Diethyl Phthalate

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  • Identifiers

    CAS number
    84-66-2

    Molecular formula
    C12H14O4

    SMILES
    CCOC(=O)C1=CC=CC=C1C(=O)OCC

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1621.0
    • Carbowax: 2321.67

  • Odor profile

    Floral 55.08%
    Odorless 49.81%
    Fruity 40.54%
    Grape 35.3%
    Winey 33.16%
    Balsamic 32.05%
    Herbal 29.11%
    Phenolic 27.24%
    Sweet 27.14%
    Animal 24.68%

    Scent© AI

  • Properties

    XLogP3-AA
    2.5

    Molecular weight
    222.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 27 °F (NTP, 1992)
    • -40.5 °C
    • -67 - -44 °C
    • -41 °F

    Boiling point

    • 568 °F at 760 mmHg (NTP, 1992)
    • 295 °C
    • 563 °F

    Flash point est.
    144.36 ˚C

    Flash point expt.

    • 284 °F (NTP, 1992)
    • 161 °C
    • 322 °F (161 °C) (Open cup)
    • 117 °C c.c.
    • 284 °F
    • (oc) 322 °F

    Solubility expt.

    • less than 1 mg/mL at 66 °F (NTP, 1992)
    • Miscible with ethanol, ethyl ether. Soluble in acetone, benzene, carbon tetrachloride
    • MISCIBLE WITH VEGETABLE OILS
    • Miscible with alcohols, ketones, esters, aromatic hydrocarbons; partly miscible with aliphatic solvents
    • Miscible with many organic solvents
    • In water, 1,080 mg/L at 25 °C
    • Solubility in water at 25 °C: none
    • (77 °F): 0.1%

  • Synonyms

    • DIETHYL PHTHALATE
    • 84-66-2
    • Ethyl phthalate
    • phthalic acid diethyl ester
    • Anozol
    • diethyl benzene-1,2-dicarboxylate
    • Diethylphthalate
    • Neantine
    • Phthalol
    • Solvanol
    • Diethyl o-phthalate
    • Palatinol A
    • Placidol E
    • Unimoll DA
    • Phthalsaeurediaethylester
    • o-Bis(ethoxycarbonyl)benzene
    • Diethyl 1,2-benzenedicarboxylate
    • 1,2-Diethyl phthalate
    • Estol 1550
    • 1,2-Benzenedicarboxylic acid, diethyl ester
    • Di-n-ethyl phthalate
    • o-Benzenedicarboxylic acid diethyl ester
    • Diethyl o-phenylenediacetate
    • Phthalic acid, diethyl ester
    • RCRA waste number U088
    • diethyl phtalate
    • Diethylester kyseliny ftalove
    • NCI-C60048
    • NSC 8905
    • 1,2-benzenedicarboxylic acid diethyl ester
    • CCRIS 2675
    • HSDB 926
    • CHEBI:34698
    • DPX-F5384
    • NSC-8905
    • EINECS 201-550-6
    • UNII-UF064M00AF
    • Diethyl-o-phthalate
    • 1,2-diethyl benzene-1,2-dicarboxylate
    • BRN 1912500
    • O-phthalic acid, diethyl ester
    • UF064M00AF
    • DTXSID7021780
    • AI3-00329
    • Diethyl phthalate (NF)
    • Diethyl phthalate [NF]
    • DTXCID901780
    • PHTHALIC ACID ETHYL ESTER
    • EC 201-550-6
    • 1,2-Benzenedicarboxylic acid, 1,2-diethyl ester
    • 4-09-00-03172 (Beilstein Handbook Reference)
    • NCGC00090974-03
    • o-Benzenedicarboxylic acid, diethyl ester
    • Diethyl phthalate, 99%
    • DIETHYL PHTHALATE (II)
    • DIETHYL PHTHALATE [II]
    • DIETHYL PHTHALATE (MART.)
    • DIETHYL PHTHALATE [MART.]
    • DIETHYL PHTHALATE (USP-RS)
    • DIETHYL PHTHALATE [USP-RS]
    • CAS-84-66-2
    • DIETHYL PHTHALATE (EP MONOGRAPH)
    • DIETHYL PHTHALATE [EP MONOGRAPH]
    • SMR000857334
    • Phthalsaeurediaethylester [German]
    • Diethyl phthalate, PESTANAL(R), analytical standard
    • Diethylester kyseliny ftalove [Czech]
    • RCRA waste no. U088
    • Diethy phthalate
    • Phthalic acid, bis-ethyl ester
    • Kodaflex DEP
    • MFCD00009111
    • Diethyl phthalic acid
    • Diethyl Phthalate, NF
    • diethyl 1,2-benzenedioate
    • bmse000846
    • Epitope ID:140105
    • WLN: 2OVR BVO2
    • Diethyl phthalate, >=99%
    • Diethyl phthalate, 99.5%
    • SCHEMBL22296
    • MLS001336021
    • MLS001336022
    • MLS002152901
    • MLS002177800
    • BIDD:ER0639
    • DIETHYL PHTHALATE (0)
    • CHEMBL388558
    • Diethyl phthalate, >=99.5%
    • DIETHYL PHTHALATE [HSDB]
    • Diethyl-1,2-benzenedicarboxylate
    • DIETHYL PHTHALATE [VANDF]
    • ETHYL PHTHALATE [WHO-DD]
    • NSC8905
    • Diethyl phthalate, LR, >=99%
    • Phthalic acid, bis-isodecyl ester
    • HMS2233J05
    • HMS3369G01
    • PHTHALIC ACID,DIETHYL ESTER
    • Diethyl phthalate/dimethyl phthalate
    • STR04116
    • Tox21_111050
    • Tox21_201874
    • Tox21_300183
    • BBL011577
    • STL163320
    • AKOS000119867
    • PHTHALIC ACID ETHYL ESTER [MI]
    • NCGC00090974-01
    • NCGC00090974-02
    • NCGC00090974-04
    • NCGC00090974-05
    • NCGC00090974-06
    • NCGC00254098-01
    • NCGC00259423-01
    • benzene-1,2-dicarboxylic acid diethyl ester
    • CS-0013981
    • NS00009893
    • P0296
    • Diethyl ester of 1,2-Benzenedicarboxylic acid
    • EN300-20094
    • D03804
    • Diethyl phthalate, SAJ special grade, >=98.0%
    • Q419811
    • F1908-0104
    • Diethyl phthalate, European Pharmacopoeia (EP) Reference Standard
    • Diethyl phthalate, United States Pharmacopeia (USP) Reference Standard
    • Diethyl Phthalate, Pharmaceutical Secondary Standard; Certified Reference Material

  • Applications

    Diethyl phthalate (DEP, CAS 84-66-2) is a colorless, faint-odor liquid phthalate ester widely employed as a plasticizer for cellulose acetate, polyvinyl acetate and other resins; a fragrance carrier in perfumes, cosmetics and nail lacquers; a solvent for printing inks, lubricants and adhesives; a solubility modifier in aerosol insecticides, a stabilizer for nitrocellulose in fireworks, photographic films and magnetic tapes, and a flow-property improver in fuels, while also serving as a reference solvent in chromatographic laboratory analyses.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 58.17
    methanol 67.84
    isopropanol 41.22
    water 0.14
    ethyl acetate 482.3
    n-propanol 53.67
    acetone 627.38
    n-butanol 54.48
    acetonitrile 558.53
    DMF 1745.87
    toluene 399.4
    isobutanol 45.52
    1,4-dioxane 459.92
    methyl acetate 583.24
    THF 638.4
    2-butanone 538.69
    n-pentanol 49.1
    sec-butanol 62.71
    n-hexane 24.05
    ethylene glycol 17.48
    NMP 2076.36
    cyclohexane 55.87
    DMSO 1004.68
    n-butyl acetate 346.84
    n-octanol 41.93
    chloroform 1703.58
    n-propyl acetate 297.91
    acetic acid 241.96
    dichloromethane 2275.82
    cyclohexanone 939.96
    propylene glycol 16.24
    isopropyl acetate 238.62
    DMAc 1578.38
    2-ethoxyethanol 126.84
    isopentanol 61.74
    n-heptane 10.79
    ethyl formate 277.3
    1,2-dichloroethane 1629.17
    n-hexanol 60.11
    2-methoxyethanol 196.37
    isobutyl acetate 120.49
    tetrachloromethane 187.0
    n-pentyl acetate 173.59
    transcutol 319.41
    n-heptanol 36.41
    ethylbenzene 209.66
    MIBK 167.13
    2-propoxyethanol 156.99
    tert-butanol 83.53
    MTBE 184.89
    2-butoxyethanol 96.27
    propionic acid 196.02
    o-xylene 262.71
    formic acid 79.81
    diethyl ether 204.99
    m-xylene 207.47
    p-xylene 273.2
    chlorobenzene 732.69
    dimethyl carbonate 355.17
    n-octane 7.13
    formamide 293.04
    cyclopentanone 1215.64
    2-pentanone 356.57
    anisole 370.95
    cyclopentyl methyl ether 350.03
    gamma-butyrolactone 1539.28
    1-methoxy-2-propanol 133.07
    pyridine 1108.0
    3-pentanone 439.65
    furfural 1270.59
    n-dodecane 6.32
    diethylene glycol 97.9
    diisopropyl ether 65.0
    tert-amyl alcohol 106.11
    acetylacetone 563.8
    n-hexadecane 7.9
    acetophenone 455.65
    methyl propionate 515.68
    isopentyl acetate 255.51
    trichloroethylene 3195.96
    n-nonanol 40.85
    cyclohexanol 126.35
    benzyl alcohol 232.55
    2-ethylhexanol 63.33
    isooctanol 32.78
    dipropyl ether 93.32
    1,2-dichlorobenzene 772.57
    ethyl lactate 104.23
    propylene carbonate 711.78
    n-methylformamide 480.12
    2-pentanol 48.2
    n-pentane 14.6
    1-propoxy-2-propanol 115.65
    1-methoxy-2-propyl acetate 257.46
    2-(2-methoxypropoxy) propanol 117.83
    mesitylene 115.54
    ε-caprolactone 760.78
    p-cymene 88.68
    epichlorohydrin 1460.44
    1,1,1-trichloroethane 1071.87
    2-aminoethanol 35.41
    morpholine-4-carbaldehyde 937.27
    sulfolane 1708.48
    2,2,4-trimethylpentane 13.93
    2-methyltetrahydrofuran 532.48
    n-hexyl acetate 206.63
    isooctane 6.81
    2-(2-butoxyethoxy)ethanol 121.58
    sec-butyl acetate 174.49
    tert-butyl acetate 232.95
    decalin 41.46
    glycerin 40.7
    diglyme 345.93
    acrylic acid 255.56
    isopropyl myristate 74.47
    n-butyric acid 224.74
    acetyl acetate 361.15
    di(2-ethylhexyl) phthalate 82.15
    ethyl propionate 295.61
    nitromethane 1081.62
    1,2-diethoxyethane 195.81
    benzonitrile 488.48
    trioctyl phosphate 54.12
    1-bromopropane 493.29
    gamma-valerolactone 1134.53
    n-decanol 30.27
    triethyl phosphate 137.16
    4-methyl-2-pentanol 34.04
    propionitrile 307.9
    vinylene carbonate 688.43
    1,1,2-trichlorotrifluoroethane 696.84
    DMS 362.61
    cumene 109.31
    2-octanol 31.08
    2-hexanone 240.23
    octyl acetate 101.43
    limonene 123.14
    1,2-dimethoxyethane 385.76
    ethyl orthosilicate 110.43
    tributyl phosphate 82.25
    diacetone alcohol 188.35
    N,N-dimethylaniline 253.34
    acrylonitrile 578.16
    aniline 373.57
    1,3-propanediol 54.85
    bromobenzene 928.93
    dibromomethane 1315.24
    1,1,2,2-tetrachloroethane 2113.69
    2-methyl-cyclohexyl acetate 185.61
    tetrabutyl urea 122.78
    diisobutyl methanol 41.62
    2-phenylethanol 189.15
    styrene 309.25
    dioctyl adipate 123.04
    dimethyl sulfate 677.96
    ethyl butyrate 225.33
    methyl lactate 161.79
    butyl lactate 111.56
    diethyl carbonate 192.19
    propanediol butyl ether 68.74
    triethyl orthoformate 139.1
    p-tert-butyltoluene 80.72
    methyl 4-tert-butylbenzoate 211.35
    morpholine 514.32
    tert-butylamine 55.9
    n-dodecanol 23.24
    dimethoxymethane 466.86
    ethylene carbonate 513.94
    cyrene 209.03
    2-ethoxyethyl acetate 252.29
    2-ethylhexyl acetate 229.43
    1,2,4-trichlorobenzene 928.97
    4-methylpyridine 1050.66
    dibutyl ether 92.41
    2,6-dimethyl-4-heptanol 41.62
    DEF 731.29
    dimethyl isosorbide 309.5
    tetrachloroethylene 1247.17
    eugenol 188.19
    triacetin 231.76
    span 80 94.94
    1,4-butanediol 25.76
    1,1-dichloroethane 1072.36
    2-methyl-1-pentanol 65.8
    methyl formate 427.72
    2-methyl-1-butanol 66.63
    n-decane 10.08
    butyronitrile 233.27
    3,7-dimethyl-1-octanol 47.47
    1-chlorooctane 61.05
    1-chlorotetradecane 26.55
    n-nonane 9.16
    undecane 7.76
    tert-butylcyclohexane 25.5
    cyclooctane 17.59
    cyclopentanol 142.89
    tetrahydropyran 373.9
    tert-amyl methyl ether 187.82
    2,5,8-trioxanonane 216.29
    1-hexene 86.22
    2-isopropoxyethanol 101.21
    2,2,2-trifluoroethanol 159.54
    methyl butyrate 396.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Boldo leaf Boldea fragrans Juss. (Peumus boldus Mol.) 0.3%
Genet absolute 1 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.12%