Cyclobutanol

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  • Identifiers

    CAS number
    2919-23-5

    Molecular formula
    C4H8O

    SMILES
    C1CC(C1)O

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Alcoholic 49.69%
    Solvent 48.15%
    Fermented 47.62%
    Ethereal 43.65%
    Mint 34.81%
    Musty 31.1%
    Odorless 30.76%
    Camphoreous 30.46%
    Oily 30.28%
    Fruity 30.03%

     

    Flavor
    Bitter 30.16%
    Sweet 28.88%
    Camphor 28.36%
    Minty 27.17%
    Phenol 23.93%
    Cauliflower 23.69%
    Warm 23.66%
    Caramel 23.29%
    Alkaline 22.04%
    Medicinal 22.03%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    8.74 (weak base)

    Molecular weight
    72.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    126°C

    Flash point

    • 19.15 ˚C est.

  • Synonyms

    • Cyclobutanol
    • 2919-23-5
    • Cyclobutyl alcohol
    • Hydroxycyclobutane
    • AD482C8GST
    • DTXSID5062712
    • RefChem:129400
    • DTXCID4037950
    • 220-858-1
    • MFCD00001318
    • Cyclobutyl hydroxide
    • EINECS 220-858-1
    • Cyclobutanol, >=99%
    • UNII-AD482C8GST
    • SCHEMBL4955
    • SCHEMBL21796
    • SCHEMBL127435
    • SCHEMBL181060
    • SCHEMBL289020
    • SCHEMBL990954
    • CHEMBL449234
    • orb2940277
    • SCHEMBL20494381
    • SCHEMBL21827626
    • BDBM36188
    • KTHXBEHDVMTNOH-UHFFFAOYSA-
    • BBL102818
    • STL556626
    • AKOS005254853
    • CS-W013758
    • GS-3302
    • HY-W013042
    • SB83781
    • DB-016114
    • NS00028651
    • EN300-61113
    • 919C235
    • F003407
    • Q9756613
    • F0001-2563
    • InChI=1/C4H8O/c5-4-2-1-3-4/h4-5H,1-3H2
    • 2919-23-5

  • Applications

    Cyclobutanol (CAS 2919-23-5) is primarily used as a reactive intermediate in organic synthesis, enabling the introduction of cyclobutyl motifs in a range of downstream chemicals. In industry it is commonly employed to prepare cyclobutyl derivatives for pharmaceuticals and agrochemicals, and serves as a building block in specialty polymers and resins. As a small cyclic alcohol, it can also function as a solvent or co-reactant in niche formulations for coatings and inks or cleaning products, depending on formulation needs and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 492.1
    methanol 724.28
    isopropanol 298.58
    water 26.37
    ethyl acetate 71.17
    n-propanol 331.69
    acetone 141.73
    n-butanol 297.71
    acetonitrile 115.83
    DMF 170.83
    toluene 11.77
    isobutanol 186.51
    1,4-dioxane 127.78
    methyl acetate 82.56
    THF 242.7
    2-butanone 95.39
    n-pentanol 161.53
    sec-butanol 208.18
    n-hexane 17.12
    ethylene glycol 236.92
    NMP 142.74
    cyclohexane 12.96
    DMSO 219.26
    n-butyl acetate 84.12
    n-octanol 73.56
    chloroform 191.21
    n-propyl acetate 56.91
    acetic acid 533.95
    dichloromethane 108.55
    cyclohexanone 114.62
    propylene glycol 298.65
    isopropyl acetate 43.78
    DMAc 106.79
    2-ethoxyethanol 193.66
    isopentanol 179.17
    n-heptane 18.79
    ethyl formate 86.05
    1,2-dichloroethane 57.04
    n-hexanol 177.26
    2-methoxyethanol 370.72
    isobutyl acetate 37.82
    tetrachloromethane 42.88
    n-pentyl acetate 56.88
    transcutol 396.77
    n-heptanol 90.87
    ethylbenzene 9.09
    MIBK 44.63
    2-propoxyethanol 246.93
    tert-butanol 227.89
    MTBE 62.66
    2-butoxyethanol 167.45
    propionic acid 291.06
    o-xylene 11.23
    formic acid 303.13
    diethyl ether 66.77
    m-xylene 11.67
    p-xylene 14.18
    chlorobenzene 28.74
    dimethyl carbonate 22.93
    n-octane 6.92
    formamide 260.13
    cyclopentanone 175.76
    2-pentanone 78.68
    anisole 29.05
    cyclopentyl methyl ether 77.43
    gamma-butyrolactone 198.74
    1-methoxy-2-propanol 252.69
    pyridine 99.48
    3-pentanone 44.44
    furfural 158.22
    n-dodecane 4.88
    diethylene glycol 239.37
    diisopropyl ether 19.55
    tert-amyl alcohol 156.47
    acetylacetone 62.3
    n-hexadecane 4.88
    acetophenone 32.4
    methyl propionate 61.1
    isopentyl acetate 64.3
    trichloroethylene 113.77
    n-nonanol 61.3
    cyclohexanol 119.37
    benzyl alcohol 51.82
    2-ethylhexanol 86.09
    isooctanol 66.87
    dipropyl ether 61.59
    1,2-dichlorobenzene 27.39
    ethyl lactate 50.79
    propylene carbonate 102.11
    n-methylformamide 198.4
    2-pentanol 143.7
    n-pentane 16.63
    1-propoxy-2-propanol 182.34
    1-methoxy-2-propyl acetate 61.91
    2-(2-methoxypropoxy) propanol 99.98
    mesitylene 8.73
    ε-caprolactone 109.71
    p-cymene 14.24
    epichlorohydrin 133.94
    1,1,1-trichloroethane 56.54
    2-aminoethanol 400.68
    morpholine-4-carbaldehyde 147.24
    sulfolane 180.14
    2,2,4-trimethylpentane 8.49
    2-methyltetrahydrofuran 141.99
    n-hexyl acetate 68.05
    isooctane 7.11
    2-(2-butoxyethoxy)ethanol 161.18
    sec-butyl acetate 32.69
    tert-butyl acetate 44.32
    decalin 6.39
    glycerin 363.9
    diglyme 207.16
    acrylic acid 268.9
    isopropyl myristate 24.79
    n-butyric acid 305.46
    acetyl acetate 45.37
    di(2-ethylhexyl) phthalate 32.31
    ethyl propionate 39.34
    nitromethane 261.85
    1,2-diethoxyethane 74.54
    benzonitrile 51.32
    trioctyl phosphate 27.37
    1-bromopropane 40.68
    gamma-valerolactone 181.94
    n-decanol 43.19
    triethyl phosphate 25.48
    4-methyl-2-pentanol 67.83
    propionitrile 108.64
    vinylene carbonate 85.75
    1,1,2-trichlorotrifluoroethane 198.18
    DMS 34.36
    cumene 10.02
    2-octanol 50.99
    2-hexanone 61.58
    octyl acetate 35.25
    limonene 23.0
    1,2-dimethoxyethane 130.71
    ethyl orthosilicate 26.75
    tributyl phosphate 30.45
    diacetone alcohol 93.28
    N,N-dimethylaniline 22.97
    acrylonitrile 127.99
    aniline 56.35
    1,3-propanediol 382.32
    bromobenzene 19.05
    dibromomethane 74.64
    1,1,2,2-tetrachloroethane 107.58
    2-methyl-cyclohexyl acetate 43.98
    tetrabutyl urea 36.37
    diisobutyl methanol 40.02
    2-phenylethanol 60.7
    styrene 12.22
    dioctyl adipate 37.66
    dimethyl sulfate 36.59
    ethyl butyrate 53.53
    methyl lactate 76.8
    butyl lactate 71.2
    diethyl carbonate 31.39
    propanediol butyl ether 170.94
    triethyl orthoformate 42.1
    p-tert-butyltoluene 14.29
    methyl 4-tert-butylbenzoate 50.02
    morpholine 195.4
    tert-butylamine 138.03
    n-dodecanol 31.31
    dimethoxymethane 75.86
    ethylene carbonate 71.36
    cyrene 67.22
    2-ethoxyethyl acetate 61.51
    2-ethylhexyl acetate 48.81
    1,2,4-trichlorobenzene 32.6
    4-methylpyridine 61.03
    dibutyl ether 46.93
    2,6-dimethyl-4-heptanol 40.02
    DEF 76.28
    dimethyl isosorbide 100.78
    tetrachloroethylene 92.28
    eugenol 64.71
    triacetin 63.41
    span 80 114.28
    1,4-butanediol 148.94
    1,1-dichloroethane 65.63
    2-methyl-1-pentanol 101.09
    methyl formate 100.39
    2-methyl-1-butanol 158.0
    n-decane 8.32
    butyronitrile 119.78
    3,7-dimethyl-1-octanol 61.75
    1-chlorooctane 24.21
    1-chlorotetradecane 9.47
    n-nonane 8.49
    undecane 6.11
    tert-butylcyclohexane 7.58
    cyclooctane 4.83
    cyclopentanol 175.29
    tetrahydropyran 122.62
    tert-amyl methyl ether 48.16
    2,5,8-trioxanonane 140.81
    1-hexene 43.81
    2-isopropoxyethanol 114.78
    2,2,2-trifluoroethanol 178.1
    methyl butyrate 60.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction