Cyclizine hydrochloride

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  • Identifiers

    CAS number
    303-25-3

    Molecular formula
    C18H23ClN2

    SMILES
    CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Animal 38.31%
    Fishy 38.1%
    Sweet 30.59%
    Floral 27.49%
    Cheesy 26.47%
    Earthy 24.62%
    Odorless 24.46%
    Honey 23.77%
    Burnt 23.47%
    Ripe 22.88%

     

    Flavor
    Bitter 55.58%
    Fruity 25.23%
    Waxy 21.31%
    Very strong 20.13%
    Alkaline 19.87%
    Indole 19.75%
    Nitrile 19.74%
    Moth ball 19.64%
    Cedarleaf 19.59%
    Naphthelene 19.15%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.88 (neutral)

    Molecular weight
    302.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    391°C

    Flash point

    • 170.37 ˚C est.

  • Synonyms

    • Cyclizine hydrochloride
    • 303-25-3
    • CYCLIZINE HCl
    • Marezine hydrochloride
    • Echnatol
    • Fortravel
    • Reis-fit
    • Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)
    • Marzine
    • Valoid
    • 1-(diphenylmethyl)-4-methylpiperazine hydrochloride
    • 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride
    • 1-benzhydryl-4-methylpiperazine;hydrochloride
    • cyclizine monohydrochloride
    • W0O1NHP4WE
    • NSC-169102
    • (+-)-1-Diphenylmethyl-4-methylpiperazine hydrochloride
    • 7380-29-2
    • Dihydrochlorid
    • Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride
    • CHEBI:51045
    • N-Benzhydryl-N'-methylpiperazine monohydrochloride
    • Cyclizine chloride
    • 1-benzhydryl-4-methylpiperazin-4-ium;chloride
    • Collox
    • Marezine;N-Methyl-N'-benzhydrylpiperazine; NSC 26608; Nautazine; Ne-Devomit; Neo-Devomit
    • Cyclizini hydrochloridum
    • UNII-W0O1NHP4WE
    • Cyclizine hydrochloride (USP)
    • SR-05000001595
    • Cyclizine hydrochloride [USP:BAN]
    • Prestwick_789
    • EINECS 206-136-9
    • component of Diconal
    • CYCLIZINEHCL
    • NSC 169102
    • N-Benzhydryl-N'-methylpiperazine hydrochloride
    • SCHEMBL97825
    • MLS002153853
    • piperazine,1-(diphenylmethyl)-4-methyl-,hydrochloride
    • CHEMBL1324714
    • HMS1569F21
    • BCP30021
    • Cyclizine HCl;Marezine hydrochloride
    • CYCLIZINE HYDROCHLORIDE [MI]
    • NSC169102
    • AKOS028113205
    • CCG-220510
    • CYCLIZINE HYDROCHLORIDE [MART.]
    • FC20679
    • CYCLIZINE HYDROCHLORIDE [USP-RS]
    • CYCLIZINE HYDROCHLORIDE [WHO-DD]
    • NCGC00180957-01
    • AS-80830
    • SMR001233212
    • WLN: T6N DNTJ A1 DYR & R & GH
    • 1-benzhydryl-4-methylpiperazine hydrochloride
    • CYCLIZINE HYDROCHLORIDE [EP IMPURITY]
    • NS00079307
    • CYCLIZINE HYDROCHLORIDE [EP MONOGRAPH]
    • CYCLIZINE HYDROCHLORIDE [USP MONOGRAPH]
    • D03622
    • F87280
    • EN300-18536064
    • SR-05000001595-3
    • Q27122290
    • Z3245419176
    • (.+-.)-1-Diphenylmethyl-4-methylpiperazine hydrochloride
    • 1-(Diphenylmethyl)-4-methylpiperazine hydrochloride;Marezine hydrochloride;Marzine

  • Applications

    Cyclizine hydrochloride is primarily used as an active pharmaceutical ingredient with antiemetic activity, notably for motion sickness and related nausea; the hydrochloride salt improves solubility and facilitates formulation as oral dosage forms and injectables for human use; it is also used in veterinary medicine as an antiemetic for animals; and it may serve as an intermediate or synthetic precursor in the manufacture of related antihistamines or other pharmaceutical intermediates.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 62.62
    methanol 57.0
    isopropanol 31.31
    water 0.97
    ethyl acetate 140.61
    n-propanol 75.12
    acetone 183.53
    n-butanol 66.5
    acetonitrile 86.85
    DMF 305.53
    toluene 107.31
    isobutanol 60.68
    1,4-dioxane 277.33
    methyl acetate 161.57
    THF 400.61
    2-butanone 173.91
    n-pentanol 56.94
    sec-butanol 39.09
    n-hexane 11.31
    ethylene glycol 42.66
    NMP 280.6
    cyclohexane 36.19
    DMSO 357.29
    n-butyl acetate 137.14
    n-octanol 25.43
    chloroform 1136.33
    n-propyl acetate 113.97
    acetic acid 183.99
    dichloromethane 1096.68
    cyclohexanone 330.02
    propylene glycol 43.86
    isopropyl acetate 76.58
    DMAc 290.89
    2-ethoxyethanol 134.35
    isopentanol 57.25
    n-heptane 13.35
    ethyl formate 207.9
    1,2-dichloroethane 657.87
    n-hexanol 76.07
    2-methoxyethanol 173.82
    isobutyl acetate 86.2
    tetrachloromethane 125.39
    n-pentyl acetate 65.83
    transcutol 295.18
    n-heptanol 39.28
    ethylbenzene 49.23
    MIBK 68.2
    2-propoxyethanol 159.78
    tert-butanol 39.66
    MTBE 44.47
    2-butoxyethanol 92.81
    propionic acid 132.95
    o-xylene 70.19
    formic acid 67.77
    diethyl ether 79.85
    m-xylene 62.13
    p-xylene 68.22
    chlorobenzene 241.62
    dimethyl carbonate 107.22
    n-octane 5.87
    formamide 97.65
    cyclopentanone 419.66
    2-pentanone 121.38
    anisole 93.78
    cyclopentyl methyl ether 159.48
    gamma-butyrolactone 519.74
    1-methoxy-2-propanol 102.57
    pyridine 324.7
    3-pentanone 148.27
    furfural 494.56
    n-dodecane 4.09
    diethylene glycol 137.23
    diisopropyl ether 23.77
    tert-amyl alcohol 39.2
    acetylacetone 156.64
    n-hexadecane 4.72
    acetophenone 120.54
    methyl propionate 156.65
    isopentyl acetate 118.6
    trichloroethylene 1140.09
    n-nonanol 27.44
    cyclohexanol 92.4
    benzyl alcohol 103.85
    2-ethylhexanol 60.37
    isooctanol 35.19
    dipropyl ether 84.91
    1,2-dichlorobenzene 233.08
    ethyl lactate 81.4
    propylene carbonate 291.25
    n-methylformamide 163.56
    2-pentanol 36.43
    n-pentane 11.0
    1-propoxy-2-propanol 107.34
    1-methoxy-2-propyl acetate 141.02
    2-(2-methoxypropoxy) propanol 81.87
    mesitylene 39.47
    ε-caprolactone 255.66
    p-cymene 43.74
    epichlorohydrin 609.94
    1,1,1-trichloroethane 382.62
    2-aminoethanol 60.36
    morpholine-4-carbaldehyde 304.39
    sulfolane 540.06
    2,2,4-trimethylpentane 7.96
    2-methyltetrahydrofuran 195.3
    n-hexyl acetate 65.76
    isooctane 4.55
    2-(2-butoxyethoxy)ethanol 111.04
    sec-butyl acetate 68.06
    tert-butyl acetate 74.05
    decalin 14.79
    glycerin 78.29
    diglyme 246.1
    acrylic acid 159.13
    isopropyl myristate 32.09
    n-butyric acid 171.18
    acetyl acetate 122.49
    di(2-ethylhexyl) phthalate 48.76
    ethyl propionate 98.32
    nitromethane 322.65
    1,2-diethoxyethane 110.34
    benzonitrile 130.39
    trioctyl phosphate 31.95
    1-bromopropane 212.59
    gamma-valerolactone 471.76
    n-decanol 22.4
    triethyl phosphate 76.05
    4-methyl-2-pentanol 28.29
    propionitrile 102.23
    vinylene carbonate 305.15
    1,1,2-trichlorotrifluoroethane 439.18
    DMS 101.83
    cumene 39.97
    2-octanol 19.05
    2-hexanone 94.83
    octyl acetate 43.02
    limonene 61.08
    1,2-dimethoxyethane 200.6
    ethyl orthosilicate 67.36
    tributyl phosphate 42.76
    diacetone alcohol 83.01
    N,N-dimethylaniline 68.3
    acrylonitrile 144.4
    aniline 144.45
    1,3-propanediol 75.31
    bromobenzene 253.81
    dibromomethane 605.49
    1,1,2,2-tetrachloroethane 856.93
    2-methyl-cyclohexyl acetate 97.0
    tetrabutyl urea 49.44
    diisobutyl methanol 32.2
    2-phenylethanol 98.08
    styrene 64.71
    dioctyl adipate 60.77
    dimethyl sulfate 185.26
    ethyl butyrate 118.32
    methyl lactate 102.93
    butyl lactate 67.58
    diethyl carbonate 97.84
    propanediol butyl ether 57.72
    triethyl orthoformate 92.17
    p-tert-butyltoluene 37.78
    methyl 4-tert-butylbenzoate 88.53
    morpholine 277.86
    tert-butylamine 26.7
    n-dodecanol 19.14
    dimethoxymethane 186.86
    ethylene carbonate 259.62
    cyrene 119.52
    2-ethoxyethyl acetate 105.94
    2-ethylhexyl acetate 101.5
    1,2,4-trichlorobenzene 276.48
    4-methylpyridine 220.51
    dibutyl ether 45.23
    2,6-dimethyl-4-heptanol 32.2
    DEF 174.23
    dimethyl isosorbide 169.25
    tetrachloroethylene 574.8
    eugenol 84.35
    triacetin 96.05
    span 80 66.16
    1,4-butanediol 45.5
    1,1-dichloroethane 404.87
    2-methyl-1-pentanol 56.54
    methyl formate 214.65
    2-methyl-1-butanol 60.12
    n-decane 6.76
    butyronitrile 93.51
    3,7-dimethyl-1-octanol 31.13
    1-chlorooctane 28.78
    1-chlorotetradecane 12.83
    n-nonane 6.34
    undecane 5.03
    tert-butylcyclohexane 10.82
    cyclooctane 11.84
    cyclopentanol 105.49
    tetrahydropyran 238.79
    tert-amyl methyl ether 45.96
    2,5,8-trioxanonane 160.47
    1-hexene 38.29
    2-isopropoxyethanol 86.84
    2,2,2-trifluoroethanol 119.1
    methyl butyrate 140.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction