Cyclopentadecanone

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  • Identifiers

    CAS number
    502-72-7

    Molecular formula
    C15H28O

    SMILES
    C1CCCCCCCC(=O)CCCCCC1

  • Odor profile

    Musk 91.33%
    Animal 69.77%
    Powdery 61.36%
    Amber 53.4%
    Dry 45.1%
    Natural 39.88%
    Woody 39.33%
    Clean 38.1%
    Sweet 36.33%
    Floral 32.1%

    Scent© AI

  • Properties

    XLogP3-AA
    5.8

    Molecular weight
    224.38 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    323°C

    Flash point est.
    143.31 ˚C

  • Synonyms

    • CYCLOPENTADECANONE
    • 502-72-7
    • Exaltone
    • Normuscone
    • Normuscon
    • EINECS 207-951-2
    • UNII-T09G246LET
    • MFCD00001266
    • NSC 63900
    • BRN 1618444
    • T09G246LET
    • DTXSID2047141
    • AI3-37209
    • NSC-63900
    • DTXCID0027141
    • CPE-218
    • 4-07-00-00113 (Beilstein Handbook Reference)
    • Exalton
    • cyclopentadecanon
    • cylcopentadecanone
    • NSC63900
    • Cyclopentadecanone, 98%
    • NCIOpen2_002840
    • SCHEMBL111707
    • WLN: L-15 VTJ
    • CHEMBL3188770
    • CYCLOPENTADECANONE [INCI]
    • Tox21_302465
    • AKOS015964063
    • AC-9863
    • NCGC00256661-01
    • AS-57009
    • CAS-502-72-7
    • SY048774
    • DB-051749
    • C1422
    • CS-0204727
    • NS00012174
    • D78409
    • Q27289500
    • 207-951-2
    • Silvanone Supra

  • Applications

    Cyclopentadecanone (CAS 502-72-7) is a 15-membered macrocyclic ketone with a soft, warm, clean musk odor, widely used in fine fragrances, cosmetics, and home/personal care as both a musk note and a fixative to deliver long-lasting substantivity and diffusion on skin, hair, and fabrics; thanks to its low volatility and good stability to alkali, light, and oxidation, it performs well in detergents, fabric softeners, cleaners, and sprays; in fragrance technology it is also microencapsulated or converted to acetals/ketals for controlled release, and employed as a reference in GC-MS, odor-threshold, and sensory studies; in product development it often substitutes for animal-derived musks (e.g., natural muscone), offering better biodegradability than many polycyclic musks and a favorable safety profile when used within IFRA/REACH guidance; in synthesis and perfumery chemistry it serves as a building block for musk derivatives (e.g., 3‑methylcyclopentadecanone), pro-fragrances, and calibration standards; additionally, at trace levels it may be used as a flavor modifier imparting ambrette/musky nuances where permitted by local regulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 306.59
    methanol 206.81
    isopropanol 407.36
    water 0.03
    ethyl acetate 1363.07
    n-propanol 431.46
    acetone 1158.81
    n-butanol 454.75
    acetonitrile 565.01
    DMF 1557.81
    toluene 883.78
    isobutanol 408.26
    1,4-dioxane 1497.53
    methyl acetate 809.31
    THF 2869.3
    2-butanone 1138.9
    n-pentanol 303.05
    sec-butanol 433.73
    n-hexane 375.28
    ethylene glycol 32.87
    NMP 1838.37
    cyclohexane 866.03
    DMSO 1066.18
    n-butyl acetate 1325.17
    n-octanol 273.56
    chloroform 3762.25
    n-propyl acetate 1058.89
    acetic acid 440.65
    dichloromethane 3112.58
    cyclohexanone 2583.22
    propylene glycol 98.77
    isopropyl acetate 1178.15
    DMAc 1199.88
    2-ethoxyethanol 420.85
    isopentanol 518.13
    n-heptane 336.15
    ethyl formate 588.71
    1,2-dichloroethane 2135.55
    n-hexanol 421.21
    2-methoxyethanol 684.03
    isobutyl acetate 754.08
    tetrachloromethane 749.19
    n-pentyl acetate 1058.84
    transcutol 2366.89
    n-heptanol 261.55
    ethylbenzene 476.08
    MIBK 901.94
    2-propoxyethanol 659.15
    tert-butanol 627.8
    MTBE 994.89
    2-butoxyethanol 554.77
    propionic acid 543.19
    o-xylene 565.8
    formic acid 69.36
    diethyl ether 1108.87
    m-xylene 578.87
    p-xylene 638.55
    chlorobenzene 1275.55
    dimethyl carbonate 364.21
    n-octane 107.63
    formamide 150.17
    cyclopentanone 2756.32
    2-pentanone 1251.08
    anisole 766.83
    cyclopentyl methyl ether 1736.18
    gamma-butyrolactone 2602.93
    1-methoxy-2-propanol 710.93
    pyridine 1928.46
    3-pentanone 1091.82
    furfural 1875.49
    n-dodecane 57.68
    diethylene glycol 293.34
    diisopropyl ether 563.87
    tert-amyl alcohol 569.74
    acetylacetone 1450.38
    n-hexadecane 72.05
    acetophenone 775.96
    methyl propionate 919.25
    isopentyl acetate 1185.71
    trichloroethylene 3660.22
    n-nonanol 277.65
    cyclohexanol 881.96
    benzyl alcohol 451.18
    2-ethylhexanol 449.05
    isooctanol 284.24
    dipropyl ether 1172.69
    1,2-dichlorobenzene 1277.79
    ethyl lactate 333.91
    propylene carbonate 1480.86
    n-methylformamide 498.79
    2-pentanol 452.03
    n-pentane 246.87
    1-propoxy-2-propanol 742.68
    1-methoxy-2-propyl acetate 1039.69
    2-(2-methoxypropoxy) propanol 531.03
    mesitylene 437.22
    ε-caprolactone 1906.21
    p-cymene 374.96
    epichlorohydrin 2303.33
    1,1,1-trichloroethane 2375.64
    2-aminoethanol 124.54
    morpholine-4-carbaldehyde 1526.16
    sulfolane 2798.69
    2,2,4-trimethylpentane 122.23
    2-methyltetrahydrofuran 2045.14
    n-hexyl acetate 1089.14
    isooctane 105.5
    2-(2-butoxyethoxy)ethanol 770.98
    sec-butyl acetate 825.46
    tert-butyl acetate 1226.8
    decalin 300.74
    glycerin 154.97
    diglyme 1632.21
    acrylic acid 403.39
    isopropyl myristate 450.44
    n-butyric acid 1108.05
    acetyl acetate 927.35
    di(2-ethylhexyl) phthalate 295.7
    ethyl propionate 959.6
    nitromethane 977.67
    1,2-diethoxyethane 1345.75
    benzonitrile 873.41
    trioctyl phosphate 226.64
    1-bromopropane 1397.5
    gamma-valerolactone 2671.91
    n-decanol 194.14
    triethyl phosphate 488.45
    4-methyl-2-pentanol 330.59
    propionitrile 762.25
    vinylene carbonate 1161.48
    1,1,2-trichlorotrifluoroethane 1404.92
    DMS 765.41
    cumene 326.82
    2-octanol 240.68
    2-hexanone 881.46
    octyl acetate 499.99
    limonene 635.6
    1,2-dimethoxyethane 1239.02
    ethyl orthosilicate 476.35
    tributyl phosphate 340.08
    diacetone alcohol 838.19
    N,N-dimethylaniline 513.03
    acrylonitrile 826.77
    aniline 801.02
    1,3-propanediol 286.42
    bromobenzene 1597.28
    dibromomethane 2207.26
    1,1,2,2-tetrachloroethane 3325.5
    2-methyl-cyclohexyl acetate 767.11
    tetrabutyl urea 430.71
    diisobutyl methanol 375.14
    2-phenylethanol 452.43
    styrene 632.67
    dioctyl adipate 607.41
    dimethyl sulfate 620.89
    ethyl butyrate 1115.43
    methyl lactate 361.54
    butyl lactate 606.26
    diethyl carbonate 663.18
    propanediol butyl ether 421.34
    triethyl orthoformate 813.54
    p-tert-butyltoluene 362.5
    methyl 4-tert-butylbenzoate 721.4
    morpholine 1705.69
    tert-butylamine 515.44
    n-dodecanol 151.89
    dimethoxymethane 889.2
    ethylene carbonate 1131.54
    cyrene 457.35
    2-ethoxyethyl acetate 1022.14
    2-ethylhexyl acetate 997.5
    1,2,4-trichlorobenzene 1370.46
    4-methylpyridine 1676.2
    dibutyl ether 991.52
    2,6-dimethyl-4-heptanol 375.14
    DEF 1491.09
    dimethyl isosorbide 1054.76
    tetrachloroethylene 2252.61
    eugenol 517.73
    triacetin 969.73
    span 80 583.9
    1,4-butanediol 96.96
    1,1-dichloroethane 2063.39
    2-methyl-1-pentanol 343.61
    methyl formate 362.42
    2-methyl-1-butanol 457.94
    n-decane 120.57
    butyronitrile 861.07
    3,7-dimethyl-1-octanol 387.06
    1-chlorooctane 438.81
    1-chlorotetradecane 162.89
    n-nonane 128.59
    undecane 77.78
    tert-butylcyclohexane 226.27
    cyclooctane 302.97
    cyclopentanol 872.43
    tetrahydropyran 2138.64
    tert-amyl methyl ether 849.89
    2,5,8-trioxanonane 957.41
    1-hexene 692.99
    2-isopropoxyethanol 409.27
    2,2,2-trifluoroethanol 211.36
    methyl butyrate 1266.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Civet secretion (China) 68916-26-7 Viverra zibetha L., fam. Viverridae 0.85%
Angelica root (Brazil) 1b CO2 extract 8015-64-3 Angelica archangelica L., fam. Apiaceae (Umbelliferae) 1.0%