Cyperolone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    13741-46-3

    Molecular formula
    C15H24O2

    SMILES
    CC(=C)[C@@H]1CC[C@]2(CC[C@@H]([C@]2(C1)C(=O)C)O)C

  • Odor profile

    Woody 77.25%
    Herbal 53.65%
    Mint 46.53%
    Camphoreous 45.59%
    Sweet 42.78%
    Fresh 39.79%
    Pine 36.88%
    Earthy 36.84%
    Dry 36.68%
    Floral 36.49%

    Scent© AI

  • Properties

    XLogP3-AA
    3.5

    Molecular weight
    236.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    348°C

    Flash point est.
    150.63 ˚C

  • Synonyms

    • Cyperolone
    • 13741-46-3
    • 1-[(3S,3aR,5R,7aS)-3-hydroxy-7a-methyl-5-prop-1-en-2-yl-2,3,4,5,6,7-hexahydro-1H-inden-3a-yl]ethanone
    • SCHEMBL19419895
    • CHEBI:80814
    • DTXSID90415700
    • C16946
    • Q27149856

  • Applications

    Cyperolone (CAS 13741-46-3) is a synthetic steroid reported to exhibit antiandrogen activity; in R&D it is mainly used as a reference/tool compound for androgen receptor studies (cell-based screening, receptor binding, reporter assays), as a lead/scaffold for structure–activity optimization of steroidal antiandrogens, as an analytical reference when developing/validating LC–MS methods for androgen/hormone panels and in vitro metabolism work, and as a building block to generate derivatives (e.g., esters or ring-modified analogs) with improved potency, selectivity, and formulation properties; preclinically, it has been applied in mechanism and proof‑of‑concept models of androgen-driven conditions such as acne, seborrhea, hirsutism, androgenic alopecia, and prostate disorders, including topical delivery studies to suppress sebaceous activity and PK/PD comparisons versus other antiandrogens; it is not widely approved for therapeutic use and is typically supplied “for research use only,” requiring standard laboratory handling, storage, and safety compliance.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 343.33
    methanol 600.31
    isopropanol 478.45
    water 2.76
    ethyl acetate 246.75
    n-propanol 333.7
    acetone 414.11
    n-butanol 340.38
    acetonitrile 375.78
    DMF 872.79
    toluene 323.61
    isobutanol 252.45
    1,4-dioxane 1162.73
    methyl acetate 252.68
    THF 1825.26
    2-butanone 301.44
    n-pentanol 143.73
    sec-butanol 222.78
    n-hexane 6.35
    ethylene glycol 71.38
    NMP 366.66
    cyclohexane 37.13
    DMSO 336.32
    n-butyl acetate 183.61
    n-octanol 84.91
    chloroform 907.73
    n-propyl acetate 141.83
    acetic acid 220.54
    dichloromethane 652.11
    cyclohexanone 517.81
    propylene glycol 123.04
    isopropyl acetate 199.3
    DMAc 331.15
    2-ethoxyethanol 211.39
    isopentanol 265.06
    n-heptane 10.19
    ethyl formate 244.24
    1,2-dichloroethane 293.76
    n-hexanol 219.98
    2-methoxyethanol 619.38
    isobutyl acetate 107.17
    tetrachloromethane 118.14
    n-pentyl acetate 127.74
    transcutol 689.73
    n-heptanol 97.96
    ethylbenzene 99.57
    MIBK 207.93
    2-propoxyethanol 431.63
    tert-butanol 482.16
    MTBE 196.33
    2-butoxyethanol 197.16
    propionic acid 169.01
    o-xylene 141.66
    formic acid 129.14
    diethyl ether 202.19
    m-xylene 208.35
    p-xylene 151.87
    chlorobenzene 309.14
    dimethyl carbonate 135.38
    n-octane 4.48
    formamide 254.5
    cyclopentanone 699.1
    2-pentanone 250.66
    anisole 228.57
    cyclopentyl methyl ether 366.81
    gamma-butyrolactone 667.47
    1-methoxy-2-propanol 556.13
    pyridine 657.62
    3-pentanone 149.31
    furfural 573.51
    n-dodecane 4.39
    diethylene glycol 336.36
    diisopropyl ether 64.91
    tert-amyl alcohol 184.76
    acetylacetone 334.26
    n-hexadecane 5.36
    acetophenone 184.77
    methyl propionate 190.84
    isopentyl acetate 183.26
    trichloroethylene 613.52
    n-nonanol 79.47
    cyclohexanol 276.24
    benzyl alcohol 205.96
    2-ethylhexanol 98.59
    isooctanol 79.08
    dipropyl ether 109.31
    1,2-dichlorobenzene 244.02
    ethyl lactate 88.41
    propylene carbonate 351.38
    n-methylformamide 391.71
    2-pentanol 177.82
    n-pentane 11.87
    1-propoxy-2-propanol 306.31
    1-methoxy-2-propyl acetate 254.86
    2-(2-methoxypropoxy) propanol 184.23
    mesitylene 121.51
    ε-caprolactone 363.46
    p-cymene 68.54
    epichlorohydrin 696.7
    1,1,1-trichloroethane 308.66
    2-aminoethanol 170.04
    morpholine-4-carbaldehyde 589.37
    sulfolane 433.81
    2,2,4-trimethylpentane 7.68
    2-methyltetrahydrofuran 571.01
    n-hexyl acetate 167.78
    isooctane 10.14
    2-(2-butoxyethoxy)ethanol 280.68
    sec-butyl acetate 108.35
    tert-butyl acetate 214.26
    decalin 14.45
    glycerin 187.08
    diglyme 472.92
    acrylic acid 148.11
    isopropyl myristate 71.54
    n-butyric acid 302.16
    acetyl acetate 196.26
    di(2-ethylhexyl) phthalate 84.96
    ethyl propionate 127.84
    nitromethane 472.3
    1,2-diethoxyethane 223.98
    benzonitrile 326.64
    trioctyl phosphate 59.76
    1-bromopropane 155.14
    gamma-valerolactone 835.41
    n-decanol 57.84
    triethyl phosphate 71.32
    4-methyl-2-pentanol 128.91
    propionitrile 321.65
    vinylene carbonate 364.42
    1,1,2-trichlorotrifluoroethane 325.11
    DMS 154.27
    cumene 66.52
    2-octanol 64.94
    2-hexanone 136.58
    octyl acetate 85.03
    limonene 81.36
    1,2-dimethoxyethane 482.74
    ethyl orthosilicate 69.88
    tributyl phosphate 69.9
    diacetone alcohol 272.98
    N,N-dimethylaniline 139.46
    acrylonitrile 378.92
    aniline 352.74
    1,3-propanediol 342.89
    bromobenzene 309.07
    dibromomethane 354.49
    1,1,2,2-tetrachloroethane 463.06
    2-methyl-cyclohexyl acetate 125.56
    tetrabutyl urea 93.63
    diisobutyl methanol 77.7
    2-phenylethanol 250.79
    styrene 124.49
    dioctyl adipate 100.04
    dimethyl sulfate 161.72
    ethyl butyrate 128.44
    methyl lactate 156.94
    butyl lactate 124.24
    diethyl carbonate 94.8
    propanediol butyl ether 189.44
    triethyl orthoformate 106.51
    p-tert-butyltoluene 71.52
    methyl 4-tert-butylbenzoate 167.97
    morpholine 1135.92
    tert-butylamine 237.96
    n-dodecanol 41.79
    dimethoxymethane 597.61
    ethylene carbonate 308.97
    cyrene 191.49
    2-ethoxyethyl acetate 190.3
    2-ethylhexyl acetate 132.69
    1,2,4-trichlorobenzene 270.74
    4-methylpyridine 584.98
    dibutyl ether 83.44
    2,6-dimethyl-4-heptanol 77.7
    DEF 223.26
    dimethyl isosorbide 357.47
    tetrachloroethylene 270.01
    eugenol 178.7
    triacetin 157.46
    span 80 168.49
    1,4-butanediol 83.38
    1,1-dichloroethane 329.54
    2-methyl-1-pentanol 113.78
    methyl formate 330.63
    2-methyl-1-butanol 184.17
    n-decane 7.84
    butyronitrile 352.4
    3,7-dimethyl-1-octanol 95.92
    1-chlorooctane 43.1
    1-chlorotetradecane 16.71
    n-nonane 6.3
    undecane 5.69
    tert-butylcyclohexane 12.19
    cyclooctane 9.66
    cyclopentanol 361.65
    tetrahydropyran 785.16
    tert-amyl methyl ether 102.88
    2,5,8-trioxanonane 307.03
    1-hexene 33.83
    2-isopropoxyethanol 147.76
    2,2,2-trifluoroethanol 105.93
    methyl butyrate 162.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cyperus scariosus Cyperus scariosus R.Br., fam. Cupressaceae 0.55%