    cyrene 100.17
    2-ethoxyethyl acetate 51.48
    2-ethylhexyl acetate 39.39
    1,2,4-trichlorobenzene 98.36
    4-methylpyridine 94.93
    dibutyl ether 39.57
    2,6-dimethyl-4-heptanol 24.08
    DEF 91.44
    dimethyl isosorbide 138.77
    tetrachloroethylene 156.61
    eugenol 63.96
    triacetin 85.33
    span 80 60.31
    1,4-butanediol 33.44
    1,1-dichloroethane 142.55
    2-methyl-1-pentanol 44.44
    methyl formate 66.32
    2-methyl-1-butanol 43.33
    n-decane 5.91
    butyronitrile 43.28
    3,7-dimethyl-1-octanol 31.24
    1-chlorooctane 20.96
    1-chlorotetradecane 10.68
    n-nonane 5.34
    undecane 4.52
    tert-butylcyclohexane 8.38
    cyclooctane 5.85
    cyclopentanol 60.37
    tetrahydropyran 117.09
    tert-amyl methyl ether 65.66
    2,5,8-trioxanonane 174.22
    1-hexene 21.23
    2-isopropoxyethanol 81.0
    2,2,2-trifluoroethanol 74.19
    methyl butyrate 65.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Chicory root, roasted 1a 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.03%
Chicory root, roasted 1b 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.12%