Cyclizine hydrochloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    303-25-3

    Molecular formula
    C18H23ClN2

    SMILES
    CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Odorless 40.21%
    Fishy 31.65%
    Animal 31.52%
    Sweet 25.98%
    Bitter 24.95%
    Phenolic 23.19%
    Musty 21.96%
    Floral 20.32%
    Earthy 19.54%
    Honey 19.35%

    Scent© AI

  • Properties

    pKa est.
    -341889.03 (strong acid)

    Molecular weight
    302.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    409°C

    Flash point est.
    106.75 ˚C

  • Synonyms

    • Cyclizine hydrochloride
    • 303-25-3
    • CYCLIZINE HCl
    • Marezine hydrochloride
    • Echnatol
    • Fortravel
    • Reis-fit
    • Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)
    • Marzine
    • Valoid
    • 1-(diphenylmethyl)-4-methylpiperazine hydrochloride
    • 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride
    • 1-benzhydryl-4-methylpiperazine;hydrochloride
    • cyclizine monohydrochloride
    • W0O1NHP4WE
    • NSC-169102
    • (+-)-1-Diphenylmethyl-4-methylpiperazine hydrochloride
    • 7380-29-2
    • Dihydrochlorid
    • Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride
    • CHEBI:51045
    • N-Benzhydryl-N'-methylpiperazine monohydrochloride
    • Cyclizine chloride
    • 1-benzhydryl-4-methylpiperazin-4-ium;chloride
    • Collox
    • Marezine;N-Methyl-N'-benzhydrylpiperazine; NSC 26608; Nautazine; Ne-Devomit; Neo-Devomit
    • Cyclizini hydrochloridum
    • UNII-W0O1NHP4WE
    • Cyclizine hydrochloride (USP)
    • SR-05000001595
    • Cyclizine hydrochloride [USP:BAN]
    • Prestwick_789
    • EINECS 206-136-9
    • component of Diconal
    • CYCLIZINEHCL
    • NSC 169102
    • N-Benzhydryl-N'-methylpiperazine hydrochloride
    • SCHEMBL97825
    • MLS002153853
    • piperazine,1-(diphenylmethyl)-4-methyl-,hydrochloride
    • CHEMBL1324714
    • HMS1569F21
    • BCP30021
    • Cyclizine HCl;Marezine hydrochloride
    • CYCLIZINE HYDROCHLORIDE [MI]
    • NSC169102
    • AKOS028113205
    • CCG-220510
    • CYCLIZINE HYDROCHLORIDE [MART.]
    • FC20679
    • CYCLIZINE HYDROCHLORIDE [USP-RS]
    • CYCLIZINE HYDROCHLORIDE [WHO-DD]
    • NCGC00180957-01
    • AS-80830
    • SMR001233212
    • WLN: T6N DNTJ A1 DYR & R & GH
    • 1-benzhydryl-4-methylpiperazine hydrochloride
    • CYCLIZINE HYDROCHLORIDE [EP IMPURITY]
    • NS00079307
    • CYCLIZINE HYDROCHLORIDE [EP MONOGRAPH]
    • CYCLIZINE HYDROCHLORIDE [USP MONOGRAPH]
    • D03622
    • F87280
    • EN300-18536064
    • SR-05000001595-3
    • Q27122290
    • Z3245419176
    • (.+-.)-1-Diphenylmethyl-4-methylpiperazine hydrochloride
    • 1-(Diphenylmethyl)-4-methylpiperazine hydrochloride;Marezine hydrochloride;Marzine

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 37.25
    methanol 228.52
    isopropanol 3.39
    water 176.6
    ethyl acetate 0.86
    n-propanol 15.07
    acetone 1.46
    n-butanol 5.84
    acetonitrile 2.61
    DMF 18.53
    toluene 0.12
    isobutanol 7.29
    1,4-dioxane 1.78
    methyl acetate 1.09
    THF 0.75
    2-butanone 0.7
    n-pentanol 7.96
    sec-butanol 2.15
    n-hexane 0.3
    ethylene glycol 203.81
    NMP 23.09
    cyclohexane 0.2
    DMSO 28.56
    n-butyl acetate 3.1
    n-octanol 2.05
    chloroform 28.62
    n-propyl acetate 2.61
    acetic acid 81.86
    dichloromethane 30.06
    cyclohexanone 3.14
    propylene glycol 30.21
    isopropyl acetate 0.68
    DMAc 18.9
    2-ethoxyethanol 35.29
    isopentanol 3.9
    n-heptane 0.37
    ethyl formate 7.38
    1,2-dichloroethane 10.63
    n-hexanol 7.26
    2-methoxyethanol 55.99
    isobutyl acetate 1.91
    tetrachloromethane 3.89
    n-pentyl acetate 2.46
    transcutol 38.66
    n-heptanol 6.51
    ethylbenzene 0.42
    MIBK 0.73
    2-propoxyethanol 27.29
    tert-butanol 2.3
    MTBE 0.24
    2-butoxyethanol 24.36
    propionic acid 22.28
    o-xylene 0.5
    formic acid 438.23
    diethyl ether 0.46
    m-xylene 0.42
    p-xylene 0.6
    chlorobenzene 1.06
    dimethyl carbonate 2.13
    n-octane 0.2
    formamide 295.73
    cyclopentanone 2.28
    2-pentanone 0.61
    anisole 0.99
    cyclopentyl methyl ether 0.65
    gamma-butyrolactone 6.9
    1-methoxy-2-propanol 11.76
    pyridine 2.39
    3-pentanone 0.67
    furfural 19.44
    n-dodecane 0.12
    diethylene glycol 73.57
    diisopropyl ether 0.22
    tert-amyl alcohol 2.04
    acetylacetone 1.6
    n-hexadecane 0.12
    acetophenone 3.81
    methyl propionate 1.49
    isopentyl acetate 2.9
    trichloroethylene 19.52
    n-nonanol 2.18
    cyclohexanol 2.61
    benzyl alcohol 6.09
    2-ethylhexanol 3.71
    isooctanol 4.93
    dipropyl ether 1.38
    1,2-dichlorobenzene 3.65
    ethyl lactate 9.26
    propylene carbonate 7.1
    n-methylformamide 42.7
    2-pentanol 1.19
    n-pentane 0.21
    1-propoxy-2-propanol 11.03
    1-methoxy-2-propyl acetate 4.71
    2-(2-methoxypropoxy) propanol 13.29
    mesitylene 0.54
    ε-caprolactone 5.43
    p-cymene 1.52
    epichlorohydrin 5.64
    1,1,1-trichloroethane 2.66
    2-aminoethanol 144.55
    morpholine-4-carbaldehyde 22.12
    sulfolane 19.42
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 0.54
    n-hexyl acetate 2.03
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 17.93
    sec-butyl acetate 1.12
    tert-butyl acetate 0.82
    decalin 0.26
    glycerin 108.27
    diglyme 24.72
    acrylic acid 35.01
    isopropyl myristate 0.86
    n-butyric acid 13.33
    acetyl acetate 1.91
    di(2-ethylhexyl) phthalate 4.89
    ethyl propionate 1.73
    nitromethane 34.73
    1,2-diethoxyethane 2.75
    benzonitrile 3.34
    trioctyl phosphate 2.95
    1-bromopropane 1.85
    gamma-valerolactone 10.79
    n-decanol 1.67
    triethyl phosphate 3.97
    4-methyl-2-pentanol 1.3
    propionitrile 2.53
    vinylene carbonate 11.78
    1,1,2-trichlorotrifluoroethane 60.05
    DMS 3.69
    cumene 1.0
    2-octanol 1.68
    2-hexanone 1.41
    octyl acetate 1.41
    limonene 1.47
    1,2-dimethoxyethane 10.18
    ethyl orthosilicate 3.53
    tributyl phosphate 3.35
    diacetone alcohol 3.63
    N,N-dimethylaniline 2.25
    acrylonitrile 6.69
    aniline 1.25
    1,3-propanediol 59.68
    bromobenzene 0.74
    dibromomethane 13.14
    1,1,2,2-tetrachloroethane 18.25
    2-methyl-cyclohexyl acetate 4.51
    tetrabutyl urea 5.02
    diisobutyl methanol 1.61
    2-phenylethanol 7.68
    styrene 0.36
    dioctyl adipate 2.74
    dimethyl sulfate 6.81
    ethyl butyrate 2.71
    methyl lactate 10.08
    butyl lactate 9.64
    diethyl carbonate 2.93
    propanediol butyl ether 16.58
    triethyl orthoformate 3.12
    p-tert-butyltoluene 1.23
    methyl 4-tert-butylbenzoate 7.57
    morpholine 3.61
    tert-butylamine 1.24
    n-dodecanol 1.24
    dimethoxymethane 4.7
    ethylene carbonate 7.63
    cyrene 22.25
    2-ethoxyethyl acetate 4.61
    2-ethylhexyl acetate 2.58
    1,2,4-trichlorobenzene 4.56
    4-methylpyridine 1.06
    dibutyl ether 0.67
    2,6-dimethyl-4-heptanol 1.61
    DEF 3.43
    dimethyl isosorbide 16.43
    tetrachloroethylene 23.74
    eugenol 14.77
    triacetin 5.98
    span 80 12.13
    1,4-butanediol 38.78
    1,1-dichloroethane 2.43
    2-methyl-1-pentanol 5.58
    methyl formate 18.8
    2-methyl-1-butanol 4.77
    n-decane 0.17
    butyronitrile 1.84
    3,7-dimethyl-1-octanol 2.0
    1-chlorooctane 0.58
    1-chlorotetradecane 0.32
    n-nonane 0.15
    undecane 0.14
    tert-butylcyclohexane 0.23
    cyclooctane 0.13
    cyclopentanol 2.51
    tetrahydropyran 0.57
    tert-amyl methyl ether 0.42
    2,5,8-trioxanonane 18.99
    1-hexene 0.63
    2-isopropoxyethanol 12.83
    2,2,2-trifluoroethanol 53.89
    methyl butyrate 3.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction