Molecular formula
C10H18O6

SMILES
CCOC(=O)[C@@H]([C@@H](C(=O)OCC)OC)OC

Fragrance
Fruity	89.66%
Caramellic	41.33%
Buttery	37.66%
Winey	37.33%
Sweet	33.9%
Tropical	31.48%
Apple	30.55%
Pineapple	28.52%
Ethereal	26.85%
Fatty	24.9%

 

Flavor
Fruity	57.29%
Bitter	43.87%
Mild	36.67%
Odorless	32.17%
Creamy	29.87%
Waxy	28.32%
Wine	28.0%
Fatty	25.91%
Grape	23.35%
Bland	22.71%

 

Odor impact est.
Low

XLogP3-AA
0.6

pKa est.
5.09 (weak acid)

Molecular weight
234.25 g/mol

Vapor pressure est.

• hPa @ 20°C
• hPa @ 25°C

Evaporation rate
Slow

Boiling point est.
259°C

Flash point

• 105.43 ˚C est.

Diethyl (2R,3S)-2,3-dimethoxybutanedioate is primarily used as an organic synthesis intermediate and a protected diacid derivative. It is commonly evaluated as a chiral building block for the preparation of advanced pharmaceuticals and fine chemicals, leveraging its diester functionality for selective transformations and its 2,3-dimethoxy substituents as temporary protecting groups. In polymer and materials chemistry, it can serve as a precursor to specialty monomers or as a scaffold for developing asymmetric catalysts and ligands in research settings. It may also appear as a starting material in method development for esterification, acetal formation, or cross-coupling workflows, and as a diester handle in process chemistry to facilitate purification and isolation of intermediates.

gpt-5-nano

Solvent	Solubility (g/L)
ethanol	136.54
methanol	239.03
isopropanol	87.44
water	6.94
ethyl acetate	193.04
n-propanol	105.43
acetone	264.76
n-butanol	85.8
acetonitrile	219.81
DMF	517.58
toluene	91.78
isobutanol	79.14
1,4-dioxane	363.29
methyl acetate	234.7
THF	362.03
2-butanone	174.24
n-pentanol	69.53
sec-butanol	93.44
n-hexane	9.83
ethylene glycol	119.21
NMP	824.64
cyclohexane	57.2
DMSO	621.9
n-butyl acetate	120.02
n-octanol	34.0
chloroform	1008.27
n-propyl acetate	105.29
acetic acid	588.38
dichloromethane	1096.32
cyclohexanone	424.11
propylene glycol	74.53
isopropyl acetate	90.49
DMAc	520.45
2-ethoxyethanol	177.7
isopentanol	67.79
n-heptane	8.3
ethyl formate	238.11
1,2-dichloroethane	631.39
n-hexanol	65.29
2-methoxyethanol	315.96
isobutyl acetate	56.53
tetrachloromethane	197.58
n-pentyl acetate	78.1
transcutol	177.44
n-heptanol	36.07
ethylbenzene	59.63
MIBK	56.98
2-propoxyethanol	154.23
tert-butanol	111.11
MTBE	75.28
2-butoxyethanol	90.18
propionic acid	252.4
o-xylene	93.36
formic acid	398.85
diethyl ether	83.86
m-xylene	54.32
p-xylene	90.1
chlorobenzene	279.66
dimethyl carbonate	123.37
n-octane	4.71
formamide	535.64
cyclopentanone	430.1
2-pentanone	106.07
anisole	109.48
cyclopentyl methyl ether	143.56
gamma-butyrolactone	700.51
1-methoxy-2-propanol	150.05
pyridine	471.49
3-pentanone	121.57
furfural	783.97
n-dodecane	3.84
diethylene glycol	188.94
diisopropyl ether	21.08
tert-amyl alcohol	114.98
acetylacetone	196.46
n-hexadecane	4.51
acetophenone	160.39
methyl propionate	182.15
isopentyl acetate	103.61
trichloroethylene	1162.76
n-nonanol	31.51
cyclohexanol	186.07
benzyl alcohol	158.85
2-ethylhexanol	48.52
isooctanol	30.13
dipropyl ether	41.05
1,2-dichlorobenzene	286.87
ethyl lactate	85.78
propylene carbonate	410.77
n-methylformamide	349.29
2-pentanol	49.14
n-pentane	10.98
1-propoxy-2-propanol	89.62
1-methoxy-2-propyl acetate	110.23
2-(2-methoxypropoxy) propanol	77.27
mesitylene	37.69
ε-caprolactone	394.26
p-cymene	46.41
epichlorohydrin	602.35
1,1,1-trichloroethane	461.72
2-aminoethanol	127.65
morpholine-4-carbaldehyde	474.5
sulfolane	873.64
2,2,4-trimethylpentane	9.55
2-methyltetrahydrofuran	266.93
n-hexyl acetate	86.48
isooctane	3.91
2-(2-butoxyethoxy)ethanol	90.61
sec-butyl acetate	61.6
tert-butyl acetate	86.13
decalin	21.89
glycerin	160.84
diglyme	198.27
acrylic acid	331.93
isopropyl myristate	30.07
n-butyric acid	250.98
acetyl acetate	194.99
di(2-ethylhexyl) phthalate	53.2
ethyl propionate	104.38
nitromethane	735.54
1,2-diethoxyethane	74.75
benzonitrile	230.1
trioctyl phosphate	36.67
1-bromopropane	175.94
gamma-valerolactone	554.23
n-decanol	22.8
triethyl phosphate	83.06
4-methyl-2-pentanol	27.99
propionitrile	148.6
vinylene carbonate	430.56
1,1,2-trichlorotrifluoroethane	647.09
DMS	135.5
cumene	41.9
2-octanol	26.72
2-hexanone	76.77
octyl acetate	43.96
limonene	65.75
1,2-dimethoxyethane	262.87
ethyl orthosilicate	69.05
tributyl phosphate	45.59
diacetone alcohol	113.75
N,N-dimethylaniline	88.69
acrylonitrile	252.88
aniline	176.81
1,3-propanediol	160.81
bromobenzene	263.11
dibromomethane	609.03
1,1,2,2-tetrachloroethane	965.76
2-methyl-cyclohexyl acetate	95.61
tetrabutyl urea	65.47
diisobutyl methanol	27.87
2-phenylethanol	119.24
styrene	82.83
dioctyl adipate	61.03
dimethyl sulfate	263.14
ethyl butyrate	95.46
methyl lactate	137.95
butyl lactate	70.36
diethyl carbonate	91.09
propanediol butyl ether	74.27
triethyl orthoformate	77.04
p-tert-butyltoluene	41.38
methyl 4-tert-butylbenzoate	108.42
morpholine	378.46
tert-butylamine	65.96
n-dodecanol	17.59
dimethoxymethane	187.27
ethylene carbonate	343.78
cyrene	167.84
2-ethoxyethyl acetate	98.48
2-ethylhexyl acetate	90.82
1,2,4-trichlorobenzene	355.73
4-methylpyridine	320.71
dibutyl ether	33.91
2,6-dimethyl-4-heptanol	27.87
DEF	212.16
dimethyl isosorbide	177.31
tetrachloroethylene	783.95
eugenol	107.6
triacetin	107.95
span 80	72.02
1,4-butanediol	85.11
1,1-dichloroethane	393.45
2-methyl-1-pentanol	67.14
methyl formate	358.16
2-methyl-1-butanol	77.92
n-decane	6.27
butyronitrile	131.53
3,7-dimethyl-1-octanol	34.68
1-chlorooctane	31.44
1-chlorotetradecane	13.42
n-nonane	5.94
undecane	4.76
tert-butylcyclohexane	12.42
cyclooctane	13.93
cyclopentanol	203.3
tetrahydropyran	249.75
tert-amyl methyl ether	72.57
2,5,8-trioxanonane	134.58
1-hexene	31.52
2-isopropoxyethanol	103.91
2,2,2-trifluoroethanol	351.92
methyl butyrate	157.22

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