D-Methionine

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  • Identifiers

    CAS number
    348-67-4

    Molecular formula
    C5H11NO2S

    SMILES
    CSCC[C@H](C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Sulfurous 66.52%
    Meaty 66.22%
    Savory 52.04%
    Roasted 46.35%
    Onion 37.54%
    Cooked 36.59%
    Cheesy 34.4%
    Sweet 31.48%
    Cabbage 29.11%
    Alliaceous 28.17%

     

    Flavor
    Sulfurous 49.96%
    Sulfury 43.72%
    Odorless 32.95%
    Roasted 31.45%
    Onion 30.37%
    Mild 30.35%
    Cooked 30.25%
    Cabbage 26.47%
    Meaty 24.36%
    Tomato 22.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.9

    pKa est.
    5.21 (weak acid)

    Molecular weight
    149.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    301°C

    Melting point expt.

    • 213 dec °C

    Flash point

    • 140.35 ˚C est.

  • Synonyms

    • D-Methionine
    • 348-67-4
    • (R)-Methionine
    • D-Methionin
    • D-Metionien
    • METHIONINE, D-
    • (2R)-2-amino-4-(methylsulfanyl)butanoic acid
    • (R)-2-amino-4-(methylthio)butanoic acid
    • Methionine D-
    • Methionine d-form
    • (2R)-2-amino-4-methylsulfanylbutanoic acid
    • D-Metionien [Australian]
    • D-2-Amino-4-(methylthio)butyric acid
    • CHEBI:16867
    • EINECS 206-483-6
    • NSC 45689
    • METHIONINE D-FORM [MI]
    • 868496F25R
    • DTXSID90883369
    • NSC-45689
    • D-Metionien (Australian)
    • RefChem:584336
    • DTXCID201022906
    • 206-483-6
    • H-D-Met-OH
    • MRx-1024
    • MFCD00002622
    • R-Methionine
    • D-2-Amino-4-(methylthio)butanoic acid
    • CHEMBL1234268
    • MED
    • (R)-2-Amino-4-(methylmercapto)butyric acid
    • M02939
    • (R)-Methionine; MRX 1024; NSC 45689; S-Methyl-D-homocysteine
    • UNII-868496F25R
    • D-Met
    • D-Met-OH
    • bmse000450
    • D-Methionine;MRX-1024
    • MRX-1024,D-Methionine
    • SCHEMBL126688
    • S-METHYL-D-HOMOCYSTEINE
    • orb1706139
    • D-Methionine, >=98% (HPLC)
    • BDBM50463194
    • EBC-26092
    • s4494
    • SBB006710
    • AKOS015852500
    • AC-8661
    • CS-7880
    • DB02893
    • FM36951
    • NCGC00163337-01
    • AC-12369
    • DS-15125
    • HY-13694
    • SY004418
    • D-Methionine, puriss., >=99.0% (NT)
    • DB-038140
    • M0102
    • NS00079639
    • EN300-72154
    • C00855
    • 348M674
    • Q27093862
    • Z1147215595
    • 348-67-4

  • Applications

    Applications of D-Methionine include serving as a methionine source in animal feeds for livestock, poultry, and companion animals to meet essential amino acid requirements; used as a chemical intermediate or building block in the synthesis of pharmaceuticals and other fine chemicals in its D- configuration; employed as a research reagent and analytical standard in biochemical laboratories; and may be used as a precursor for the production of specialty sulfur-containing compounds in industrial chemical manufacture.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.78
    methanol 1.89
    isopropanol 0.53
    water 34.5
    ethyl acetate 0.25
    n-propanol 0.48
    acetone 0.64
    n-butanol 0.4
    acetonitrile 0.21
    DMF 4.08
    toluene 0.14
    isobutanol 0.5
    1,4-dioxane 1.45
    methyl acetate 0.17
    THF 2.46
    2-butanone 0.25
    n-pentanol 0.65
    sec-butanol 0.37
    n-hexane 0.08
    ethylene glycol 11.7
    NMP 30.18
    cyclohexane 0.23
    DMSO 31.48
    n-butyl acetate 0.99
    n-octanol 0.84
    chloroform 0.14
    n-propyl acetate 0.47
    acetic acid 14.0
    dichloromethane 0.23
    cyclohexanone 3.78
    propylene glycol 5.45
    isopropyl acetate 0.44
    DMAc 6.62
    2-ethoxyethanol 5.07
    isopentanol 0.79
    n-heptane 0.24
    ethyl formate 0.56
    1,2-dichloroethane 0.23
    n-hexanol 1.54
    2-methoxyethanol 6.51
    isobutyl acetate 0.47
    tetrachloromethane 0.12
    n-pentyl acetate 0.98
    transcutol 12.79
    n-heptanol 1.67
    ethylbenzene 0.24
    MIBK 0.74
    2-propoxyethanol 6.73
    tert-butanol 1.55
    MTBE 0.23
    2-butoxyethanol 6.16
    propionic acid 2.28
    o-xylene 0.49
    formic acid 31.76
    diethyl ether 0.08
    m-xylene 0.39
    p-xylene 0.42
    chlorobenzene 0.21
    dimethyl carbonate 0.42
    n-octane 0.12
    formamide 16.84
    cyclopentanone 4.06
    2-pentanone 0.4
    anisole 0.48
    cyclopentyl methyl ether 0.98
    gamma-butyrolactone 5.7
    1-methoxy-2-propanol 4.08
    pyridine 0.73
    3-pentanone 0.27
    furfural 9.51
    n-dodecane 0.09
    diethylene glycol 16.5
    diisopropyl ether 0.19
    tert-amyl alcohol 1.18
    acetylacetone 2.09
    n-hexadecane 0.1
    acetophenone 1.59
    methyl propionate 0.29
    isopentyl acetate 1.45
    trichloroethylene 0.45
    n-nonanol 0.93
    cyclohexanol 1.62
    benzyl alcohol 1.64
    2-ethylhexanol 1.38
    isooctanol 1.68
    dipropyl ether 0.52
    1,2-dichlorobenzene 0.5
    ethyl lactate 1.92
    propylene carbonate 3.76
    n-methylformamide 2.16
    2-pentanol 0.32
    n-pentane 0.04
    1-propoxy-2-propanol 4.86
    1-methoxy-2-propyl acetate 2.74
    2-(2-methoxypropoxy) propanol 7.42
    mesitylene 0.58
    ε-caprolactone 4.14
    p-cymene 0.83
    epichlorohydrin 1.58
    1,1,1-trichloroethane 0.17
    2-aminoethanol 7.86
    morpholine-4-carbaldehyde 18.14
    sulfolane 36.36
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 1.11
    n-hexyl acetate 1.16
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 9.51
    sec-butyl acetate 0.41
    tert-butyl acetate 1.14
    decalin 0.22
    glycerin 22.31
    diglyme 11.39
    acrylic acid 4.84
    isopropyl myristate 0.75
    n-butyric acid 2.38
    acetyl acetate 0.73
    di(2-ethylhexyl) phthalate 2.56
    ethyl propionate 0.38
    nitromethane 4.8
    1,2-diethoxyethane 1.01
    benzonitrile 0.86
    trioctyl phosphate 1.85
    1-bromopropane 0.07
    gamma-valerolactone 12.28
    n-decanol 0.78
    triethyl phosphate 1.48
    4-methyl-2-pentanol 0.62
    propionitrile 0.14
    vinylene carbonate 2.76
    1,1,2-trichlorotrifluoroethane 9.8
    DMS 1.32
    cumene 0.43
    2-octanol 0.86
    2-hexanone 0.52
    octyl acetate 1.01
    limonene 1.0
    1,2-dimethoxyethane 2.59
    ethyl orthosilicate 1.43
    tributyl phosphate 1.55
    diacetone alcohol 5.41
    N,N-dimethylaniline 1.04
    acrylonitrile 0.38
    aniline 0.48
    1,3-propanediol 5.92
    bromobenzene 0.18
    dibromomethane 0.15
    1,1,2,2-tetrachloroethane 0.58
    2-methyl-cyclohexyl acetate 2.66
    tetrabutyl urea 2.93
    diisobutyl methanol 1.32
    2-phenylethanol 2.37
    styrene 0.17
    dioctyl adipate 1.72
    dimethyl sulfate 2.55
    ethyl butyrate 0.99
    methyl lactate 2.73
    butyl lactate 3.28
    diethyl carbonate 0.76
    propanediol butyl ether 7.82
    triethyl orthoformate 1.37
    p-tert-butyltoluene 0.86
    methyl 4-tert-butylbenzoate 5.15
    morpholine 1.67
    tert-butylamine 0.58
    n-dodecanol 0.65
    dimethoxymethane 1.04
    ethylene carbonate 1.93
    cyrene 18.56
    2-ethoxyethyl acetate 1.61
    2-ethylhexyl acetate 1.06
    1,2,4-trichlorobenzene 0.76
    4-methylpyridine 0.51
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 1.32
    DEF 1.23
    dimethyl isosorbide 15.48
    tetrachloroethylene 0.67
    eugenol 6.49
    triacetin 3.12
    span 80 9.19
    1,4-butanediol 4.13
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.97
    methyl formate 1.47
    2-methyl-1-butanol 0.56
    n-decane 0.11
    butyronitrile 0.19
    3,7-dimethyl-1-octanol 1.09
    1-chlorooctane 0.25
    1-chlorotetradecane 0.17
    n-nonane 0.1
    undecane 0.1
    tert-butylcyclohexane 0.16
    cyclooctane 0.17
    cyclopentanol 2.47
    tetrahydropyran 0.48
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 13.16
    1-hexene 0.11
    2-isopropoxyethanol 3.32
    2,2,2-trifluoroethanol 5.87
    methyl butyrate 0.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction