Diazolidinylurea

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  • Identifiers

    CAS number
    78491-02-8

    Molecular formula
    C8H14N4O7

    SMILES
    C(NC(=O)N(CO)C1C(=O)N(C(=O)N1CO)CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 68.95%
    Savory 29.6%
    Cooling 26.57%
    Sweet 22.74%
    Meaty 20.72%
    Fishy 19.85%
    Bitter 16.35%
    Alcoholic 15.66%
    Cooked 15.34%
    Mint 14.77%

     

    Flavor
    Bitter 60.15%
    Odorless 53.36%
    Very mild 28.77%
    Bland 27.5%
    Sweet-like 24.56%
    Mild 22.31%
    Yeast 21.09%
    Nitrile 19.27%
    Bread crust 18.64%
    Roasted peanuts 18.62%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -2.5

    pKa est.
    4.54 (weak acid)

    Molecular weight
    278.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    336°C

    Flash point

    • 304.19 ˚C est.

  • Synonyms

    • DIAZOLIDINYL UREA
    • 78491-02-8
    • Diazolidinylurea
    • Germall 11
    • Imidazolidinyl urea 11
    • N,N'-Bis(hydroxymethyl) urea
    • DTXSID0029559
    • N9VX1IBW6K
    • H5RIZ3MPW4
    • DTXCID009559
    • Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-
    • GERMABEN II-E
    • RefChem:586353
    • 5-(1,3-bis(hydroxymethyl)ureido)-1,3-bis(hydroxymethyl)imidazol-2,5(3H,5H)dione
    • 1-(1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl)urea
    • 1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
    • MFCD03547942
    • N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea
    • n-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-n,n'-bis(hydroxymethyl)urea
    • Germall II
    • 1-[1,3-bis(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
    • Diazolidinyl Urea (Technical Grade)
    • N-[1,3-bis(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(h ydroxymethyl)amino]carboxamide
    • CAS-78491-02-8
    • C8H14N4O7
    • EINECS 278-928-2
    • UNII-H5RIZ3MPW4
    • UNII-N9VX1IBW6K
    • SOROIESOUPGGFO-UHFFFAOYSA-N
    • N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea; Diazolidinylurea; Germaben II-E; Germall II; N-Hydroxymethyl-N-[1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N'-hydroxymethylurea
    • EC 278-928-2
    • Diazolidinyl urea, >=95%
    • N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl) urea
    • N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea
    • SCHEMBL34370
    • orb1299200
    • orb3025689
    • CHEMBL3187032
    • N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
    • CHEBI:136014
    • HMS5084O04
    • Tox21_202068
    • Tox21_303365
    • AC1192
    • EBC-26417
    • MSK157349
    • s5292
    • SBB003028
    • AKOS016010254
    • CCG-267223
    • CS-W010066
    • DB14173
    • HY-W009350
    • Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-N,N'-bis(hyd- roxymethyl)-
    • NCGC00249159-01
    • NCGC00257237-01
    • NCGC00259617-01
    • AS-73729
    • FD153249
    • ST056226
    • SY033470
    • DB-056316
    • D3769
    • NS00001993
    • EN300-18632140
    • Q5272201
    • W-104279
    • 1,3-Bis(hydroxymethyl)-5-[1,3-bis(hydroxymethyl)ureido]hydantoin
    • N,N'-BIS(HYDROXYMETHYL)-N'-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)UREA
    • N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-urea
    • N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bishydroxymethylurea
    • N-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N,N'-bis(hydroxymethyl)urea
    • N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'-hydroxy-methylurea
    • N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N inverted exclamation mark -bis(hydroxymethyl)urea
    • 78491-02-8

  • Applications

    Diazolidinylurea (CAS 78491-02-8) is primarily used as a formaldehyde-releasing preservative to inhibit microbial growth in cosmetics and personal care products such as creams, lotions, shampoos, and makeup. It may also be used in some household cleaning products to extend shelf life. In certain industrial formulations, including water-based coatings, inks, and adhesives, it serves as an antimicrobial preservative to control microbial contamination and product stability. It may also function as an intermediate in the synthesis of other preservative chemistries in the broader chemical industry. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.26
    methanol 11.38
    isopropanol 1.1
    water 97.67
    ethyl acetate 0.56
    n-propanol 1.66
    acetone 0.96
    n-butanol 1.2
    acetonitrile 1.5
    DMF 89.04
    toluene 0.27
    isobutanol 0.84
    1,4-dioxane 2.03
    methyl acetate 1.15
    THF 3.38
    2-butanone 1.25
    n-pentanol 0.59
    sec-butanol 1.03
    n-hexane 0.07
    ethylene glycol 16.46
    NMP 146.98
    cyclohexane 0.16
    DMSO 127.31
    n-butyl acetate 0.83
    n-octanol 0.31
    chloroform 0.59
    n-propyl acetate 0.48
    acetic acid 6.35
    dichloromethane 1.18
    cyclohexanone 3.72
    propylene glycol 9.26
    isopropyl acetate 0.29
    DMAc 71.98
    2-ethoxyethanol 5.07
    isopentanol 0.65
    n-heptane 0.12
    ethyl formate 2.36
    1,2-dichloroethane 0.95
    n-hexanol 0.75
    2-methoxyethanol 19.46
    isobutyl acetate 0.18
    tetrachloromethane 0.28
    n-pentyl acetate 0.39
    transcutol 1.93
    n-heptanol 0.53
    ethylbenzene 0.19
    MIBK 0.46
    2-propoxyethanol 5.72
    tert-butanol 0.89
    MTBE 0.25
    2-butoxyethanol 2.54
    propionic acid 4.12
    o-xylene 0.4
    formic acid 95.97
    diethyl ether 0.44
    m-xylene 0.24
    p-xylene 0.27
    chlorobenzene 0.21
    dimethyl carbonate 3.1
    n-octane 0.05
    formamide 92.91
    cyclopentanone 5.77
    2-pentanone 0.87
    anisole 0.33
    cyclopentyl methyl ether 1.33
    gamma-butyrolactone 12.94
    1-methoxy-2-propanol 8.18
    pyridine 2.92
    3-pentanone 1.1
    furfural 17.19
    n-dodecane 0.02
    diethylene glycol 13.48
    diisopropyl ether 0.09
    tert-amyl alcohol 1.01
    acetylacetone 0.96
    n-hexadecane 0.03
    acetophenone 1.05
    methyl propionate 2.21
    isopentyl acetate 0.54
    trichloroethylene 1.45
    n-nonanol 0.3
    cyclohexanol 1.34
    benzyl alcohol 1.05
    2-ethylhexanol 0.41
    isooctanol 0.31
    dipropyl ether 0.58
    1,2-dichlorobenzene 0.33
    ethyl lactate 2.35
    propylene carbonate 4.98
    n-methylformamide 41.77
    2-pentanol 0.52
    n-pentane 0.09
    1-propoxy-2-propanol 3.0
    1-methoxy-2-propyl acetate 1.66
    2-(2-methoxypropoxy) propanol 1.92
    mesitylene 0.18
    ε-caprolactone 4.46
    p-cymene 0.23
    epichlorohydrin 4.28
    1,1,1-trichloroethane 0.26
    2-aminoethanol 11.63
    morpholine-4-carbaldehyde 39.61
    sulfolane 43.92
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 1.37
    n-hexyl acetate 0.37
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 1.89
    sec-butyl acetate 0.21
    tert-butyl acetate 0.33
    decalin 0.06
    glycerin 37.04
    diglyme 3.86
    acrylic acid 8.66
    isopropyl myristate 0.14
    n-butyric acid 2.43
    acetyl acetate 0.38
    di(2-ethylhexyl) phthalate 0.45
    ethyl propionate 0.62
    nitromethane 15.52
    1,2-diethoxyethane 0.43
    benzonitrile 1.01
    trioctyl phosphate 0.4
    1-bromopropane 0.37
    gamma-valerolactone 15.97
    n-decanol 0.22
    triethyl phosphate 1.04
    4-methyl-2-pentanol 0.23
    propionitrile 1.41
    vinylene carbonate 6.08
    1,1,2-trichlorotrifluoroethane 18.17
    DMS 0.93
    cumene 0.13
    2-octanol 0.23
    2-hexanone 0.5
    octyl acetate 0.24
    limonene 0.32
    1,2-dimethoxyethane 4.43
    ethyl orthosilicate 0.72
    tributyl phosphate 0.44
    diacetone alcohol 1.81
    N,N-dimethylaniline 0.59
    acrylonitrile 3.46
    aniline 0.86
    1,3-propanediol 7.93
    bromobenzene 0.17
    dibromomethane 0.6
    1,1,2,2-tetrachloroethane 1.32
    2-methyl-cyclohexyl acetate 0.68
    tetrabutyl urea 0.97
    diisobutyl methanol 0.22
    2-phenylethanol 1.01
    styrene 0.16
    dioctyl adipate 0.35
    dimethyl sulfate 14.48
    ethyl butyrate 0.81
    methyl lactate 9.16
    butyl lactate 1.26
    diethyl carbonate 0.72
    propanediol butyl ether 2.19
    triethyl orthoformate 0.82
    p-tert-butyltoluene 0.19
    methyl 4-tert-butylbenzoate 1.24
    morpholine 4.56
    tert-butylamine 0.36
    n-dodecanol 0.16
    dimethoxymethane 8.01
    ethylene carbonate 3.57
    cyrene 8.76
    2-ethoxyethyl acetate 0.57
    2-ethylhexyl acetate 0.48
    1,2,4-trichlorobenzene 0.52
    4-methylpyridine 1.89
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.22
    DEF 6.15
    dimethyl isosorbide 4.1
    tetrachloroethylene 1.2
    eugenol 1.67
    triacetin 0.7
    span 80 1.49
    1,4-butanediol 3.25
    1,1-dichloroethane 0.28
    2-methyl-1-pentanol 0.41
    methyl formate 18.41
    2-methyl-1-butanol 0.83
    n-decane 0.04
    butyronitrile 1.0
    3,7-dimethyl-1-octanol 0.2
    1-chlorooctane 0.1
    1-chlorotetradecane 0.04
    n-nonane 0.05
    undecane 0.03
    tert-butylcyclohexane 0.03
    cyclooctane 0.08
    cyclopentanol 2.21
    tetrahydropyran 1.05
    tert-amyl methyl ether 0.44
    2,5,8-trioxanonane 2.81
    1-hexene 0.15
    2-isopropoxyethanol 1.64
    2,2,2-trifluoroethanol 15.08
    methyl butyrate 1.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction