D&C Red No. 27

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  • Identifiers

    CAS number
    13473-26-2

    Molecular formula
    C20H4Br4Cl4O5

    SMILES
    C1=C2C(=C(C(=C1Br)O)Br)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)Br)O)Br

    Safety labels

  • Odor profile

    Fragrance
    Odorless 53.33%
    Phenolic 36.05%
    Burnt 29.96%
    Smoky 22.12%
    Dry 18.73%
    Spicy 17.14%
    Savory 16.51%
    Animal 16.28%
    Medicinal 15.82%
    Bitter 14.12%

     

    Flavor
    Bitter 91.07%
    Odorless 33.13%
    Bland 23.06%
    Sweet-like 20.92%
    Very strong 19.05%
    Nitrile 18.93%
    Cedarleaf 18.8%
    Indole 18.73%
    Rotten 18.41%
    Scallion 18.21%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.7

    pKa est.
    7.17 (neutral)

    Molecular weight
    785.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    848°C

    Flash point

    • 253.23 ˚C est.

  • Synonyms

    • D & C Red no. 27
    • Phloxine O
    • Acid Phloxine PB
    • Solvent Red 48
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein
    • Phloxine BBN Supra
    • Tetrachlorotetrabromofluorescein
    • C.I. Solvent Red 48
    • Japan Red 218
    • D&C Red No. 27
    • D&C red no.27
    • D&C Red 27
    • C,I, Solvent Red 48
    • C.I. 45410A
    • D and C Red No. 27
    • Red No. 218
    • CCRIS 4905
    • CI 45410:1
    • EINECS 236-747-6
    • 2LRS185U6K
    • DTXSID2031089
    • TETRACHLOROEOSIN
    • CI Solvent Red 48
    • DC RED NO. 27
    • DYE DC RED NO. 27
    • AKA218
    • RED 27
    • Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-
    • DTXCID0011089
    • PHLOXINE B LACTONE [MI]
    • CHEBI:156496
    • D&C RED NO. 27 [II]
    • C.I. 45410:1
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[[2]benzofuran-1,9'-xanthen]-3-one
    • 2',4',5',7'-Tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
    • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-
    • D&C RED NO. 27 (II)
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro((2)benzofuran-1,9'-xanthen)-3-one
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one
    • RefChem:581458
    • PHLOXINE B LACTONE
    • AKA218 [INCI]
    • RED 27 [INCI]
    • SOLVENT RED 48 [INCI]
    • 2',4',5',7'-Tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro(i-sobenzofuran-1(3H), 9'-(9H)xanthen)-3-one
    • 13473-26-2
    • 2',4',5',7'-Tetrabromo-3,4,5,6-tetrachlorofluorescein
    • Phloxine B (free base)
    • MFCD00067282
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
    • CAS-13473-26-2
    • UNII-2LRS185U6K
    • SCHEMBL111115
    • orb1987400
    • CHEMBL1580759
    • SCHEMBL29380916
    • SCHEMBL30023355
    • SCHEMBL31648221
    • ZYIBVBKZZZDFOY-UHFFFAOYSA-N
    • Tox21_202165
    • Tox21_303604
    • D & C RED #27 [VANDF]
    • AKOS040744507
    • D & C RED #27 LAKE [VANDF]
    • NCGC00091490-01
    • NCGC00091490-02
    • NCGC00091490-03
    • NCGC00257462-01
    • NCGC00259714-01
    • 2',4',5',7'-Tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro(i- sobenzofuran-1(3H), 9'-(9H)xanthen)-3-one
    • AS-78332
    • CS-0064162
    • NS00009855
    • D92290
    • Q27254902
    • 2,4,5,7-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN
    • 2',4',5',7'-TETRABROMO-4,5,6,7- TETRACHLOROFLUORESCEIN
    • 2',4',5',7'-tetrabromo-3,4,5,6-tetrachlorofluorescein, AldrichCPR
    • 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-spiro[isobenzofuran-3,9'-xanthene]-1-one
    • Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-
    • 13473-26-2

  • Applications

    D&C Red No. 27, CAS 13473-26-2, is primarily used as a cosmetic and personal care colorant, appearing in products such as lipstick, eye makeup, and other makeup formulations under D&C approvals. It may also be used in topical pharmaceutical dosage forms as a colorant. In industry, it is employed as a colorant for coatings and printing inks in non-food applications, and as a pigment in plastics and polymers to achieve specific coloration. Use in other applications is contingent on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.87
    methanol 0.79
    isopropanol 0.56
    water 0.02
    ethyl acetate 2.98
    n-propanol 1.11
    acetone 1.89
    n-butanol 0.98
    acetonitrile 1.1
    DMF 12.9
    toluene 2.95
    isobutanol 0.85
    1,4-dioxane 7.41
    methyl acetate 2.55
    THF 22.89
    2-butanone 3.41
    n-pentanol 1.49
    sec-butanol 0.89
    n-hexane 0.2
    ethylene glycol 0.89
    NMP 25.28
    cyclohexane 0.29
    DMSO 3.31
    n-butyl acetate 7.39
    n-octanol 4.32
    chloroform 3.46
    n-propyl acetate 5.11
    acetic acid 1.5
    dichloromethane 2.73
    cyclohexanone 8.58
    propylene glycol 0.86
    isopropyl acetate 3.44
    DMAc 15.34
    2-ethoxyethanol 5.01
    isopentanol 1.0
    n-heptane 0.56
    ethyl formate 2.28
    1,2-dichloroethane 1.63
    n-hexanol 2.36
    2-methoxyethanol 5.94
    isobutyl acetate 4.38
    tetrachloromethane 0.45
    n-pentyl acetate 10.52
    transcutol 18.03
    n-heptanol 3.31
    ethylbenzene 2.29
    MIBK 3.41
    2-propoxyethanol 11.71
    tert-butanol 0.63
    MTBE 1.48
    2-butoxyethanol 9.22
    propionic acid 1.67
    o-xylene 2.25
    formic acid 1.47
    diethyl ether 1.67
    m-xylene 2.43
    p-xylene 2.51
    chlorobenzene 2.2
    dimethyl carbonate 4.86
    n-octane 0.54
    formamide 2.65
    cyclopentanone 13.91
    2-pentanone 3.68
    anisole 5.67
    cyclopentyl methyl ether 10.52
    gamma-butyrolactone 14.46
    1-methoxy-2-propanol 5.59
    pyridine 8.95
    3-pentanone 3.39
    furfural 14.23
    n-dodecane 0.62
    diethylene glycol 6.65
    diisopropyl ether 1.04
    tert-amyl alcohol 1.03
    acetylacetone 5.93
    n-hexadecane 0.75
    acetophenone 7.82
    methyl propionate 4.68
    isopentyl acetate 6.82
    trichloroethylene 5.45
    n-nonanol 5.19
    cyclohexanol 2.14
    benzyl alcohol 4.34
    2-ethylhexanol 3.24
    isooctanol 3.09
    dipropyl ether 5.25
    1,2-dichlorobenzene 2.48
    ethyl lactate 4.25
    propylene carbonate 7.53
    n-methylformamide 4.36
    2-pentanol 0.88
    n-pentane 0.15
    1-propoxy-2-propanol 10.98
    1-methoxy-2-propyl acetate 12.75
    2-(2-methoxypropoxy) propanol 12.9
    mesitylene 1.68
    ε-caprolactone 11.91
    p-cymene 3.1
    epichlorohydrin 11.63
    1,1,1-trichloroethane 1.27
    2-aminoethanol 1.38
    morpholine-4-carbaldehyde 29.05
    sulfolane 15.28
    2,2,4-trimethylpentane 0.17
    2-methyltetrahydrofuran 8.67
    n-hexyl acetate 11.3
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 14.27
    sec-butyl acetate 4.32
    tert-butyl acetate 4.76
    decalin 0.38
    glycerin 2.43
    diglyme 18.62
    acrylic acid 2.18
    isopropyl myristate 6.88
    n-butyric acid 2.15
    acetyl acetate 2.39
    di(2-ethylhexyl) phthalate 6.66
    ethyl propionate 5.14
    nitromethane 3.42
    1,2-diethoxyethane 9.4
    benzonitrile 5.02
    trioctyl phosphate 5.18
    1-bromopropane 1.27
    gamma-valerolactone 26.43
    n-decanol 4.14
    triethyl phosphate 4.2
    4-methyl-2-pentanol 0.95
    propionitrile 1.81
    vinylene carbonate 7.65
    1,1,2-trichlorotrifluoroethane 11.3
    DMS 8.93
    cumene 1.78
    2-octanol 3.43
    2-hexanone 5.24
    octyl acetate 7.91
    limonene 3.48
    1,2-dimethoxyethane 10.59
    ethyl orthosilicate 4.39
    tributyl phosphate 5.51
    diacetone alcohol 5.01
    N,N-dimethylaniline 6.58
    acrylonitrile 2.87
    aniline 3.56
    1,3-propanediol 1.62
    bromobenzene 2.44
    dibromomethane 1.68
    1,1,2,2-tetrachloroethane 4.29
    2-methyl-cyclohexyl acetate 8.32
    tetrabutyl urea 11.73
    diisobutyl methanol 2.12
    2-phenylethanol 6.71
    styrene 2.24
    dioctyl adipate 8.71
    dimethyl sulfate 6.24
    ethyl butyrate 6.54
    methyl lactate 4.93
    butyl lactate 10.15
    diethyl carbonate 3.83
    propanediol butyl ether 9.03
    triethyl orthoformate 7.63
    p-tert-butyltoluene 3.06
    methyl 4-tert-butylbenzoate 10.82
    morpholine 10.15
    tert-butylamine 0.42
    n-dodecanol 3.22
    dimethoxymethane 10.49
    ethylene carbonate 5.68
    cyrene 14.79
    2-ethoxyethyl acetate 12.94
    2-ethylhexyl acetate 7.28
    1,2,4-trichlorobenzene 4.05
    4-methylpyridine 7.82
    dibutyl ether 6.39
    2,6-dimethyl-4-heptanol 2.12
    DEF 8.66
    dimethyl isosorbide 30.36
    tetrachloroethylene 2.85
    eugenol 13.39
    triacetin 10.37
    span 80 11.92
    1,4-butanediol 1.12
    1,1-dichloroethane 1.18
    2-methyl-1-pentanol 1.52
    methyl formate 3.5
    2-methyl-1-butanol 1.13
    n-decane 0.99
    butyronitrile 1.69
    3,7-dimethyl-1-octanol 3.9
    1-chlorooctane 2.79
    1-chlorotetradecane 1.57
    n-nonane 0.78
    undecane 0.77
    tert-butylcyclohexane 0.33
    cyclooctane 0.25
    cyclopentanol 3.09
    tetrahydropyran 5.35
    tert-amyl methyl ether 2.68
    2,5,8-trioxanonane 16.5
    1-hexene 0.79
    2-isopropoxyethanol 4.37
    2,2,2-trifluoroethanol 1.22
    methyl butyrate 5.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction