Cyclohexyl formate

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  • Identifiers

    CAS number
    4351-54-6

    Molecular formula
    C7H12O2

    SMILES
    C1CCC(CC1)OC=O

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Fruity 92.44%
    Sweet 68.47%
    Green 66.29%
    Ethereal 55.69%
    Banana 50.84%
    Floral 47.59%
    Apple 47.39%
    Fresh 45.32%
    Woody 41.96%
    Rummy 36.89%

     

    Flavor
    Fruity 46.64%
    Green 40.34%
    Fruit 29.0%
    Spicy 26.95%
    Herbal 24.51%
    Floral 24.06%
    Fatty 23.57%
    Minty 23.5%
    Fresh 22.84%
    Pineapple 22.12%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    7.41 (neutral)

    Molecular weight
    128.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point

    • 162.00 to 163.00 °C. @ 760.00 mm Hg

    Flash point

    • 61.08 ˚C est.

    Solubility expt.

    • insoluble in water; soluble in acetic and formic acid
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • CYCLOHEXYL FORMATE
    • Formic acid, cyclohexyl ester
    • 4351-54-6
    • Cyclohexanol, formate
    • FEMA No. 2353
    • UNII-ESO2F2836U
    • ESO2F2836U
    • EINECS 224-415-3
    • NSC 11766
    • Cyclohexyl ester of formic acid
    • AI3-30436
    • NSC-11766
    • formic acid cyclohexyl ester
    • DTXSID2063426
    • CYCLOHEXYL FORMATE [FHFI]
    • Formic acid, cyclohexyl ester (purified)
    • cyclohexyl ormate
    • SCHEMBL9432
    • DTXCID3040271
    • FEMA 2353
    • CHEBI:173489
    • BCP29270
    • NSC11766
    • AKOS006273757
    • DB-318967
    • NS00045221
    • Q27277345
    • Cyclohexyl ester of formic acid;Formic acid, cyclohexyl ester
    • 224-415-3

  • Applications

    Cyclohexyl formate (CAS 4351-54-6) is primarily used as a fragrance ingredient in perfumery, where it can also function as a solvent or a fixative in certain formulations. It is commonly found in cosmetics and personal care products as a fragrance additive, and in household products such as air fresheners and cleaners as a fragrance carrier and solvent. In coatings and inks, it may serve as a processing solvent for resin- or pigment-containing systems. In industrial manufacturing, it can act as an intermediate in organic synthesis or as a specialty solvent, subject to formulation requirements and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 556.38
    methanol 577.52
    isopropanol 438.03
    water 0.56
    ethyl acetate 799.85
    n-propanol 412.85
    acetone 1356.94
    n-butanol 370.54
    acetonitrile 786.04
    DMF 1277.64
    toluene 228.52
    isobutanol 307.01
    1,4-dioxane 947.52
    methyl acetate 792.19
    THF 1582.35
    2-butanone 844.0
    n-pentanol 203.84
    sec-butanol 321.56
    n-hexane 40.74
    ethylene glycol 133.24
    NMP 1238.13
    cyclohexane 107.82
    DMSO 1767.71
    n-butyl acetate 505.32
    n-octanol 134.94
    chloroform 2485.37
    n-propyl acetate 388.65
    acetic acid 922.27
    dichloromethane 2527.89
    cyclohexanone 1330.48
    propylene glycol 181.4
    isopropyl acetate 411.21
    DMAc 593.23
    2-ethoxyethanol 291.4
    isopentanol 303.09
    n-heptane 34.15
    ethyl formate 533.76
    1,2-dichloroethane 1587.16
    n-hexanol 269.2
    2-methoxyethanol 660.13
    isobutyl acetate 215.66
    tetrachloromethane 253.42
    n-pentyl acetate 268.09
    transcutol 1521.19
    n-heptanol 115.18
    ethylbenzene 125.15
    MIBK 325.36
    2-propoxyethanol 452.38
    tert-butanol 464.85
    MTBE 331.29
    2-butoxyethanol 253.53
    propionic acid 698.9
    o-xylene 151.87
    formic acid 250.14
    diethyl ether 418.38
    m-xylene 162.09
    p-xylene 172.24
    chlorobenzene 638.59
    dimethyl carbonate 239.09
    n-octane 15.91
    formamide 447.62
    cyclopentanone 1803.94
    2-pentanone 664.46
    anisole 293.72
    cyclopentyl methyl ether 570.93
    gamma-butyrolactone 2208.97
    1-methoxy-2-propanol 510.56
    pyridine 1072.06
    3-pentanone 460.58
    furfural 1328.0
    n-dodecane 14.12
    diethylene glycol 338.85
    diisopropyl ether 112.66
    tert-amyl alcohol 323.53
    acetylacetone 825.82
    n-hexadecane 16.62
    acetophenone 309.9
    methyl propionate 584.2
    isopentyl acetate 382.56
    trichloroethylene 2935.12
    n-nonanol 115.87
    cyclohexanol 410.28
    benzyl alcohol 233.02
    2-ethylhexanol 160.58
    isooctanol 101.46
    dipropyl ether 224.53
    1,2-dichlorobenzene 569.44
    ethyl lactate 169.51
    propylene carbonate 990.38
    n-methylformamide 743.14
    2-pentanol 246.62
    n-pentane 38.08
    1-propoxy-2-propanol 365.27
    1-methoxy-2-propyl acetate 444.42
    2-(2-methoxypropoxy) propanol 275.73
    mesitylene 110.46
    ε-caprolactone 976.75
    p-cymene 95.45
    epichlorohydrin 1848.24
    1,1,1-trichloroethane 1225.39
    2-aminoethanol 237.75
    morpholine-4-carbaldehyde 904.54
    sulfolane 2253.79
    2,2,4-trimethylpentane 21.87
    2-methyltetrahydrofuran 993.28
    n-hexyl acetate 390.35
    isooctane 19.26
    2-(2-butoxyethoxy)ethanol 399.77
    sec-butyl acetate 237.74
    tert-butyl acetate 389.19
    decalin 40.18
    glycerin 240.6
    diglyme 711.83
    acrylic acid 667.08
    isopropyl myristate 135.5
    n-butyric acid 865.78
    acetyl acetate 508.97
    di(2-ethylhexyl) phthalate 132.51
    ethyl propionate 356.88
    nitromethane 1714.63
    1,2-diethoxyethane 430.85
    benzonitrile 483.32
    trioctyl phosphate 99.97
    1-bromopropane 676.56
    gamma-valerolactone 1483.62
    n-decanol 86.8
    triethyl phosphate 130.24
    4-methyl-2-pentanol 138.88
    propionitrile 585.52
    vinylene carbonate 799.44
    1,1,2-trichlorotrifluoroethane 906.52
    DMS 371.8
    cumene 85.21
    2-octanol 89.56
    2-hexanone 363.63
    octyl acetate 174.92
    limonene 147.91
    1,2-dimethoxyethane 569.3
    ethyl orthosilicate 115.0
    tributyl phosphate 136.07
    diacetone alcohol 452.27
    N,N-dimethylaniline 165.92
    acrylonitrile 873.56
    aniline 344.71
    1,3-propanediol 374.96
    bromobenzene 688.4
    dibromomethane 1501.62
    1,1,2,2-tetrachloroethane 2080.0
    2-methyl-cyclohexyl acetate 224.45
    tetrabutyl urea 164.9
    diisobutyl methanol 113.24
    2-phenylethanol 247.61
    styrene 184.97
    dioctyl adipate 205.66
    dimethyl sulfate 427.13
    ethyl butyrate 336.8
    methyl lactate 270.48
    butyl lactate 228.29
    diethyl carbonate 227.68
    propanediol butyl ether 286.38
    triethyl orthoformate 189.83
    p-tert-butyltoluene 92.85
    methyl 4-tert-butylbenzoate 261.07
    morpholine 1066.77
    tert-butylamine 260.97
    n-dodecanol 67.03
    dimethoxymethane 511.49
    ethylene carbonate 651.99
    cyrene 251.68
    2-ethoxyethyl acetate 388.08
    2-ethylhexyl acetate 277.61
    1,2,4-trichlorobenzene 629.05
    4-methylpyridine 749.82
    dibutyl ether 202.56
    2,6-dimethyl-4-heptanol 113.24
    DEF 622.15
    dimethyl isosorbide 500.7
    tetrachloroethylene 1270.6
    eugenol 261.56
    triacetin 375.59
    span 80 271.56
    1,4-butanediol 123.49
    1,1-dichloroethane 1511.01
    2-methyl-1-pentanol 175.59
    methyl formate 599.63
    2-methyl-1-butanol 258.02
    n-decane 22.87
    butyronitrile 540.04
    3,7-dimethyl-1-octanol 156.17
    1-chlorooctane 117.24
    1-chlorotetradecane 45.8
    n-nonane 22.9
    undecane 17.45
    tert-butylcyclohexane 33.6
    cyclooctane 28.03
    cyclopentanol 628.39
    tetrahydropyran 1010.48
    tert-amyl methyl ether 223.14
    2,5,8-trioxanonane 457.39
    1-hexene 156.78
    2-isopropoxyethanol 214.44
    2,2,2-trifluoroethanol 321.4
    methyl butyrate 493.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction