Diethoxymethane

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  • Identifiers

    CAS number
    462-95-3

    Molecular formula
    C5H12O2

    SMILES
    CCOCOCC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 89.61%
    Fruity 77.7%
    Sweet 70.64%
    Alcoholic 57.34%
    Rummy 50.36%
    Solvent 41.68%
    Fermented 40.92%
    Cognac 40.46%
    Winey 35.99%
    Pungent 34.24%

     

    Flavor
    Sweet 79.04%
    Green 65.32%
    Fruit 49.68%
    Ether 47.08%
    Earthy 46.4%
    Vegetable 40.83%
    Alcohol 40.52%
    Alcoholic 35.89%
    Ethereal 35.4%
    Fruity 34.5%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    7.93 (neutral)

    Molecular weight
    104.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    87°C

    Flash point

    • 2.57 ˚C est.

  • Synonyms

    • Diethoxymethane
    • 462-95-3
    • Diethoxy methane
    • Ethylal
    • Formaldehyde diethyl acetal
    • Diethylformal
    • Methane, diethoxy-
    • Ethoxymethyl ethyl ether
    • ethoxymethoxyethane
    • 1,1-DIETHOXYMETHANE
    • 3,5-Dioxaheptene
    • Ethane, 1,1'-[methylenebis(oxy)]bis-
    • 3,5-Dioxaheptane
    • NSC 6754
    • CCRIS 6891
    • Ethane, 1,1'-(methylenebis(oxy))bis-
    • EINECS 207-330-6
    • UNII-56IT408V5Y
    • BRN 1697253
    • DTXSID6052112
    • AI3-24286
    • 56IT408V5Y
    • NSC-6754
    • DTXCID8030681
    • EC 207-330-6
    • 4-01-00-03027 (Beilstein Handbook Reference)
    • UN 2373
    • (ethoxymethoxy)ethane
    • MFCD00009246
    • UN2373
    • 1-(Ethoxymethoxy)ethane
    • ETHYLAL [INCI]
    • formaldehyde diethylacetal
    • formaldehyde-diethylacetal
    • 1-(Ethoxymethoxy)ethane #
    • Formaldehyde, diethyl acetal
    • SCHEMBL23303
    • Methylene Glycol Diethyl Ether
    • WLN: 2O1O2
    • CH2(OC2H5)2
    • NSC6754
    • Ethane,1'-[methylenebis(oxy)]bis-
    • Tox21_303824
    • AKOS009031568
    • NCGC00357101-01
    • CAS-462-95-3
    • LS-13091
    • DB-051368
    • D0457
    • NS00003935
    • EN300-19769
    • Diethoxymethane [UN2373] [Flammable liquid]
    • Q10426203
    • Diethoxymethane, 99.7%, contains 50-150 ppm BHT as stabilizer
    • Formaldehyde diethyl acetal, absolute, over molecular sieve (H2O <=0.01%), >=99.0% (GC)
    • 207-330-6

  • Applications

    Diethoxymethane, CAS 462-95-3, is primarily used in organic synthesis as an aldehyde protecting group by forming the diethyl acetal CH(OEt)2 to mask carbonyls during multi-step sequences. It also serves as an intermediate for preparing other acetals and ethers and can function as a reagent in acetalization reactions. In chemical manufacturing, it may be employed as a solvent or reaction medium in specialized processes. Because it hydrolyzes under acidic conditions to formaldehyde and ethanol, it can act as a formaldehyde-equivalent source in certain synthetic routes. In polymer and resin chemistry, it provides acetal building blocks used to introduce acetal linkages in selected materials. All applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 739.2
    methanol 823.77
    isopropanol 686.63
    water 5.91
    ethyl acetate 368.2
    n-propanol 688.79
    acetone 587.55
    n-butanol 589.64
    acetonitrile 742.79
    DMF 661.08
    toluene 249.47
    isobutanol 485.41
    1,4-dioxane 827.01
    methyl acetate 443.63
    THF 1039.46
    2-butanone 463.24
    n-pentanol 335.1
    sec-butanol 669.28
    n-hexane 215.53
    ethylene glycol 218.56
    NMP 778.13
    cyclohexane 512.06
    DMSO 707.24
    n-butyl acetate 287.11
    n-octanol 248.35
    chloroform 2817.37
    n-propyl acetate 240.76
    acetic acid 1264.34
    dichloromethane 2244.86
    cyclohexanone 791.23
    propylene glycol 307.0
    isopropyl acetate 190.6
    DMAc 540.68
    2-ethoxyethanol 391.32
    isopentanol 346.18
    n-heptane 229.51
    ethyl formate 330.68
    1,2-dichloroethane 918.58
    n-hexanol 351.2
    2-methoxyethanol 701.66
    isobutyl acetate 150.21
    tetrachloromethane 618.51
    n-pentyl acetate 235.77
    transcutol 633.23
    n-heptanol 205.18
    ethylbenzene 157.18
    MIBK 138.38
    2-propoxyethanol 378.88
    tert-butanol 676.84
    MTBE 353.68
    2-butoxyethanol 281.95
    propionic acid 734.3
    o-xylene 188.13
    formic acid 301.46
    diethyl ether 430.89
    m-xylene 135.28
    p-xylene 247.43
    chlorobenzene 477.48
    dimethyl carbonate 100.58
    n-octane 76.18
    formamide 337.79
    cyclopentanone 818.91
    2-pentanone 292.37
    anisole 256.28
    cyclopentyl methyl ether 454.12
    gamma-butyrolactone 907.0
    1-methoxy-2-propanol 465.23
    pyridine 1001.54
    3-pentanone 261.49
    furfural 844.37
    n-dodecane 50.73
    diethylene glycol 281.14
    diisopropyl ether 102.54
    tert-amyl alcohol 622.95
    acetylacetone 250.31
    n-hexadecane 55.47
    acetophenone 248.66
    methyl propionate 291.99
    isopentyl acetate 215.21
    trichloroethylene 1726.17
    n-nonanol 213.75
    cyclohexanol 674.33
    benzyl alcohol 278.0
    2-ethylhexanol 256.81
    isooctanol 167.37
    dipropyl ether 324.29
    1,2-dichlorobenzene 446.24
    ethyl lactate 175.87
    propylene carbonate 492.41
    n-methylformamide 452.74
    2-pentanol 383.79
    n-pentane 226.05
    1-propoxy-2-propanol 354.63
    1-methoxy-2-propyl acetate 186.99
    2-(2-methoxypropoxy) propanol 228.65
    mesitylene 90.4
    ε-caprolactone 645.41
    p-cymene 129.78
    epichlorohydrin 838.4
    1,1,1-trichloroethane 1048.11
    2-aminoethanol 394.24
    morpholine-4-carbaldehyde 618.17
    sulfolane 983.2
    2,2,4-trimethylpentane 82.03
    2-methyltetrahydrofuran 856.33
    n-hexyl acetate 326.73
    isooctane 41.31
    2-(2-butoxyethoxy)ethanol 283.67
    sec-butyl acetate 149.91
    tert-butyl acetate 163.45
    decalin 117.05
    glycerin 350.59
    diglyme 543.31
    acrylic acid 693.09
    isopropyl myristate 144.92
    n-butyric acid 709.47
    acetyl acetate 251.86
    di(2-ethylhexyl) phthalate 136.77
    ethyl propionate 227.21
    nitromethane 950.84
    1,2-diethoxyethane 273.6
    benzonitrile 452.65
    trioctyl phosphate 106.9
    1-bromopropane 745.99
    gamma-valerolactone 756.08
    n-decanol 150.18
    triethyl phosphate 158.88
    4-methyl-2-pentanol 149.31
    propionitrile 614.97
    vinylene carbonate 475.86
    1,1,2-trichlorotrifluoroethane 854.12
    DMS 190.51
    cumene 117.73
    2-octanol 178.35
    2-hexanone 234.73
    octyl acetate 181.83
    limonene 228.51
    1,2-dimethoxyethane 618.81
    ethyl orthosilicate 151.25
    tributyl phosphate 131.79
    diacetone alcohol 216.6
    N,N-dimethylaniline 196.19
    acrylonitrile 693.85
    aniline 400.55
    1,3-propanediol 471.38
    bromobenzene 505.25
    dibromomethane 1605.94
    1,1,2,2-tetrachloroethane 1483.35
    2-methyl-cyclohexyl acetate 216.14
    tetrabutyl urea 167.48
    diisobutyl methanol 138.44
    2-phenylethanol 221.7
    styrene 223.18
    dioctyl adipate 229.29
    dimethyl sulfate 180.36
    ethyl butyrate 263.14
    methyl lactate 206.51
    butyl lactate 206.6
    diethyl carbonate 201.64
    propanediol butyl ether 259.79
    triethyl orthoformate 222.63
    p-tert-butyltoluene 121.57
    methyl 4-tert-butylbenzoate 240.9
    morpholine 990.11
    tert-butylamine 535.2
    n-dodecanol 119.42
    dimethoxymethane 283.45
    ethylene carbonate 380.86
    cyrene 240.51
    2-ethoxyethyl acetate 218.67
    2-ethylhexyl acetate 189.83
    1,2,4-trichlorobenzene 536.25
    4-methylpyridine 710.84
    dibutyl ether 303.28
    2,6-dimethyl-4-heptanol 138.44
    DEF 404.72
    dimethyl isosorbide 346.49
    tetrachloroethylene 1072.29
    eugenol 232.42
    triacetin 297.92
    span 80 307.98
    1,4-butanediol 203.41
    1,1-dichloroethane 1084.47
    2-methyl-1-pentanol 252.87
    methyl formate 305.07
    2-methyl-1-butanol 403.48
    n-decane 87.99
    butyronitrile 579.5
    3,7-dimethyl-1-octanol 206.98
    1-chlorooctane 213.42
    1-chlorotetradecane 90.19
    n-nonane 97.51
    undecane 62.31
    tert-butylcyclohexane 101.03
    cyclooctane 125.1
    cyclopentanol 772.49
    tetrahydropyran 999.8
    tert-amyl methyl ether 274.48
    2,5,8-trioxanonane 369.12
    1-hexene 402.45
    2-isopropoxyethanol 251.64
    2,2,2-trifluoroethanol 325.92
    methyl butyrate 337.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction