Diethylene glycol diethyl ether

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  • Identifiers

    CAS number
    112-36-7

    Molecular formula
    C8H18O3

    SMILES
    CCOCCOCCOCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 71.06%
    Alcoholic 53.31%
    Fruity 42.57%
    Sweet 37.07%
    Solvent 34.95%
    Fermented 30.89%
    Pungent 22.51%
    Musty 21.72%
    Oily 20.4%
    Nutty 20.09%

     

    Flavor
    Sweet 57.59%
    Vegetable 41.92%
    Green 39.95%
    Earthy 38.79%
    Alcoholic 38.47%
    Fruit 36.14%
    Musty 32.24%
    Ether 30.97%
    Alcohol 30.04%
    Fusel 26.06%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    5.23 (weak acid)

    Molecular weight
    162.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Melting point expt.

    • -47.7 °F (NTP, 1992)
    • -45 °C
    • -44 °C

    Boiling point

    • 372 °F at 760 mmHg (NTP, 1992)
    • 188 °C
    • 189 °C

    Flash point

    • 70.17 ˚C est.
    • 130 °F (NTP, 1992)
    • 180 °F (82 °C) (Open Cup)
    • 71 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
    • Very soluble in ethanol, organic solvents; soluble in ethyl ether
    • Soluble in hydrocarbons
    • Infinite /1.0X10+6 mg/L/ solubility water at 25 °C
    • Solubility in water: very good

  • Synonyms

    • DIETHYLENE GLYCOL DIETHYL ETHER
    • 112-36-7
    • 1-Ethoxy-2-(2-ethoxyethoxy)ethane
    • 2-Ethoxyethyl ether
    • Diethyl carbitol
    • Bis(2-ethoxyethyl) ether
    • DEGDEE
    • Ethane, 1,1'-oxybis[2-ethoxy-
    • HSDB 68
    • Ethane, 1,1'-oxybis(2-ethoxy-
    • Glycol, diethylene-, diethyl ether
    • EINECS 203-963-7
    • UNII-ZH086O935Z
    • diethoxydiglycol
    • diethyleneglycol diethyl ether
    • BRN 1699259
    • DTXSID3025047
    • HISOLVE EDE
    • AI3-19428
    • ZH086O935Z
    • 1,1'-oxybis(2-ethoxy)ethane
    • DTXCID505047
    • CHEBI:44664
    • EC 203-963-7
    • 4-01-00-02394 (Beilstein Handbook Reference)
    • DIETHYLENE GLYCOL DIETHYL ETHER [MI]
    • DIETHYLENE GLYCOL DIETHYL ETHER [HSDB]
    • bis(2-ethoxyethyl)ether
    • 3,6,9Trioxaundecane
    • Bis(2ethoxyethyl) ether
    • RefChem:133495
    • Ether, bis(2ethoxyethyl)
    • 2(2Ethoxyethoxy)1ethoxyethane
    • Ethane, 1,1'oxybis(2ethoxy
    • Bis(2,2-diethoxyethyl) ether
    • DIETHOXYDIGLYCOL [INCI]
    • 1,1'-oxybis(2-ethoxyethane)
    • 1Ethoxy2(betaethoxyethoxy)ethane
    • 1,1'-Oxybis(2-ethoxy-ethane)
    • Glycol, diethylene, diethyl ether
    • Ethanol, 2,2'oxybis, diethyl ether
    • 2,2'-OXYBISETHANOL DIETHYL ETHER
    • InChI=1/C8H18O3/c1-3-9-5-7-11-8-6-10-4-2/h3-8H2,1-2H
    • RRQYJINTUHWNHW-UHFFFAOYSA-N
    • Ethyl diglyme
    • Diethyldiethylene glycol
    • 3,6,9-Trioxaundecane
    • Ether, bis(2-ethoxyethyl)
    • diethyleneglycoldiethylether
    • Diethylether diethylenglykolu
    • 2-(2-Ethoxyethoxy)-1-ethoxyethane
    • MFCD00009254
    • Ethyldiglyme
    • Ethanol, 2,2'-oxybis-, diethyl ether
    • 1-Ethoxy-2-(beta-ethoxyethoxy)ethane
    • Ethanol, 2,2'-oxybis-, diethyl ether; Ethyldiglyme; Hisolve EDE
    • P4G
    • Diethylether diethylenglykolu [Czech]
    • ethoxyethyl ether
    • (1-ethoxy)-ethyl ether
    • diethyleneglycol diethylether
    • 1,5-diethoxy-3-oxapentane
    • SCHEMBL16596
    • Diethylene glycol diethylether
    • SCHEMBL145416
    • SCHEMBL593115
    • orb2944145
    • SCHEMBL3649805
    • SCHEMBL3676058
    • SCHEMBL4216111
    • CHEMBL1235106
    • MSK2602
    • Ethane, 1,1'-oxybis[2-ethoxy-]
    • Tox21_302050
    • 1-ethoxy-2-(2-ethoxyethoxyl)ethane
    • EBC-47379
    • MSK2602-100M
    • 1-ethoxy-2-(2-ethoxyethoxy)-ethane
    • AKOS015915322
    • MSK2602-1000M
    • 1-Ethoxy-2-(2-ethoxyethoxy)ethane #
    • DB08357
    • 1-Ethoxy-2-(.beta.-ethoxyethoxy)ethane
    • NCGC00164135-01
    • NCGC00255128-01
    • CAS-112-36-7
    • B0489
    • Diethylene glycol diethyl ether, HPLC Grade
    • NS00004273
    • F862397
    • Diethylene glycol diethyl ether, for HPLC, >=99%
    • Q5275148
    • Diethylene glycol diethyl ether, reagent grade, >=98%
    • F8881-4182
    • Z1255402671
    • 2-Ethoxyethyl ether, Bis(2-ethoxyethyl) ether, Diethyldiglycol
    • Diethylene glycol diethyl ether Solution in Methanol, 100ug/mL
    • Diethylene glycol diethyl ether Solution in Methanol, 1000ug/mL
    • Diethylene glycol diethyl ether, Vetec(TM) reagent grade, 98+ %
    • 112-36-7

  • Applications

    Diethylene glycol diethyl ether (CAS 112-36-7) is a polar, high-boiling solvent used as a reaction medium and processing solvent in industrial manufacturing. It is commonly used as an intermediate in organic synthesis and as a processing aid in plastics and polymer formulations. In coatings and inks applications, DEGDEE serves as a solvent for paints, inks, and adhesives; it also appears in cleaning formulations and industrial detergents as a solvent component. Additionally, it can function as a processing solvent or additive in polymer processing. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 236.23
    methanol 371.39
    isopropanol 141.14
    water 3.6
    ethyl acetate 187.12
    n-propanol 178.76
    acetone 207.55
    n-butanol 139.9
    acetonitrile 238.83
    DMF 310.35
    toluene 124.46
    isobutanol 114.42
    1,4-dioxane 483.53
    methyl acetate 196.5
    THF 545.72
    2-butanone 154.51
    n-pentanol 91.69
    sec-butanol 139.28
    n-hexane 61.4
    ethylene glycol 99.62
    NMP 416.8
    cyclohexane 269.86
    DMSO 551.5
    n-butyl acetate 144.53
    n-octanol 55.12
    chloroform 1235.29
    n-propyl acetate 118.09
    acetic acid 573.6
    dichloromethane 1104.95
    cyclohexanone 375.6
    propylene glycol 95.73
    isopropyl acetate 88.74
    DMAc 300.47
    2-ethoxyethanol 188.44
    isopentanol 89.61
    n-heptane 72.24
    ethyl formate 150.85
    1,2-dichloroethane 531.18
    n-hexanol 98.61
    2-methoxyethanol 320.07
    isobutyl acetate 67.48
    tetrachloromethane 291.52
    n-pentyl acetate 85.59
    transcutol 401.22
    n-heptanol 48.61
    ethylbenzene 65.97
    MIBK 51.11
    2-propoxyethanol 176.93
    tert-butanol 177.3
    MTBE 118.82
    2-butoxyethanol 98.13
    propionic acid 272.95
    o-xylene 91.52
    formic acid 246.01
    diethyl ether 184.94
    m-xylene 66.72
    p-xylene 96.21
    chlorobenzene 221.61
    dimethyl carbonate 54.89
    n-octane 20.98
    formamide 261.82
    cyclopentanone 351.86
    2-pentanone 101.37
    anisole 116.65
    cyclopentyl methyl ether 235.98
    gamma-butyrolactone 440.75
    1-methoxy-2-propanol 166.87
    pyridine 496.12
    3-pentanone 113.45
    furfural 523.98
    n-dodecane 13.93
    diethylene glycol 167.48
    diisopropyl ether 41.25
    tert-amyl alcohol 142.08
    acetylacetone 136.61
    n-hexadecane 15.64
    acetophenone 120.32
    methyl propionate 131.77
    isopentyl acetate 106.6
    trichloroethylene 924.31
    n-nonanol 53.01
    cyclohexanol 239.72
    benzyl alcohol 116.93
    2-ethylhexanol 79.71
    isooctanol 40.02
    dipropyl ether 139.89
    1,2-dichlorobenzene 227.75
    ethyl lactate 79.69
    propylene carbonate 226.54
    n-methylformamide 212.76
    2-pentanol 80.69
    n-pentane 59.58
    1-propoxy-2-propanol 132.38
    1-methoxy-2-propyl acetate 113.92
    2-(2-methoxypropoxy) propanol 114.45
    mesitylene 45.22
    ε-caprolactone 308.74
    p-cymene 57.0
    epichlorohydrin 434.5
    1,1,1-trichloroethane 493.62
    2-aminoethanol 151.52
    morpholine-4-carbaldehyde 381.47
    sulfolane 533.66
    2,2,4-trimethylpentane 23.11
    2-methyltetrahydrofuran 349.0
    n-hexyl acetate 104.31
    isooctane 10.82
    2-(2-butoxyethoxy)ethanol 134.16
    sec-butyl acetate 74.27
    tert-butyl acetate 85.31
    decalin 53.36
    glycerin 157.2
    diglyme 290.49
    acrylic acid 284.73
    isopropyl myristate 52.0
    n-butyric acid 256.62
    acetyl acetate 174.72
    di(2-ethylhexyl) phthalate 56.49
    ethyl propionate 112.9
    nitromethane 513.47
    1,2-diethoxyethane 165.04
    benzonitrile 169.81
    trioctyl phosphate 36.89
    1-bromopropane 303.2
    gamma-valerolactone 434.9
    n-decanol 38.87
    triethyl phosphate 100.97
    4-methyl-2-pentanol 37.39
    propionitrile 190.43
    vinylene carbonate 245.55
    1,1,2-trichlorotrifluoroethane 533.28
    DMS 114.2
    cumene 46.42
    2-octanol 34.86
    2-hexanone 93.93
    octyl acetate 62.23
    limonene 95.54
    1,2-dimethoxyethane 321.1
    ethyl orthosilicate 94.94
    tributyl phosphate 55.89
    diacetone alcohol 92.57
    N,N-dimethylaniline 89.99
    acrylonitrile 253.67
    aniline 182.73
    1,3-propanediol 166.96
    bromobenzene 244.98
    dibromomethane 742.45
    1,1,2,2-tetrachloroethane 838.18
    2-methyl-cyclohexyl acetate 112.99
    tetrabutyl urea 73.11
    diisobutyl methanol 49.33
    2-phenylethanol 102.84
    styrene 97.12
    dioctyl adipate 99.77
    dimethyl sulfate 117.46
    ethyl butyrate 132.38
    methyl lactate 88.16
    butyl lactate 77.31
    diethyl carbonate 110.86
    propanediol butyl ether 84.24
    triethyl orthoformate 122.27
    p-tert-butyltoluene 56.56
    methyl 4-tert-butylbenzoate 102.22
    morpholine 528.05
    tert-butylamine 136.82
    n-dodecanol 31.8
    dimethoxymethane 158.06
    ethylene carbonate 202.91
    cyrene 126.61
    2-ethoxyethyl acetate 110.44
    2-ethylhexyl acetate 99.23
    1,2,4-trichlorobenzene 277.71
    4-methylpyridine 281.36
    dibutyl ether 112.51
    2,6-dimethyl-4-heptanol 49.33
    DEF 186.11
    dimethyl isosorbide 207.51
    tetrachloroethylene 698.2
    eugenol 101.69
    triacetin 151.28
    span 80 120.09
    1,4-butanediol 73.43
    1,1-dichloroethane 450.28
    2-methyl-1-pentanol 70.02
    methyl formate 157.53
    2-methyl-1-butanol 94.94
    n-decane 25.12
    butyronitrile 159.3
    3,7-dimethyl-1-octanol 59.12
    1-chlorooctane 62.96
    1-chlorotetradecane 28.5
    n-nonane 25.92
    undecane 17.41
    tert-butylcyclohexane 35.75
    cyclooctane 60.72
    cyclopentanol 255.23
    tetrahydropyran 466.84
    tert-amyl methyl ether 98.08
    2,5,8-trioxanonane 221.43
    1-hexene 110.62
    2-isopropoxyethanol 109.37
    2,2,2-trifluoroethanol 221.43
    methyl butyrate 144.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction