Cycloaltilisin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    152130-62-6

    Molecular formula
    C26H26O7

    SMILES
    CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C3=C(O2)C4=CC(=C(C=C4OC3C=C(C)C)OC)O)C

    Safety labels

  • Odor profile

    Fragrance
    Spicy 47.3%
    Phenolic 45.84%
    Woody 34.59%
    Smoky 29.0%
    Dry 25.88%
    Sweet 25.52%
    Odorless 25.27%
    Herbal 25.25%
    Burnt 24.62%
    Fruity 24.17%

     

    Flavor
    Bitter 90.59%
    Cedarleaf 19.83%
    Parsley 19.77%
    Bland 19.65%
    Lovage 19.33%
    Heather 17.95%
    Ripe apricot 17.92%
    Sweet-like 17.89%
    Eugenol 17.87%
    Red fruit 17.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    9.97 (weak base)

    Molecular weight
    450.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1647°C

    Melting point expt.

    • 186 - 188 °C

    Flash point

    • 261.26 ˚C est.

  • Synonyms

    • Cycloaltilisin
    • CHEBI:176143
    • DTXSID501102214
    • LMPK12110935
    • 152130-62-6
    • (+)-2,8,10-Trihydroxy-3-methoxy-11-(3-methyl-2-buten-1-yl)-6-(2-methyl-1-propen-1-yl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
    • (+)-2,8,10-Trihydroxy-3-methoxy-11-(3-methyl-2-butenyl)-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
    • 2,8,10-trihydroxy-3-methoxy-11-(3-methylbut-2-enyl)-6-(2-methylprop-1-enyl)-6H-chromeno[4,3-b]chromen-7-one
    • 152130-62-6

  • Applications

    Cycloaltilisin (CAS 152130-62-6) is an enzyme protease with robust activity under processing conditions, making it a versatile biocatalyst across several industrial and consumer sectors. In household cleaning and laundry/dishwashing, it helps hydrolyze protein stains to boost cleaning performance. In industrial manufacturing, it serves as a biocatalyst for peptide synthesis and controlled protein hydrolysis to produce proteolytic hydrolysates and specialty enzymes. In leather processing and textile finishing, subtilisin-family enzymes are used for dehairing and bating steps. In food processing, it is evaluated for proteolysis-based applications such as production of protein hydrolysates and flavor peptides, and for meat tenderization. In animal nutrition, it may be added to feeds to improve protein digestibility. In cosmetics and personal care, protease enzymes are used in enzymatic cleansers and exfoliating formulations. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.4
    methanol 3.02
    isopropanol 2.18
    water 0.01
    ethyl acetate 7.52
    n-propanol 3.58
    acetone 12.41
    n-butanol 2.47
    acetonitrile 4.73
    DMF 47.67
    toluene 2.19
    isobutanol 2.55
    1,4-dioxane 15.38
    methyl acetate 13.38
    THF 42.83
    2-butanone 15.92
    n-pentanol 2.68
    sec-butanol 2.65
    n-hexane 0.08
    ethylene glycol 2.85
    NMP 101.68
    cyclohexane 0.13
    DMSO 57.1
    n-butyl acetate 7.71
    n-octanol 1.56
    chloroform 27.24
    n-propyl acetate 7.62
    acetic acid 34.38
    dichloromethane 18.9
    cyclohexanone 24.77
    propylene glycol 6.24
    isopropyl acetate 5.3
    DMAc 90.17
    2-ethoxyethanol 13.6
    isopentanol 2.34
    n-heptane 0.1
    ethyl formate 6.53
    1,2-dichloroethane 11.01
    n-hexanol 2.09
    2-methoxyethanol 22.88
    isobutyl acetate 5.66
    tetrachloromethane 1.39
    n-pentyl acetate 6.85
    transcutol 51.49
    n-heptanol 2.04
    ethylbenzene 1.11
    MIBK 5.24
    2-propoxyethanol 21.25
    tert-butanol 3.06
    MTBE 2.4
    2-butoxyethanol 12.93
    propionic acid 14.77
    o-xylene 1.5
    formic acid 10.11
    diethyl ether 2.08
    m-xylene 1.35
    p-xylene 1.96
    chlorobenzene 4.38
    dimethyl carbonate 16.35
    n-octane 0.05
    formamide 12.7
    cyclopentanone 45.83
    2-pentanone 8.01
    anisole 4.79
    cyclopentyl methyl ether 8.09
    gamma-butyrolactone 62.72
    1-methoxy-2-propanol 19.65
    pyridine 19.25
    3-pentanone 8.08
    furfural 40.95
    n-dodecane 0.07
    diethylene glycol 19.82
    diisopropyl ether 0.64
    tert-amyl alcohol 3.17
    acetylacetone 17.54
    n-hexadecane 0.08
    acetophenone 10.12
    methyl propionate 14.3
    isopentyl acetate 7.98
    trichloroethylene 44.25
    n-nonanol 1.83
    cyclohexanol 3.42
    benzyl alcohol 7.3
    2-ethylhexanol 1.77
    isooctanol 2.02
    dipropyl ether 2.7
    1,2-dichlorobenzene 4.81
    ethyl lactate 9.66
    propylene carbonate 24.81
    n-methylformamide 16.51
    2-pentanol 1.56
    n-pentane 0.07
    1-propoxy-2-propanol 15.32
    1-methoxy-2-propyl acetate 18.9
    2-(2-methoxypropoxy) propanol 18.11
    mesitylene 0.68
    ε-caprolactone 26.23
    p-cymene 1.27
    epichlorohydrin 57.74
    1,1,1-trichloroethane 8.98
    2-aminoethanol 4.96
    morpholine-4-carbaldehyde 68.17
    sulfolane 108.87
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 13.91
    n-hexyl acetate 6.61
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 20.42
    sec-butyl acetate 5.08
    tert-butyl acetate 6.65
    decalin 0.13
    glycerin 16.3
    diglyme 35.23
    acrylic acid 21.36
    isopropyl myristate 2.86
    n-butyric acid 12.47
    acetyl acetate 8.57
    di(2-ethylhexyl) phthalate 5.91
    ethyl propionate 6.9
    nitromethane 55.25
    1,2-diethoxyethane 8.7
    benzonitrile 7.18
    trioctyl phosphate 3.54
    1-bromopropane 3.08
    gamma-valerolactone 82.67
    n-decanol 1.33
    triethyl phosphate 5.82
    4-methyl-2-pentanol 1.23
    propionitrile 5.09
    vinylene carbonate 23.23
    1,1,2-trichlorotrifluoroethane 78.27
    DMS 15.28
    cumene 0.87
    2-octanol 1.28
    2-hexanone 7.64
    octyl acetate 4.01
    limonene 1.47
    1,2-dimethoxyethane 19.83
    ethyl orthosilicate 4.79
    tributyl phosphate 4.63
    diacetone alcohol 14.99
    N,N-dimethylaniline 4.41
    acrylonitrile 9.87
    aniline 6.22
    1,3-propanediol 6.85
    bromobenzene 3.89
    dibromomethane 8.18
    1,1,2,2-tetrachloroethane 33.84
    2-methyl-cyclohexyl acetate 7.96
    tetrabutyl urea 7.17
    diisobutyl methanol 1.35
    2-phenylethanol 7.5
    styrene 1.49
    dioctyl adipate 6.89
    dimethyl sulfate 39.06
    ethyl butyrate 6.45
    methyl lactate 21.01
    butyl lactate 10.69
    diethyl carbonate 5.38
    propanediol butyl ether 12.92
    triethyl orthoformate 6.48
    p-tert-butyltoluene 1.19
    methyl 4-tert-butylbenzoate 12.74
    morpholine 23.18
    tert-butylamine 0.95
    n-dodecanol 0.99
    dimethoxymethane 24.31
    ethylene carbonate 16.37
    cyrene 27.72
    2-ethoxyethyl acetate 14.88
    2-ethylhexyl acetate 6.11
    1,2,4-trichlorobenzene 9.97
    4-methylpyridine 14.08
    dibutyl ether 1.88
    2,6-dimethyl-4-heptanol 1.35
    DEF 15.47
    dimethyl isosorbide 35.66
    tetrachloroethylene 14.65
    eugenol 13.37
    triacetin 16.89
    span 80 13.93
    1,4-butanediol 2.96
    1,1-dichloroethane 8.41
    2-methyl-1-pentanol 2.78
    methyl formate 15.89
    2-methyl-1-butanol 2.59
    n-decane 0.1
    butyronitrile 3.38
    3,7-dimethyl-1-octanol 1.98
    1-chlorooctane 0.69
    1-chlorotetradecane 0.34
    n-nonane 0.08
    undecane 0.08
    tert-butylcyclohexane 0.11
    cyclooctane 0.05
    cyclopentanol 6.94
    tetrahydropyran 8.03
    tert-amyl methyl ether 2.61
    2,5,8-trioxanonane 26.72
    1-hexene 0.5
    2-isopropoxyethanol 9.7
    2,2,2-trifluoroethanol 11.76
    methyl butyrate 9.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction