Diacetoxy-6-gingerdiol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    143615-75-2

    Molecular formula
    C21H32O6

    SMILES
    CCCCC[C@@H](C[C@@H](CCC1=CC(=C(C=C1)O)OC)OC(=O)C)OC(=O)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 67.17%
    Sweet 45.58%
    Balsamic 35.73%
    Fresh 34.85%
    Spicy 32.19%
    Odorless 29.28%
    Jasmin 29.26%
    Vanilla 26.83%
    Lily 25.0%
    Powdery 24.16%

     

    Flavor
    Fruity 46.61%
    Woody 46.25%
    Floral 38.95%
    Herbal 37.34%
    Sweet 34.46%
    Tropical 29.87%
    Mild 29.82%
    Bitter 27.27%
    Oily 25.28%
    Spicy 24.88%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.8

    pKa est.
    7.96 (neutral)

    Molecular weight
    380.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    449°C

    Flash point

    • 178.92 ˚C est.

  • Synonyms

    • Diacetoxy-6-gingerdiol
    • 143615-75-2
    • [(3R,5S)-3-acetyloxy-1-(4-hydroxy-3-methoxyphenyl)decan-5-yl] acetate
    • ((3R,5S)-3-acetyloxy-1-(4-hydroxy-3-methoxyphenyl)decan-5-yl) acetate
    • RefChem:132549
    • SCHEMBL23370749
    • SCHEMBL30065179
    • DTXSID801314313
    • AKOS040760369
    • DA-72728
    • MS-26228
    • HY-133865
    • CS-0134522
    • E88752
    • (3r,5s)-3,5-diacetoxy-1-(4-hydroxy-3-methoxyphenyl)decane
    • 143615-75-2

  • Applications

    Diacetoxy-6-gingerdiol (CAS 143615-75-2) is primarily used as a synthetic intermediate in fragrance chemistry, where the acetyl-protected gingerdiol scaffold enables controlled transformations and later deacetylation to furnish gingerdiol-derived aroma compounds. It is commonly evaluated as an odorant precursor and aroma ingredient in perfumery and cosmetic formulations, enabling ginger-derived notes in fragrances and personal care products. The compound may also be explored as a building block for flavor/aroma applications, providing a chiral diol-derived platform for downstream aroma chemistry. In broader industrial manufacturing, it is used in research and development as an intermediate in the synthesis of fragrance-related chemistries and materials, and as a protected diol building block for selective reactions. Ultimately, its use is subject to local regulations and formulation limits, and it is typically handled with appropriate safety and purification controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 176.85
    methanol 331.03
    isopropanol 104.66
    water 0.37
    ethyl acetate 176.03
    n-propanol 127.83
    acetone 542.96
    n-butanol 82.59
    acetonitrile 141.72
    DMF 617.53
    toluene 37.43
    isobutanol 86.96
    1,4-dioxane 243.37
    methyl acetate 174.27
    THF 648.23
    2-butanone 197.95
    n-pentanol 75.36
    sec-butanol 86.87
    n-hexane 1.89
    ethylene glycol 28.91
    NMP 586.7
    cyclohexane 3.01
    DMSO 1342.03
    n-butyl acetate 66.77
    n-octanol 22.41
    chloroform 355.84
    n-propyl acetate 81.66
    acetic acid 481.2
    dichloromethane 445.85
    cyclohexanone 342.48
    propylene glycol 57.92
    isopropyl acetate 107.9
    DMAc 825.42
    2-ethoxyethanol 198.55
    isopentanol 71.17
    n-heptane 0.88
    ethyl formate 86.33
    1,2-dichloroethane 292.13
    n-hexanol 34.78
    2-methoxyethanol 320.17
    isobutyl acetate 54.15
    tetrachloromethane 29.4
    n-pentyl acetate 55.3
    transcutol 463.51
    n-heptanol 22.0
    ethylbenzene 23.05
    MIBK 97.84
    2-propoxyethanol 151.33
    tert-butanol 144.49
    MTBE 86.65
    2-butoxyethanol 81.26
    propionic acid 166.88
    o-xylene 30.43
    formic acid 158.15
    diethyl ether 73.18
    m-xylene 25.56
    p-xylene 32.73
    chlorobenzene 84.37
    dimethyl carbonate 104.25
    n-octane 0.83
    formamide 224.99
    cyclopentanone 462.93
    2-pentanone 166.93
    anisole 76.09
    cyclopentyl methyl ether 148.92
    gamma-butyrolactone 536.69
    1-methoxy-2-propanol 219.31
    pyridine 156.56
    3-pentanone 130.71
    furfural 314.19
    n-dodecane 1.12
    diethylene glycol 133.73
    diisopropyl ether 16.2
    tert-amyl alcohol 107.24
    acetylacetone 314.53
    n-hexadecane 1.3
    acetophenone 103.48
    methyl propionate 174.05
    isopentyl acetate 67.06
    trichloroethylene 505.41
    n-nonanol 23.44
    cyclohexanol 94.53
    benzyl alcohol 81.61
    2-ethylhexanol 22.64
    isooctanol 20.67
    dipropyl ether 29.36
    1,2-dichlorobenzene 88.14
    ethyl lactate 61.21
    propylene carbonate 218.72
    n-methylformamide 222.03
    2-pentanol 41.57
    n-pentane 1.15
    1-propoxy-2-propanol 89.09
    1-methoxy-2-propyl acetate 116.0
    2-(2-methoxypropoxy) propanol 109.94
    mesitylene 15.5
    ε-caprolactone 269.41
    p-cymene 13.68
    epichlorohydrin 510.48
    1,1,1-trichloroethane 181.16
    2-aminoethanol 83.82
    morpholine-4-carbaldehyde 389.6
    sulfolane 709.9
    2,2,4-trimethylpentane 2.17
    2-methyltetrahydrofuran 242.17
    n-hexyl acetate 75.91
    isooctane 1.14
    2-(2-butoxyethoxy)ethanol 130.79
    sec-butyl acetate 56.03
    tert-butyl acetate 119.85
    decalin 3.75
    glycerin 103.97
    diglyme 270.45
    acrylic acid 154.51
    isopropyl myristate 28.46
    n-butyric acid 180.33
    acetyl acetate 148.2
    di(2-ethylhexyl) phthalate 44.18
    ethyl propionate 82.27
    nitromethane 726.22
    1,2-diethoxyethane 99.79
    benzonitrile 75.64
    trioctyl phosphate 26.41
    1-bromopropane 87.0
    gamma-valerolactone 546.67
    n-decanol 16.73
    triethyl phosphate 48.61
    4-methyl-2-pentanol 26.73
    propionitrile 84.34
    vinylene carbonate 181.41
    1,1,2-trichlorotrifluoroethane 325.9
    DMS 102.52
    cumene 17.52
    2-octanol 15.14
    2-hexanone 89.19
    octyl acetate 39.92
    limonene 20.57
    1,2-dimethoxyethane 287.36
    ethyl orthosilicate 44.57
    tributyl phosphate 37.94
    diacetone alcohol 157.59
    N,N-dimethylaniline 53.42
    acrylonitrile 114.6
    aniline 80.0
    1,3-propanediol 121.72
    bromobenzene 77.6
    dibromomethane 231.32
    1,1,2,2-tetrachloroethane 382.01
    2-methyl-cyclohexyl acetate 65.35
    tetrabutyl urea 53.6
    diisobutyl methanol 15.53
    2-phenylethanol 57.95
    styrene 30.38
    dioctyl adipate 60.51
    dimethyl sulfate 250.77
    ethyl butyrate 60.92
    methyl lactate 102.47
    butyl lactate 60.62
    diethyl carbonate 50.56
    propanediol butyl ether 80.51
    triethyl orthoformate 52.87
    p-tert-butyltoluene 12.4
    methyl 4-tert-butylbenzoate 99.6
    morpholine 317.61
    tert-butylamine 46.71
    n-dodecanol 12.32
    dimethoxymethane 344.38
    ethylene carbonate 155.91
    cyrene 135.22
    2-ethoxyethyl acetate 108.24
    2-ethylhexyl acetate 50.08
    1,2,4-trichlorobenzene 114.3
    4-methylpyridine 163.74
    dibutyl ether 31.24
    2,6-dimethyl-4-heptanol 15.53
    DEF 206.35
    dimethyl isosorbide 195.43
    tetrachloroethylene 201.63
    eugenol 83.26
    triacetin 131.44
    span 80 82.4
    1,4-butanediol 59.77
    1,1-dichloroethane 209.78
    2-methyl-1-pentanol 68.63
    methyl formate 170.58
    2-methyl-1-butanol 75.45
    n-decane 1.91
    butyronitrile 74.57
    3,7-dimethyl-1-octanol 25.86
    1-chlorooctane 13.45
    1-chlorotetradecane 5.5
    n-nonane 1.53
    undecane 1.41
    tert-butylcyclohexane 2.92
    cyclooctane 0.98
    cyclopentanol 123.66
    tetrahydropyran 183.95
    tert-amyl methyl ether 68.21
    2,5,8-trioxanonane 192.2
    1-hexene 12.96
    2-isopropoxyethanol 121.18
    2,2,2-trifluoroethanol 155.56
    methyl butyrate 107.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction