D-Serine

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  • Identifiers

    CAS number
    312-84-5

    Molecular formula
    C3H7NO3

    SMILES
    C([C@H](C(=O)O)N)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 71.33%
    Sweet 37.95%
    Savory 25.23%
    Bitter 18.51%
    Meaty 17.87%
    Caramellic 16.55%
    Milky 16.19%
    Fishy 15.56%
    Buttery 15.43%
    Sharp 15.27%

     

    Flavor
    Odorless 74.21%
    Mild 32.39%
    Sour 27.28%
    Very mild 26.04%
    Bland 25.37%
    Acidic 24.45%
    Yeast 24.12%
    Sweet-like 23.58%
    Faint 21.87%
    Formyl 20.42%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.1

    pKa est.
    5.01 (weak acid)

    Molecular weight
    105.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    297°C

    Melting point expt.

    • 229 dec °C
    • 229 °C

    Flash point

    • 179.0 ˚C est.

    Solubility expt.

    • 364000 mg/L (at 20 °C)
    • 364 mg/mL at 20 °C

  • Synonyms

    • D-serine
    • 312-84-5
    • (2R)-2-amino-3-hydroxypropanoic acid
    • (R)-Serine
    • (R)-2-amino-3-hydroxypropanoic acid
    • Serine D-form
    • Serine, D-
    • D-Serin
    • EINECS 206-229-4
    • NSC 77689
    • DTXSID9041021
    • AI3-18476
    • 1K77H2Z9B1
    • (D)-SERINE
    • SERINE D-FORM [MI]
    • DTXCID7021021
    • CHEBI:16523
    • NSC77689
    • NSC-77689
    • (R)-2-Amino-3-hydroxy-propionic acid
    • RefChem:585037
    • 206-229-4
    • (2R)-2-azaniumyl-3-hydroxypropanoate
    • H-D-Ser-OH
    • MFCD00004269
    • (2R)-2-amino-3-hydroxy-propanoic acid
    • CHEMBL285123
    • DSN
    • NCGC00094363-03
    • D-2-Amino-3-hydroxypropionic Acid
    • (2R)-2-amino-3-hydroxypropanoate
    • UNII-1K77H2Z9B1
    • D-Serine; Serine, D- (8CI); (R)-2-Amino-3-hydroxypropanoic acid; (R)-Serine; NSC 77689
    • D-b-Hydroxyalanine
    • D-Ser
    • [3h]-d-serine
    • (2R)-serine
    • 1pb8
    • Biomol-NT_000197
    • Lopac0_001088
    • SCHEMBL43094
    • BPBio1_001226
    • GTPL4171
    • orb1298971
    • BDBM23167
    • D-Serine, >=98% (TLC)
    • MSK1479
    • (R)-2-amino-3-hydroxypropanoate
    • HMS3263I18
    • CS-D1751
    • Tox21_111269
    • Tox21_501088
    • EBC-03039
    • HB0267
    • s6224
    • (R)-2-Amino-3-hydroxypropionic acid
    • AKOS006239590
    • AKOS015854121
    • CCG-205165
    • DB03929
    • FS27815
    • LP01088
    • R(-)-2-Amino-3-hydroxypropionic acid
    • SDCCGSBI-0051058.P002
    • NCGC00094363-01
    • NCGC00094363-02
    • NCGC00094363-04
    • NCGC00094363-05
    • NCGC00094363-06
    • NCGC00094363-07
    • NCGC00094363-10
    • NCGC00261773-01
    • AC-24073
    • AS-11730
    • CAS-312-84-5
    • SY005114
    • DB-029708
    • HY-100808
    • EU-0101088
    • NS00079277
    • S0033
    • EN300-67234
    • 12S845
    • C00740
    • S 4250
    • D-Serine / (R)-2-Amino-3-hydroxypropanoic acid
    • F011887
    • BRD-K71822263-001-03-2
    • Q27077119
    • Z1070067572
    • DD977692-169B-4266-88C3-E07F0B21A5BF
    • 13095-79-9
    • 312-84-5

  • Applications

    D-Serine (CAS 312-84-5) is primarily used as a chiral building block and intermediate in pharmaceutical synthesis and in the development of D-amino acid-containing compounds and peptidomimetics; it is also employed as an analytical reference standard or substrate for enantioselectivity assessments in analytical laboratories; in bioscience research and enzymology, it serves as a substrate for enzymes such as D-amino acid oxidase and related systems, supporting enzyme studies and catalyst evaluation; and it is used as a starting material for enantioselective synthesis, providing the D-configuration framework for final products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.06
    methanol 0.26
    isopropanol 0.02
    water 223.11
    ethyl acetate 0.04
    n-propanol 0.04
    acetone 0.15
    n-butanol 0.02
    acetonitrile 0.22
    DMF 5.34
    toluene 0.03
    isobutanol 0.03
    1,4-dioxane 0.13
    methyl acetate 0.04
    THF 0.15
    2-butanone 0.07
    n-pentanol 0.03
    sec-butanol 0.03
    n-hexane 0.03
    ethylene glycol 3.44
    NMP 15.4
    cyclohexane 0.06
    DMSO 13.53
    n-butyl acetate 0.05
    n-octanol 0.06
    chloroform 0.01
    n-propyl acetate 0.03
    acetic acid 2.64
    dichloromethane 0.02
    cyclohexanone 0.3
    propylene glycol 0.89
    isopropyl acetate 0.04
    DMAc 4.9
    2-ethoxyethanol 0.37
    isopentanol 0.04
    n-heptane 0.08
    ethyl formate 0.08
    1,2-dichloroethane 0.03
    n-hexanol 0.07
    2-methoxyethanol 0.8
    isobutyl acetate 0.02
    tetrachloromethane 0.03
    n-pentyl acetate 0.06
    transcutol 1.13
    n-heptanol 0.1
    ethylbenzene 0.02
    MIBK 0.1
    2-propoxyethanol 0.45
    tert-butanol 0.07
    MTBE 0.03
    2-butoxyethanol 0.4
    propionic acid 0.33
    o-xylene 0.07
    formic acid 31.18
    diethyl ether 0.03
    m-xylene 0.06
    p-xylene 0.03
    chlorobenzene 0.01
    dimethyl carbonate 0.17
    n-octane 0.03
    formamide 12.33
    cyclopentanone 0.46
    2-pentanone 0.08
    anisole 0.04
    cyclopentyl methyl ether 0.15
    gamma-butyrolactone 0.55
    1-methoxy-2-propanol 0.4
    pyridine 0.1
    3-pentanone 0.11
    furfural 1.11
    n-dodecane 0.01
    diethylene glycol 1.98
    diisopropyl ether 0.03
    tert-amyl alcohol 0.1
    acetylacetone 0.34
    n-hexadecane 0.01
    acetophenone 0.1
    methyl propionate 0.09
    isopentyl acetate 0.06
    trichloroethylene 0.04
    n-nonanol 0.06
    cyclohexanol 0.11
    benzyl alcohol 0.08
    2-ethylhexanol 0.08
    isooctanol 0.1
    dipropyl ether 0.1
    1,2-dichlorobenzene 0.02
    ethyl lactate 0.19
    propylene carbonate 0.23
    n-methylformamide 1.37
    2-pentanol 0.03
    n-pentane 0.02
    1-propoxy-2-propanol 0.34
    1-methoxy-2-propyl acetate 0.18
    2-(2-methoxypropoxy) propanol 0.76
    mesitylene 0.07
    ε-caprolactone 0.26
    p-cymene 0.07
    epichlorohydrin 0.11
    1,1,1-trichloroethane 0.02
    2-aminoethanol 1.2
    morpholine-4-carbaldehyde 4.13
    sulfolane 5.72
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.1
    n-hexyl acetate 0.06
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.75
    sec-butyl acetate 0.03
    tert-butyl acetate 0.1
    decalin 0.03
    glycerin 7.89
    diglyme 1.21
    acrylic acid 1.1
    isopropyl myristate 0.04
    n-butyric acid 0.19
    acetyl acetate 0.08
    di(2-ethylhexyl) phthalate 0.12
    ethyl propionate 0.04
    nitromethane 1.88
    1,2-diethoxyethane 0.08
    benzonitrile 0.04
    trioctyl phosphate 0.1
    1-bromopropane 0.01
    gamma-valerolactone 1.16
    n-decanol 0.05
    triethyl phosphate 0.13
    4-methyl-2-pentanol 0.05
    propionitrile 0.05
    vinylene carbonate 0.19
    1,1,2-trichlorotrifluoroethane 1.33
    DMS 0.1
    cumene 0.03
    2-octanol 0.06
    2-hexanone 0.05
    octyl acetate 0.05
    limonene 0.11
    1,2-dimethoxyethane 0.31
    ethyl orthosilicate 0.12
    tributyl phosphate 0.1
    diacetone alcohol 0.52
    N,N-dimethylaniline 0.12
    acrylonitrile 0.11
    aniline 0.08
    1,3-propanediol 0.42
    bromobenzene 0.01
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.04
    2-methyl-cyclohexyl acetate 0.1
    tetrabutyl urea 0.26
    diisobutyl methanol 0.11
    2-phenylethanol 0.1
    styrene 0.02
    dioctyl adipate 0.08
    dimethyl sulfate 0.96
    ethyl butyrate 0.08
    methyl lactate 0.58
    butyl lactate 0.21
    diethyl carbonate 0.04
    propanediol butyl ether 0.63
    triethyl orthoformate 0.11
    p-tert-butyltoluene 0.07
    methyl 4-tert-butylbenzoate 0.43
    morpholine 0.17
    tert-butylamine 0.04
    n-dodecanol 0.04
    dimethoxymethane 0.38
    ethylene carbonate 0.13
    cyrene 1.85
    2-ethoxyethyl acetate 0.09
    2-ethylhexyl acetate 0.05
    1,2,4-trichlorobenzene 0.03
    4-methylpyridine 0.08
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.11
    DEF 0.45
    dimethyl isosorbide 1.24
    tetrachloroethylene 0.07
    eugenol 0.54
    triacetin 0.21
    span 80 0.71
    1,4-butanediol 0.27
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.04
    methyl formate 0.77
    2-methyl-1-butanol 0.04
    n-decane 0.02
    butyronitrile 0.03
    3,7-dimethyl-1-octanol 0.06
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.02
    cyclooctane 0.05
    cyclopentanol 0.15
    tetrahydropyran 0.05
    tert-amyl methyl ether 0.06
    2,5,8-trioxanonane 1.48
    1-hexene 0.02
    2-isopropoxyethanol 0.19
    2,2,2-trifluoroethanol 2.93
    methyl butyrate 0.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction