Diflufenican

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  • Identifiers

    CAS number
    83164-33-4

    Molecular formula
    C19H11F5N2O2

    SMILES
    C1=CC(=CC(=C1)OC2=C(C=CC=N2)C(=O)NC3=C(C=C(C=C3)F)F)C(F)(F)F

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 49.23%
    Fruity 34.15%
    Grape 32.86%
    Savory 25.47%
    Cooked 23.04%
    Animal 22.61%
    Meaty 22.28%
    Bitter 20.79%
    Fatty 20.73%
    Milky 20.55%

     

    Flavor
    Bitter 80.88%
    Odorless 43.18%
    Bland 25.92%
    Mild 23.75%
    Sweet-like 20.17%
    Nitrile 19.74%
    Very strong 18.96%
    Cedarleaf 18.92%
    Indole 18.81%
    Scallion 18.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.6

    pKa est.
    6.01 (neutral)

    Molecular weight
    394.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    491°C

    Flash point

    • 191.22 ˚C est.

  • Synonyms

    • Diflufenican
    • 83164-33-4
    • N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]pyridine-3-carboxamide
    • BRODAL
    • DTXSID4041494
    • 3T8D1VDO6K
    • 2',4'-Difluoro-2-(alpha,alpha,alpha-trifluoro-m-tolyloxy)nicotinanilide
    • ARDENT
    • FENICAN
    • N-(2,4-Difluorophenyl)-2-(3-(trifluoromethyl)phenoxy)-3-pyridinecarboxamide
    • DTXCID2021494
    • CHEBI:81824
    • RPA 41670H
    • RPA-41670H
    • n-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide
    • N-(2,4-difluorophenyl)-2-(3-(trifluoromethyl)phenoxy)pyridine-3-carboxamide
    • RefChem:133580
    • 953-443-5
    • N-(2,4-Difluorophenyl)-2-(3-(trifluoromethyl)phenoxy)nicotinamide
    • MFCD01311804
    • C19H11F5N2O2
    • Diflufenicanil
    • N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]nicotinamide
    • N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)nicotinamide
    • 3-Pyridinecarboxamide, N-(2,4-difluorophenyl)-2-(3-(trifluoromethyl)phenoxy)-
    • Diflufenican [BSI:ISO]
    • 3-Pyridinecarboxamide, N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-
    • UNII-3T8D1VDO6K
    • BRN 4212494
    • Canyon
    • M&B 38544
    • Diflufenican 10 microg/mL in Acetone
    • Diflufenican (Standard)
    • Diflufenican 10 microg/mL in Acetonitrile
    • Diflufenican 100 microg/mL in Acetonitrile
    • DIFLUFENICAN [MI]
    • DIFLUFENICAN [ISO]
    • SCHEMBL22023
    • MLS000327776
    • orb1705286
    • CHEMBL1425995
    • SCHEMBL29373740
    • HMS2460K07
    • HY-W040206R
    • KXB00929
    • MSK22328
    • Tox21_300818
    • AKOS005110259
    • CS-W020946
    • DS-1276
    • HY-W040206
    • MS-3566
    • NCGC00166198-01
    • NCGC00166198-02
    • NCGC00254722-01
    • AC-19982
    • SMR000180823
    • SY102136
    • CAS-83164-33-4
    • DB-056688
    • D4108
    • NS00008837
    • M & B 38544
    • C18549
    • Diflufenican, PESTANAL(R), analytical standard
    • 164D334
    • F079422
    • Q424793
    • N-(2,4-Difluorophenyl)-2-(3-(trifluoromethyl)-phenoxy)nicotinamide
    • 2',4'-DIFLUORO-2-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYLOXY)NICOTINANILIDE
    • Diflufenican,2',4'-difluoro-2-(alpha,alpha,alpha,trifluoro-m-tolyloxy) nicotinanilide
    • 83164-33-4

  • Applications

    Diflufenican (CAS 83164-33-4) is an herbicide active ingredient used in crop protection formulations to control weeds in soil, typically applied as a pre-emergence treatment or early post-emergence. It is commonly formulated in tank-mixed products to broaden the spectrum of control and align with farming practices. Typical applications include weed management in cereals (such as wheat and barley) and in oilseed crops (such as canola/rapeseed), soil-applied treatments in appropriate cropping systems, and use within crop protection programs subject to local regulations and label restrictions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.75
    methanol 4.46
    isopropanol 1.52
    water 0.01
    ethyl acetate 55.93
    n-propanol 3.93
    acetone 36.49
    n-butanol 4.84
    acetonitrile 13.01
    DMF 6.67
    toluene 19.66
    isobutanol 2.58
    1,4-dioxane 35.63
    methyl acetate 38.51
    THF 102.27
    2-butanone 61.88
    n-pentanol 4.12
    sec-butanol 5.8
    n-hexane 0.08
    ethylene glycol 0.23
    NMP 20.13
    cyclohexane 0.27
    DMSO 37.42
    n-butyl acetate 18.47
    n-octanol 3.58
    chloroform 11.29
    n-propyl acetate 21.22
    acetic acid 10.64
    dichloromethane 15.55
    cyclohexanone 54.99
    propylene glycol 0.53
    isopropyl acetate 27.77
    DMAc 50.42
    2-ethoxyethanol 18.08
    isopentanol 6.13
    n-heptane 0.18
    ethyl formate 16.07
    1,2-dichloroethane 11.07
    n-hexanol 4.31
    2-methoxyethanol 20.06
    isobutyl acetate 6.04
    tetrachloromethane 0.43
    n-pentyl acetate 11.71
    transcutol 62.94
    n-heptanol 3.9
    ethylbenzene 6.37
    MIBK 16.71
    2-propoxyethanol 21.78
    tert-butanol 3.56
    MTBE 12.26
    2-butoxyethanol 15.29
    propionic acid 5.77
    o-xylene 9.86
    formic acid 3.08
    diethyl ether 19.18
    m-xylene 6.48
    p-xylene 4.99
    chlorobenzene 3.81
    dimethyl carbonate 9.35
    n-octane 0.11
    formamide 8.17
    cyclopentanone 46.57
    2-pentanone 39.96
    anisole 19.13
    cyclopentyl methyl ether 19.19
    gamma-butyrolactone 42.88
    1-methoxy-2-propanol 12.94
    pyridine 38.09
    3-pentanone 31.34
    furfural 31.08
    n-dodecane 0.21
    diethylene glycol 8.73
    diisopropyl ether 3.28
    tert-amyl alcohol 8.97
    acetylacetone 51.06
    n-hexadecane 0.25
    acetophenone 20.57
    methyl propionate 27.47
    isopentyl acetate 14.38
    trichloroethylene 22.64
    n-nonanol 4.26
    cyclohexanol 6.38
    benzyl alcohol 9.35
    2-ethylhexanol 4.29
    isooctanol 3.5
    dipropyl ether 8.59
    1,2-dichlorobenzene 3.07
    ethyl lactate 8.18
    propylene carbonate 15.85
    n-methylformamide 7.2
    2-pentanol 3.91
    n-pentane 0.16
    1-propoxy-2-propanol 14.54
    1-methoxy-2-propyl acetate 28.05
    2-(2-methoxypropoxy) propanol 24.79
    mesitylene 2.26
    ε-caprolactone 51.02
    p-cymene 3.41
    epichlorohydrin 65.85
    1,1,1-trichloroethane 5.55
    2-aminoethanol 1.04
    morpholine-4-carbaldehyde 29.82
    sulfolane 33.97
    2,2,4-trimethylpentane 0.26
    2-methyltetrahydrofuran 50.59
    n-hexyl acetate 14.01
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 30.64
    sec-butyl acetate 16.03
    tert-butyl acetate 21.39
    decalin 0.22
    glycerin 1.47
    diglyme 59.79
    acrylic acid 4.46
    isopropyl myristate 7.25
    n-butyric acid 12.64
    acetyl acetate 25.66
    di(2-ethylhexyl) phthalate 6.95
    ethyl propionate 26.19
    nitromethane 45.14
    1,2-diethoxyethane 29.15
    benzonitrile 11.32
    trioctyl phosphate 4.02
    1-bromopropane 8.27
    gamma-valerolactone 74.17
    n-decanol 3.45
    triethyl phosphate 8.43
    4-methyl-2-pentanol 3.31
    propionitrile 11.12
    vinylene carbonate 13.5
    1,1,2-trichlorotrifluoroethane 17.5
    DMS 13.88
    cumene 2.73
    2-octanol 2.93
    2-hexanone 25.32
    octyl acetate 9.7
    limonene 4.51
    1,2-dimethoxyethane 54.07
    ethyl orthosilicate 7.74
    tributyl phosphate 5.74
    diacetone alcohol 20.39
    N,N-dimethylaniline 8.5
    acrylonitrile 12.42
    aniline 10.91
    1,3-propanediol 3.46
    bromobenzene 3.63
    dibromomethane 8.49
    1,1,2,2-tetrachloroethane 14.35
    2-methyl-cyclohexyl acetate 11.45
    tetrabutyl urea 10.7
    diisobutyl methanol 2.8
    2-phenylethanol 11.77
    styrene 5.94
    dioctyl adipate 12.46
    dimethyl sulfate 11.18
    ethyl butyrate 20.45
    methyl lactate 8.8
    butyl lactate 7.97
    diethyl carbonate 12.29
    propanediol butyl ether 6.4
    triethyl orthoformate 13.21
    p-tert-butyltoluene 2.69
    methyl 4-tert-butylbenzoate 15.51
    morpholine 33.31
    tert-butylamine 1.66
    n-dodecanol 2.72
    dimethoxymethane 21.42
    ethylene carbonate 12.36
    cyrene 15.44
    2-ethoxyethyl acetate 25.73
    2-ethylhexyl acetate 11.17
    1,2,4-trichlorobenzene 5.47
    4-methylpyridine 32.04
    dibutyl ether 8.63
    2,6-dimethyl-4-heptanol 2.8
    DEF 29.52
    dimethyl isosorbide 36.61
    tetrachloroethylene 6.88
    eugenol 14.25
    triacetin 17.11
    span 80 11.73
    1,4-butanediol 1.05
    1,1-dichloroethane 7.42
    2-methyl-1-pentanol 6.96
    methyl formate 7.85
    2-methyl-1-butanol 6.76
    n-decane 0.29
    butyronitrile 11.48
    3,7-dimethyl-1-octanol 4.51
    1-chlorooctane 1.78
    1-chlorotetradecane 0.98
    n-nonane 0.2
    undecane 0.24
    tert-butylcyclohexane 0.16
    cyclooctane 0.1
    cyclopentanol 4.16
    tetrahydropyran 32.59
    tert-amyl methyl ether 16.4
    2,5,8-trioxanonane 48.99
    1-hexene 1.15
    2-isopropoxyethanol 11.74
    2,2,2-trifluoroethanol 2.82
    methyl butyrate 27.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction