Diacetylcurcumin

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  • Identifiers

    CAS number
    19697-86-0

    Molecular formula
    C25H24O8

    SMILES
    CC(=O)OC1=C(C=C(C=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)OC(=O)C)OC)OC

    Safety labels

  • Odor profile

    Fragrance
    Fruity 44.74%
    Sweet 43.96%
    Balsamic 43.87%
    Vanilla 43.55%
    Spicy 43.07%
    Powdery 36.37%
    Woody 36.14%
    Caramellic 34.62%
    Creamy 32.87%
    Dry 32.84%

     

    Flavor
    Odorless 34.42%
    Fruity 30.12%
    Powdery 24.86%
    Bitter 23.84%
    Mild 23.81%
    Very mild 21.45%
    Sweet 21.28%
    Heliotropin 20.08%
    Ethyl benzoate 19.84%
    Faint 19.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    7.52 (neutral)

    Molecular weight
    452.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    528°C

    Flash point

    • 236.32 ˚C est.

  • Synonyms

    • diacetylcurcumin
    • 19697-86-0
    • 5PUQ5907YX
    • RefChem:132563
    • Curcumin 4,4'-diacetate
    • [4-[(1E,6E)-7-(4-acetyloxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenyl] acetate
    • Curcumin bis-acetate
    • ((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-4,1-phenylene) diacetate
    • [4-[(1E,6E)-7-(4-acetoxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl] acetate
    • 4,4'-Diacetylcurcumin
    • UNII-5PUQ5907YX
    • DIACETYL CURCUMIN
    • CURCUMIN DIACETATE
    • CHEMBL261297
    • SCHEMBL14418061
    • MFCD06200735
    • AS-77165
    • D93392
    • Q27262709
    • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-(acetyloxy)-3-methoxyphenyl)-
    • 1,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(4-(ACETYLOXY)-3-METHOXYPHENYL)-, (E,E)-
    • 1,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)-, DIACETATE
    • Acetic acid, 4-[7-(4-acetoxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl ester
    • 19697-86-0

  • Applications

    Diacetylcurcumin (CAS 19697-86-0) is primarily used as an intermediate in the synthesis of curcumin-related compounds, enabling downstream diversification of the diketone core and the phenolic units. In industrial manufacturing, it is commonly evaluated as a precursor for curcumin derivatives in cosmetics and personal care, as a pigment precursor for polymers and plastics, as a colorant or pigment additive for coatings and inks, and as a research reagent in routes toward functional materials development, with actual use subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.0
    methanol 2.08
    isopropanol 2.05
    water 0.0
    ethyl acetate 9.04
    n-propanol 2.48
    acetone 42.38
    n-butanol 1.48
    acetonitrile 13.37
    DMF 51.36
    toluene 2.8
    isobutanol 1.7
    1,4-dioxane 29.28
    methyl acetate 19.56
    THF 218.11
    2-butanone 27.87
    n-pentanol 1.87
    sec-butanol 2.61
    n-hexane 0.39
    ethylene glycol 0.62
    NMP 72.99
    cyclohexane 0.46
    DMSO 314.56
    n-butyl acetate 5.45
    n-octanol 1.36
    chloroform 40.93
    n-propyl acetate 7.69
    acetic acid 9.45
    dichloromethane 52.96
    cyclohexanone 32.16
    propylene glycol 0.98
    isopropyl acetate 4.17
    DMAc 126.8
    2-ethoxyethanol 8.57
    isopentanol 1.26
    n-heptane 0.2
    ethyl formate 7.8
    1,2-dichloroethane 29.12
    n-hexanol 0.98
    2-methoxyethanol 9.45
    isobutyl acetate 3.67
    tetrachloromethane 2.17
    n-pentyl acetate 3.33
    transcutol 11.15
    n-heptanol 0.93
    ethylbenzene 2.22
    MIBK 3.83
    2-propoxyethanol 7.37
    tert-butanol 2.94
    MTBE 4.57
    2-butoxyethanol 4.38
    propionic acid 5.57
    o-xylene 1.83
    formic acid 2.98
    diethyl ether 5.68
    m-xylene 0.86
    p-xylene 3.77
    chlorobenzene 5.77
    dimethyl carbonate 8.48
    n-octane 0.14
    formamide 8.29
    cyclopentanone 87.76
    2-pentanone 9.96
    anisole 7.92
    cyclopentyl methyl ether 11.05
    gamma-butyrolactone 79.24
    1-methoxy-2-propanol 6.09
    pyridine 26.28
    3-pentanone 12.47
    furfural 29.79
    n-dodecane 0.17
    diethylene glycol 4.28
    diisopropyl ether 0.8
    tert-amyl alcohol 3.03
    acetylacetone 18.25
    n-hexadecane 0.19
    acetophenone 9.96
    methyl propionate 11.54
    isopentyl acetate 4.57
    trichloroethylene 48.74
    n-nonanol 1.59
    cyclohexanol 2.81
    benzyl alcohol 5.21
    2-ethylhexanol 1.08
    isooctanol 0.9
    dipropyl ether 3.82
    1,2-dichlorobenzene 5.52
    ethyl lactate 3.95
    propylene carbonate 16.04
    n-methylformamide 13.23
    2-pentanol 0.95
    n-pentane 0.16
    1-propoxy-2-propanol 5.09
    1-methoxy-2-propyl acetate 7.04
    2-(2-methoxypropoxy) propanol 8.54
    mesitylene 0.47
    ε-caprolactone 20.2
    p-cymene 0.88
    epichlorohydrin 71.93
    1,1,1-trichloroethane 14.62
    2-aminoethanol 1.35
    morpholine-4-carbaldehyde 36.34
    sulfolane 118.06
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 37.96
    n-hexyl acetate 4.46
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 7.44
    sec-butyl acetate 4.13
    tert-butyl acetate 4.25
    decalin 0.32
    glycerin 1.9
    diglyme 19.05
    acrylic acid 6.09
    isopropyl myristate 2.43
    n-butyric acid 4.26
    acetyl acetate 6.78
    di(2-ethylhexyl) phthalate 3.1
    ethyl propionate 7.9
    nitromethane 46.42
    1,2-diethoxyethane 8.08
    benzonitrile 6.82
    trioctyl phosphate 1.92
    1-bromopropane 9.25
    gamma-valerolactone 57.66
    n-decanol 1.26
    triethyl phosphate 5.3
    4-methyl-2-pentanol 0.55
    propionitrile 8.2
    vinylene carbonate 12.78
    1,1,2-trichlorotrifluoroethane 25.69
    DMS 7.0
    cumene 1.26
    2-octanol 0.77
    2-hexanone 10.58
    octyl acetate 3.23
    limonene 1.25
    1,2-dimethoxyethane 32.69
    ethyl orthosilicate 4.44
    tributyl phosphate 2.91
    diacetone alcohol 5.17
    N,N-dimethylaniline 5.37
    acrylonitrile 11.69
    aniline 4.45
    1,3-propanediol 2.03
    bromobenzene 5.6
    dibromomethane 26.07
    1,1,2,2-tetrachloroethane 38.44
    2-methyl-cyclohexyl acetate 5.58
    tetrabutyl urea 5.78
    diisobutyl methanol 0.68
    2-phenylethanol 3.07
    styrene 2.95
    dioctyl adipate 5.62
    dimethyl sulfate 23.28
    ethyl butyrate 6.39
    methyl lactate 4.97
    butyl lactate 2.79
    diethyl carbonate 5.17
    propanediol butyl ether 2.73
    triethyl orthoformate 5.81
    p-tert-butyltoluene 0.67
    methyl 4-tert-butylbenzoate 6.61
    morpholine 30.62
    tert-butylamine 1.23
    n-dodecanol 1.01
    dimethoxymethane 21.33
    ethylene carbonate 11.09
    cyrene 12.86
    2-ethoxyethyl acetate 6.64
    2-ethylhexyl acetate 4.02
    1,2,4-trichlorobenzene 8.4
    4-methylpyridine 15.47
    dibutyl ether 3.91
    2,6-dimethyl-4-heptanol 0.68
    DEF 15.28
    dimethyl isosorbide 17.16
    tetrachloroethylene 17.59
    eugenol 5.95
    triacetin 7.07
    span 80 4.34
    1,4-butanediol 1.37
    1,1-dichloroethane 16.71
    2-methyl-1-pentanol 1.9
    methyl formate 14.17
    2-methyl-1-butanol 1.54
    n-decane 0.29
    butyronitrile 5.17
    3,7-dimethyl-1-octanol 1.24
    1-chlorooctane 1.46
    1-chlorotetradecane 0.66
    n-nonane 0.24
    undecane 0.21
    tert-butylcyclohexane 0.2
    cyclooctane 0.1
    cyclopentanol 6.45
    tetrahydropyran 23.02
    tert-amyl methyl ether 4.16
    2,5,8-trioxanonane 15.36
    1-hexene 1.78
    2-isopropoxyethanol 5.87
    2,2,2-trifluoroethanol 5.16
    methyl butyrate 10.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction