Cyclononadecanone

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  • Identifiers

    CAS number
    6907-38-6

    Molecular formula
    C19H36O

    SMILES
    C1CCCCCCCCCC(=O)CCCCCCCC1

  • Odor profile

    Musk 91.97%
    Animal 67.82%
    Powdery 61.72%
    Amber 56.57%
    Dry 48.26%
    Sweet 40.88%
    Woody 39.68%
    Natural 38.27%
    Clean 37.56%
    Balsamic 31.28%

    Scent© AI

  • Properties

    XLogP3-AA
    8.0

    pKa est.
    9.77 (weak base)

    Molecular weight
    280.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    383°C

    Flash point est.
    169.9 ˚C

  • Synonyms

    • Cyclononadecanone
    • 6907-38-6
    • DTXSID10499486
    • DTXCID30450296

  • Applications

    Cyclononadecanone (CAS 6907-38-6) is a macrocyclic ketone used primarily in the fragrance industry as a soft, warm, long-lasting musk component for fine fragrances, cosmetics, and home/personal care; it functions as a fixative that extends longevity, improves diffusion and cleanliness of the dry-down, and blends well with floral, woody, amber, and musky accords; beyond direct odor use it serves as a building block/intermediate to prepare related macrolactones and macrocyclic musks (via transformations such as reduction, Baeyer–Villiger oxidation, amination, etc.), as a reference standard in GC–MS/LC–MS method development for tracking macrocyclic musks in fragrance/cosmetic matrices and in structure–odor relationship studies, and as a model substrate for large-ring chemistry and ring-closing strategies (e.g., metathesis) in academic research and industrial R&D.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 46.64
    methanol 30.16
    isopropanol 68.86
    water 0.01
    ethyl acetate 530.37
    n-propanol 82.32
    acetone 294.23
    n-butanol 101.35
    acetonitrile 127.9
    DMF 426.38
    toluene 339.21
    isobutanol 88.27
    1,4-dioxane 525.99
    methyl acetate 293.17
    THF 1241.96
    2-butanone 396.79
    n-pentanol 81.7
    sec-butanol 99.5
    n-hexane 103.54
    ethylene glycol 4.6
    NMP 880.27
    cyclohexane 379.11
    DMSO 361.77
    n-butyl acetate 595.8
    n-octanol 109.11
    chloroform 1694.67
    n-propyl acetate 505.07
    acetic acid 108.64
    dichloromethane 1529.03
    cyclohexanone 1163.36
    propylene glycol 16.48
    isopropyl acetate 516.99
    DMAc 531.2
    2-ethoxyethanol 137.2
    isopentanol 141.08
    n-heptane 151.76
    ethyl formate 204.37
    1,2-dichloroethane 975.37
    n-hexanol 119.2
    2-methoxyethanol 166.91
    isobutyl acetate 372.38
    tetrachloromethane 334.41
    n-pentyl acetate 607.53
    transcutol 952.03
    n-heptanol 99.35
    ethylbenzene 220.31
    MIBK 423.87
    2-propoxyethanol 214.62
    tert-butanol 141.44
    MTBE 313.58
    2-butoxyethanol 226.6
    propionic acid 148.77
    o-xylene 252.36
    formic acid 15.03
    diethyl ether 323.01
    m-xylene 251.73
    p-xylene 299.15
    chlorobenzene 577.96
    dimethyl carbonate 138.45
    n-octane 50.27
    formamide 36.68
    cyclopentanone 1274.88
    2-pentanone 479.51
    anisole 375.42
    cyclopentyl methyl ether 785.08
    gamma-butyrolactone 1229.21
    1-methoxy-2-propanol 219.79
    pyridine 743.88
    3-pentanone 429.92
    furfural 859.35
    n-dodecane 26.22
    diethylene glycol 76.84
    diisopropyl ether 219.87
    tert-amyl alcohol 150.56
    acetylacetone 652.57
    n-hexadecane 33.43
    acetophenone 435.79
    methyl propionate 368.34
    isopentyl acetate 557.26
    trichloroethylene 1745.67
    n-nonanol 120.04
    cyclohexanol 286.51
    benzyl alcohol 191.08
    2-ethylhexanol 174.05
    isooctanol 117.36
    dipropyl ether 533.67
    1,2-dichlorobenzene 672.55
    ethyl lactate 166.65
    propylene carbonate 752.91
    n-methylformamide 119.19
    2-pentanol 117.62
    n-pentane 65.76
    1-propoxy-2-propanol 285.86
    1-methoxy-2-propyl acetate 495.66
    2-(2-methoxypropoxy) propanol 250.02
    mesitylene 203.02
    ε-caprolactone 944.94
    p-cymene 202.12
    epichlorohydrin 1093.71
    1,1,1-trichloroethane 1147.78
    2-aminoethanol 21.52
    morpholine-4-carbaldehyde 658.26
    sulfolane 1527.12
    2,2,4-trimethylpentane 50.0
    2-methyltetrahydrofuran 886.44
    n-hexyl acetate 552.97
    isooctane 39.21
    2-(2-butoxyethoxy)ethanol 341.05
    sec-butyl acetate 430.14
    tert-butyl acetate 591.69
    decalin 135.64
    glycerin 32.88
    diglyme 816.24
    acrylic acid 109.77
    isopropyl myristate 247.27
    n-butyric acid 356.09
    acetyl acetate 405.79
    di(2-ethylhexyl) phthalate 156.07
    ethyl propionate 479.22
    nitromethane 303.38
    1,2-diethoxyethane 610.45
    benzonitrile 367.53
    trioctyl phosphate 118.98
    1-bromopropane 579.09
    gamma-valerolactone 1263.32
    n-decanol 83.83
    triethyl phosphate 312.52
    4-methyl-2-pentanol 103.77
    propionitrile 196.39
    vinylene carbonate 553.51
    1,1,2-trichlorotrifluoroethane 613.49
    DMS 381.42
    cumene 161.52
    2-octanol 99.59
    2-hexanone 396.65
    octyl acetate 262.29
    limonene 348.15
    1,2-dimethoxyethane 495.56
    ethyl orthosilicate 296.04
    tributyl phosphate 181.27
    diacetone alcohol 359.68
    N,N-dimethylaniline 267.01
    acrylonitrile 209.94
    aniline 273.52
    1,3-propanediol 55.19
    bromobenzene 773.75
    dibromomethane 1013.13
    1,1,2,2-tetrachloroethane 1597.74
    2-methyl-cyclohexyl acetate 459.59
    tetrabutyl urea 242.35
    diisobutyl methanol 166.29
    2-phenylethanol 199.59
    styrene 286.39
    dioctyl adipate 344.74
    dimethyl sulfate 274.33
    ethyl butyrate 632.8
    methyl lactate 133.13
    butyl lactate 307.54
    diethyl carbonate 378.16
    propanediol butyl ether 160.87
    triethyl orthoformate 477.88
    p-tert-butyltoluene 184.58
    methyl 4-tert-butylbenzoate 421.46
    morpholine 590.15
    tert-butylamine 120.43
    n-dodecanol 65.94
    dimethoxymethane 310.96
    ethylene carbonate 525.29
    cyrene 279.25
    2-ethoxyethyl acetate 547.3
    2-ethylhexyl acetate 505.89
    1,2,4-trichlorobenzene 737.53
    4-methylpyridine 658.72
    dibutyl ether 472.23
    2,6-dimethyl-4-heptanol 166.29
    DEF 590.16
    dimethyl isosorbide 656.62
    tetrachloroethylene 987.21
    eugenol 279.74
    triacetin 568.68
    span 80 274.17
    1,4-butanediol 21.77
    1,1-dichloroethane 828.0
    2-methyl-1-pentanol 112.55
    methyl formate 102.53
    2-methyl-1-butanol 121.34
    n-decane 58.5
    butyronitrile 250.56
    3,7-dimethyl-1-octanol 157.6
    1-chlorooctane 225.13
    1-chlorotetradecane 80.57
    n-nonane 58.4
    undecane 36.8
    tert-butylcyclohexane 97.66
    cyclooctane 128.68
    cyclopentanol 284.88
    tetrahydropyran 802.64
    tert-amyl methyl ether 322.43
    2,5,8-trioxanonane 485.55
    1-hexene 200.56
    2-isopropoxyethanol 152.19
    2,2,2-trifluoroethanol 65.42
    methyl butyrate 621.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Civet secretion (China) 68916-26-7 Viverra zibetha L., fam. Viverridae 1.02%