D-Homoserine

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  • Identifiers

    CAS number
    6027-21-0

    Molecular formula
    C4H9NO3

    SMILES
    C(CO)[C@H](C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 69.31%
    Sweet 40.83%
    Savory 28.44%
    Buttery 19.13%
    Meaty 19.12%
    Fishy 19.03%
    Milky 18.99%
    Bitter 18.18%
    Alcoholic 18.08%
    Oily 15.54%

     

    Flavor
    Odorless 73.48%
    Mild 31.36%
    Sweet-like 25.0%
    Bland 24.72%
    Very mild 24.13%
    Acidic 23.87%
    Sour 23.61%
    Yeast 23.06%
    Faint 21.38%
    Very slight 20.52%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.4

    pKa est.
    5.74 (weak acid)

    Molecular weight
    119.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    323°C

    Flash point

    • 165.37 ˚C est.

  • Synonyms

    • D-Homoserine
    • 6027-21-0
    • H-D-Homoser-OH
    • (2R)-2-amino-4-hydroxybutanoic acid
    • MFCD00077786
    • (R)-2-amino-4-hydroxybutanoic acid
    • Homocystine, D-
    • H-D-Hse-OH
    • 5VK5MQ3TVS
    • (2R)-2-amino-4-hydroxy-butanoic acid
    • H-D-HoSer-OH
    • Homoserine, D-
    • NSC-206298
    • (R)-2-Amino-4-hydroxybutyric Acid
    • NSC 206298
    • UNII-5VK5MQ3TVS
    • HOMOSERINE, (R)-
    • SCHEMBL60060
    • CHEMBL4076295
    • CHEBI:30654
    • DTXSID10209022
    • H-D-HSer-OH, D-Hse, D-HoSer
    • FD1121
    • AKOS016015444
    • AC-5666
    • CS-W011215
    • DS-0575
    • EBC-253137
    • HY-W010499
    • SY014844
    • DB-031318
    • H1224
    • NS00125693
    • D-Homoserine, Vetec(TM) reagent grade, 98%
    • EN300-50993
    • BUTYRIC ACID, 2-AMINO-4-HYDROXY-, D-
    • M06115
    • 027H210
    • Q27113921
    • 3B4E88AC-FE9C-43E4-9644-5ED105A9B4F9
    • Z608345098
    • 6027-21-0

  • Applications

    D-Homoserine (CAS 6027-21-0) is primarily used as a building block and intermediate in organic synthesis and pharmaceutical development, serving as a non-native amino acid derivative for the preparation of amino acid esters, amides, and peptidomimetics, and as a chiral building block for enantioselective syntheses related to threonine/methionine pathways. In biotechnology and life-science research, it is commonly used as a substrate or analytical standard in enzyme assays and in studies of amino acid biosynthesis. It is also employed as a reagent for functionalization and for chiral-resolution studies in synthetic routes. As a process development precursor, it may be evaluated as a precursor to other amino acid pathways and derivatives, depending on reaction conditions. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.1
    methanol 0.29
    isopropanol 0.07
    water 128.74
    ethyl acetate 0.3
    n-propanol 0.07
    acetone 0.43
    n-butanol 0.06
    acetonitrile 0.16
    DMF 4.22
    toluene 0.09
    isobutanol 0.07
    1,4-dioxane 0.71
    methyl acetate 0.14
    THF 0.49
    2-butanone 0.16
    n-pentanol 0.06
    sec-butanol 0.08
    n-hexane 0.04
    ethylene glycol 7.34
    NMP 18.35
    cyclohexane 0.09
    DMSO 16.74
    n-butyl acetate 0.19
    n-octanol 0.15
    chloroform 0.1
    n-propyl acetate 0.1
    acetic acid 5.07
    dichloromethane 0.13
    cyclohexanone 0.94
    propylene glycol 2.12
    isopropyl acetate 0.25
    DMAc 7.14
    2-ethoxyethanol 0.99
    isopentanol 0.1
    n-heptane 0.11
    ethyl formate 0.43
    1,2-dichloroethane 0.13
    n-hexanol 0.22
    2-methoxyethanol 2.05
    isobutyl acetate 0.06
    tetrachloromethane 0.21
    n-pentyl acetate 0.16
    transcutol 2.08
    n-heptanol 0.26
    ethylbenzene 0.09
    MIBK 0.27
    2-propoxyethanol 1.49
    tert-butanol 0.29
    MTBE 0.1
    2-butoxyethanol 1.07
    propionic acid 0.86
    o-xylene 0.3
    formic acid 49.52
    diethyl ether 0.06
    m-xylene 0.24
    p-xylene 0.13
    chlorobenzene 0.07
    dimethyl carbonate 0.57
    n-octane 0.05
    formamide 13.11
    cyclopentanone 1.1
    2-pentanone 0.22
    anisole 0.16
    cyclopentyl methyl ether 0.42
    gamma-butyrolactone 2.1
    1-methoxy-2-propanol 1.21
    pyridine 0.27
    3-pentanone 0.25
    furfural 5.2
    n-dodecane 0.03
    diethylene glycol 7.01
    diisopropyl ether 0.09
    tert-amyl alcohol 0.33
    acetylacetone 1.29
    n-hexadecane 0.03
    acetophenone 0.45
    methyl propionate 0.35
    isopentyl acetate 0.22
    trichloroethylene 0.26
    n-nonanol 0.16
    cyclohexanol 0.31
    benzyl alcohol 0.31
    2-ethylhexanol 0.25
    isooctanol 0.25
    dipropyl ether 0.18
    1,2-dichlorobenzene 0.16
    ethyl lactate 0.66
    propylene carbonate 1.24
    n-methylformamide 1.61
    2-pentanol 0.07
    n-pentane 0.02
    1-propoxy-2-propanol 0.95
    1-methoxy-2-propyl acetate 0.72
    2-(2-methoxypropoxy) propanol 2.1
    mesitylene 0.29
    ε-caprolactone 1.07
    p-cymene 0.25
    epichlorohydrin 0.48
    1,1,1-trichloroethane 0.13
    2-aminoethanol 2.11
    morpholine-4-carbaldehyde 9.32
    sulfolane 13.61
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 0.3
    n-hexyl acetate 0.19
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 1.92
    sec-butyl acetate 0.1
    tert-butyl acetate 0.43
    decalin 0.07
    glycerin 18.61
    diglyme 3.16
    acrylic acid 2.34
    isopropyl myristate 0.12
    n-butyric acid 0.66
    acetyl acetate 0.54
    di(2-ethylhexyl) phthalate 0.47
    ethyl propionate 0.18
    nitromethane 3.68
    1,2-diethoxyethane 0.19
    benzonitrile 0.21
    trioctyl phosphate 0.34
    1-bromopropane 0.03
    gamma-valerolactone 3.36
    n-decanol 0.14
    triethyl phosphate 0.48
    4-methyl-2-pentanol 0.13
    propionitrile 0.07
    vinylene carbonate 1.14
    1,1,2-trichlorotrifluoroethane 6.39
    DMS 0.39
    cumene 0.13
    2-octanol 0.15
    2-hexanone 0.11
    octyl acetate 0.17
    limonene 0.31
    1,2-dimethoxyethane 0.98
    ethyl orthosilicate 0.44
    tributyl phosphate 0.32
    diacetone alcohol 1.88
    N,N-dimethylaniline 0.4
    acrylonitrile 0.19
    aniline 0.21
    1,3-propanediol 1.24
    bromobenzene 0.06
    dibromomethane 0.08
    1,1,2,2-tetrachloroethane 0.33
    2-methyl-cyclohexyl acetate 0.37
    tetrabutyl urea 0.64
    diisobutyl methanol 0.32
    2-phenylethanol 0.47
    styrene 0.06
    dioctyl adipate 0.24
    dimethyl sulfate 3.38
    ethyl butyrate 0.25
    methyl lactate 1.99
    butyl lactate 0.58
    diethyl carbonate 0.19
    propanediol butyl ether 1.51
    triethyl orthoformate 0.35
    p-tert-butyltoluene 0.27
    methyl 4-tert-butylbenzoate 1.36
    morpholine 0.54
    tert-butylamine 0.11
    n-dodecanol 0.12
    dimethoxymethane 0.92
    ethylene carbonate 0.72
    cyrene 5.08
    2-ethoxyethyl acetate 0.31
    2-ethylhexyl acetate 0.18
    1,2,4-trichlorobenzene 0.21
    4-methylpyridine 0.25
    dibutyl ether 0.08
    2,6-dimethyl-4-heptanol 0.32
    DEF 1.03
    dimethyl isosorbide 4.03
    tetrachloroethylene 0.56
    eugenol 1.67
    triacetin 0.66
    span 80 1.83
    1,4-butanediol 0.73
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.11
    methyl formate 1.73
    2-methyl-1-butanol 0.11
    n-decane 0.04
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.06
    1-chlorotetradecane 0.04
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.05
    cyclooctane 0.09
    cyclopentanol 0.42
    tetrahydropyran 0.14
    tert-amyl methyl ether 0.19
    2,5,8-trioxanonane 4.06
    1-hexene 0.04
    2-isopropoxyethanol 0.58
    2,2,2-trifluoroethanol 8.65
    methyl butyrate 0.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction