Dehydroandrosterone

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  • Identifiers

    CAS number
    2283-82-1

    Molecular formula
    C19H28O2

    SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@H](C4)O)C

    Safety labels

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 75.96%
    Cedar 41.25%
    Fruity 41.06%
    Amber 39.01%
    Balsamic 35.78%
    Fresh 34.99%
    Dry 33.59%
    Spicy 33.23%
    Herbal 32.65%
    Earthy 32.0%

     

    Flavor
    Bitter 36.88%
    Minty 29.05%
    Spicy 28.15%
    Herbal 26.64%
    Camphor 25.53%
    Earthy 24.4%
    Fresh 24.19%
    Beet 23.68%
    Soil 23.63%
    Herb 22.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.56 (neutral)

    Molecular weight
    288.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    455°C

    Melting point expt.

    • 148 - 150 °C

    Flash point

    • 192.81 ˚C est.

  • Synonyms

    • Dehydroandrosterone
    • 2283-82-1
    • Isoandrostenolone
    • Prasterone, 3alpha-Isomer
    • Androst-5-en-17-one, 3-hydroxy-, (3alpha)-
    • DTXSID20177384
    • RefChem:131459
    • DTXCID4099875
    • Dehydro Androsterone
    • (3R,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
    • (3R,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one
    • 5-Androsten-3alpha-ol-17-one
    • 5-Androsten-3a-ol-17-one
    • 5-Androsten-3.beta.-ol-17-one
    • 5-Androstene-3.beta.-ol-17-one
    • 5-Androsten-3-.beta.-ol-17-one
    • Dehydroandrosteron
    • 3-.beta.-Hydroxy-5-androsten-17-one
    • 3.beta.-Hydroxyandrost-5-en-17-one #
    • (3aS,3bR,7R,9aR,9bS,11aS)-7-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one
    • 3alpha-Hydroxyandrost-5-en-17-one
    • Prasterone, (3alpha)-
    • W9LD7Y7MBC
    • Androst-5-en-3a-ol-17-one
    • D5-Androstene-3a-ol-17-one
    • SCHEMBL1251757
    • 3a-Hydroxy-5-androsten-17-one
    • 3a-hydroxyandrost-5-en-17-one
    • MSK8512
    • Androst-5-en-3alpha-ol-17-one
    • 3a-hydroxy-Androst-5-en-17-one
    • 3alpha-Hydroxy-5-androsten-17-one
    • LMST02020103
    • MSK8512-100M
    • 3alpha-Hydroxy-androst-5-ene-17-one
    • FA46908
    • (3alpha)-3-Hydroxyandrost-5-en-17-one
    • CS-0450124
    • 283D821
    • Dehydroandrosteron Solution in Methanol, 100ug/mL
    • 2283-82-1

  • Applications

    Dehydroandrosterone (CAS 2283-82-1) is primarily used as an intermediate in the synthesis of steroidal pharmaceuticals and related steroid compounds, serving as a building block for pharmaceutical APIs. It may also be employed as a reagent in organic synthesis for laboratory research and development, and as an analytical standard or reference material to support method development and quality control. In some cases it is used as a precursor in downstream synthetic pathways and for process development, with use subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 64.9
    methanol 79.52
    isopropanol 49.67
    water 0.85
    ethyl acetate 94.94
    n-propanol 60.28
    acetone 128.25
    n-butanol 63.97
    acetonitrile 50.39
    DMF 121.59
    toluene 188.48
    isobutanol 33.26
    1,4-dioxane 259.96
    methyl acetate 50.45
    THF 297.84
    2-butanone 65.15
    n-pentanol 13.99
    sec-butanol 10.7
    n-hexane 0.96
    ethylene glycol 12.38
    NMP 31.51
    cyclohexane 8.4
    DMSO 69.86
    n-butyl acetate 56.21
    n-octanol 9.57
    chloroform 261.25
    n-propyl acetate 37.66
    acetic acid 43.26
    dichloromethane 148.15
    cyclohexanone 123.53
    propylene glycol 9.99
    isopropyl acetate 97.99
    DMAc 71.45
    2-ethoxyethanol 53.24
    isopentanol 47.92
    n-heptane 1.34
    ethyl formate 40.09
    1,2-dichloroethane 93.53
    n-hexanol 30.91
    2-methoxyethanol 153.56
    isobutyl acetate 37.57
    tetrachloromethane 30.92
    n-pentyl acetate 37.82
    transcutol 339.35
    n-heptanol 19.79
    ethylbenzene 34.82
    MIBK 74.7
    2-propoxyethanol 120.33
    tert-butanol 45.95
    MTBE 28.13
    2-butoxyethanol 69.18
    propionic acid 27.4
    o-xylene 60.98
    formic acid 25.79
    diethyl ether 67.41
    m-xylene 94.0
    p-xylene 40.84
    chlorobenzene 95.63
    dimethyl carbonate 56.29
    n-octane 0.71
    formamide 55.15
    cyclopentanone 127.64
    2-pentanone 84.31
    anisole 83.89
    cyclopentyl methyl ether 78.32
    gamma-butyrolactone 117.9
    1-methoxy-2-propanol 120.63
    pyridine 190.23
    3-pentanone 59.18
    furfural 125.3
    n-dodecane 0.67
    diethylene glycol 99.03
    diisopropyl ether 20.58
    tert-amyl alcohol 11.02
    acetylacetone 158.04
    n-hexadecane 0.86
    acetophenone 65.78
    methyl propionate 64.48
    isopentyl acetate 68.14
    trichloroethylene 189.89
    n-nonanol 11.89
    cyclohexanol 36.16
    benzyl alcohol 54.82
    2-ethylhexanol 17.12
    isooctanol 18.07
    dipropyl ether 26.33
    1,2-dichlorobenzene 81.28
    ethyl lactate 27.81
    propylene carbonate 64.94
    n-methylformamide 67.92
    2-pentanol 21.2
    n-pentane 2.25
    1-propoxy-2-propanol 72.93
    1-methoxy-2-propyl acetate 122.37
    2-(2-methoxypropoxy) propanol 62.31
    mesitylene 45.74
    ε-caprolactone 87.2
    p-cymene 20.52
    epichlorohydrin 151.47
    1,1,1-trichloroethane 82.48
    2-aminoethanol 29.43
    morpholine-4-carbaldehyde 122.55
    sulfolane 78.96
    2,2,4-trimethylpentane 1.04
    2-methyltetrahydrofuran 58.06
    n-hexyl acetate 36.63
    isooctane 1.78
    2-(2-butoxyethoxy)ethanol 92.05
    sec-butyl acetate 36.4
    tert-butyl acetate 89.48
    decalin 3.01
    glycerin 31.55
    diglyme 200.32
    acrylic acid 28.37
    isopropyl myristate 18.97
    n-butyric acid 77.37
    acetyl acetate 92.57
    di(2-ethylhexyl) phthalate 26.83
    ethyl propionate 43.64
    nitromethane 99.94
    1,2-diethoxyethane 78.19
    benzonitrile 79.47
    trioctyl phosphate 16.55
    1-bromopropane 37.97
    gamma-valerolactone 217.17
    n-decanol 8.77
    triethyl phosphate 28.12
    4-methyl-2-pentanol 23.99
    propionitrile 67.08
    vinylene carbonate 87.71
    1,1,2-trichlorotrifluoroethane 89.5
    DMS 62.08
    cumene 20.41
    2-octanol 8.96
    2-hexanone 28.18
    octyl acetate 19.86
    limonene 18.25
    1,2-dimethoxyethane 120.55
    ethyl orthosilicate 27.78
    tributyl phosphate 18.35
    diacetone alcohol 72.43
    N,N-dimethylaniline 43.41
    acrylonitrile 88.22
    aniline 130.36
    1,3-propanediol 75.8
    bromobenzene 97.65
    dibromomethane 92.0
    1,1,2,2-tetrachloroethane 139.71
    2-methyl-cyclohexyl acetate 40.66
    tetrabutyl urea 23.61
    diisobutyl methanol 16.92
    2-phenylethanol 72.58
    styrene 41.5
    dioctyl adipate 29.92
    dimethyl sulfate 60.27
    ethyl butyrate 46.32
    methyl lactate 40.72
    butyl lactate 38.87
    diethyl carbonate 36.81
    propanediol butyl ether 42.23
    triethyl orthoformate 42.16
    p-tert-butyltoluene 20.85
    methyl 4-tert-butylbenzoate 64.35
    morpholine 187.93
    tert-butylamine 24.92
    n-dodecanol 6.45
    dimethoxymethane 206.91
    ethylene carbonate 80.89
    cyrene 52.28
    2-ethoxyethyl acetate 89.38
    2-ethylhexyl acetate 44.91
    1,2,4-trichlorobenzene 87.38
    4-methylpyridine 155.48
    dibutyl ether 13.95
    2,6-dimethyl-4-heptanol 16.92
    DEF 52.33
    dimethyl isosorbide 105.11
    tetrachloroethylene 102.76
    eugenol 67.73
    triacetin 64.2
    span 80 44.25
    1,4-butanediol 13.68
    1,1-dichloroethane 81.86
    2-methyl-1-pentanol 13.56
    methyl formate 47.95
    2-methyl-1-butanol 23.01
    n-decane 1.27
    butyronitrile 58.82
    3,7-dimethyl-1-octanol 14.7
    1-chlorooctane 6.22
    1-chlorotetradecane 2.67
    n-nonane 0.95
    undecane 0.89
    tert-butylcyclohexane 2.2
    cyclooctane 2.87
    cyclopentanol 25.61
    tetrahydropyran 149.83
    tert-amyl methyl ether 14.25
    2,5,8-trioxanonane 121.75
    1-hexene 4.55
    2-isopropoxyethanol 36.99
    2,2,2-trifluoroethanol 28.33
    methyl butyrate 44.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction