Cyclopropylamine

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  • Identifiers

    CAS number
    765-30-0

    Molecular formula
    C3H7N

    SMILES
    C1CC1N

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 77.89%
    Cheesy 50.11%
    Ripe 39.13%
    Odorless 36.59%
    Animal 35.05%
    Meaty 24.88%
    Nutty 22.96%
    Popcorn 22.2%
    Roasted 21.18%
    Musty 20.14%

     

    Flavor
    Ammoniacal 40.09%
    Animal 29.3%
    Fishy 29.2%
    Egg 26.6%
    Alkaline 25.52%
    Sulfurous 24.65%
    Sweet 24.28%
    Amine 23.43%
    Shrimp 22.18%
    Bouillon 21.43%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    6.23 (neutral)

    Molecular weight
    57.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    52°C

    Flash point

    • -9.5 ˚C est.

  • Synonyms

    • Cyclopropylamine
    • Cyclopropanamine
    • 765-30-0
    • Aminocyclopropane
    • 8PR8XTH1X1
    • NSC-56127
    • DTXSID9061099
    • CHEBI:34660
    • RefChem:581232
    • DTXCID8047890
    • 212-142-2
    • cyclopropyl amine
    • MFCD00001301
    • EINECS 212-142-2
    • NSC 56127
    • UNII-8PR8XTH1X1
    • cyclopropyamine
    • cyclopropylamin
    • cylopropylamine
    • Cycloproplyamine
    • cyclopropyl amin
    • Cyclopropaneamine
    • Cyclopropylarnine
    • cyclopropyl-amine
    • N-cyclopropylamine
    • 3-cyclopropylamine
    • Cyclopropanamine-d5
    • cyclopropane, amino-
    • Cyclopropylamine, 98%
    • CYCLOPROPANE AMINE
    • Moxifloxacin Impurity 90
    • EC 212-142-2
    • SCHEMBL5547
    • SCHEMBL67264
    • SCHEMBL143894
    • SCHEMBL385475
    • SCHEMBL1077547
    • SCHEMBL10827887
    • SCHEMBL14760742
    • SCHEMBL27575045
    • HTJDQJBWANPRPF-UHFFFAOYSA-
    • BB_SC-07203
    • CS-D1450
    • NSC56127
    • STR00451
    • GEO-00889
    • MFCD28009728
    • STL168345
    • AKOS000119334
    • FC37736
    • PB47448
    • BP-10575
    • SY344664
    • DB-000670
    • NS00004424
    • EN300-21353
    • Aminocyclopropane; Cyclopropanamine; NSC 56127
    • Cyclopropylamine; Moxifloxacin Impurity cent(c)
    • F003712
    • Q1147604
    • InChI=1/C3H7N/c4-3-1-2-3/h3H,1-2,4H2
    • F2190-0503
    • 765-30-0

  • Applications

    Cyclopropylamine (CAS 765-30-0) is a versatile building block in organic synthesis. In pharmaceutical and medicinal chemistry, it serves as a precursor to cyclopropyl-containing amines and heterocyclic scaffolds, supporting the development of drug candidates and pharmacologically active compounds. In agrochemical research and development, it is used as an intermediate for the synthesis of cyclopropylamine-derived agroactives. In general synthetic chemistry, it is employed for amide formation, reductive amination, and other transformations that install a cyclopropylamino unit on aromatic or aliphatic substrates. In polymer and materials science, it can be used to functionalize surfaces or introduce primary-amine functionality into polymeric architectures, enabling further coupling. It may also serve as a building block for ligand and catalyst synthesis in research settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 132.51
    methanol 265.34
    isopropanol 60.2
    water 15.84
    ethyl acetate 19.67
    n-propanol 80.13
    acetone 62.12
    n-butanol 55.03
    acetonitrile 37.82
    DMF 101.72
    toluene 3.79
    isobutanol 41.15
    1,4-dioxane 38.6
    methyl acetate 27.62
    THF 95.67
    2-butanone 32.77
    n-pentanol 34.78
    sec-butanol 38.1
    n-hexane 3.11
    ethylene glycol 115.85
    NMP 84.78
    cyclohexane 3.91
    DMSO 115.39
    n-butyl acetate 30.14
    n-octanol 13.62
    chloroform 33.2
    n-propyl acetate 16.97
    acetic acid 203.54
    dichloromethane 21.22
    cyclohexanone 45.47
    propylene glycol 109.23
    isopropyl acetate 10.98
    DMAc 62.22
    2-ethoxyethanol 57.62
    isopentanol 27.97
    n-heptane 5.75
    ethyl formate 25.47
    1,2-dichloroethane 12.44
    n-hexanol 48.5
    2-methoxyethanol 111.14
    isobutyl acetate 11.76
    tetrachloromethane 10.27
    n-pentyl acetate 12.89
    transcutol 76.68
    n-heptanol 21.19
    ethylbenzene 2.07
    MIBK 10.65
    2-propoxyethanol 85.91
    tert-butanol 41.49
    MTBE 15.57
    2-butoxyethanol 44.59
    propionic acid 93.9
    o-xylene 3.36
    formic acid 145.81
    diethyl ether 15.59
    m-xylene 3.25
    p-xylene 3.51
    chlorobenzene 8.76
    dimethyl carbonate 12.47
    n-octane 1.53
    formamide 98.56
    cyclopentanone 78.48
    2-pentanone 21.94
    anisole 8.46
    cyclopentyl methyl ether 25.78
    gamma-butyrolactone 81.92
    1-methoxy-2-propanol 67.93
    pyridine 32.19
    3-pentanone 16.84
    furfural 67.52
    n-dodecane 1.02
    diethylene glycol 95.4
    diisopropyl ether 4.17
    tert-amyl alcohol 29.04
    acetylacetone 22.77
    n-hexadecane 1.05
    acetophenone 11.48
    methyl propionate 23.14
    isopentyl acetate 19.45
    trichloroethylene 30.29
    n-nonanol 11.97
    cyclohexanol 31.1
    benzyl alcohol 16.49
    2-ethylhexanol 20.52
    isooctanol 12.95
    dipropyl ether 20.2
    1,2-dichlorobenzene 7.87
    ethyl lactate 19.53
    propylene carbonate 38.17
    n-methylformamide 89.59
    2-pentanol 22.96
    n-pentane 3.07
    1-propoxy-2-propanol 59.37
    1-methoxy-2-propyl acetate 27.21
    2-(2-methoxypropoxy) propanol 26.68
    mesitylene 2.25
    ε-caprolactone 37.97
    p-cymene 4.79
    epichlorohydrin 42.75
    1,1,1-trichloroethane 12.5
    2-aminoethanol 128.82
    morpholine-4-carbaldehyde 64.89
    sulfolane 89.11
    2,2,4-trimethylpentane 1.79
    2-methyltetrahydrofuran 39.15
    n-hexyl acetate 14.03
    isooctane 1.29
    2-(2-butoxyethoxy)ethanol 40.82
    sec-butyl acetate 8.6
    tert-butyl acetate 10.61
    decalin 1.57
    glycerin 136.63
    diglyme 57.28
    acrylic acid 104.5
    isopropyl myristate 6.0
    n-butyric acid 72.34
    acetyl acetate 15.46
    di(2-ethylhexyl) phthalate 10.77
    ethyl propionate 12.56
    nitromethane 114.21
    1,2-diethoxyethane 18.42
    benzonitrile 16.08
    trioctyl phosphate 8.38
    1-bromopropane 7.6
    gamma-valerolactone 79.53
    n-decanol 9.1
    triethyl phosphate 9.98
    4-methyl-2-pentanol 10.82
    propionitrile 29.59
    vinylene carbonate 32.15
    1,1,2-trichlorotrifluoroethane 76.41
    DMS 11.92
    cumene 2.2
    2-octanol 9.4
    2-hexanone 17.98
    octyl acetate 9.8
    limonene 8.18
    1,2-dimethoxyethane 46.39
    ethyl orthosilicate 9.73
    tributyl phosphate 9.74
    diacetone alcohol 24.51
    N,N-dimethylaniline 6.85
    acrylonitrile 40.71
    aniline 17.15
    1,3-propanediol 101.36
    bromobenzene 5.7
    dibromomethane 13.44
    1,1,2,2-tetrachloroethane 26.63
    2-methyl-cyclohexyl acetate 14.65
    tetrabutyl urea 12.7
    diisobutyl methanol 9.77
    2-phenylethanol 20.89
    styrene 3.25
    dioctyl adipate 10.43
    dimethyl sulfate 21.11
    ethyl butyrate 17.66
    methyl lactate 34.92
    butyl lactate 19.36
    diethyl carbonate 11.48
    propanediol butyl ether 39.78
    triethyl orthoformate 15.06
    p-tert-butyltoluene 4.76
    methyl 4-tert-butylbenzoate 13.42
    morpholine 57.84
    tert-butylamine 22.74
    n-dodecanol 7.21
    dimethoxymethane 34.6
    ethylene carbonate 26.23
    cyrene 29.81
    2-ethoxyethyl acetate 16.59
    2-ethylhexyl acetate 15.56
    1,2,4-trichlorobenzene 10.92
    4-methylpyridine 19.48
    dibutyl ether 8.42
    2,6-dimethyl-4-heptanol 9.77
    DEF 27.3
    dimethyl isosorbide 33.75
    tetrachloroethylene 24.2
    eugenol 18.09
    triacetin 18.55
    span 80 32.54
    1,4-butanediol 50.72
    1,1-dichloroethane 12.36
    2-methyl-1-pentanol 19.06
    methyl formate 51.95
    2-methyl-1-butanol 29.22
    n-decane 1.58
    butyronitrile 25.26
    3,7-dimethyl-1-octanol 11.13
    1-chlorooctane 4.18
    1-chlorotetradecane 2.06
    n-nonane 1.56
    undecane 1.22
    tert-butylcyclohexane 1.6
    cyclooctane 1.42
    cyclopentanol 56.13
    tetrahydropyran 33.44
    tert-amyl methyl ether 11.8
    2,5,8-trioxanonane 42.26
    1-hexene 6.82
    2-isopropoxyethanol 33.52
    2,2,2-trifluoroethanol 61.06
    methyl butyrate 17.99

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction