Dichlorophene

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  • Identifiers

    CAS number
    97-23-4

    Molecular formula
    C13H10Cl2O2

    SMILES
    C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 63.26%
    Smoky 37.29%
    Spicy 35.64%
    Burnt 35.53%
    Medicinal 33.05%
    Animal 29.95%
    Sweet 29.67%
    Fruity 28.93%
    Leathery 24.8%
    Meaty 24.8%

     

    Flavor
    Bitter 63.69%
    Mild 31.63%
    Phenolic 27.36%
    Fruity 24.17%
    Odorless 22.95%
    Very strong 21.11%
    Indole 20.36%
    Flat 20.17%
    Orange flower 20.1%
    Sweet-like 20.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    10.41 (weak base)

    Molecular weight
    269.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    408°C

    Melting point expt.

    • 351 to 352 °F (NTP, 1992)
    • 177-178 °C

    Flash point

    • 189.14 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 72 °F (NTP, 1992)
    • Sparingly sol in toluene; 1 g sol in 1 g of 95% ethanol, in less than 1 g of ether; sol in methanol, isopropyl ether, petroleum ether; sol (with decomp) in alkaline aq solutions
    • In water, 30 mg/L at 25 °C

  • Synonyms

    • Dichlorophen
    • dichlorophene
    • 97-23-4
    • 2,2'-Methylenebis(4-chlorophenol)
    • Didroxane
    • Anthiphen
    • Dichlorofen
    • Dichlorphen
    • Parabis
    • Trivex
    • Dicestal
    • Didroxan
    • Antiphen
    • Cordocel
    • Difentan
    • Embephen
    • Prevental
    • Taeniatol
    • Teniathane
    • Teniatol
    • Teniotol
    • Vermithana
    • Antifen
    • Halenol
    • Hyosan
    • Korium
    • Palacel
    • Dichlorophen B
    • Dichloorfeen
    • Dichlorophene 10
    • Gingivit
    • Panacide
    • Wespuril
    • Gefir
    • Fungicide M
    • Fungicide GM
    • Plath-Lyse
    • Preventol GD
    • DDDM
    • Preventol GDC
    • Diphenthane 70
    • Bis(5-chloro-2-hydroxyphenyl)methane
    • Diclorofeno
    • Sandocide
    • Phenol, 2,2'-methylenebis[4-chloro-
    • Super mosstox
    • Di-phentane-70
    • Dichlorophenum
    • Bis(chlorohydroxyphenyl)methane
    • 2,2'-Dihydroxy-5,5'-dichlorodiphenylmethane
    • 5,5'-Dichloro-2,2'-dihydroxydiphenylmethane
    • 1322-43-6
    • Giv Gard G 4-40
    • Sindar G 4
    • Bis(2-hydroxy-5-chlorophenyl)methane
    • Di-(5-chloro-2-hydroxyphenyl)methane
    • Bis-2-hydroxy-5-chlorfenylmethan
    • Caswell No. 563
    • Bis(5-chlor-2-hydroxyphenyl)-methan
    • 4,4'-Dichloro-2,2'-methylenediphenol
    • 4-chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol
    • O,O-Metilen-bis(4-cloro-fenolo)
    • Dichlorofen [Czech]
    • CCRIS 6060
    • Fungicide fx
    • HSDB 6033
    • Difent*n
    • Methanedichlorofen
    • UNII-T1J0JOU64O
    • Diclorofeno [INN-Spanish]
    • Diphentane 70
    • ((Dihydroxydichloro)diphenyl)methane
    • Dichlorophene [INN-French]
    • Dichlorophene [ISO-French]
    • Dichlorophenum [INN-Latin]
    • EINECS 202-567-1
    • G-4 Technical
    • T1J0JOU64O
    • 2,2'-Methylenebis-(4-chlorophenol)
    • NSC 38642
    • NSC-38642
    • EPA Pesticide Chemical Code 055001
    • BRN 1884514
    • DTXSID6021824
    • AI3-02370
    • G-4 Pure
    • o,o-Methyleen-bis(4-chloorfenol)
    • NSC38642
    • MFCD00002322
    • G 4
    • G-4
    • 2,2'-Methylene-bis (4-chlorophenol)
    • Phenol, 2,2'-methylenebis(4-chloro-
    • CHEMBL33845
    • MLS000069468
    • DTXCID901824
    • 2,2/'-METHYLENEBIS(4-CHLOROPHENOL)
    • CHEBI:34689
    • 2,2'-Methylenebis[4-chlorophenol]
    • O,O-Methyleen-bis-(4-chloorfenol)
    • 2,2'-methanediylbis(4-chlorophenol)
    • Dichlorofen (Czech)
    • NCGC00091325-05
    • SMR000059095
    • C13H10Cl2O2
    • Diclorofeno (INN-Spanish)
    • Dichlorophene (INN-French)
    • Dichlorophene (ISO-French)
    • Dichlorophenum (INN-Latin)
    • 2,5'-dichlorodiphenylmethane
    • DICHLOROPHEN (MART.)
    • DICHLOROPHEN [MART.]
    • 5,2'-dihydroxydiphenylmethane
    • Dichloorfeen [Dutch]
    • WLN: QR DG B1R BQ EG
    • 4-chloranyl-2-[(5-chloranyl-2-oxidanyl-phenyl)methyl]phenol
    • Phenol,2'-methylenebis[4-chloro-
    • [(Dihydroxydichloro)diphenyl]methane
    • DDM (VAN)
    • CAS-97-23-4
    • Dichlorophen [INN:BAN:DCF]
    • Dichlorophen [ISO]
    • G 4 (VAN)
    • Dichlorophen [BSI:ISO]
    • Anthipohen
    • Phenol, 2,2'-methylenebis(4-chloro)-
    • Algafen
    • Anthipen

  • Applications

    Dichlorophene (CAS 97-23-4) is used as an organic chemical intermediate with applicability across several industries. In the pharmaceutical and agrochemical sectors, it may serve as an intermediate for the synthesis of more complex compounds. In plastics, coatings, and polymers, it can act as a building block or processing additive for polymer syntheses and coating systems. In pigment and dye manufacture, it may be used as an intermediate for color-forming chemistries. It may also be evaluated for specialist stabilizer or processing-chemistry roles in formulated products, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.7
    methanol 9.75
    isopropanol 8.24
    water 0.05
    ethyl acetate 41.87
    n-propanol 13.15
    acetone 27.85
    n-butanol 11.65
    acetonitrile 11.92
    DMF 63.96
    toluene 9.36
    isobutanol 6.7
    1,4-dioxane 74.52
    methyl acetate 47.47
    THF 226.11
    2-butanone 59.75
    n-pentanol 13.08
    sec-butanol 15.05
    n-hexane 0.16
    ethylene glycol 2.89
    NMP 31.48
    cyclohexane 0.18
    DMSO 22.58
    n-butyl acetate 34.59
    n-octanol 8.28
    chloroform 29.71
    n-propyl acetate 32.17
    acetic acid 19.51
    dichloromethane 19.05
    cyclohexanone 40.19
    propylene glycol 6.98
    isopropyl acetate 31.11
    DMAc 161.34
    2-ethoxyethanol 53.85
    isopentanol 11.17
    n-heptane 0.94
    ethyl formate 20.74
    1,2-dichloroethane 11.68
    n-hexanol 12.7
    2-methoxyethanol 57.49
    isobutyl acetate 19.3
    tetrachloromethane 1.91
    n-pentyl acetate 23.76
    transcutol 154.63
    n-heptanol 10.8
    ethylbenzene 8.19
    MIBK 23.04
    2-propoxyethanol 49.02
    tert-butanol 16.02
    MTBE 33.0
    2-butoxyethanol 34.47
    propionic acid 13.84
    o-xylene 7.91
    formic acid 7.72
    diethyl ether 17.57
    m-xylene 7.11
    p-xylene 9.18
    chlorobenzene 8.49
    dimethyl carbonate 25.51
    n-octane 0.49
    formamide 33.81
    cyclopentanone 65.45
    2-pentanone 33.97
    anisole 48.36
    cyclopentyl methyl ether 31.28
    gamma-butyrolactone 77.84
    1-methoxy-2-propanol 47.48
    pyridine 53.7
    3-pentanone 26.51
    furfural 67.96
    n-dodecane 0.53
    diethylene glycol 32.44
    diisopropyl ether 6.43
    tert-amyl alcohol 22.28
    acetylacetone 56.36
    n-hexadecane 0.63
    acetophenone 42.26
    methyl propionate 38.04
    isopentyl acetate 33.93
    trichloroethylene 60.25
    n-nonanol 9.72
    cyclohexanol 10.87
    benzyl alcohol 28.5
    2-ethylhexanol 12.13
    isooctanol 9.99
    dipropyl ether 23.83
    1,2-dichlorobenzene 11.33
    ethyl lactate 21.66
    propylene carbonate 39.88
    n-methylformamide 27.19
    2-pentanol 9.9
    n-pentane 0.14
    1-propoxy-2-propanol 38.66
    1-methoxy-2-propyl acetate 58.64
    2-(2-methoxypropoxy) propanol 47.14
    mesitylene 4.69
    ε-caprolactone 50.94
    p-cymene 8.85
    epichlorohydrin 103.8
    1,1,1-trichloroethane 13.89
    2-aminoethanol 8.71
    morpholine-4-carbaldehyde 79.65
    sulfolane 43.57
    2,2,4-trimethylpentane 0.76
    2-methyltetrahydrofuran 63.15
    n-hexyl acetate 23.29
    isooctane 0.48
    2-(2-butoxyethoxy)ethanol 53.87
    sec-butyl acetate 27.31
    tert-butyl acetate 43.96
    decalin 0.71
    glycerin 13.11
    diglyme 119.81
    acrylic acid 13.62
    isopropyl myristate 13.37
    n-butyric acid 21.31
    acetyl acetate 27.31
    di(2-ethylhexyl) phthalate 13.97
    ethyl propionate 29.75
    nitromethane 58.18
    1,2-diethoxyethane 59.72
    benzonitrile 19.23
    trioctyl phosphate 8.93
    1-bromopropane 5.39
    gamma-valerolactone 115.22
    n-decanol 7.52
    triethyl phosphate 20.52
    4-methyl-2-pentanol 9.01
    propionitrile 13.17
    vinylene carbonate 35.05
    1,1,2-trichlorotrifluoroethane 64.01
    DMS 29.95
    cumene 6.02
    2-octanol 8.17
    2-hexanone 32.07
    octyl acetate 15.43
    limonene 10.72
    1,2-dimethoxyethane 112.92
    ethyl orthosilicate 22.42
    tributyl phosphate 11.69
    diacetone alcohol 45.58
    N,N-dimethylaniline 30.1
    acrylonitrile 19.51
    aniline 18.46
    1,3-propanediol 15.75
    bromobenzene 7.25
    dibromomethane 7.23
    1,1,2,2-tetrachloroethane 39.12
    2-methyl-cyclohexyl acetate 28.63
    tetrabutyl urea 17.74
    diisobutyl methanol 11.19
    2-phenylethanol 28.01
    styrene 9.1
    dioctyl adipate 22.46
    dimethyl sulfate 33.86
    ethyl butyrate 35.47
    methyl lactate 24.18
    butyl lactate 22.83
    diethyl carbonate 24.55
    propanediol butyl ether 27.87
    triethyl orthoformate 33.18
    p-tert-butyltoluene 9.39
    methyl 4-tert-butylbenzoate 35.76
    morpholine 91.27
    tert-butylamine 7.0
    n-dodecanol 5.79
    dimethoxymethane 79.29
    ethylene carbonate 25.3
    cyrene 49.14
    2-ethoxyethyl acetate 46.49
    2-ethylhexyl acetate 27.11
    1,2,4-trichlorobenzene 17.78
    4-methylpyridine 37.52
    dibutyl ether 17.46
    2,6-dimethyl-4-heptanol 11.19
    DEF 44.25
    dimethyl isosorbide 90.03
    tetrachloroethylene 19.25
    eugenol 37.64
    triacetin 39.55
    span 80 30.74
    1,4-butanediol 7.51
    1,1-dichloroethane 10.94
    2-methyl-1-pentanol 14.46
    methyl formate 23.06
    2-methyl-1-butanol 12.18
    n-decane 0.86
    butyronitrile 13.25
    3,7-dimethyl-1-octanol 11.25
    1-chlorooctane 4.57
    1-chlorotetradecane 2.17
    n-nonane 0.64
    undecane 0.66
    tert-butylcyclohexane 0.99
    cyclooctane 0.18
    cyclopentanol 11.48
    tetrahydropyran 43.96
    tert-amyl methyl ether 32.03
    2,5,8-trioxanonane 83.52
    1-hexene 1.9
    2-isopropoxyethanol 37.09
    2,2,2-trifluoroethanol 11.28
    methyl butyrate 34.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction