Diethyl Adipate

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  • Identifiers

    CAS number
    141-28-6

    Molecular formula
    C10H18O4

    SMILES
    CCOC(=O)CCCCC(=O)OCC

  • Odor profile

    Fragrance
    Fruity 83.18%
    Winey 57.95%
    Oily 41.78%
    Fatty 41.25%
    Apple 40.76%
    Sweet 37.85%
    Ethereal 33.9%
    Buttery 28.65%
    Fermented 28.52%
    Pineapple 28.18%

     

    Flavor
    Fruity 88.96%
    Pineapple 62.28%
    Apple 57.66%
    Fruit 57.16%
    Sweet 54.27%
    Green 46.47%
    Grape 45.29%
    Wine 44.95%
    Pear 43.14%
    Apricot 40.28%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    7.72 (neutral)

    Molecular weight
    202.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • -19.8 °C

    Boiling point

    • 245 °C

    Flash point

    • 112.47 ˚C est.

    Solubility expt.

    • Soluble in ethanol and ethyl ether
    • In water, 4230 mg/l @ 20 °C

  • Synonyms

    • DIETHYL ADIPATE
    • 141-28-6
    • Diethyl hexanedioate
    • Ethyl adipate
    • Hexanedioic acid, diethyl ester
    • 1,6-Diethyl hexanedioate
    • Adipic acid, diethyl ester
    • Hexanedioic acid, 1,6-diethyl ester
    • ADIPIC ACID DIETHYL ESTER
    • Hexanedioic acid, diethyl-
    • Diethylester kyseliny adipove
    • Diethylhexanedioic acid
    • NSC 19160
    • Ethyl delta-carboethoxyvalerate
    • HSDB 5413
    • EINECS 205-477-0
    • Diethylester kyseliny adipove [Czech]
    • BRN 1780035
    • AI3-00342
    • DUB DEA
    • 7B19K45L6C
    • NSC-19160
    • hexanedioic acid diethyl ester
    • DIETHYL ADIPATE [HSDB]
    • DTXSID2021999
    • Ethyl .delta.-carboethoxyvalerate
    • 68201-71-8
    • WLN: 2OV4VO2
    • diethyladipate
    • UNII-7B19K45L6C
    • MFCD00009215
    • 1,6Diethyl hexanedioate
    • Ethyl deltacarboethoxyvalerate
    • SCHEMBL50610
    • BIDD:ER0365
    • DIETHYL ADIPATE [INCI]
    • DTXCID201999
    • Diethyl adipate, >=99%, FG
    • CHEBI:34697
    • NSC3363
    • NSC-3363
    • NSC19160
    • Diethyl adipate, analytical standard
    • AKOS009031409
    • DS-5105
    • Diethyl adipate, ReagentPlus(R), 99%
    • A0162
    • NS00042075
    • EN300-19693
    • Diethyl adipate, Vetec(TM) reagent grade, 98%
    • Q27116229
    • F1905-6995
    • Z104474764
    • 205-477-0

  • Applications

    Diethyl Adipate (CAS 141-28-6) is widely used as a solvent and processing aid in industrial formulations. In perfumery and cosmetics it serves as a fragrance solvent and carrier for aroma compounds. It is used as a plasticizer and processing solvent for polymers and coatings, helping adjust viscosity and flexibility. It also functions as a solvent for inks and coatings in industrial manufacturing and as a diluent in cleaning formulations. In polymer processing and adhesives, it acts as a compatible solvent or processing aid, facilitating formulation and compatibility with active ingredients. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 83.02
    methanol 150.12
    isopropanol 83.59
    water 0.51
    ethyl acetate 185.36
    n-propanol 69.07
    acetone 312.95
    n-butanol 69.89
    acetonitrile 277.01
    DMF 515.23
    toluene 101.57
    isobutanol 63.42
    1,4-dioxane 288.29
    methyl acetate 207.86
    THF 373.12
    2-butanone 211.82
    n-pentanol 75.62
    sec-butanol 81.76
    n-hexane 22.6
    ethylene glycol 19.32
    NMP 533.35
    cyclohexane 35.75
    DMSO 592.74
    n-butyl acetate 130.17
    n-octanol 48.47
    chloroform 907.92
    n-propyl acetate 138.38
    acetic acid 319.01
    dichloromethane 906.39
    cyclohexanone 357.34
    propylene glycol 28.07
    isopropyl acetate 122.14
    DMAc 611.68
    2-ethoxyethanol 152.22
    isopentanol 73.34
    n-heptane 9.44
    ethyl formate 154.15
    1,2-dichloroethane 461.59
    n-hexanol 57.38
    2-methoxyethanol 211.69
    isobutyl acetate 83.99
    tetrachloromethane 96.04
    n-pentyl acetate 102.86
    transcutol 293.86
    n-heptanol 33.13
    ethylbenzene 79.36
    MIBK 102.29
    2-propoxyethanol 126.19
    tert-butanol 145.98
    MTBE 138.34
    2-butoxyethanol 77.48
    propionic acid 146.37
    o-xylene 88.44
    formic acid 94.36
    diethyl ether 114.73
    m-xylene 63.57
    p-xylene 122.37
    chlorobenzene 236.84
    dimethyl carbonate 73.16
    n-octane 7.68
    formamide 130.34
    cyclopentanone 396.7
    2-pentanone 153.43
    anisole 164.29
    cyclopentyl methyl ether 145.27
    gamma-butyrolactone 504.24
    1-methoxy-2-propanol 152.8
    pyridine 333.71
    3-pentanone 148.33
    furfural 486.68
    n-dodecane 7.71
    diethylene glycol 95.49
    diisopropyl ether 39.03
    tert-amyl alcohol 136.07
    acetylacetone 271.35
    n-hexadecane 8.87
    acetophenone 194.77
    methyl propionate 144.68
    isopentyl acetate 112.17
    trichloroethylene 897.97
    n-nonanol 45.2
    cyclohexanol 106.13
    benzyl alcohol 141.06
    2-ethylhexanol 46.74
    isooctanol 32.05
    dipropyl ether 59.25
    1,2-dichlorobenzene 251.14
    ethyl lactate 74.65
    propylene carbonate 265.19
    n-methylformamide 204.56
    2-pentanol 52.77
    n-pentane 12.88
    1-propoxy-2-propanol 90.22
    1-methoxy-2-propyl acetate 119.38
    2-(2-methoxypropoxy) propanol 112.87
    mesitylene 46.7
    ε-caprolactone 308.77
    p-cymene 41.75
    epichlorohydrin 457.07
    1,1,1-trichloroethane 409.25
    2-aminoethanol 42.18
    morpholine-4-carbaldehyde 399.32
    sulfolane 624.11
    2,2,4-trimethylpentane 13.69
    2-methyltetrahydrofuran 248.4
    n-hexyl acetate 143.33
    isooctane 6.99
    2-(2-butoxyethoxy)ethanol 127.4
    sec-butyl acetate 94.3
    tert-butyl acetate 137.88
    decalin 26.66
    glycerin 58.21
    diglyme 265.69
    acrylic acid 158.04
    isopropyl myristate 55.92
    n-butyric acid 179.56
    acetyl acetate 176.92
    di(2-ethylhexyl) phthalate 67.53
    ethyl propionate 139.93
    nitromethane 588.24
    1,2-diethoxyethane 135.07
    benzonitrile 215.13
    trioctyl phosphate 43.9
    1-bromopropane 210.5
    gamma-valerolactone 503.35
    n-decanol 33.28
    triethyl phosphate 79.13
    4-methyl-2-pentanol 38.57
    propionitrile 169.05
    vinylene carbonate 269.93
    1,1,2-trichlorotrifluoroethane 355.11
    DMS 128.25
    cumene 55.68
    2-octanol 32.18
    2-hexanone 148.56
    octyl acetate 72.1
    limonene 60.04
    1,2-dimethoxyethane 362.92
    ethyl orthosilicate 71.7
    tributyl phosphate 63.4
    diacetone alcohol 138.96
    N,N-dimethylaniline 127.33
    acrylonitrile 235.18
    aniline 121.11
    1,3-propanediol 76.04
    bromobenzene 260.18
    dibromomethane 543.69
    1,1,2,2-tetrachloroethane 697.04
    2-methyl-cyclohexyl acetate 102.25
    tetrabutyl urea 87.6
    diisobutyl methanol 33.91
    2-phenylethanol 89.19
    styrene 109.65
    dioctyl adipate 98.01
    dimethyl sulfate 172.15
    ethyl butyrate 113.66
    methyl lactate 82.78
    butyl lactate 77.17
    diethyl carbonate 90.7
    propanediol butyl ether 75.87
    triethyl orthoformate 84.73
    p-tert-butyltoluene 40.5
    methyl 4-tert-butylbenzoate 134.5
    morpholine 290.71
    tert-butylamine 86.89
    n-dodecanol 26.86
    dimethoxymethane 194.29
    ethylene carbonate 203.98
    cyrene 147.17
    2-ethoxyethyl acetate 131.98
    2-ethylhexyl acetate 93.11
    1,2,4-trichlorobenzene 277.37
    4-methylpyridine 337.66
    dibutyl ether 78.67
    2,6-dimethyl-4-heptanol 33.91
    DEF 249.64
    dimethyl isosorbide 208.49
    tetrachloroethylene 423.69
    eugenol 122.23
    triacetin 152.58
    span 80 101.42
    1,4-butanediol 41.48
    1,1-dichloroethane 383.87
    2-methyl-1-pentanol 79.81
    methyl formate 173.96
    2-methyl-1-butanol 69.27
    n-decane 12.42
    butyronitrile 165.97
    3,7-dimethyl-1-octanol 53.15
    1-chlorooctane 48.13
    1-chlorotetradecane 21.57
    n-nonane 11.82
    undecane 9.4
    tert-butylcyclohexane 21.37
    cyclooctane 11.19
    cyclopentanol 116.0
    tetrahydropyran 221.83
    tert-amyl methyl ether 118.4
    2,5,8-trioxanonane 194.78
    1-hexene 71.03
    2-isopropoxyethanol 106.06
    2,2,2-trifluoroethanol 113.09
    methyl butyrate 194.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction