Cyclopentadecanone, 2-methyl-

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  • Identifiers

    CAS number
    52914-66-6

    Molecular formula
    C16H30O

    SMILES
    CC1CCCCCCCCCCCCCC1=O

  • Odor profile

    Musk 83.17%
    Animal 63.58%
    Powdery 51.23%
    Amber 51.07%
    Woody 47.45%
    Dry 42.63%
    Natural 41.9%
    Clean 35.56%
    Tobacco 33.93%
    Mint 31.68%

    Scent© AI

  • Properties

    XLogP3-AA
    6.4

    pKa est.
    10.13 (weak base)

    Molecular weight
    238.41 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    325°C

    Flash point est.
    138.95 ˚C

  • Synonyms

    • 2-Methylcyclopentadecanone
    • Cyclopentadecanone, 2-methyl-
    • 52914-66-6
    • 2-methyl-cyclopentadecanone
    • SCHEMBL2160972
    • DTXSID10337571
    • XJDBBMWXVYBUTB-UHFFFAOYSA-N
    • AKOS024264071

  • Applications

    Cyclopentadecanone, 2-methyl- (CAS 52914-66-6) is a macrocyclic ketone with a warm, sweet, slightly animalic musk odor used primarily in perfumery as a premium musk ingredient and fixative for fine fragrances, cosmetics, and home care products (detergents, fabric softeners, air care, scented candles), providing long-lasting substantivity, balanced diffusion, and roundness to accords; additionally, owing to the stability and low vapor pressure of macrocyclic ketones, it is employed in controlled-release fragrance systems (microencapsulation and polymer carriers), as a reference/marker in GC–MS analysis of macrocyclic musks, in sensory studies and structure–odor modeling, and as a scaffold for synthesizing and screening new musk derivatives aligned with sustainability and improved biodegradability compared with polycyclic musks.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 822.67
    methanol 450.65
    isopropanol 1120.14
    water 0.04
    ethyl acetate 3695.43
    n-propanol 1055.66
    acetone 3153.49
    n-butanol 1217.51
    acetonitrile 1570.2
    DMF 3020.38
    toluene 2049.06
    isobutanol 1013.52
    1,4-dioxane 3354.94
    methyl acetate 2035.01
    THF 5352.29
    2-butanone 2821.41
    n-pentanol 718.88
    sec-butanol 1066.57
    n-hexane 806.83
    ethylene glycol 47.07
    NMP 2919.7
    cyclohexane 1731.31
    DMSO 1654.33
    n-butyl acetate 3704.35
    n-octanol 627.13
    chloroform 6918.42
    n-propyl acetate 2584.86
    acetic acid 838.53
    dichloromethane 6049.36
    cyclohexanone 5837.26
    propylene glycol 146.27
    isopropyl acetate 3105.09
    DMAc 2283.38
    2-ethoxyethanol 887.57
    isopentanol 1396.87
    n-heptane 627.56
    ethyl formate 1453.57
    1,2-dichloroethane 4395.86
    n-hexanol 1002.8
    2-methoxyethanol 1382.33
    isobutyl acetate 1707.65
    tetrachloromethane 1530.06
    n-pentyl acetate 2641.65
    transcutol 5119.41
    n-heptanol 618.41
    ethylbenzene 1079.95
    MIBK 2186.47
    2-propoxyethanol 1475.92
    tert-butanol 1657.38
    MTBE 2912.35
    2-butoxyethanol 1216.19
    propionic acid 1010.3
    o-xylene 1268.0
    formic acid 99.47
    diethyl ether 3161.22
    m-xylene 1339.95
    p-xylene 1449.65
    chlorobenzene 2850.25
    dimethyl carbonate 722.52
    n-octane 224.99
    formamide 241.93
    cyclopentanone 5096.41
    2-pentanone 3248.18
    anisole 1690.41
    cyclopentyl methyl ether 3345.21
    gamma-butyrolactone 4521.83
    1-methoxy-2-propanol 1452.61
    pyridine 4133.3
    3-pentanone 2426.15
    furfural 3454.44
    n-dodecane 111.05
    diethylene glycol 506.46
    diisopropyl ether 1419.28
    tert-amyl alcohol 1359.0
    acetylacetone 3213.09
    n-hexadecane 140.74
    acetophenone 1564.88
    methyl propionate 2087.64
    isopentyl acetate 3186.29
    trichloroethylene 7377.39
    n-nonanol 600.73
    cyclohexanol 2041.89
    benzyl alcohol 952.18
    2-ethylhexanol 1040.01
    isooctanol 676.16
    dipropyl ether 2550.11
    1,2-dichlorobenzene 2718.69
    ethyl lactate 625.6
    propylene carbonate 2782.57
    n-methylformamide 977.87
    2-pentanol 1195.89
    n-pentane 574.11
    1-propoxy-2-propanol 1661.67
    1-methoxy-2-propyl acetate 2508.78
    2-(2-methoxypropoxy) propanol 1047.66
    mesitylene 994.64
    ε-caprolactone 4283.36
    p-cymene 797.13
    epichlorohydrin 4560.59
    1,1,1-trichloroethane 5082.77
    2-aminoethanol 208.19
    morpholine-4-carbaldehyde 2787.92
    sulfolane 4167.85
    2,2,4-trimethylpentane 263.0
    2-methyltetrahydrofuran 4223.52
    n-hexyl acetate 2585.69
    isooctane 242.07
    2-(2-butoxyethoxy)ethanol 1500.36
    sec-butyl acetate 2013.21
    tert-butyl acetate 3079.72
    decalin 565.88
    glycerin 213.88
    diglyme 3387.32
    acrylic acid 650.11
    isopropyl myristate 943.56
    n-butyric acid 2561.5
    acetyl acetate 2063.36
    di(2-ethylhexyl) phthalate 577.5
    ethyl propionate 2239.57
    nitromethane 1870.03
    1,2-diethoxyethane 3342.44
    benzonitrile 2068.33
    trioctyl phosphate 455.3
    1-bromopropane 2998.42
    gamma-valerolactone 5256.73
    n-decanol 408.04
    triethyl phosphate 891.03
    4-methyl-2-pentanol 839.99
    propionitrile 1909.19
    vinylene carbonate 2190.57
    1,1,2-trichlorotrifluoroethane 2303.68
    DMS 1555.04
    cumene 699.89
    2-octanol 600.64
    2-hexanone 2033.03
    octyl acetate 1050.8
    limonene 1330.35
    1,2-dimethoxyethane 2703.28
    ethyl orthosilicate 893.68
    tributyl phosphate 658.23
    diacetone alcohol 1856.21
    N,N-dimethylaniline 1046.13
    acrylonitrile 1824.91
    aniline 1849.74
    1,3-propanediol 575.28
    bromobenzene 3509.02
    dibromomethane 4337.78
    1,1,2,2-tetrachloroethane 6362.53
    2-methyl-cyclohexyl acetate 1511.32
    tetrabutyl urea 812.8
    diisobutyl methanol 822.19
    2-phenylethanol 988.26
    styrene 1455.15
    dioctyl adipate 1188.07
    dimethyl sulfate 1065.73
    ethyl butyrate 2657.09
    methyl lactate 634.29
    butyl lactate 1285.69
    diethyl carbonate 1410.67
    propanediol butyl ether 797.1
    triethyl orthoformate 1731.6
    p-tert-butyltoluene 748.26
    methyl 4-tert-butylbenzoate 1415.9
    morpholine 3767.42
    tert-butylamine 1303.66
    n-dodecanol 312.66
    dimethoxymethane 1936.17
    ethylene carbonate 2290.46
    cyrene 746.84
    2-ethoxyethyl acetate 2455.86
    2-ethylhexyl acetate 2560.59
    1,2,4-trichlorobenzene 2805.65
    4-methylpyridine 4136.91
    dibutyl ether 2248.47
    2,6-dimethyl-4-heptanol 822.19
    DEF 3523.01
    dimethyl isosorbide 1909.91
    tetrachloroethylene 4142.14
    eugenol 1023.74
    triacetin 1887.91
    span 80 1065.24
    1,4-butanediol 183.86
    1,1-dichloroethane 4642.66
    2-methyl-1-pentanol 801.3
    methyl formate 673.46
    2-methyl-1-butanol 1160.85
    n-decane 242.86
    butyronitrile 2340.22
    3,7-dimethyl-1-octanol 893.35
    1-chlorooctane 951.92
    1-chlorotetradecane 327.23
    n-nonane 260.31
    undecane 153.11
    tert-butylcyclohexane 453.77
    cyclooctane 575.61
    cyclopentanol 1703.67
    tetrahydropyran 4912.19
    tert-amyl methyl ether 2079.29
    2,5,8-trioxanonane 1790.13
    1-hexene 1587.88
    2-isopropoxyethanol 838.52
    2,2,2-trifluoroethanol 337.8
    methyl butyrate 2955.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Civet secretion (China) 68916-26-7 Viverra zibetha L., fam. Viverridae 0.08%