Diethylene glycol monohexyl ether

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  • Identifiers

    CAS number
    112-59-4

    Molecular formula
    C10H22O3

    SMILES
    CCCCCCOCCOCCO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 55.04%
    Fruity 51.12%
    Oily 49.15%
    Sweet 45.26%
    Alcoholic 43.79%
    Fresh 41.57%
    Ethereal 37.75%
    Floral 33.58%
    Fermented 30.61%
    Herbal 29.56%

     

    Flavor
    Sweet 50.48%
    Green 36.55%
    Earthy 32.8%
    Mushroom 31.71%
    Oily 31.29%
    Musty 31.2%
    Fatty 31.11%
    Vegetable 30.78%
    Fruity 30.51%
    Alcoholic 30.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    6.25 (neutral)

    Molecular weight
    190.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Melting point expt.

    • -27.4 °F (USCG, 1999)
    • -28 °C
    • -33.3 °C

    Boiling point

    • 498.4 °F at 760 mmHg (USCG, 1999)
    • boiling point equals 498 ° F
    • 258 °C at 760 mm Hg; 192 °C at 100 mm Hg
    • 259.1 °C

    Flash point

    • 122.03 ˚C est.
    • 285 °F (USCG, 1999)
    • Flash point equals 285 °F
    • 271 °F (OPEN CUP)
    • 140.6 °C o.c.

    Solubility expt.

    • In water, 17,000 mg/L at 20 °C
    • Solubility in water, g/100ml at 20 °C: 1.7

  • Synonyms

    • Diethylene glycol monohexyl ether
    • 112-59-4
    • 2-(2-Hexyloxyethoxy)ethanol
    • Hexol carbitol
    • Hexyl carbitol
    • 2-(2-(hexyloxy)ethoxy)ethanol
    • n-Hexyl carbitol
    • n-Hexoxyethoxyethanol
    • 3,6-Dioxadodecanol-1
    • 2-(2-hexoxyethoxy)ethanol
    • Ethanol, 2-[2-(hexyloxy)ethoxy]-
    • Hexyldiglycol
    • Hexylkarbitol
    • Diethylene glycol n-hexyl ether
    • DIETHYLENE GLYCOL HEXYL ETHER
    • Hexylkarbitol [Czech]
    • Diethylene glycol mono(n-hexyl) ether
    • Ethanol, 2-((2-hexyloxy)ethoxy)-
    • C6E2
    • NSC 403666
    • 2-((2-Hexyloxy)ethoxy)ethanol
    • HSDB 5571
    • 3,6-Dioxa-1-dodecanol
    • Diethylene glycol mono-n-hexyl ether
    • EINECS 203-988-3
    • Ethanol, 2-(2-(hexyloxy)ethoxy)-
    • Z6X09N6YJL
    • Ethanol, 2-(2-(2-hexyloxy)ethoxy)-
    • BRN 1743959
    • CCRIS 8863
    • 2-[2-(hexyloxy)ethoxy]ethanol
    • AI3-00301
    • MFCD00010703
    • NSC-403666
    • DTXSID4026921
    • EC 203-988-3
    • 4-01-00-02396 (Beilstein Handbook Reference)
    • 2-((2-HEXYLOXY)ETHOXY)ETHANOL [HSDB]
    • DTXCID406921
    • Ethanol, 2-[(2-hexyloxy)ethoxy]-
    • CAS-112-59-4
    • DEGHE
    • Di(ethylene glycol) hexyl ether
    • UNII-Z6X09N6YJL
    • nHexyl carbitol
    • Diethylene glycol-monohexyl ether
    • Ucar Filmer EHC
    • nHexoxyethoxyethanol
    • 3,6Dioxadodecanol1
    • ETHANOL, 2-
    • SCHEMBL24452
    • 2((2Hexyloxy)ethoxy)ethanol
    • Diethylene glycol nhexyl ether
    • WLN: Q2O2O6
    • 2-(2-hexyloxy-ethoxy)-ethanol
    • CHEMBL2131110
    • Ethanol, 2((2hexyloxy)ethoxy)
    • GZMAAYIALGURDQ-UHFFFAOYSA-
    • Ethanol, 2(2(2hexyloxy)ethoxy)
    • Diethylene glycol mono(nhexyl) ether
    • Tox21_202146
    • Tox21_303108
    • NSC403666
    • AKOS015903580
    • Di(ethylene glycol) hexyl ether, 95%
    • Di(ethylene glycol) hexyl ether, 97%
    • HY-W133950
    • SB83835
    • Diethylene glycol monohexyl ether, 96%
    • NCGC00164133-01
    • NCGC00164133-02
    • NCGC00257046-01
    • NCGC00259695-01
    • BS-42440
    • DB-041101
    • 2-propanol,1-[2-(2-hydroxyethoxy)ethoxy]-
    • D0501
    • NS00008688
    • F71191
    • Q27295083
    • Diethylene glycol monohexyl ether, purum, >=95.0% (GC)
    • InChI=1/C10H22O3/c1-2-3-4-5-7-12-9-10-13-8-6-11/h11H,2-10H2,1H3
    • 203-988-3

  • Applications

    Diethylene glycol monohexyl ether (CAS 112-59-4) is a polar alkyl ether commonly used as a solvent and co-solvent in industrial formulations. In coatings, inks, and paints, it helps dissolve resin components and regulate evaporation and flow. It also serves as an effective cleaner and degreaser in industrial cleaning applications, and as a processing aid in polymer formulations such as adhesives and sealants to improve compatibility and performance. In cosmetics and personal care, it functions as a solvent and humectant, supporting dispersion and texture. Additionally, it may act as an intermediate in the synthesis of surfactants and specialty additives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2081.52
    methanol 2994.42
    isopropanol 1301.7
    water 2.1
    ethyl acetate 835.55
    n-propanol 1432.69
    acetone 1181.14
    n-butanol 1213.64
    acetonitrile 739.73
    DMF 818.81
    toluene 164.04
    isobutanol 892.9
    1,4-dioxane 1434.25
    methyl acetate 613.51
    THF 1667.01
    2-butanone 673.81
    n-pentanol 670.72
    sec-butanol 900.31
    n-hexane 113.92
    ethylene glycol 415.44
    NMP 617.78
    cyclohexane 382.2
    DMSO 3094.02
    n-butyl acetate 660.57
    n-octanol 196.67
    chloroform 1515.05
    n-propyl acetate 586.18
    acetic acid 1750.71
    dichloromethane 1713.93
    cyclohexanone 1229.87
    propylene glycol 485.9
    isopropyl acetate 446.14
    DMAc 521.82
    2-ethoxyethanol 1053.6
    isopentanol 783.66
    n-heptane 127.39
    ethyl formate 557.0
    1,2-dichloroethane 1270.78
    n-hexanol 596.19
    2-methoxyethanol 1900.7
    isobutyl acetate 307.36
    tetrachloromethane 307.99
    n-pentyl acetate 328.17
    transcutol 2273.45
    n-heptanol 213.18
    ethylbenzene 106.19
    MIBK 325.76
    2-propoxyethanol 891.18
    tert-butanol 1280.58
    MTBE 589.02
    2-butoxyethanol 451.85
    propionic acid 917.83
    o-xylene 131.06
    formic acid 592.12
    diethyl ether 919.56
    m-xylene 123.74
    p-xylene 142.95
    chlorobenzene 310.99
    dimethyl carbonate 125.33
    n-octane 35.46
    formamide 696.45
    cyclopentanone 975.44
    2-pentanone 598.46
    anisole 234.37
    cyclopentyl methyl ether 782.24
    gamma-butyrolactone 1061.95
    1-methoxy-2-propanol 1064.03
    pyridine 859.9
    3-pentanone 410.34
    furfural 907.55
    n-dodecane 20.78
    diethylene glycol 755.43
    diisopropyl ether 187.84
    tert-amyl alcohol 791.54
    acetylacetone 573.92
    n-hexadecane 23.6
    acetophenone 266.49
    methyl propionate 470.12
    isopentyl acetate 477.86
    trichloroethylene 1674.62
    n-nonanol 173.05
    cyclohexanol 1099.54
    benzyl alcohol 286.37
    2-ethylhexanol 352.41
    isooctanol 181.58
    dipropyl ether 538.45
    1,2-dichlorobenzene 302.11
    ethyl lactate 256.33
    propylene carbonate 559.61
    n-methylformamide 621.17
    2-pentanol 668.05
    n-pentane 130.35
    1-propoxy-2-propanol 729.49
    1-methoxy-2-propyl acetate 460.33
    2-(2-methoxypropoxy) propanol 327.63
    mesitylene 99.24
    ε-caprolactone 980.09
    p-cymene 113.28
    epichlorohydrin 1297.14
    1,1,1-trichloroethane 806.86
    2-aminoethanol 780.81
    morpholine-4-carbaldehyde 854.18
    sulfolane 1275.64
    2,2,4-trimethylpentane 53.84
    2-methyltetrahydrofuran 1181.14
    n-hexyl acetate 376.45
    isooctane 36.12
    2-(2-butoxyethoxy)ethanol 534.88
    sec-butyl acetate 336.46
    tert-butyl acetate 458.0
    decalin 78.31
    glycerin 589.45
    diglyme 1113.33
    acrylic acid 632.29
    isopropyl myristate 132.26
    n-butyric acid 1419.71
    acetyl acetate 476.2
    di(2-ethylhexyl) phthalate 123.15
    ethyl propionate 420.39
    nitromethane 1691.39
    1,2-diethoxyethane 753.49
    benzonitrile 344.77
    trioctyl phosphate 104.39
    1-bromopropane 734.05
    gamma-valerolactone 1298.28
    n-decanol 118.27
    triethyl phosphate 202.08
    4-methyl-2-pentanol 278.95
    propionitrile 630.27
    vinylene carbonate 491.87
    1,1,2-trichlorotrifluoroethane 1182.63
    DMS 246.99
    cumene 86.78
    2-octanol 132.57
    2-hexanone 460.94
    octyl acetate 167.45
    limonene 224.01
    1,2-dimethoxyethane 1327.92
    ethyl orthosilicate 208.71
    tributyl phosphate 148.51
    diacetone alcohol 495.24
    N,N-dimethylaniline 161.45
    acrylonitrile 641.08
    aniline 340.99
    1,3-propanediol 1195.38
    bromobenzene 303.85
    dibromomethane 1199.72
    1,1,2,2-tetrachloroethane 1470.32
    2-methyl-cyclohexyl acetate 312.6
    tetrabutyl urea 179.53
    diisobutyl methanol 197.9
    2-phenylethanol 268.53
    styrene 141.0
    dioctyl adipate 239.98
    dimethyl sulfate 253.88
    ethyl butyrate 498.34
    methyl lactate 266.04
    butyl lactate 295.79
    diethyl carbonate 276.81
    propanediol butyl ether 390.9
    triethyl orthoformate 355.87
    p-tert-butyltoluene 107.44
    methyl 4-tert-butylbenzoate 233.16
    morpholine 1882.59
    tert-butylamine 745.85
    n-dodecanol 90.28
    dimethoxymethane 595.23
    ethylene carbonate 500.37
    cyrene 282.03
    2-ethoxyethyl acetate 382.14
    2-ethylhexyl acetate 360.11
    1,2,4-trichlorobenzene 338.36
    4-methylpyridine 555.24
    dibutyl ether 371.92
    2,6-dimethyl-4-heptanol 197.9
    DEF 697.56
    dimethyl isosorbide 511.4
    tetrachloroethylene 1178.57
    eugenol 236.01
    triacetin 380.28
    span 80 372.8
    1,4-butanediol 408.79
    1,1-dichloroethane 908.12
    2-methyl-1-pentanol 443.75
    methyl formate 405.77
    2-methyl-1-butanol 707.69
    n-decane 42.06
    butyronitrile 698.8
    3,7-dimethyl-1-octanol 210.62
    1-chlorooctane 147.69
    1-chlorotetradecane 50.97
    n-nonane 45.24
    undecane 27.35
    tert-butylcyclohexane 62.09
    cyclooctane 84.11
    cyclopentanol 1022.59
    tetrahydropyran 1735.48
    tert-amyl methyl ether 394.86
    2,5,8-trioxanonane 647.46
    1-hexene 303.43
    2-isopropoxyethanol 599.52
    2,2,2-trifluoroethanol 442.31
    methyl butyrate 648.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction