Cyclooctadecanone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    6907-37-5

    Molecular formula
    C18H34O

    SMILES
    C1CCCCCCCCC(=O)CCCCCCCC1

  • Odor profile

    Musk 91.99%
    Animal 68.4%
    Powdery 61.96%
    Amber 56.05%
    Dry 47.68%
    Sweet 39.8%
    Woody 39.5%
    Natural 38.8%
    Clean 37.84%
    Balsamic 31.43%

    Scent© AI

  • Properties

    XLogP3-AA
    7.4

    pKa est.
    9.85 (weak base)

    Molecular weight
    266.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    368°C

    Flash point est.
    164.73 ˚C

  • Synonyms

    • Cyclooctadecanone
    • 6907-37-5
    • DTXSID30219123
    • NSC 167955
    • NSC167955
    • SCHEMBL1954314
    • DTXCID50141614
    • NSC-167955

  • Applications

    Cyclooctadecanone (CAS 6907-37-5) is a macrocyclic ketone with a soft, slightly animalic musky odor, used primarily in the fragrance and cosmetics industry as a high-end musk note and long-lasting fixative in fine perfumery, personal care, and (at premium tiers) home products; in organic synthesis it serves as a versatile macrocyclic scaffold for preparing derivatives (oximes/hydrazones, the corresponding alcohol by reduction, lactones via Baeyer–Villiger oxidation, or α-functionalized analogs) to tune olfactory profiles, access macrocyclic musk/lactone building blocks, and pheromone-like compounds; in research it is employed as a GC–MS/HPLC reference standard for identifying macrocyclic ketones, as a model molecule to study conformational flexibility, hydrophobic interactions, and crystal packing of large rings, and as a starting point in supramolecular and soft-materials exploration; additionally, owing to a generally favorable safety and environmental profile relative to some nitro or polycyclic musks, it is of interest for “green” fragrance formulation and more sustainable fragrance delivery systems.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 63.55
    methanol 40.46
    isopropanol 93.18
    water 0.01
    ethyl acetate 623.52
    n-propanol 110.31
    acetone 363.45
    n-butanol 131.8
    acetonitrile 164.55
    DMF 501.16
    toluene 419.59
    isobutanol 113.6
    1,4-dioxane 625.03
    methyl acetate 349.92
    THF 1418.49
    2-butanone 475.89
    n-pentanol 102.97
    sec-butanol 128.89
    n-hexane 132.36
    ethylene glycol 6.06
    NMP 947.6
    cyclohexane 445.87
    DMSO 416.68
    n-butyl acetate 684.92
    n-octanol 126.07
    chloroform 1962.34
    n-propyl acetate 576.66
    acetic acid 129.74
    dichloromethane 1757.92
    cyclohexanone 1332.71
    propylene glycol 21.79
    isopropyl acetate 590.89
    DMAc 575.52
    2-ethoxyethanol 162.68
    isopentanol 177.01
    n-heptane 181.59
    ethyl formate 241.0
    1,2-dichloroethane 1128.23
    n-hexanol 150.25
    2-methoxyethanol 205.35
    isobutyl acetate 422.62
    tetrachloromethane 375.57
    n-pentyl acetate 662.08
    transcutol 1086.63
    n-heptanol 115.77
    ethylbenzene 261.55
    MIBK 483.0
    2-propoxyethanol 257.53
    tert-butanol 177.09
    MTBE 378.77
    2-butoxyethanol 256.69
    propionic acid 177.77
    o-xylene 293.16
    formic acid 17.72
    diethyl ether 401.81
    m-xylene 298.67
    p-xylene 351.55
    chlorobenzene 676.73
    dimethyl carbonate 156.95
    n-octane 58.51
    formamide 43.11
    cyclopentanone 1436.15
    2-pentanone 570.12
    anisole 433.26
    cyclopentyl methyl ether 895.89
    gamma-butyrolactone 1364.43
    1-methoxy-2-propanol 265.29
    pyridine 896.44
    3-pentanone 499.75
    furfural 972.2
    n-dodecane 31.09
    diethylene glycol 93.81
    diisopropyl ether 257.85
    tert-amyl alcohol 185.29
    acetylacetone 739.08
    n-hexadecane 39.43
    acetophenone 487.18
    methyl propionate 429.68
    isopentyl acetate 627.37
    trichloroethylene 1995.66
    n-nonanol 137.15
    cyclohexanol 344.71
    benzyl alcohol 224.89
    2-ethylhexanol 207.34
    isooctanol 134.97
    dipropyl ether 614.54
    1,2-dichlorobenzene 761.09
    ethyl lactate 186.73
    propylene carbonate 833.3
    n-methylformamide 143.3
    2-pentanol 149.97
    n-pentane 84.13
    1-propoxy-2-propanol 332.16
    1-methoxy-2-propyl acetate 554.38
    2-(2-methoxypropoxy) propanol 281.84
    mesitylene 234.17
    ε-caprolactone 1062.64
    p-cymene 229.45
    epichlorohydrin 1237.37
    1,1,1-trichloroethane 1309.6
    2-aminoethanol 27.89
    morpholine-4-carbaldehyde 734.51
    sulfolane 1635.49
    2,2,4-trimethylpentane 57.92
    2-methyltetrahydrofuran 1022.8
    n-hexyl acetate 616.24
    isooctane 46.75
    2-(2-butoxyethoxy)ethanol 386.09
    sec-butyl acetate 485.57
    tert-butyl acetate 657.8
    decalin 159.12
    glycerin 40.74
    diglyme 895.82
    acrylic acid 131.24
    isopropyl myristate 276.26
    n-butyric acid 426.58
    acetyl acetate 460.95
    di(2-ethylhexyl) phthalate 173.55
    ethyl propionate 538.31
    nitromethane 350.55
    1,2-diethoxyethane 695.31
    benzonitrile 434.96
    trioctyl phosphate 132.25
    1-bromopropane 694.17
    gamma-valerolactone 1401.8
    n-decanol 97.46
    triethyl phosphate 334.38
    4-methyl-2-pentanol 126.23
    propionitrile 252.17
    vinylene carbonate 613.92
    1,1,2-trichlorotrifluoroethane 684.14
    DMS 426.44
    cumene 186.84
    2-octanol 115.57
    2-hexanone 460.94
    octyl acetate 293.59
    limonene 387.91
    1,2-dimethoxyethane 570.57
    ethyl orthosilicate 317.63
    tributyl phosphate 201.61
    diacetone alcohol 404.42
    N,N-dimethylaniline 301.89
    acrylonitrile 269.35
    aniline 333.75
    1,3-propanediol 70.56
    bromobenzene 907.28
    dibromomethane 1184.99
    1,1,2,2-tetrachloroethane 1805.2
    2-methyl-cyclohexyl acetate 501.33
    tetrabutyl urea 265.02
    diisobutyl methanol 191.4
    2-phenylethanol 232.51
    styrene 342.99
    dioctyl adipate 380.97
    dimethyl sulfate 296.1
    ethyl butyrate 701.62
    methyl lactate 150.65
    butyl lactate 334.99
    diethyl carbonate 419.22
    propanediol butyl ether 185.12
    triethyl orthoformate 516.52
    p-tert-butyltoluene 210.6
    methyl 4-tert-butylbenzoate 455.59
    morpholine 696.34
    tert-butylamine 151.49
    n-dodecanol 77.13
    dimethoxymethane 363.57
    ethylene carbonate 589.59
    cyrene 300.44
    2-ethoxyethyl acetate 594.82
    2-ethylhexyl acetate 564.71
    1,2,4-trichlorobenzene 829.65
    4-methylpyridine 784.98
    dibutyl ether 534.53
    2,6-dimethyl-4-heptanol 191.4
    DEF 674.62
    dimethyl isosorbide 703.63
    tetrachloroethylene 1124.7
    eugenol 307.47
    triacetin 613.24
    span 80 311.89
    1,4-butanediol 27.63
    1,1-dichloroethane 983.8
    2-methyl-1-pentanol 136.33
    methyl formate 121.61
    2-methyl-1-butanol 152.13
    n-decane 67.91
    butyronitrile 314.52
    3,7-dimethyl-1-octanol 182.95
    1-chlorooctane 257.01
    1-chlorotetradecane 93.18
    n-nonane 68.6
    undecane 43.18
    tert-butylcyclohexane 115.01
    cyclooctane 152.06
    cyclopentanol 338.05
    tetrahydropyran 950.77
    tert-amyl methyl ether 378.58
    2,5,8-trioxanonane 534.91
    1-hexene 257.74
    2-isopropoxyethanol 179.61
    2,2,2-trifluoroethanol 73.51
    methyl butyrate 704.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Civet secretion (China) 68916-26-7 Viverra zibetha L., fam. Viverridae 7.98%