Diethylenetriaminepentaacetic acid

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  • Identifiers

    CAS number
    67-43-6

    Molecular formula
    C14H23N3O10

    SMILES
    C(CN(CC(=O)O)CC(=O)O)N(CCN(CC(=O)O)CC(=O)O)CC(=O)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 66.15%
    Sweet 33.22%
    Savory 28.64%
    Fishy 21.27%
    Alcoholic 19.37%
    Meaty 19.07%
    Clean 15.82%
    Cooked 15.3%
    Oily 14.98%
    Milky 14.3%

     

    Flavor
    Odorless 67.38%
    Mild 37.31%
    Bitter 35.22%
    Bland 34.36%
    Very mild 25.35%
    Yeast 22.98%
    Sweet-like 22.48%
    Faint 21.3%
    Nitrile 19.21%
    Bay oil 19.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -8.5

    pKa est.
    1.61 (strong acid)

    Molecular weight
    393.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 219-220 ºC

    Boiling point

    • Decomposes

    Flash point

    • 377.21 ˚C est.

    Solubility expt.

    • Highly soluble

  • Synonyms

    • Pentetic acid
    • diethylenetriaminepentaacetic acid
    • 67-43-6
    • DTPA
    • Detapac
    • Detarex
    • Titriplex V
    • Monaquest CAI
    • Perma kleer
    • Dabeersen 503
    • CHEL 330 acid
    • Penthanil
    • Penthamil
    • Chel DTPA
    • Dissolvine D
    • Pentacarboxymethyldiethylenetriamine
    • Diethylenetriamine Pentaacetic Acid
    • Acido pentetico
    • Acide pentetique
    • (Diethylenetrinitrilo)pentaacetic acid
    • Diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
    • Acidum penteticum
    • DTP-A
    • 1,1,4,7,7-Diethylenetriaminepentaacetic acid
    • NSC-7340
    • Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
    • Diethylene triamine pentaacetic acid
    • NANODTPA
    • 7A314HQM0I
    • DTXSID2023434
    • Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-
    • NSC7340
    • (Diethylenetriamine)pentaacetic acid
    • NANODTPA COMPONENT DTPA
    • DTXCID603434
    • N-Carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
    • (((Carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid
    • CHEBI:35739
    • NANODTPA ZN-DTPA COMPONENT DTPA
    • NANO-DTPA CAPSULE COMPONENT DTPA
    • [[(Carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid
    • CaDTPA
    • Pentaind
    • CaNa-DTPA
    • Indium DTPA
    • RefChem:56262
    • Pentetate, Calcium Trisodium
    • V09AX01
    • V09CA01
    • Pentaacetic Acid, Diethylenetriamine
    • Kit for the preparation of Technetium Tc 99m Pentetate
    • 2,2',2'',2''',2''''-(ethane-1,2-diylnitrilo)pentaacetic acid;N,N-bis(2-(bis(carboxymethyl)amino)ethyl)glycine
    • 200-652-8
    • Hamp-Ex Acid
    • DETPA
    • H5dtpa
    • 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
    • MFCD00004289
    • N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine
    • Monaquest
    • Diethylenetriaminepentacetic acid
    • N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycine
    • NSC 7340
    • N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine
    • 3,6,9-Triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-
    • Acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-
    • N,N-Bis(2-(bis(carboxymethyl)amino)ethyl)glycine
    • 2,2',2'',2'''-((((Carboxymethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetic acid
    • Acetic acid, 2,2',2'',2'''-(((carboxymethyl)imino)bis(2,1-ethanediylnitrilo))tetrakis-
    • Diethylenetriaminepentaacetic acid;DTPA
    • CAS-67-43-6
    • NCGC00015360-05
    • 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetic acid
    • Penthamil (VAN)
    • N,N,N',N'',N''-diethylenetriaminepentaacetic acid
    • C14H23N3O10
    • [[(carboxymethyl)imino]bis(1,2-ethanediylnitrilo)tetraacetic acid]
    • 2,2',2'',2''',2''''-(ethane-1,2-diylnitrilo)pentaacetic acid
    • Diethylenetriaminepentaacetic acid, 99%
    • Acide pentetique [INN-French]
    • Acido pentetico [INN-Spanish]
    • Acidum penteticum [INN-Latin]
    • N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine
    • SR-01000075826
    • EINECS 200-652-8
    • BRN 1810219
    • 2-(bis{2-[bis(carboxymethyl)amino]ethyl}amino)acetic acid
    • UNII-7A314HQM0I
    • Acetic acid, [(carboxymethylimino)bis(ethylenenitrilo)]tetra-
    • pentetic-acid
    • Pentetic?Acid
    • Acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2,1-ethanediylnitrilo)]tetrakis-
    • Pentetic acid [USAN:USP:INN:BAN]
    • 2,2'-(Carboxymethylimino)bis(ethyliminodiessigsaeure)
    • Pentetic acid; DTPA
    • Plexene D (Salt/Mix)
    • Syntron C (Salt/Mix)
    • Kiresuto P (Salt/Mix)
    • Tetralon B (Salt/Mix)
    • 9-Propylamino-phenanthren
    • Prestwick0_000941
    • Prestwick1_000941
    • Prestwick2_000941
    • Prestwick3_000941
    • Lopac-D-6518
    • PENTETATE [VANDF]
    • Pentetic acid (Standard)
    • Chel 330 (Salt/Mix)
    • CHEMBL780
    • EC 200-652-8
    • Pentetic acid (USP/INN)
    • PENTETIC ACID [II]
    • PENTETIC ACID [MI]
    • PENTETIC ACID [INN]
    • Lopac0_000431
    • SCHEMBL17138
    • BSPBio_000902
    • PENTETIC ACID [USAN]
    • 4-04-00-02454 (Beilstein Handbook Reference)
    • PENTETIC ACID [VANDF]
    • SPBio_003061
    • PENTETIC ACID [MART.]
    • BPBio1_000994
    • orb1310634
    • PENTETIC ACID [USP-RS]
    • PENTETIC ACID [WHO-DD]
    • HY-B1335R
    • 67-43-6

  • Applications

    Diethylenetriaminepentaacetic acid (DTPA), CAS 67-43-6, is a versatile chelating agent used across multiple industries. Real-world applications include sequestering metal ions in detergents and household care products to soften water and stabilize formulations; acting as a chelant in industrial coatings, inks, and metal finishing to stabilize metals and prevent salt deposition; enabling agricultural micronutrient delivery via metal-DTPA chelates such as Fe-DTPA or Zn-DTPA for soil and foliar fertilization; serving as a ligand in medical imaging and radiopharmaceuticals, notably forming Gd-DTPA complexes used as MRI contrast agents; and supporting analytical chemistry and environmental work by complexing metals for trace metal analysis and remediation workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.06
    methanol 0.48
    isopropanol 0.01
    water 1.21
    ethyl acetate 0.01
    n-propanol 0.04
    acetone 0.01
    n-butanol 0.02
    acetonitrile 0.01
    DMF 3.29
    toluene 0.01
    isobutanol 0.02
    1,4-dioxane 0.01
    methyl acetate 0.01
    THF 0.03
    2-butanone 0.02
    n-pentanol 0.01
    sec-butanol 0.02
    n-hexane 0.0
    ethylene glycol 0.35
    NMP 8.78
    cyclohexane 0.0
    DMSO 4.71
    n-butyl acetate 0.01
    n-octanol 0.01
    chloroform 0.01
    n-propyl acetate 0.01
    acetic acid 0.23
    dichloromethane 0.02
    cyclohexanone 0.04
    propylene glycol 0.32
    isopropyl acetate 0.0
    DMAc 3.3
    2-ethoxyethanol 0.08
    isopentanol 0.01
    n-heptane 0.0
    ethyl formate 0.03
    1,2-dichloroethane 0.01
    n-hexanol 0.01
    2-methoxyethanol 0.51
    isobutyl acetate 0.0
    tetrachloromethane 0.0
    n-pentyl acetate 0.01
    transcutol 0.15
    n-heptanol 0.01
    ethylbenzene 0.0
    MIBK 0.01
    2-propoxyethanol 0.11
    tert-butanol 0.01
    MTBE 0.0
    2-butoxyethanol 0.06
    propionic acid 0.12
    o-xylene 0.01
    formic acid 3.72
    diethyl ether 0.0
    m-xylene 0.01
    p-xylene 0.0
    chlorobenzene 0.0
    dimethyl carbonate 0.07
    n-octane 0.0
    formamide 3.15
    cyclopentanone 0.09
    2-pentanone 0.01
    anisole 0.01
    cyclopentyl methyl ether 0.03
    gamma-butyrolactone 0.19
    1-methoxy-2-propanol 0.26
    pyridine 0.04
    3-pentanone 0.02
    furfural 0.4
    n-dodecane 0.0
    diethylene glycol 0.2
    diisopropyl ether 0.0
    tert-amyl alcohol 0.02
    acetylacetone 0.02
    n-hexadecane 0.0
    acetophenone 0.02
    methyl propionate 0.05
    isopentyl acetate 0.01
    trichloroethylene 0.03
    n-nonanol 0.01
    cyclohexanol 0.02
    benzyl alcohol 0.02
    2-ethylhexanol 0.01
    isooctanol 0.0
    dipropyl ether 0.01
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.06
    propylene carbonate 0.06
    n-methylformamide 1.26
    2-pentanol 0.01
    n-pentane 0.0
    1-propoxy-2-propanol 0.08
    1-methoxy-2-propyl acetate 0.04
    2-(2-methoxypropoxy) propanol 0.09
    mesitylene 0.0
    ε-caprolactone 0.06
    p-cymene 0.01
    epichlorohydrin 0.06
    1,1,1-trichloroethane 0.0
    2-aminoethanol 0.5
    morpholine-4-carbaldehyde 1.09
    sulfolane 2.6
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.01
    n-hexyl acetate 0.01
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.06
    sec-butyl acetate 0.0
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 1.87
    diglyme 0.13
    acrylic acid 0.3
    isopropyl myristate 0.0
    n-butyric acid 0.06
    acetyl acetate 0.0
    di(2-ethylhexyl) phthalate 0.01
    ethyl propionate 0.01
    nitromethane 0.25
    1,2-diethoxyethane 0.01
    benzonitrile 0.01
    trioctyl phosphate 0.01
    1-bromopropane 0.01
    gamma-valerolactone 0.34
    n-decanol 0.0
    triethyl phosphate 0.03
    4-methyl-2-pentanol 0.0
    propionitrile 0.01
    vinylene carbonate 0.08
    1,1,2-trichlorotrifluoroethane 0.7
    DMS 0.02
    cumene 0.0
    2-octanol 0.0
    2-hexanone 0.01
    octyl acetate 0.0
    limonene 0.01
    1,2-dimethoxyethane 0.06
    ethyl orthosilicate 0.02
    tributyl phosphate 0.01
    diacetone alcohol 0.04
    N,N-dimethylaniline 0.03
    acrylonitrile 0.04
    aniline 0.02
    1,3-propanediol 0.14
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.03
    2-methyl-cyclohexyl acetate 0.01
    tetrabutyl urea 0.03
    diisobutyl methanol 0.0
    2-phenylethanol 0.01
    styrene 0.0
    dioctyl adipate 0.0
    dimethyl sulfate 0.65
    ethyl butyrate 0.01
    methyl lactate 0.34
    butyl lactate 0.04
    diethyl carbonate 0.01
    propanediol butyl ether 0.08
    triethyl orthoformate 0.02
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.05
    morpholine 0.03
    tert-butylamine 0.0
    n-dodecanol 0.0
    dimethoxymethane 0.19
    ethylene carbonate 0.03
    cyrene 0.26
    2-ethoxyethyl acetate 0.01
    2-ethylhexyl acetate 0.01
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.03
    dibutyl ether 0.0
    2,6-dimethyl-4-heptanol 0.0
    DEF 0.15
    dimethyl isosorbide 0.18
    tetrachloroethylene 0.03
    eugenol 0.05
    triacetin 0.02
    span 80 0.05
    1,4-butanediol 0.03
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.01
    methyl formate 0.38
    2-methyl-1-butanol 0.02
    n-decane 0.0
    butyronitrile 0.01
    3,7-dimethyl-1-octanol 0.0
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.02
    tetrahydropyran 0.01
    tert-amyl methyl ether 0.01
    2,5,8-trioxanonane 0.09
    1-hexene 0.0
    2-isopropoxyethanol 0.02
    2,2,2-trifluoroethanol 0.21
    methyl butyrate 0.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction