Cyclooctane

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  • Identifiers

    CAS number
    292-64-8

    Molecular formula
    C8H16

    SMILES
    C1CCCCCCC1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 64.39%
    Musk 52.24%
    Dry 41.24%
    Amber 36.16%
    Woody 31.14%
    Animal 26.21%
    Waxy 21.06%
    Powdery 19.67%
    Clean 16.82%
    Cedar 16.56%

     

    Flavor
    Animal 28.65%
    Alkane 22.06%
    Ammoniacal 20.95%
    Shrimp 19.48%
    Alkaline 19.29%
    Rotten 18.04%
    Beet 17.79%
    Tar 17.59%
    Soil 17.48%
    Tarry 17.48%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    4.5

    pKa est.
    9.94 (weak base)

    Molecular weight
    112.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    142°C

    Flash point

    • 31.07 ˚C est.

  • Synonyms

    • CYCLOOCTANE
    • 292-64-8
    • Octamethylene
    • Cyclooctan
    • KKZ3KBS654
    • 1,2-CYCLOOCTANE
    • EINECS 206-031-8
    • NSC 72426
    • NSC-72426
    • AI3-26694
    • DTXSID9075377
    • UNII-KKZ3KBS654
    • MFCD00004162
    • Cyclooctane, >=99%
    • Cambridge id 6337558
    • Cambridge id 6511221
    • Cambridge id 6544558
    • CHEMBL452651
    • Cyclooctane, analytical standard
    • DTXCID4037952
    • CHEBI:229287
    • NSC72426
    • AKOS015916198
    • Cyclooctane, purum, >=99.0% (GC)
    • LS-13495
    • DB-047557
    • NS00021995
    • D89258
    • Q86495
    • InChI=1/C8H16/c1-2-4-6-8-7-5-3-1/h1-8H
    • 206-031-8

  • Applications

    Cyclooctane, CAS number: 292-64-8, is primarily used as a nonpolar solvent and reaction medium in organic synthesis; its low reactivity and nonpolar character make it suitable for dissolving nonpolar substrates and serving as a processing solvent in various steps. It can also function as a starting material or intermediate for synthesizing cyclooctyl derivatives used in specialty applications in the pharmaceutical and agrochemical sectors. In industrial coatings, inks, and adhesives, cyclooctane acts as a diluent/solvent to adjust viscosity and aid processing. In the plastics and polymer sector, it may be used as a solvent or processing aid in resin formulations. It can also be used as a laboratory solvent or reference standard in chemical research, with usage subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 281.25
    methanol 210.45
    isopropanol 255.34
    water 0.03
    ethyl acetate 1068.38
    n-propanol 345.92
    acetone 756.62
    n-butanol 437.57
    acetonitrile 432.59
    DMF 493.93
    toluene 942.24
    isobutanol 274.48
    1,4-dioxane 1458.82
    methyl acetate 580.71
    THF 3173.33
    2-butanone 805.13
    n-pentanol 291.09
    sec-butanol 351.03
    n-hexane 977.79
    ethylene glycol 25.27
    NMP 993.43
    cyclohexane 1812.57
    DMSO 667.36
    n-butyl acetate 2359.13
    n-octanol 265.07
    chloroform 2746.29
    n-propyl acetate 808.95
    acetic acid 293.84
    dichloromethane 2371.77
    cyclohexanone 1782.68
    propylene glycol 50.9
    isopropyl acetate 762.91
    DMAc 382.66
    2-ethoxyethanol 289.23
    isopentanol 388.05
    n-heptane 1885.14
    ethyl formate 418.63
    1,2-dichloroethane 1519.97
    n-hexanol 773.71
    2-methoxyethanol 418.76
    isobutyl acetate 534.62
    tetrachloromethane 833.38
    n-pentyl acetate 785.5
    transcutol 1389.28
    n-heptanol 298.06
    ethylbenzene 422.74
    MIBK 560.49
    2-propoxyethanol 756.15
    tert-butanol 414.24
    MTBE 837.48
    2-butoxyethanol 392.54
    propionic acid 325.84
    o-xylene 480.18
    formic acid 33.39
    diethyl ether 1606.09
    m-xylene 474.21
    p-xylene 495.21
    chlorobenzene 1025.44
    dimethyl carbonate 163.26
    n-octane 413.06
    formamide 59.24
    cyclopentanone 1888.86
    2-pentanone 906.15
    anisole 506.37
    cyclopentyl methyl ether 1789.95
    gamma-butyrolactone 1679.68
    1-methoxy-2-propanol 377.23
    pyridine 1517.6
    3-pentanone 770.23
    furfural 1011.05
    n-dodecane 158.62
    diethylene glycol 247.09
    diisopropyl ether 607.13
    tert-amyl alcohol 431.67
    acetylacetone 740.96
    n-hexadecane 187.28
    acetophenone 402.21
    methyl propionate 566.31
    isopentyl acetate 1518.71
    trichloroethylene 2227.05
    n-nonanol 273.01
    cyclohexanol 693.64
    benzyl alcohol 256.18
    2-ethylhexanol 870.91
    isooctanol 281.58
    dipropyl ether 2982.11
    1,2-dichlorobenzene 853.88
    ethyl lactate 177.76
    propylene carbonate 978.35
    n-methylformamide 206.57
    2-pentanol 407.39
    n-pentane 727.4
    1-propoxy-2-propanol 955.71
    1-methoxy-2-propyl acetate 1006.07
    2-(2-methoxypropoxy) propanol 331.74
    mesitylene 339.39
    ε-caprolactone 1396.04
    p-cymene 559.54
    epichlorohydrin 1520.24
    1,1,1-trichloroethane 1814.3
    2-aminoethanol 78.64
    morpholine-4-carbaldehyde 765.11
    sulfolane 1565.69
    2,2,4-trimethylpentane 216.03
    2-methyltetrahydrofuran 2542.23
    n-hexyl acetate 784.64
    isooctane 199.46
    2-(2-butoxyethoxy)ethanol 492.42
    sec-butyl acetate 567.04
    tert-butyl acetate 811.79
    decalin 456.44
    glycerin 71.88
    diglyme 1069.04
    acrylic acid 224.98
    isopropyl myristate 417.23
    n-butyric acid 713.16
    acetyl acetate 631.69
    di(2-ethylhexyl) phthalate 199.26
    ethyl propionate 693.91
    nitromethane 481.52
    1,2-diethoxyethane 1721.26
    benzonitrile 561.04
    trioctyl phosphate 188.24
    1-bromopropane 1843.96
    gamma-valerolactone 1439.14
    n-decanol 214.81
    triethyl phosphate 439.58
    4-methyl-2-pentanol 244.76
    propionitrile 630.0
    vinylene carbonate 686.18
    1,1,2-trichlorotrifluoroethane 682.31
    DMS 381.72
    cumene 266.23
    2-octanol 236.55
    2-hexanone 786.17
    octyl acetate 406.83
    limonene 1196.75
    1,2-dimethoxyethane 935.28
    ethyl orthosilicate 477.81
    tributyl phosphate 296.72
    diacetone alcohol 450.74
    N,N-dimethylaniline 328.91
    acrylonitrile 527.81
    aniline 556.12
    1,3-propanediol 154.74
    bromobenzene 1303.59
    dibromomethane 2122.89
    1,1,2,2-tetrachloroethane 1858.15
    2-methyl-cyclohexyl acetate 783.54
    tetrabutyl urea 355.46
    diisobutyl methanol 652.27
    2-phenylethanol 434.34
    styrene 550.51
    dioctyl adipate 437.0
    dimethyl sulfate 224.43
    ethyl butyrate 1752.45
    methyl lactate 144.64
    butyl lactate 332.2
    diethyl carbonate 764.49
    propanediol butyl ether 204.63
    triethyl orthoformate 1063.47
    p-tert-butyltoluene 537.06
    methyl 4-tert-butylbenzoate 365.41
    morpholine 1424.23
    tert-butylamine 435.52
    n-dodecanol 189.63
    dimethoxymethane 557.22
    ethylene carbonate 690.31
    cyrene 263.02
    2-ethoxyethyl acetate 663.91
    2-ethylhexyl acetate 1413.03
    1,2,4-trichlorobenzene 848.67
    4-methylpyridine 1209.18
    dibutyl ether 1484.61
    2,6-dimethyl-4-heptanol 652.27
    DEF 856.77
    dimethyl isosorbide 829.57
    tetrachloroethylene 1391.51
    eugenol 271.4
    triacetin 467.84
    span 80 409.28
    1,4-butanediol 52.38
    1,1-dichloroethane 1469.09
    2-methyl-1-pentanol 286.33
    methyl formate 169.59
    2-methyl-1-butanol 371.01
    n-decane 323.19
    butyronitrile 787.87
    3,7-dimethyl-1-octanol 429.45
    1-chlorooctane 587.21
    1-chlorotetradecane 239.36
    n-nonane 380.48
    undecane 211.91
    tert-butylcyclohexane 350.63
    cyclooctane 732.86
    cyclopentanol 668.03
    tetrahydropyran 2506.55
    tert-amyl methyl ether 706.88
    2,5,8-trioxanonane 673.84
    1-hexene 1297.2
    2-isopropoxyethanol 248.33
    2,2,2-trifluoroethanol 80.11
    methyl butyrate 840.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction