Dichlorofluoromethane

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  • Identifiers

    CAS number
    75-43-4

    Molecular formula
    CHCl2F

    SMILES
    C(F)(Cl)Cl

    Safety labels

    Compressed Gas
    Compressed Gas

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 47.91%
    Fishy 35.63%
    Cheesy 23.7%
    Green 22.56%
    Ripe 20.97%
    Meaty 19.14%
    Oily 19.09%
    Sweet 18.89%
    Musty 18.18%
    Fruity 18.1%

     

    Flavor
    Odorless 35.68%
    Sulfurous 27.0%
    Fishy 26.05%
    Sulfury 23.91%
    Meaty 23.74%
    Ammoniacal 23.0%
    Glue 19.28%
    Bloody 19.14%
    Rotten 18.61%
    Onion 18.41%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    4.51 (weak acid)

    Molecular weight
    102.92 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -211 °F (USCG, 1999)
    • -130.4 °C
    • -135 °C
    • -211 °F

    Boiling point

    • 48 °F at 760 mmHg (USCG, 1999)
    • 8.9 °C
    • Heat of vaporization = 5.79 Kcal/mol at 25 °C; 6.01 kcal/mol at the boiling point
    • 48 °F

    Flash point

    • -4.62 ˚C est.

    Solubility expt.

    • 0.7 % at 86 °F (NIOSH, 2024)
    • In water, 1.88X10+04 mg/L at 25 °C
    • Soluble in carbon tetrachloride
    • 69 parts/100 parts acetic acid; 108 parts/100 parts dioxane
    • > 10% in ethyl alcohol; > 10% in ethyl ether;> 10% in chloroform
    • 0.95% weight at 25 deg in water
    • Solubility in water, g/100ml at 20 °C: 1 (poor)
    • (86 °F): 0.7%

  • Synonyms

    • Dichlorofluoromethane
    • Dichloromonofluoromethane
    • dichloro(fluoro)methane
    • 75-43-4
    • Fluorodichloromethane
    • Methane, dichlorofluoro-
    • Refrigerant 21
    • Monofluorodichloromethane
    • Algofrene type 5
    • HCFC-21
    • Arcton 7
    • Genetron 21
    • R 21 (refrigerant)
    • Freon F 21
    • Halon 112
    • Dwuchlorofluorometan
    • FREON 21
    • CHCl2F
    • HSDB 142
    • UNII-7GAO4CRJ0B
    • 7GAO4CRJ0B
    • Fluorocarbon-21
    • EINECS 200-869-8
    • UN1029
    • BRN 1731041
    • CHFCl2
    • F 21
    • Dichloro-fluoro-methane
    • REFRIGERANT-21
    • FREON-21
    • HALON-112
    • DICHLORMONOFLUOROMETHANE
    • DTXSID7052498
    • DICHLOROFLUOROMETHANE [II]
    • 4-01-00-00039 (Beilstein Handbook Reference)
    • DICHLOROFLUOROMETHANE [HSDB]
    • UN 1029
    • Fluorocarbon 21
    • Racon 21
    • DICHLOROFLUOROMETHANE (II)
    • Dwuchlorofluorometan [Polish]
    • HCFC 21
    • CFC-21
    • FC-21
    • Genetron21
    • Freon21
    • Halon112
    • Methane, dichlorofluoro
    • HALOCARBON 21
    • Dichlorofluoromethane, 98%
    • SCHEMBL9376
    • CFC21
    • Dichlorofluoromethane (ACGIH)
    • REFRIGERANT GAS R-21
    • F 21 (FLUOROCARBON)
    • AF 22 (FLUOROCARBON)
    • CFC 21
    • CHEMBL116813
    • DTXCID8031071
    • Dichloromonofluoromethane (OSHA)
    • DTXSID50168649
    • AF 22
    • AKOS015915816
    • R-21
    • DESFLURANE IMPURITY C [EP IMPURITY]
    • Dichlorofluoromethane or Refrigerant gas R21
    • NS00020118
    • Dichlorofluoromethane 100 microg/mL in Methanol
    • Q418163
    • Dichlorofluoromethane or Refrigerant gas R21 [UN1029] [Nonflammable gas]

  • Applications

    Dichlorofluoromethane (CAS 75-43-4) is used in industry primarily as a specialty solvent and processing medium for halogenated organic chemistry. It also serves as an intermediate in the synthesis of other halogenated and fluorinated compounds, providing a platform for selective halogenation steps and acting as a building block for niche chemical products. It may be used as a cleaning or degreasing solvent for equipment and formulations in certain manufacturing environments, subject to safety and regulatory constraints, and can function as a processing aid or formulation component in coatings and adhesives where a volatile halogenated solvent is appropriate; in research and development, it is employed for formulation screening and reaction optimization involving halogenated systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 347.57
    methanol 551.45
    isopropanol 266.66
    water 296.56
    ethyl acetate 153.78
    n-propanol 224.06
    acetone 646.99
    n-butanol 176.02
    acetonitrile 455.87
    DMF 1350.91
    toluene 68.87
    isobutanol 158.83
    1,4-dioxane 337.49
    methyl acetate 236.39
    THF 420.6
    2-butanone 288.22
    n-pentanol 144.25
    sec-butanol 186.21
    n-hexane 38.38
    ethylene glycol 296.89
    NMP 892.01
    cyclohexane 59.52
    DMSO 1481.09
    n-butyl acetate 107.61
    n-octanol 96.64
    chloroform 216.44
    n-propyl acetate 146.86
    acetic acid 478.52
    dichloromethane 297.66
    cyclohexanone 285.63
    propylene glycol 155.1
    isopropyl acetate 103.77
    DMAc 962.75
    2-ethoxyethanol 358.24
    isopentanol 142.54
    n-heptane 52.97
    ethyl formate 170.21
    1,2-dichloroethane 230.08
    n-hexanol 101.65
    2-methoxyethanol 498.57
    isobutyl acetate 79.68
    tetrachloromethane 65.95
    n-pentyl acetate 89.62
    transcutol 523.12
    n-heptanol 78.51
    ethylbenzene 51.44
    MIBK 126.63
    2-propoxyethanol 222.54
    tert-butanol 273.28
    MTBE 176.53
    2-butoxyethanol 154.95
    propionic acid 180.78
    o-xylene 89.51
    formic acid 438.44
    diethyl ether 214.68
    m-xylene 67.13
    p-xylene 70.65
    chlorobenzene 73.35
    dimethyl carbonate 136.28
    n-octane 21.81
    formamide 713.42
    cyclopentanone 360.58
    2-pentanone 220.12
    anisole 150.74
    cyclopentyl methyl ether 202.84
    gamma-butyrolactone 321.93
    1-methoxy-2-propanol 329.97
    pyridine 287.96
    3-pentanone 204.06
    furfural 378.5
    n-dodecane 17.64
    diethylene glycol 283.53
    diisopropyl ether 74.78
    tert-amyl alcohol 194.21
    acetylacetone 258.35
    n-hexadecane 18.74
    acetophenone 180.88
    methyl propionate 187.07
    isopentyl acetate 84.25
    trichloroethylene 296.77
    n-nonanol 85.83
    cyclohexanol 168.71
    benzyl alcohol 139.49
    2-ethylhexanol 77.81
    isooctanol 65.96
    dipropyl ether 144.96
    1,2-dichlorobenzene 78.79
    ethyl lactate 101.68
    propylene carbonate 142.88
    n-methylformamide 593.93
    2-pentanol 133.47
    n-pentane 57.37
    1-propoxy-2-propanol 166.57
    1-methoxy-2-propyl acetate 120.34
    2-(2-methoxypropoxy) propanol 184.02
    mesitylene 59.48
    ε-caprolactone 199.92
    p-cymene 60.98
    epichlorohydrin 298.38
    1,1,1-trichloroethane 140.59
    2-aminoethanol 293.81
    morpholine-4-carbaldehyde 704.67
    sulfolane 490.25
    2,2,4-trimethylpentane 26.23
    2-methyltetrahydrofuran 253.26
    n-hexyl acetate 107.07
    isooctane 18.51
    2-(2-butoxyethoxy)ethanol 206.81
    sec-butyl acetate 86.44
    tert-butyl acetate 111.2
    decalin 25.27
    glycerin 244.94
    diglyme 445.44
    acrylic acid 228.01
    isopropyl myristate 62.58
    n-butyric acid 158.36
    acetyl acetate 118.97
    di(2-ethylhexyl) phthalate 63.06
    ethyl propionate 123.57
    nitromethane 775.2
    1,2-diethoxyethane 190.41
    benzonitrile 147.06
    trioctyl phosphate 51.76
    1-bromopropane 131.39
    gamma-valerolactone 419.01
    n-decanol 70.59
    triethyl phosphate 75.47
    4-methyl-2-pentanol 79.97
    propionitrile 214.26
    vinylene carbonate 143.83
    1,1,2-trichlorotrifluoroethane 311.37
    DMS 107.43
    cumene 48.64
    2-octanol 62.59
    2-hexanone 176.85
    octyl acetate 77.64
    limonene 90.39
    1,2-dimethoxyethane 562.09
    ethyl orthosilicate 73.98
    tributyl phosphate 59.04
    diacetone alcohol 167.83
    N,N-dimethylaniline 179.05
    acrylonitrile 287.91
    aniline 130.61
    1,3-propanediol 252.16
    bromobenzene 58.19
    dibromomethane 200.37
    1,1,2,2-tetrachloroethane 234.02
    2-methyl-cyclohexyl acetate 85.96
    tetrabutyl urea 115.35
    diisobutyl methanol 68.67
    2-phenylethanol 98.68
    styrene 66.78
    dioctyl adipate 93.42
    dimethyl sulfate 254.14
    ethyl butyrate 117.89
    methyl lactate 155.13
    butyl lactate 88.82
    diethyl carbonate 81.17
    propanediol butyl ether 155.84
    triethyl orthoformate 94.84
    p-tert-butyltoluene 59.26
    methyl 4-tert-butylbenzoate 150.64
    morpholine 425.96
    tert-butylamine 191.93
    n-dodecanol 61.7
    dimethoxymethane 471.39
    ethylene carbonate 115.88
    cyrene 203.48
    2-ethoxyethyl acetate 111.54
    2-ethylhexyl acetate 71.11
    1,2,4-trichlorobenzene 101.35
    4-methylpyridine 235.65
    dibutyl ether 103.67
    2,6-dimethyl-4-heptanol 68.67
    DEF 380.08
    dimethyl isosorbide 242.54
    tetrachloroethylene 204.85
    eugenol 164.8
    triacetin 137.46
    span 80 142.11
    1,4-butanediol 159.44
    1,1-dichloroethane 170.49
    2-methyl-1-pentanol 114.74
    methyl formate 402.02
    2-methyl-1-butanol 138.22
    n-decane 26.08
    butyronitrile 182.71
    3,7-dimethyl-1-octanol 86.51
    1-chlorooctane 62.26
    1-chlorotetradecane 33.33
    n-nonane 26.67
    undecane 20.46
    tert-butylcyclohexane 22.15
    cyclooctane 26.37
    cyclopentanol 201.85
    tetrahydropyran 235.93
    tert-amyl methyl ether 159.8
    2,5,8-trioxanonane 329.96
    1-hexene 76.86
    2-isopropoxyethanol 228.89
    2,2,2-trifluoroethanol 280.15
    methyl butyrate 173.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction