(Cyclohexylmethyl)pyrazine

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  • Identifiers

    CAS number
    28217-92-7

    Molecular formula
    C11H16N2

    SMILES
    C1CCC(CC1)CC2=NC=CN=C2

  • Odor profile

    Fragrance
    Green 83.51%
    Earthy 67.67%
    Nutty 67.52%
    Musty 49.47%
    Vegetable 48.31%
    Roasted 47.69%
    Cocoa 37.36%
    Potato 32.3%
    Herbal 31.69%
    Hazelnut 29.76%

     

    Flavor
    Roasted 37.2%
    Earthy 36.51%
    Musty 34.12%
    Green 27.71%
    Fruity 25.79%
    Cereal 25.13%
    Vegetable 24.33%
    Peanut 23.59%
    Nut 23.39%
    Animal 23.36%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    5.1 (weak acid)

    Molecular weight
    176.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point

    • 100.00 °C. @ 4.00 mm Hg

    Flash point

    • 133.78 ˚C est.

    Solubility expt.

    • slightly
    • slightly soluble in water; soluble in oils
    • miscible at room temperature (in ethanol)

  • Synonyms

    • (Cyclohexylmethyl)pyrazine
    • 2-(Cyclohexylmethyl)pyrazine
    • 28217-92-7
    • Cyclohexylmethyl pyrazine
    • Pyrazine, (cyclohexylmethyl)-
    • 2-Pyrazine cyclohexyl methane
    • (2-Pyrazinylmethyl)cyclohexane
    • 2-Pyrazinyl cyclohexyl methane
    • FEMA No. 3631
    • Pyrazine, 2-(cyclohexylmethyl)-
    • EINECS 248-905-1
    • UNII-48RW2FS80G
    • 48RW2FS80G
    • DTXSID8067367
    • FEMA 3631
    • CHEBI:173485
    • CYCLOHEXYLMETHYL PYRAZINE [FHFI]
    • 2-cyclohexylmethylpyrazine
    • cyclohexyl methyl pyrazine
    • (cyclohexylmethyl)-Pyrazine
    • 2-(Cyclohexylmethyl)-Pyrazine
    • SCHEMBL3507744
    • DTXCID5037783
    • DGJZDAIWCSVZBI-UHFFFAOYSA-N
    • AKOS006370718
    • DB-116365
    • NS00021985
    • G82860
    • Q27259172
    • 248-905-1

  • Applications

    (Cyclohexylmethyl)pyrazine (CAS 28217-92-7) is primarily used as a fragrance ingredient in perfumery and cosmetics, contributing pyrazine-like nutty, roasted, and green aroma notes and often functioning as an odorant with potential to act as a fixative to improve scent longevity in formulations. It may be evaluated for flavor/aroma applications as part of savory or roasted profiles under appropriate regulatory controls. In industrial manufacturing, it can serve as an intermediate for the synthesis of fragrance-related compounds. It may also find use in household products such as air fresheners and cleaners to impart or enhance fragrance, and could be considered for coatings or inks as a scent additive. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 280.19
    methanol 317.88
    isopropanol 153.24
    water 0.18
    ethyl acetate 457.26
    n-propanol 242.3
    acetone 562.45
    n-butanol 231.36
    acetonitrile 250.33
    DMF 724.77
    toluene 371.82
    isobutanol 167.02
    1,4-dioxane 589.93
    methyl acetate 328.46
    THF 934.71
    2-butanone 419.69
    n-pentanol 119.75
    sec-butanol 122.5
    n-hexane 14.24
    ethylene glycol 82.01
    NMP 518.5
    cyclohexane 61.81
    DMSO 1011.85
    n-butyl acetate 345.03
    n-octanol 33.7
    chloroform 1733.7
    n-propyl acetate 181.34
    acetic acid 391.51
    dichloromethane 1807.43
    cyclohexanone 769.92
    propylene glycol 97.5
    isopropyl acetate 220.11
    DMAc 428.55
    2-ethoxyethanol 210.89
    isopentanol 178.13
    n-heptane 17.39
    ethyl formate 352.29
    1,2-dichloroethane 1234.41
    n-hexanol 177.46
    2-methoxyethanol 558.93
    isobutyl acetate 113.8
    tetrachloromethane 178.57
    n-pentyl acetate 110.89
    transcutol 1032.15
    n-heptanol 50.14
    ethylbenzene 88.48
    MIBK 164.99
    2-propoxyethanol 337.65
    tert-butanol 145.56
    MTBE 136.24
    2-butoxyethanol 133.86
    propionic acid 282.48
    o-xylene 150.02
    formic acid 121.26
    diethyl ether 243.71
    m-xylene 183.08
    p-xylene 114.12
    chlorobenzene 575.32
    dimethyl carbonate 145.67
    n-octane 4.99
    formamide 182.1
    cyclopentanone 905.7
    2-pentanone 373.65
    anisole 173.48
    cyclopentyl methyl ether 411.08
    gamma-butyrolactone 1023.45
    1-methoxy-2-propanol 335.71
    pyridine 952.42
    3-pentanone 294.45
    furfural 913.88
    n-dodecane 4.18
    diethylene glycol 266.68
    diisopropyl ether 50.78
    tert-amyl alcohol 104.08
    acetylacetone 418.79
    n-hexadecane 4.98
    acetophenone 176.44
    methyl propionate 350.55
    isopentyl acetate 239.08
    trichloroethylene 2346.96
    n-nonanol 34.68
    cyclohexanol 238.42
    benzyl alcohol 175.0
    2-ethylhexanol 101.21
    isooctanol 41.84
    dipropyl ether 155.36
    1,2-dichlorobenzene 446.04
    ethyl lactate 87.31
    propylene carbonate 507.87
    n-methylformamide 399.54
    2-pentanol 113.58
    n-pentane 17.67
    1-propoxy-2-propanol 232.66
    1-methoxy-2-propyl acetate 296.68
    2-(2-methoxypropoxy) propanol 123.98
    mesitylene 90.42
    ε-caprolactone 513.89
    p-cymene 66.62
    epichlorohydrin 1144.66
    1,1,1-trichloroethane 680.17
    2-aminoethanol 149.14
    morpholine-4-carbaldehyde 525.99
    sulfolane 1004.71
    2,2,4-trimethylpentane 11.12
    2-methyltetrahydrofuran 587.83
    n-hexyl acetate 119.3
    isooctane 8.17
    2-(2-butoxyethoxy)ethanol 204.72
    sec-butyl acetate 106.52
    tert-butyl acetate 177.35
    decalin 21.19
    glycerin 156.29
    diglyme 452.24
    acrylic acid 281.42
    isopropyl myristate 44.92
    n-butyric acid 461.03
    acetyl acetate 251.27
    di(2-ethylhexyl) phthalate 61.9
    ethyl propionate 160.85
    nitromethane 660.04
    1,2-diethoxyethane 302.81
    benzonitrile 301.02
    trioctyl phosphate 38.99
    1-bromopropane 441.79
    gamma-valerolactone 904.54
    n-decanol 28.09
    triethyl phosphate 79.26
    4-methyl-2-pentanol 63.12
    propionitrile 283.42
    vinylene carbonate 440.57
    1,1,2-trichlorotrifluoroethane 647.8
    DMS 147.7
    cumene 55.06
    2-octanol 25.94
    2-hexanone 164.05
    octyl acetate 60.03
    limonene 102.4
    1,2-dimethoxyethane 356.03
    ethyl orthosilicate 77.44
    tributyl phosphate 57.01
    diacetone alcohol 190.16
    N,N-dimethylaniline 101.38
    acrylonitrile 396.79
    aniline 437.51
    1,3-propanediol 219.53
    bromobenzene 640.21
    dibromomethane 1019.79
    1,1,2,2-tetrachloroethane 1534.92
    2-methyl-cyclohexyl acetate 125.54
    tetrabutyl urea 71.74
    diisobutyl methanol 56.34
    2-phenylethanol 180.57
    styrene 142.39
    dioctyl adipate 81.34
    dimethyl sulfate 233.92
    ethyl butyrate 202.85
    methyl lactate 153.99
    butyl lactate 97.11
    diethyl carbonate 129.22
    propanediol butyl ether 104.67
    triethyl orthoformate 128.98
    p-tert-butyltoluene 60.58
    methyl 4-tert-butylbenzoate 115.1
    morpholine 666.01
    tert-butylamine 92.21
    n-dodecanol 23.4
    dimethoxymethane 439.28
    ethylene carbonate 381.36
    cyrene 130.24
    2-ethoxyethyl acetate 200.83
    2-ethylhexyl acetate 186.36
    1,2,4-trichlorobenzene 470.9
    4-methylpyridine 682.44
    dibutyl ether 75.3
    2,6-dimethyl-4-heptanol 56.34
    DEF 394.61
    dimethyl isosorbide 264.3
    tetrachloroethylene 998.76
    eugenol 113.73
    triacetin 127.9
    span 80 108.49
    1,4-butanediol 74.13
    1,1-dichloroethane 780.41
    2-methyl-1-pentanol 103.34
    methyl formate 342.95
    2-methyl-1-butanol 149.89
    n-decane 6.31
    butyronitrile 282.03
    3,7-dimethyl-1-octanol 51.2
    1-chlorooctane 37.11
    1-chlorotetradecane 16.62
    n-nonane 5.53
    undecane 4.98
    tert-butylcyclohexane 15.83
    cyclooctane 16.99
    cyclopentanol 259.32
    tetrahydropyran 643.66
    tert-amyl methyl ether 102.2
    2,5,8-trioxanonane 260.81
    1-hexene 71.38
    2-isopropoxyethanol 125.88
    2,2,2-trifluoroethanol 131.84
    methyl butyrate 238.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction