Cyclopentylamine

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  • Identifiers

    CAS number
    1003-03-8

    Molecular formula
    C5H11N

    SMILES
    C1CCC(C1)N

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 71.37%
    Cheesy 59.83%
    Animal 41.24%
    Ripe 40.78%
    Musty 27.08%
    Meaty 24.03%
    Roasted 22.13%
    Nutty 20.49%
    Popcorn 20.16%
    Oily 19.05%

     

    Flavor
    Ammoniacal 40.12%
    Animal 32.78%
    Sweet 27.97%
    Fishy 26.47%
    Alkaline 26.05%
    Egg 25.01%
    Amine 24.32%
    Shrimp 23.12%
    Beet 21.05%
    Bitter 20.83%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    7.16 (neutral)

    Molecular weight
    85.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    104°C

    Flash point

    • 22.73 ˚C est.

  • Synonyms

    • Cyclopentylamine
    • Cyclopentanamine
    • 1003-03-8
    • Aminocyclopentane
    • 4259VRY3GN
    • NSC-32389
    • DTXSID4061387
    • RefChem:581096
    • DTXCID2032506
    • 213-697-3
    • MFCD00001380
    • Amino cyclopentane
    • Cyclopentanamine; Aminocyclopentane; NSC 32389
    • EINECS 213-697-3
    • NSC 32389
    • CB 1689
    • BRN 0635706
    • UNII-4259VRY3GN
    • cylcopentylamine
    • cyclopentyl amine
    • cyclopentyl-amine
    • N-cyclopentylamine
    • cyclo-pentyl amine
    • 1-Cyclopentylamine
    • 1-amino cyclopentane
    • cyclopentane, amino-
    • Cyclopentylamine, 99%
    • EC 213-697-3
    • SCHEMBL9222
    • SCHEMBL50030
    • 4-12-00-00004 (Beilstein Handbook Reference)
    • SCHEMBL385141
    • SCHEMBL583260
    • SCHEMBL662112
    • SCHEMBL667205
    • SCHEMBL667760
    • SCHEMBL1797081
    • CHEMBL1171859
    • SCHEMBL21751842
    • SCHEMBL22405262
    • NISGSNTVMOOSJQ-UHFFFAOYSA-
    • BB_SC-12557
    • NSC32389
    • BBL036999
    • SBB040467
    • STL196759
    • AKOS000119393
    • FC35865
    • BP-11379
    • NS00020246
    • ST45255393
    • EN300-20348
    • F049405
    • Q8457765
    • F2190-0380
    • InChI=1/C5H11N/c6-5-3-1-2-4-5/h5H,1-4,6H2
    • 1003-03-8

  • Applications

    Cyclopentylamine (CAS 1003-03-8) is primarily used as an organic building block in chemical synthesis. It serves as a versatile intermediate for the preparation of cyclopentyl-containing amines, amides and related derivatives for pharmaceuticals and agrochemicals, as well as for general synthetic routes such as acylation and reductive amination to access drug-like molecules. It is commonly used as a precursor in medicinal chemistry and process development, supporting library generation and scale-up. In industry, it can function as a reactive amine component in polymer and coating formulations, contributing to curing or crosslinking reactions in epoxy and polyurethane systems. These applications are pursued under appropriate regulatory controls and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 763.54
    methanol 1131.23
    isopropanol 451.67
    water 17.76
    ethyl acetate 363.83
    n-propanol 601.98
    acetone 485.88
    n-butanol 613.72
    acetonitrile 366.76
    DMF 443.3
    toluene 76.96
    isobutanol 326.91
    1,4-dioxane 323.35
    methyl acetate 297.69
    THF 944.06
    2-butanone 338.35
    n-pentanol 297.0
    sec-butanol 334.64
    n-hexane 38.04
    ethylene glycol 252.32
    NMP 409.41
    cyclohexane 43.31
    DMSO 428.45
    n-butyl acetate 467.22
    n-octanol 118.08
    chloroform 1042.63
    n-propyl acetate 194.87
    acetic acid 1039.77
    dichloromethane 534.64
    cyclohexanone 425.72
    propylene glycol 352.39
    isopropyl acetate 218.02
    DMAc 300.03
    2-ethoxyethanol 345.34
    isopentanol 354.15
    n-heptane 66.43
    ethyl formate 399.94
    1,2-dichloroethane 238.85
    n-hexanol 472.18
    2-methoxyethanol 726.78
    isobutyl acetate 115.06
    tetrachloromethane 225.94
    n-pentyl acetate 180.13
    transcutol 538.25
    n-heptanol 203.66
    ethylbenzene 26.68
    MIBK 144.65
    2-propoxyethanol 621.18
    tert-butanol 382.91
    MTBE 179.07
    2-butoxyethanol 375.29
    propionic acid 668.89
    o-xylene 41.83
    formic acid 497.73
    diethyl ether 236.23
    m-xylene 51.97
    p-xylene 41.59
    chlorobenzene 176.24
    dimethyl carbonate 104.42
    n-octane 17.36
    formamide 430.63
    cyclopentanone 710.75
    2-pentanone 321.14
    anisole 77.88
    cyclopentyl methyl ether 295.8
    gamma-butyrolactone 869.9
    1-methoxy-2-propanol 493.48
    pyridine 388.15
    3-pentanone 195.46
    furfural 666.01
    n-dodecane 9.98
    diethylene glycol 400.37
    diisopropyl ether 61.59
    tert-amyl alcohol 258.76
    acetylacetone 260.47
    n-hexadecane 10.37
    acetophenone 85.54
    methyl propionate 266.55
    isopentyl acetate 272.05
    trichloroethylene 564.49
    n-nonanol 103.12
    cyclohexanol 258.68
    benzyl alcohol 113.43
    2-ethylhexanol 229.27
    isooctanol 128.82
    dipropyl ether 253.67
    1,2-dichlorobenzene 132.04
    ethyl lactate 129.39
    propylene carbonate 511.35
    n-methylformamide 549.12
    2-pentanol 306.99
    n-pentane 51.21
    1-propoxy-2-propanol 541.63
    1-methoxy-2-propyl acetate 283.2
    2-(2-methoxypropoxy) propanol 132.13
    mesitylene 29.55
    ε-caprolactone 402.16
    p-cymene 46.72
    epichlorohydrin 532.38
    1,1,1-trichloroethane 308.18
    2-aminoethanol 483.18
    morpholine-4-carbaldehyde 361.5
    sulfolane 550.94
    2,2,4-trimethylpentane 20.42
    2-methyltetrahydrofuran 449.95
    n-hexyl acetate 156.07
    isooctane 16.23
    2-(2-butoxyethoxy)ethanol 234.69
    sec-butyl acetate 107.52
    tert-butyl acetate 162.19
    decalin 13.27
    glycerin 439.72
    diglyme 385.74
    acrylic acid 572.03
    isopropyl myristate 52.73
    n-butyric acid 1000.39
    acetyl acetate 228.94
    di(2-ethylhexyl) phthalate 57.14
    ethyl propionate 152.21
    nitromethane 821.09
    1,2-diethoxyethane 198.39
    benzonitrile 188.29
    trioctyl phosphate 52.39
    1-bromopropane 190.59
    gamma-valerolactone 652.34
    n-decanol 74.52
    triethyl phosphate 78.05
    4-methyl-2-pentanol 138.71
    propionitrile 378.89
    vinylene carbonate 388.33
    1,1,2-trichlorotrifluoroethane 554.18
    DMS 86.12
    cumene 22.42
    2-octanol 95.64
    2-hexanone 183.65
    octyl acetate 80.6
    limonene 81.17
    1,2-dimethoxyethane 326.74
    ethyl orthosilicate 79.36
    tributyl phosphate 67.82
    diacetone alcohol 224.39
    N,N-dimethylaniline 49.48
    acrylonitrile 435.79
    aniline 233.05
    1,3-propanediol 548.11
    bromobenzene 138.39
    dibromomethane 378.43
    1,1,2,2-tetrachloroethane 474.31
    2-methyl-cyclohexyl acetate 119.25
    tetrabutyl urea 75.42
    diisobutyl methanol 95.29
    2-phenylethanol 159.82
    styrene 43.19
    dioctyl adipate 67.8
    dimethyl sulfate 125.1
    ethyl butyrate 282.16
    methyl lactate 220.45
    butyl lactate 179.61
    diethyl carbonate 142.28
    propanediol butyl ether 223.97
    triethyl orthoformate 177.44
    p-tert-butyltoluene 45.65
    methyl 4-tert-butylbenzoate 97.95
    morpholine 471.28
    tert-butylamine 251.5
    n-dodecanol 55.84
    dimethoxymethane 263.07
    ethylene carbonate 349.37
    cyrene 108.67
    2-ethoxyethyl acetate 178.08
    2-ethylhexyl acetate 207.05
    1,2,4-trichlorobenzene 144.81
    4-methylpyridine 281.52
    dibutyl ether 124.97
    2,6-dimethyl-4-heptanol 95.29
    DEF 288.79
    dimethyl isosorbide 201.79
    tetrachloroethylene 389.24
    eugenol 108.84
    triacetin 130.77
    span 80 174.02
    1,4-butanediol 187.33
    1,1-dichloroethane 328.37
    2-methyl-1-pentanol 168.6
    methyl formate 363.16
    2-methyl-1-butanol 311.74
    n-decane 17.76
    butyronitrile 451.76
    3,7-dimethyl-1-octanol 105.59
    1-chlorooctane 54.58
    1-chlorotetradecane 20.45
    n-nonane 17.59
    undecane 12.76
    tert-butylcyclohexane 14.5
    cyclooctane 15.4
    cyclopentanol 376.98
    tetrahydropyran 384.36
    tert-amyl methyl ether 125.64
    2,5,8-trioxanonane 220.43
    1-hexene 103.73
    2-isopropoxyethanol 188.4
    2,2,2-trifluoroethanol 376.45
    methyl butyrate 224.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction