D-Galactono-1,4-Lactone

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  • Identifiers

    CAS number
    2782-07-2

    Molecular formula
    C6H10O6

    SMILES
    C([C@H]([C@H]1[C@@H]([C@H](C(=O)O1)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 75.26%
    Sweet 38.99%
    Caramellic 35.72%
    Burnt 18.88%
    Clean 17.94%
    Buttery 17.43%
    Milky 16.16%
    Sharp 15.87%
    Savory 14.99%
    Bitter 14.16%

     

    Flavor
    Sweet 57.87%
    Odorless 56.67%
    Bitter 47.44%
    Sweet-like 31.89%
    Very mild 29.14%
    Bland 22.17%
    Very slight 22.07%
    Cauliflower 21.21%
    Fenugreek 20.97%
    Seedy 19.88%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.0

    pKa est.
    4.25 (weak acid)

    Molecular weight
    178.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    968°C

    Flash point

    • 212.94 ˚C est.

  • Synonyms

    • D-galactono-1,4-lactone
    • 2782-07-2
    • gamma-D-galactonolactone
    • D-galactonic acid gamma-lactone
    • D-Galactonic acid, gamma-lactone
    • 1,4-D-Galactonolactone
    • (3R,4R,5S)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-one
    • CHEBI:15895
    • DTXSID40904659
    • (3R,4R,5S)-5-((1R)-1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-one
    • RefChem:130544
    • GlyTouCan:G97368GU
    • DTXCID801333779
    • G97368GU
    • 220-484-9
    • 5-(1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-one
    • (3R,4R,5S)-5-((R)-1,2-Dihydroxyethyl)-3,4-dihydroxydihydrofuran-2(3H)-one
    • D-Galactonic acid 1,4-lactone
    • MFCD00065019
    • D-galactono-gamma-lactone
    • D-galactonate-gamma-lactone
    • D-Galactonic 1,4-lactone
    • D-Galactono-I(3)-Iacton
    • D-galactonic acid g-lactone
    • galactonic acid gamma-lactone
    • Galactonic acid-1,4-lactone
    • SCHEMBL346605
    • D-Galactonic acid, ?-lactone
    • CHEMBL466882
    • D-Galactonic acid, |A-lactone
    • EINECS 220-484-9
    • D-(-)-galactonic acid gamma-lactone
    • AKOS006271546
    • D-GALACTONO-1 pound not4-LACTONE
    • NSC 102762
    • CS-0450439
    • C03383
    • G85016
    • Q27098286
    • 6E3F7E1D-5F52-4C31-AE17-BDEE150F1E24
    • (3R,4R,5S)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-tetrahydrofuran-2-one
    • 2782-07-2

  • Applications

    Primarily an intermediate in the biosynthesis and chemical production of ascorbic acid (vitamin C). It also serves as a versatile chiral building block for organic synthesis and pharmaceutical research, with potential use in preparing ascorbate derivatives and related vitamin C–based compounds for cosmetic and personal care applications. In R&D settings, it is commonly evaluated as a substrate for enzymatic or chemical oxidation to ascorbic acid and as a starting material in carbohydrate chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.64
    methanol 72.06
    isopropanol 3.08
    water 932.51
    ethyl acetate 0.87
    n-propanol 2.54
    acetone 1.69
    n-butanol 1.83
    acetonitrile 1.51
    DMF 243.61
    toluene 0.41
    isobutanol 1.33
    1,4-dioxane 7.66
    methyl acetate 0.75
    THF 3.42
    2-butanone 1.02
    n-pentanol 1.69
    sec-butanol 2.07
    n-hexane 0.16
    ethylene glycol 185.82
    NMP 142.83
    cyclohexane 0.83
    DMSO 1065.51
    n-butyl acetate 0.87
    n-octanol 2.07
    chloroform 0.66
    n-propyl acetate 0.57
    acetic acid 7.84
    dichloromethane 1.68
    cyclohexanone 3.63
    propylene glycol 44.98
    isopropyl acetate 0.78
    DMAc 109.19
    2-ethoxyethanol 28.84
    isopentanol 1.53
    n-heptane 0.94
    ethyl formate 1.49
    1,2-dichloroethane 1.85
    n-hexanol 2.22
    2-methoxyethanol 72.45
    isobutyl acetate 0.3
    tetrachloromethane 0.38
    n-pentyl acetate 0.92
    transcutol 23.72
    n-heptanol 2.61
    ethylbenzene 0.4
    MIBK 1.0
    2-propoxyethanol 15.73
    tert-butanol 3.31
    MTBE 0.97
    2-butoxyethanol 10.5
    propionic acid 3.58
    o-xylene 1.08
    formic acid 270.43
    diethyl ether 0.97
    m-xylene 0.81
    p-xylene 0.49
    chlorobenzene 0.29
    dimethyl carbonate 5.36
    n-octane 0.42
    formamide 215.67
    cyclopentanone 3.52
    2-pentanone 1.02
    anisole 1.23
    cyclopentyl methyl ether 2.18
    gamma-butyrolactone 6.59
    1-methoxy-2-propanol 31.26
    pyridine 2.24
    3-pentanone 1.17
    furfural 15.23
    n-dodecane 0.26
    diethylene glycol 60.98
    diisopropyl ether 0.53
    tert-amyl alcohol 2.8
    acetylacetone 3.18
    n-hexadecane 0.29
    acetophenone 2.22
    methyl propionate 2.37
    isopentyl acetate 0.7
    trichloroethylene 1.66
    n-nonanol 1.98
    cyclohexanol 3.47
    benzyl alcohol 3.41
    2-ethylhexanol 1.4
    isooctanol 1.85
    dipropyl ether 1.86
    1,2-dichlorobenzene 0.63
    ethyl lactate 4.9
    propylene carbonate 2.82
    n-methylformamide 60.15
    2-pentanol 1.37
    n-pentane 0.29
    1-propoxy-2-propanol 8.88
    1-methoxy-2-propyl acetate 3.69
    2-(2-methoxypropoxy) propanol 11.34
    mesitylene 0.9
    ε-caprolactone 3.9
    p-cymene 0.92
    epichlorohydrin 4.48
    1,1,1-trichloroethane 0.3
    2-aminoethanol 72.74
    morpholine-4-carbaldehyde 96.03
    sulfolane 61.98
    2,2,4-trimethylpentane 0.19
    2-methyltetrahydrofuran 1.72
    n-hexyl acetate 1.15
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 14.73
    sec-butyl acetate 0.39
    tert-butyl acetate 1.15
    decalin 0.28
    glycerin 180.76
    diglyme 24.78
    acrylic acid 8.69
    isopropyl myristate 0.69
    n-butyric acid 2.26
    acetyl acetate 1.0
    di(2-ethylhexyl) phthalate 1.7
    ethyl propionate 0.83
    nitromethane 16.01
    1,2-diethoxyethane 2.29
    benzonitrile 1.23
    trioctyl phosphate 1.54
    1-bromopropane 0.45
    gamma-valerolactone 18.28
    n-decanol 1.59
    triethyl phosphate 1.79
    4-methyl-2-pentanol 0.99
    propionitrile 0.84
    vinylene carbonate 3.43
    1,1,2-trichlorotrifluoroethane 29.52
    DMS 1.93
    cumene 0.47
    2-octanol 1.41
    2-hexanone 0.68
    octyl acetate 1.01
    limonene 1.38
    1,2-dimethoxyethane 13.72
    ethyl orthosilicate 1.59
    tributyl phosphate 1.1
    diacetone alcohol 6.06
    N,N-dimethylaniline 2.69
    acrylonitrile 2.45
    aniline 1.44
    1,3-propanediol 33.3
    bromobenzene 0.26
    dibromomethane 0.82
    1,1,2,2-tetrachloroethane 2.42
    2-methyl-cyclohexyl acetate 1.13
    tetrabutyl urea 3.17
    diisobutyl methanol 1.4
    2-phenylethanol 2.85
    styrene 0.36
    dioctyl adipate 1.46
    dimethyl sulfate 26.1
    ethyl butyrate 1.15
    methyl lactate 18.28
    butyl lactate 2.79
    diethyl carbonate 0.92
    propanediol butyl ether 14.0
    triethyl orthoformate 1.64
    p-tert-butyltoluene 0.94
    methyl 4-tert-butylbenzoate 5.59
    morpholine 11.85
    tert-butylamine 1.5
    n-dodecanol 1.31
    dimethoxymethane 24.0
    ethylene carbonate 2.35
    cyrene 25.52
    2-ethoxyethyl acetate 1.78
    2-ethylhexyl acetate 0.61
    1,2,4-trichlorobenzene 0.86
    4-methylpyridine 1.56
    dibutyl ether 0.88
    2,6-dimethyl-4-heptanol 1.4
    DEF 11.2
    dimethyl isosorbide 15.48
    tetrachloroethylene 2.2
    eugenol 7.74
    triacetin 3.0
    span 80 9.36
    1,4-butanediol 21.75
    1,1-dichloroethane 0.38
    2-methyl-1-pentanol 1.27
    methyl formate 20.93
    2-methyl-1-butanol 1.51
    n-decane 0.4
    butyronitrile 0.72
    3,7-dimethyl-1-octanol 1.38
    1-chlorooctane 0.63
    1-chlorotetradecane 0.37
    n-nonane 0.42
    undecane 0.32
    tert-butylcyclohexane 0.15
    cyclooctane 0.62
    cyclopentanol 3.14
    tetrahydropyran 1.73
    tert-amyl methyl ether 1.36
    2,5,8-trioxanonane 24.43
    1-hexene 0.23
    2-isopropoxyethanol 9.98
    2,2,2-trifluoroethanol 20.42
    methyl butyrate 1.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction