Diethyl Ether

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  • Identifiers

    CAS number
    60-29-7

    Molecular formula
    C4H10O

    SMILES
    CCOCC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 86.18%
    Alcoholic 54.67%
    Solvent 48.92%
    Sweet 47.95%
    Fermented 37.1%
    Rummy 34.26%
    Gassy 34.13%
    Winey 30.03%
    Musty 29.77%
    Fruity 28.43%

     

    Flavor
    Sweet 73.24%
    Green 51.87%
    Ether 48.43%
    Ethereal 46.23%
    Alcohol 44.39%
    Earthy 43.84%
    Fruit 40.3%
    Vegetable 34.39%
    Alcoholic 34.22%
    Fusel 33.75%

     

    Odor impact est.
    High

    Odor threshold

    • Odor Threshold Low: 0.3 [mmHg]. Odor threshold (100% recognition) from CHEMINFO
    • 0.83 ppm (purity not given)
    • Odor detection: in water= 5.83 ppm; in air= 5.83 mg/l (gas); in air: 7.00x10(-1) ppm /Purities not specified/
    • 0.99 mg/cu m (odor low) 3.0 mg/cu m (odor high)

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    8.12 (weak base)

    Molecular weight
    74.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -177.3 °F (NTP, 1992)
    • -116.3 °C (stable crystals); -123.3 °C (metastable crystals)
    • -116 °C
    • -177 °F

    Boiling point

    • 94.3 °F at 760 mmHg (NTP, 1992)
    • 34.6 °C at 760 mm Hg; 17.9 °C at 400 mm Hg; 2.2 °C at 200 mm Hg
    • 35 °C
    • 94 °F

    Flash point

    • -42.28 ˚C est.
    • -49 °F (NTP, 1992)
    • -45 °C
    • -45 °C, -49 °F (CLOSED CUP)
    • -45 °C c.c.
    • -49 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Miscible with lower aliphatic alcohols, benzene, chloroform, petroleum ether, fat solvents, many oils; sol in concn hydrochloric acid
    • Sol in acetone; very sol in ethanol
    • Sol in solvent naphtha, benzene, oils
    • Miscible with most organic solvents
    • In water, 6.04X10+4 mg/L at 25 °C
    • Solubility in water, g/100ml at 20 °C: 6.9 (soluble)
    • 8%

  • Synonyms

    • DIETHYL ETHER
    • ether
    • Ethyl ether
    • Ethoxyethane
    • 60-29-7
    • Pronarcol
    • Diethyl oxide
    • Ethyl oxide
    • Aether
    • DIETHYLETHER
    • Solvent ether
    • Anesthetic ether
    • Anaesthetic ether
    • 3-Oxapentane
    • Ether, ethyl
    • Diaethylaether
    • Dwuetylowy eter
    • Ether ethylique
    • Etere etilico
    • Ethane, 1,1'-oxybis-
    • Anesthesia ether
    • Oxyde d'ethyle
    • 1,1'-Oxybisethane
    • Diethylaether
    • 1,1'-oxydiethane
    • Sulfuric ether
    • aether pro narcosi
    • Ethyl ether, tech.
    • RCRA waste number U117
    • Etherum
    • NSC 100036
    • MFCD00011646
    • NSC-100036
    • DTXSID3021720
    • CHEBI:35702
    • 0F5N573A2Y
    • (C2H5)2O
    • Ether [JAN]
    • Diaethylaether [German]
    • Etere etilico [Italian]
    • Dwuetylowy eter [Polish]
    • Ether ethylique [French]
    • Oxyde d'ethyle [French]
    • Ether, Diethyl
    • 667919-88-2
    • HSDB 70
    • Et2O
    • Ether [USP:JAN]
    • ETHER, ANHYDROUS
    • ethane, 1,1'-oxybis
    • EINECS 200-467-2
    • UN1155
    • RCRA waste no. U117
    • dietylether
    • Diethyether
    • di ethylether
    • di-ethylether
    • diehtyl ether
    • diethyl-ether
    • ether anhydrous
    • ethoxy-ethane
    • monoethyl ether
    • Anhydrous ether
    • diethl ether
    • diethy ether
    • dietyl ether
    • ehtyl ether
    • ethyl-ether
    • diethyI ether
    • UNII-0F5N573A2Y
    • 2-ethoxyethane
    • AI3-24233
    • di ethyl ether
    • di-ethyl ether
    • ethyl ether-
    • EtOEt
    • Ether anaesthesicus
    • 1-Ethoxyethane #
    • Ethane,1'-oxybis-
    • Diethyl ether [Anaesthetics, volatile]
    • 1,1' -oxybisethane
    • 1,1'-oxy-bisethane
    • 1,1'-oxybis ethane
    • OEt2
    • 1,1'-oxobis(ethane)
    • 1,1'-oxybis(ethane)
    • ETHERUM [HPUS]
    • ETHER [VANDF]
    • ETHER [HSDB]
    • Ether (JP17/USP)
    • ETHER [II]
    • ETHYL ETHER [MI]
    • EC 200-467-2
    • O(Et)2
    • Diethyl ether or ethyl ether
    • Diethylether (Peptide Grade)
    • ETHER [EP MONOGRAPH]
    • Diethyl ether, >=99.5%
    • CHEMBL16264
    • ETHER [USP MONOGRAPH]
    • ETHYL ETHER [WHO-DD]
    • Ethyl ether anhydrous A.C.S.
    • SOLVENT ETHER [MART.]
    • DTXCID101720
    • O(CH2CH3)2
    • WLN: 2O2
    • Diethyl ether, p.a., 99.0%
    • Diethyl ether, p.a., 99.5%
    • Diethyl ether, analytical standard
    • ANAESTHETIC ETHER [WHO-IP]
    • DIETHYL ETHER (ETHYL ETHER)
    • O(C2H5)2
    • Diethylether (Peptide Grade), 99%
    • NSC100036
    • STL445704
    • AKOS015950740
    • Diethyl ether, ACS reagent, 99.5%
    • DB13598
    • Diethyl ether, Spectrophotometric Grade
    • UN 1155
    • ETHER ANAESTHESICUS [WHO-IP LATIN]
    • Diethylether 100 microg/mL in Acetonitrile
    • D3479
    • Diethyl ether, SAJ first grade, >=99.0%
    • NS00001638
    • Diethyl ether, JIS special grade, >=99.5%
    • D01772
    • Diethyl ether, UV HPLC spectroscopic, 99.9%

  • Applications

    Diethyl ether is a versatile industrial solvent used across multiple sectors: it acts as a nonpolar solvent for coatings, inks, and adhesives; as a reaction medium and purification solvent in pharmaceutical and chemical manufacturing; as a preferred solvent for Grignard and other organometallic syntheses; as an extraction and purification solvent for essential oils and fragrance ingredients; as a laboratory solvent for chromatography and sample preparation; and as a processing solvent in certain polymer and plastics applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 417.77
    methanol 497.75
    isopropanol 265.04
    water 2.86
    ethyl acetate 289.94
    n-propanol 347.81
    acetone 298.74
    n-butanol 314.61
    acetonitrile 362.12
    DMF 272.58
    toluene 190.63
    isobutanol 208.43
    1,4-dioxane 644.25
    methyl acetate 273.16
    THF 814.07
    2-butanone 274.17
    n-pentanol 180.1
    sec-butanol 279.36
    n-hexane 183.48
    ethylene glycol 126.24
    NMP 532.16
    cyclohexane 366.38
    DMSO 358.99
    n-butyl acetate 234.43
    n-octanol 120.08
    chloroform 1324.37
    n-propyl acetate 141.85
    acetic acid 532.82
    dichloromethane 1169.49
    cyclohexanone 497.46
    propylene glycol 144.6
    isopropyl acetate 129.48
    DMAc 270.06
    2-ethoxyethanol 230.32
    isopentanol 193.09
    n-heptane 185.75
    ethyl formate 172.81
    1,2-dichloroethane 565.33
    n-hexanol 250.85
    2-methoxyethanol 417.9
    isobutyl acetate 83.22
    tetrachloromethane 402.01
    n-pentyl acetate 146.61
    transcutol 599.45
    n-heptanol 104.76
    ethylbenzene 92.32
    MIBK 90.03
    2-propoxyethanol 318.42
    tert-butanol 274.21
    MTBE 242.53
    2-butoxyethanol 154.96
    propionic acid 340.22
    o-xylene 118.25
    formic acid 186.04
    diethyl ether 407.89
    m-xylene 93.98
    p-xylene 113.9
    chlorobenzene 283.65
    dimethyl carbonate 48.61
    n-octane 52.79
    formamide 186.75
    cyclopentanone 511.2
    2-pentanone 203.98
    anisole 163.52
    cyclopentyl methyl ether 377.92
    gamma-butyrolactone 532.03
    1-methoxy-2-propanol 249.08
    pyridine 561.0
    3-pentanone 198.56
    furfural 469.29
    n-dodecane 32.49
    diethylene glycol 253.61
    diisopropyl ether 87.5
    tert-amyl alcohol 262.1
    acetylacetone 180.97
    n-hexadecane 35.89
    acetophenone 129.71
    methyl propionate 183.85
    isopentyl acetate 165.65
    trichloroethylene 858.77
    n-nonanol 108.64
    cyclohexanol 386.0
    benzyl alcohol 144.88
    2-ethylhexanol 170.97
    isooctanol 79.0
    dipropyl ether 255.26
    1,2-dichlorobenzene 242.26
    ethyl lactate 75.04
    propylene carbonate 235.83
    n-methylformamide 200.31
    2-pentanol 189.39
    n-pentane 174.36
    1-propoxy-2-propanol 247.13
    1-methoxy-2-propyl acetate 171.83
    2-(2-methoxypropoxy) propanol 161.42
    mesitylene 56.24
    ε-caprolactone 418.72
    p-cymene 89.67
    epichlorohydrin 530.36
    1,1,1-trichloroethane 592.63
    2-aminoethanol 224.41
    morpholine-4-carbaldehyde 438.55
    sulfolane 532.55
    2,2,4-trimethylpentane 53.99
    2-methyltetrahydrofuran 703.76
    n-hexyl acetate 195.77
    isooctane 28.11
    2-(2-butoxyethoxy)ethanol 200.45
    sec-butyl acetate 92.4
    tert-butyl acetate 123.54
    decalin 82.28
    glycerin 185.9
    diglyme 364.45
    acrylic acid 294.01
    isopropyl myristate 90.93
    n-butyric acid 362.33
    acetyl acetate 186.65
    di(2-ethylhexyl) phthalate 83.14
    ethyl propionate 132.51
    nitromethane 446.11
    1,2-diethoxyethane 284.5
    benzonitrile 199.57
    trioctyl phosphate 53.59
    1-bromopropane 492.7
    gamma-valerolactone 510.35
    n-decanol 80.25
    triethyl phosphate 88.53
    4-methyl-2-pentanol 78.72
    propionitrile 299.22
    vinylene carbonate 207.81
    1,1,2-trichlorotrifluoroethane 455.53
    DMS 138.02
    cumene 64.51
    2-octanol 82.2
    2-hexanone 144.55
    octyl acetate 110.77
    limonene 167.24
    1,2-dimethoxyethane 351.2
    ethyl orthosilicate 90.28
    tributyl phosphate 77.38
    diacetone alcohol 136.89
    N,N-dimethylaniline 101.04
    acrylonitrile 322.34
    aniline 253.24
    1,3-propanediol 246.99
    bromobenzene 296.83
    dibromomethane 903.61
    1,1,2,2-tetrachloroethane 728.56
    2-methyl-cyclohexyl acetate 147.85
    tetrabutyl urea 93.28
    diisobutyl methanol 83.33
    2-phenylethanol 156.43
    styrene 128.49
    dioctyl adipate 133.5
    dimethyl sulfate 82.87
    ethyl butyrate 176.81
    methyl lactate 93.69
    butyl lactate 101.7
    diethyl carbonate 104.91
    propanediol butyl ether 121.34
    triethyl orthoformate 134.07
    p-tert-butyltoluene 85.5
    methyl 4-tert-butylbenzoate 127.42
    morpholine 702.75
    tert-butylamine 222.7
    n-dodecanol 64.8
    dimethoxymethane 176.75
    ethylene carbonate 177.74
    cyrene 131.13
    2-ethoxyethyl acetate 179.07
    2-ethylhexyl acetate 159.66
    1,2,4-trichlorobenzene 303.18
    4-methylpyridine 381.72
    dibutyl ether 202.9
    2,6-dimethyl-4-heptanol 83.33
    DEF 246.8
    dimethyl isosorbide 270.39
    tetrachloroethylene 622.78
    eugenol 124.62
    triacetin 177.85
    span 80 182.19
    1,4-butanediol 93.35
    1,1-dichloroethane 546.79
    2-methyl-1-pentanol 137.7
    methyl formate 134.62
    2-methyl-1-butanol 219.91
    n-decane 57.65
    butyronitrile 263.8
    3,7-dimethyl-1-octanol 131.28
    1-chlorooctane 129.83
    1-chlorotetradecane 56.76
    n-nonane 64.44
    undecane 40.41
    tert-butylcyclohexane 66.42
    cyclooctane 99.03
    cyclopentanol 401.09
    tetrahydropyran 716.09
    tert-amyl methyl ether 210.55
    2,5,8-trioxanonane 270.0
    1-hexene 260.03
    2-isopropoxyethanol 152.65
    2,2,2-trifluoroethanol 149.32
    methyl butyrate 158.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction