Cyclopropane

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  • Identifiers

    CAS number
    75-19-4

    Molecular formula
    C3H6

    SMILES
    C1CC1

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Sweet 64.39%
    Musk 52.24%
    Dry 41.24%
    Amber 36.16%
    Woody 31.14%
    Animal 26.21%
    Waxy 21.06%
    Powdery 19.67%
    Clean 16.82%
    Cedar 16.56%

     

    Flavor
    Animal 28.65%
    Alkane 22.06%
    Ammoniacal 20.95%
    Shrimp 19.48%
    Alkaline 19.29%
    Rotten 18.04%
    Beet 17.79%
    Tar 17.59%
    Soil 17.48%
    Tarry 17.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    7.94 (neutral)

    Molecular weight
    42.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -197.3 °F (USCG, 1999)
    • -127.4 °C

    Boiling point

    • -27.2 °F at 760 mmHg (USCG, 1999)
    • -32.8 °C @ 760 MM HG

    Flash point

    • -76.17 ˚C est.

    Solubility expt.

    • OSTWALD SOLUBILITY COEFFICIENT (37 °C) IN H2O: 0.20; IN BLOOD: 0.42 AND IN OIL: 11.9
    • FREELY SOL IN ALCOHOL, ETHER; SOL IN FIXED OILS, CONCN SULFURIC ACID; 1 VOL DISSOLVES IN ABOUT 2.7 VOL OF WATER AT 15 °C
    • Soluble in benzene; very soluble in ethanol, ether.
    • 3.81X10+2 mg/l water at 35 °C

  • Synonyms

    • CYCLOPROPANE
    • Trimethylene
    • 75-19-4
    • ciclopropano
    • cyclopropanum
    • Zyklopropan
    • Trimethylene (cyclic)
    • Cyclopropan
    • HSDB 812
    • EINECS 200-847-8
    • RC 270
    • CHEBI:30365
    • UNII-99TB643425
    • 99TB643425
    • DTXSID4058786
    • CYCLOPROPANE (MART.)
    • CYCLOPROPANE [MART.]
    • Cyclopropane [INN]
    • CYCLOPROPANE (USP IMPURITY)
    • CYCLOPROPANE [USP IMPURITY]
    • Cyclopropanum [INN-Latin]
    • Ciclopropano [INN-Spanish]
    • Cyclopropane [USP:INN]
    • UN1027
    • Cyclopropnane
    • Cyclopropane [Anaesthetics, volatile]
    • MFCD00001268
    • Cyclopropane, >=99%
    • Cyclopropane (USP/INN)
    • CYCLOPROPANE [MI]
    • CYCLOPROPANE [HSDB]
    • CYCLOPROPANE [WHO-DD]
    • CYCLOPROPANE, LIQUEFIED
    • CHEMBL1796999
    • DTXCID1047734
    • CYCLOPROPANE, (LIQUEFIED)
    • DTXSID30178882
    • AKOS015915611
    • DB13984
    • UN 1027
    • Cyclopropane [UN1027] [Flammable gas]
    • InChI=1/C3H6/c1-2-3-1/h1-3H
    • NS00037687
    • D03627
    • Q80250
    • 200-847-8

  • Applications

    Cyclopropane (CAS 75-19-4) is primarily used as a reactive building block and intermediate in organic synthesis, enabling the preparation of cyclopropyl-containing compounds for pharmaceuticals and agrochemicals. It also serves as a precursor for cyclopropane-containing monomers and intermediates used in polymers and plastics, including materials used in coatings. In industrial manufacturing and research, cyclopropane is used to synthesize specialty intermediates and to explore new reaction pathways and functionalization strategies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 121.51
    methanol 95.98
    isopropanol 85.84
    water 0.02
    ethyl acetate 217.84
    n-propanol 110.84
    acetone 261.45
    n-butanol 117.96
    acetonitrile 183.02
    DMF 243.8
    toluene 140.73
    isobutanol 72.66
    1,4-dioxane 305.47
    methyl acetate 174.79
    THF 575.86
    2-butanone 208.9
    n-pentanol 74.21
    sec-butanol 84.07
    n-hexane 83.26
    ethylene glycol 24.94
    NMP 330.64
    cyclohexane 187.19
    DMSO 341.17
    n-butyl acetate 379.01
    n-octanol 65.38
    chloroform 597.38
    n-propyl acetate 171.9
    acetic acid 181.25
    dichloromethane 601.37
    cyclohexanone 468.17
    propylene glycol 31.34
    isopropyl acetate 122.78
    DMAc 124.84
    2-ethoxyethanol 85.29
    isopentanol 91.16
    n-heptane 152.32
    ethyl formate 140.23
    1,2-dichloroethane 377.73
    n-hexanol 138.93
    2-methoxyethanol 151.75
    isobutyl acetate 101.22
    tetrachloromethane 128.7
    n-pentyl acetate 139.33
    transcutol 393.28
    n-heptanol 57.06
    ethylbenzene 76.14
    MIBK 100.53
    2-propoxyethanol 161.27
    tert-butanol 91.64
    MTBE 105.08
    2-butoxyethanol 93.12
    propionic acid 141.32
    o-xylene 70.0
    formic acid 29.35
    diethyl ether 192.02
    m-xylene 71.51
    p-xylene 98.43
    chlorobenzene 266.04
    dimethyl carbonate 64.43
    n-octane 42.61
    formamide 48.06
    cyclopentanone 569.88
    2-pentanone 204.13
    anisole 118.94
    cyclopentyl methyl ether 261.44
    gamma-butyrolactone 578.6
    1-methoxy-2-propanol 111.11
    pyridine 443.58
    3-pentanone 159.82
    furfural 455.57
    n-dodecane 21.78
    diethylene glycol 96.33
    diisopropyl ether 62.58
    tert-amyl alcohol 79.52
    acetylacetone 219.21
    n-hexadecane 25.65
    acetophenone 128.15
    methyl propionate 149.72
    isopentyl acetate 247.76
    trichloroethylene 655.39
    n-nonanol 59.5
    cyclohexanol 148.53
    benzyl alcohol 89.95
    2-ethylhexanol 123.35
    isooctanol 49.13
    dipropyl ether 279.69
    1,2-dichlorobenzene 235.4
    ethyl lactate 56.98
    propylene carbonate 338.28
    n-methylformamide 122.33
    2-pentanol 82.56
    n-pentane 70.93
    1-propoxy-2-propanol 169.87
    1-methoxy-2-propyl acetate 185.17
    2-(2-methoxypropoxy) propanol 89.43
    mesitylene 48.23
    ε-caprolactone 337.4
    p-cymene 84.7
    epichlorohydrin 439.26
    1,1,1-trichloroethane 349.08
    2-aminoethanol 45.57
    morpholine-4-carbaldehyde 257.26
    sulfolane 596.69
    2,2,4-trimethylpentane 23.04
    2-methyltetrahydrofuran 383.93
    n-hexyl acetate 164.76
    isooctane 23.03
    2-(2-butoxyethoxy)ethanol 134.69
    sec-butyl acetate 96.87
    tert-butyl acetate 113.27
    decalin 48.0
    glycerin 48.44
    diglyme 279.59
    acrylic acid 135.65
    isopropyl myristate 79.0
    n-butyric acid 227.06
    acetyl acetate 149.68
    di(2-ethylhexyl) phthalate 52.26
    ethyl propionate 129.11
    nitromethane 289.84
    1,2-diethoxyethane 266.69
    benzonitrile 218.4
    trioctyl phosphate 46.78
    1-bromopropane 284.6
    gamma-valerolactone 449.56
    n-decanol 45.7
    triethyl phosphate 85.92
    4-methyl-2-pentanol 46.12
    propionitrile 179.14
    vinylene carbonate 269.69
    1,1,2-trichlorotrifluoroethane 278.9
    DMS 118.68
    cumene 47.52
    2-octanol 45.23
    2-hexanone 169.56
    octyl acetate 84.41
    limonene 144.28
    1,2-dimethoxyethane 222.12
    ethyl orthosilicate 81.23
    tributyl phosphate 70.66
    diacetone alcohol 111.25
    N,N-dimethylaniline 74.23
    acrylonitrile 234.24
    aniline 128.01
    1,3-propanediol 81.33
    bromobenzene 306.9
    dibromomethane 455.94
    1,1,2,2-tetrachloroethane 484.78
    2-methyl-cyclohexyl acetate 144.65
    tetrabutyl urea 88.41
    diisobutyl methanol 91.58
    2-phenylethanol 121.37
    styrene 115.48
    dioctyl adipate 105.59
    dimethyl sulfate 99.6
    ethyl butyrate 256.52
    methyl lactate 63.8
    butyl lactate 95.38
    diethyl carbonate 151.37
    propanediol butyl ether 75.2
    triethyl orthoformate 151.43
    p-tert-butyltoluene 76.27
    methyl 4-tert-butylbenzoate 88.1
    morpholine 305.55
    tert-butylamine 73.52
    n-dodecanol 38.71
    dimethoxymethane 148.54
    ethylene carbonate 220.98
    cyrene 87.71
    2-ethoxyethyl acetate 140.91
    2-ethylhexyl acetate 213.51
    1,2,4-trichlorobenzene 235.2
    4-methylpyridine 314.29
    dibutyl ether 200.87
    2,6-dimethyl-4-heptanol 91.58
    DEF 193.31
    dimethyl isosorbide 205.79
    tetrachloroethylene 351.82
    eugenol 85.89
    triacetin 127.59
    span 80 108.44
    1,4-butanediol 29.84
    1,1-dichloroethane 313.67
    2-methyl-1-pentanol 62.4
    methyl formate 107.71
    2-methyl-1-butanol 80.8
    n-decane 39.3
    butyronitrile 203.29
    3,7-dimethyl-1-octanol 83.71
    1-chlorooctane 94.58
    1-chlorotetradecane 41.3
    n-nonane 45.45
    undecane 27.78
    tert-butylcyclohexane 37.74
    cyclooctane 67.06
    cyclopentanol 174.1
    tetrahydropyran 390.67
    tert-amyl methyl ether 87.41
    2,5,8-trioxanonane 182.27
    1-hexene 161.01
    2-isopropoxyethanol 61.93
    2,2,2-trifluoroethanol 51.55
    methyl butyrate 185.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction