Cyflufenamid

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  • Identifiers

    CAS number
    180409-60-3

    Molecular formula
    C20H17F5N2O2

    SMILES
    C1CC1CO/N=C(/C2=C(C=CC(=C2F)F)C(F)(F)F)\NC(=O)CC3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 42.22%
    Fruity 30.71%
    Grape 28.56%
    Savory 28.2%
    Cooling 26.29%
    Meaty 22.54%
    Animal 22.33%
    Fatty 22.32%
    Milky 22.19%
    Cooked 21.96%

     

    Flavor
    Bitter 70.03%
    Odorless 44.77%
    Bland 27.11%
    Mild 25.7%
    Sweet-like 20.64%
    Nitrile 19.75%
    Orange flower 18.88%
    Cedarleaf 18.67%
    Scallion 18.56%
    Very strong 18.42%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    6.39 (neutral)

    Molecular weight
    412.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    457°C

    Flash point

    • 133.8 ˚C est.

  • Synonyms

    • Cyflufenamid
    • 180409-60-3
    • 79ID05OQ82
    • (N(Z))-N-(((Cyclopropylmethoxy)amino)(2,3-difluoro-6-(trifluoromethyl)phenyl)methylene)benzeneacetamide
    • N-((Z)-((Cyclopropylmethoxy)imino)(2,3-difluoro-6-(trifluoromethyl)phenyl)methyl)-2-phenylacetamide
    • CHEBI:81797
    • DTXSID30431727
    • [N(Z)]-N-[[(cyclopropylmethoxy)amino][2,3-difluoro-6-(trifluoromethyl)phenyl]methylene]benzeneacetamide
    • N-{(Z)-[(Cyclopropylmethoxy)imino][2,3-difluoro-6-(trifluoromethyl)phenyl]methyl}-2-phenylacetamide
    • RefChem:581331
    • DTXCID20382557
    • (1Z)-N-((Z)-((cyclopropylmethoxy)imino)(2,3-difluoro-6-(trifluoromethyl)phenyl)methyl)-2-phenylethanimidic acid
    • 605-896-2
    • Cyflufenamid [ISO]
    • UNII-79ID05OQ82
    • Cyflufenamid 10 microg/mL in Cyclohexane
    • MFCD16652594
    • N-[(Z)-N-(cyclopropylmethoxy)-C-[2,3-difluoro-6-(trifluoromethyl)phenyl]carbonimidoyl]-2-phenylacetamide
    • CYFLUFENAMID [MI]
    • SCHEMBL674131
    • CHEMBL2251733
    • SCHEMBL21768961
    • SCHEMBL29457669
    • MSK21238
    • N-{(Z)-[(cyclopropylmethoxy)amino][2,3-difluoro-6-(trifluoromethyl)phenyl]methylene}-2-phenylacetamide
    • 149-(E)-FB
    • N-[(cyclopropylmethoxyamino)-[2,3-difluoro-6-(trifluoromethyl)phenyl]methylidene]-2-phenylacetamide
    • NS00002257
    • C18516
    • H55062
    • Cyflufenamid, PESTANAL(R), analytical standard
    • Q1147675
    • (Z)-N-[alpha-(cyclopropylmethoxyimino)-2,3-difluoro-6-(trifluoromethyl)benzyl]-2-phenylacetamide
    • 180409-60-3

  • Applications

    Cyflufenamid is an agricultural fungicide used to protect crops by controlling fungal diseases across several crop groups, including vegetables, fruit crops, and ornamental plants, in both field and greenhouse cultivation. It is typically formulated into crop protection products for foliar application or seed treatments, aiming to reduce disease pressure and safeguard yield and quality. Applications are considered within integrated pest management programs and are subject to local regulations, with use varying by crop and region.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 50.45
    methanol 72.37
    isopropanol 24.0
    water 0.01
    ethyl acetate 109.08
    n-propanol 37.06
    acetone 149.54
    n-butanol 27.07
    acetonitrile 79.44
    DMF 266.31
    toluene 48.03
    isobutanol 19.1
    1,4-dioxane 112.1
    methyl acetate 163.15
    THF 307.36
    2-butanone 151.48
    n-pentanol 19.41
    sec-butanol 29.77
    n-hexane 0.7
    ethylene glycol 10.26
    NMP 306.6
    cyclohexane 1.1
    DMSO 356.5
    n-butyl acetate 46.88
    n-octanol 5.14
    chloroform 158.57
    n-propyl acetate 63.67
    acetic acid 184.62
    dichloromethane 223.61
    cyclohexanone 126.19
    propylene glycol 15.36
    isopropyl acetate 56.8
    DMAc 407.03
    2-ethoxyethanol 95.09
    isopentanol 20.48
    n-heptane 0.74
    ethyl formate 63.04
    1,2-dichloroethane 119.55
    n-hexanol 15.98
    2-methoxyethanol 171.28
    isobutyl acetate 22.08
    tetrachloromethane 8.97
    n-pentyl acetate 29.18
    transcutol 209.5
    n-heptanol 7.94
    ethylbenzene 18.56
    MIBK 37.14
    2-propoxyethanol 83.72
    tert-butanol 23.61
    MTBE 35.53
    2-butoxyethanol 44.15
    propionic acid 73.39
    o-xylene 23.46
    formic acid 75.43
    diethyl ether 46.05
    m-xylene 17.49
    p-xylene 17.06
    chlorobenzene 39.63
    dimethyl carbonate 83.31
    n-octane 0.28
    formamide 150.92
    cyclopentanone 207.47
    2-pentanone 85.08
    anisole 80.94
    cyclopentyl methyl ether 62.8
    gamma-butyrolactone 266.19
    1-methoxy-2-propanol 102.6
    pyridine 205.72
    3-pentanone 73.16
    furfural 248.71
    n-dodecane 0.3
    diethylene glycol 62.87
    diisopropyl ether 8.36
    tert-amyl alcohol 30.66
    acetylacetone 164.45
    n-hexadecane 0.36
    acetophenone 94.59
    methyl propionate 121.01
    isopentyl acetate 34.42
    trichloroethylene 319.84
    n-nonanol 6.1
    cyclohexanol 22.3
    benzyl alcohol 60.63
    2-ethylhexanol 10.1
    isooctanol 6.42
    dipropyl ether 19.61
    1,2-dichlorobenzene 38.93
    ethyl lactate 45.82
    propylene carbonate 105.64
    n-methylformamide 136.55
    2-pentanol 16.99
    n-pentane 0.92
    1-propoxy-2-propanol 50.2
    1-methoxy-2-propyl acetate 89.78
    2-(2-methoxypropoxy) propanol 62.74
    mesitylene 6.62
    ε-caprolactone 133.18
    p-cymene 8.91
    epichlorohydrin 375.59
    1,1,1-trichloroethane 75.76
    2-aminoethanol 27.45
    morpholine-4-carbaldehyde 284.36
    sulfolane 308.82
    2,2,4-trimethylpentane 0.83
    2-methyltetrahydrofuran 131.28
    n-hexyl acetate 30.61
    isooctane 0.34
    2-(2-butoxyethoxy)ethanol 72.0
    sec-butyl acetate 38.33
    tert-butyl acetate 54.9
    decalin 0.91
    glycerin 30.94
    diglyme 160.44
    acrylic acid 93.2
    isopropyl myristate 11.05
    n-butyric acid 76.37
    acetyl acetate 95.72
    di(2-ethylhexyl) phthalate 18.05
    ethyl propionate 62.36
    nitromethane 442.12
    1,2-diethoxyethane 54.09
    benzonitrile 53.73
    trioctyl phosphate 8.15
    1-bromopropane 47.7
    gamma-valerolactone 327.49
    n-decanol 4.6
    triethyl phosphate 24.7
    4-methyl-2-pentanol 9.36
    propionitrile 49.75
    vinylene carbonate 105.74
    1,1,2-trichlorotrifluoroethane 266.42
    DMS 75.86
    cumene 9.07
    2-octanol 4.3
    2-hexanone 53.52
    octyl acetate 16.69
    limonene 12.34
    1,2-dimethoxyethane 149.39
    ethyl orthosilicate 20.57
    tributyl phosphate 12.07
    diacetone alcohol 75.48
    N,N-dimethylaniline 39.16
    acrylonitrile 99.2
    aniline 56.82
    1,3-propanediol 39.33
    bromobenzene 43.53
    dibromomethane 100.29
    1,1,2,2-tetrachloroethane 179.24
    2-methyl-cyclohexyl acetate 33.24
    tetrabutyl urea 19.55
    diisobutyl methanol 6.0
    2-phenylethanol 46.13
    styrene 27.22
    dioctyl adipate 26.54
    dimethyl sulfate 148.16
    ethyl butyrate 43.03
    methyl lactate 81.68
    butyl lactate 28.57
    diethyl carbonate 35.31
    propanediol butyl ether 29.63
    triethyl orthoformate 30.03
    p-tert-butyltoluene 7.35
    methyl 4-tert-butylbenzoate 53.46
    morpholine 173.71
    tert-butylamine 9.83
    n-dodecanol 3.41
    dimethoxymethane 180.08
    ethylene carbonate 69.24
    cyrene 85.0
    2-ethoxyethyl acetate 81.65
    2-ethylhexyl acetate 26.51
    1,2,4-trichlorobenzene 69.06
    4-methylpyridine 151.03
    dibutyl ether 10.48
    2,6-dimethyl-4-heptanol 6.0
    DEF 128.02
    dimethyl isosorbide 116.17
    tetrachloroethylene 94.38
    eugenol 52.12
    triacetin 80.8
    span 80 41.02
    1,4-butanediol 12.9
    1,1-dichloroethane 82.02
    2-methyl-1-pentanol 19.45
    methyl formate 112.38
    2-methyl-1-butanol 24.49
    n-decane 0.45
    butyronitrile 36.08
    3,7-dimethyl-1-octanol 7.11
    1-chlorooctane 3.57
    1-chlorotetradecane 1.58
    n-nonane 0.34
    undecane 0.36
    tert-butylcyclohexane 0.69
    cyclooctane 0.39
    cyclopentanol 29.9
    tetrahydropyran 78.12
    tert-amyl methyl ether 38.35
    2,5,8-trioxanonane 118.51
    1-hexene 6.22
    2-isopropoxyethanol 53.46
    2,2,2-trifluoroethanol 48.3
    methyl butyrate 76.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction