Cyclamic acid

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  • Identifiers

    CAS number
    100-88-9

    Molecular formula
    C6H13NO3S

    SMILES
    C1CCC(CC1)NS(=O)(=O)O

  • Odor profile

    Fragrance
    Odorless 70.95%
    Savory 21.7%
    Cooked 20.38%
    Roasted 16.86%
    Meaty 16.63%
    Pungent 16.33%
    Fishy 14.63%
    Fresh 14.25%
    Sulfurous 14.17%
    Cooling 13.8%

     

    Flavor
    Bitter 73.51%
    Odorless 27.2%
    Bland 22.35%
    Nitrile 20.97%
    Alkaline 19.6%
    Cedarleaf 19.53%
    Shrimp 19.17%
    Taco 19.06%
    Formyl 18.95%
    Gooseberry 18.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    7.63 (neutral)

    Molecular weight
    179.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    342°C

    Melting point expt.

    • 169 - 170 °C

    Flash point

    • 175.89 ˚C est.

    Solubility expt.

    • 1000000 mg/L @ 25 °C (exp)

  • Synonyms

    • Cyclamic acid
    • 100-88-9
    • Cyclohexylsulfamic acid
    • N-Cyclohexylsulfamic acid
    • CYCLAMATE
    • Cyclohexanesulfamic acid
    • Hexamic acid
    • Sucaryl
    • Sucaryl acid
    • Cyclohexylaminesulphonic acid
    • Sulfamic acid, cyclohexyl-
    • N-Cyclohexylsulphamic acid
    • Cyclohexylamidosulfuric acid
    • Cyclohexylaminesulfonic acid
    • Sulfamic acid, N-cyclohexyl-
    • Cyclohexylsulphamic acid
    • Cyclohexanesulphamic acid
    • Zyklamat
    • Cyclohexylamidosulphuric acid
    • Cylamic acid
    • Cyclohexylamine sulfamic acid
    • Cyclohexylamide sulfate
    • NSC 220327
    • Hexamic acid (TN)
    • Cyclamate, Potassium
    • NSC-220327
    • Cyclamate, sodium salt
    • HN3OFO5036
    • Cyclohexylsulfamic acid;Cyclamate
    • DTXSID5041809
    • INS NO.952(I)
    • CHEBI:15964
    • INS-952(I)
    • Asugryn
    • NSC220327
    • NCGC00165999-01
    • Cyclamic acid (USAN)
    • E-952(I)
    • CYCLAMIC ACID [USAN]
    • DTXCID3021809
    • Cyclamates
    • Cyclamsaeure
    • Cyclamate, Calcium
    • Cyclamic acid [USAN:BAN]
    • CAS-100-88-9
    • N-?Cyclohexylsulfamic Acid(Cyclamic Acid)
    • HSDB 275
    • N-Cyclohexylsulfamsaeure
    • E952
    • EINECS 202-898-1
    • Sulfuric acid monoamide, N-cyclohexyl-
    • BRN 2208885
    • UNII-HN3OFO5036
    • cyclamic-acid
    • N-(Cyclohexyl)aminosulfonsaeure
    • Sucaryl acidxine
    • Cyclamic acid
    • Cyclamate Calcium (2:1) Salt
    • (Cyclamic Acid)
    • MFCD00065234
    • Cyclohexylamide sulphate
    • cyclohexyl-sulfamic acid
    • n-cyclohexyl-sulfamic acid
    • bmse000657
    • N-?Cyclohexylsulfamic Acid
    • N-cyclo-hexylsulphamic acid
    • CYCLAMIC ACID [II]
    • CYCLAMIC ACID [MI]
    • SCHEMBL6227
    • Cyclamic acid, BAN, USAN
    • CYCLAMIC ACID [HSDB]
    • 4-12-00-00102 (Beilstein Handbook Reference)
    • CYCLAMIC ACID [MART.]
    • CyclohexansulfamidsA currencyure
    • Cyclohexylamine-N-sulfonic acid
    • CYCLAMIC ACID [USP-RS]
    • CYCLAMIC ACID [WHO-DD]
    • CHEMBL1206440
    • GTPL12470
    • HMS3264K03
    • HMS3652C17
    • Pharmakon1600-01301015
    • HY-B0541
    • N-Cyclohexyl-Sulfuric acid monoamide
    • Tox21_112285
    • Tox21_301008
    • NSC760133
    • s4015
    • STL356798
    • AKOS015913947
    • Tox21_112285_1
    • CCG-213726
    • FC20675
    • NSC-760133
    • NCGC00165999-02
    • NCGC00165999-03
    • NCGC00254910-01
    • AS-59382
    • N-Cyclohexylsulfamic acid, >=98.0% (T)
    • NS00000401
    • SW219574-1
    • C02824
    • D02442
    • E78799
    • AB01563182_01
    • AB01563182_02
    • SR-01000940120
    • Q2130929
    • SR-01000940120-2
    • BRD-K50785021-001-02-1
    • BRD-K50785021-001-03-9
    • BRD-K50785021-001-04-7
    • N-Cyclohexylsulfamic acid; Hexamic acid; Sucaryl acid
    • Cyclamic acid, United States Pharmacopeia (USP) Reference Standard

  • Applications

    Cyclamic acid (CAS 100-88-9) is primarily used as an intermediate to produce cyclamate-based artificial sweeteners (sodium cyclamate, calcium cyclamate) for food and beverage applications where permitted; it also serves as a starting material in the industrial synthesis of sulfonamide/sulfonate derivatives; in research and development it is used as a reagent for developing related cyclamate compounds; and it can be employed as an analytical reference material or calibrant for quality control and analytical methods detecting cyclamate in products, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.9
    methanol 53.68
    isopropanol 21.97
    water 3.87
    ethyl acetate 7.5
    n-propanol 20.05
    acetone 24.97
    n-butanol 18.52
    acetonitrile 9.54
    DMF 95.66
    toluene 3.2
    isobutanol 11.18
    1,4-dioxane 20.29
    methyl acetate 8.5
    THF 57.69
    2-butanone 13.5
    n-pentanol 10.84
    sec-butanol 13.82
    n-hexane 0.32
    ethylene glycol 26.89
    NMP 126.51
    cyclohexane 1.01
    DMSO 145.25
    n-butyl acetate 11.28
    n-octanol 6.05
    chloroform 6.77
    n-propyl acetate 5.9
    acetic acid 28.37
    dichloromethane 8.18
    cyclohexanone 44.56
    propylene glycol 37.17
    isopropyl acetate 6.82
    DMAc 63.31
    2-ethoxyethanol 25.06
    isopentanol 12.7
    n-heptane 0.66
    ethyl formate 14.18
    1,2-dichloroethane 8.84
    n-hexanol 16.38
    2-methoxyethanol 64.21
    isobutyl acetate 3.65
    tetrachloromethane 1.25
    n-pentyl acetate 8.36
    transcutol 30.07
    n-heptanol 9.12
    ethylbenzene 2.25
    MIBK 9.64
    2-propoxyethanol 38.46
    tert-butanol 17.7
    MTBE 3.1
    2-butoxyethanol 20.32
    propionic acid 21.06
    o-xylene 4.48
    formic acid 27.48
    diethyl ether 3.12
    m-xylene 3.89
    p-xylene 3.12
    chlorobenzene 5.8
    dimethyl carbonate 6.53
    n-octane 0.35
    formamide 46.38
    cyclopentanone 66.29
    2-pentanone 13.12
    anisole 5.76
    cyclopentyl methyl ether 10.61
    gamma-butyrolactone 66.75
    1-methoxy-2-propanol 47.24
    pyridine 20.5
    3-pentanone 6.88
    furfural 64.2
    n-dodecane 0.34
    diethylene glycol 43.82
    diisopropyl ether 1.51
    tert-amyl alcohol 12.47
    acetylacetone 26.15
    n-hexadecane 0.39
    acetophenone 13.24
    methyl propionate 9.01
    isopentyl acetate 10.55
    trichloroethylene 14.74
    n-nonanol 6.02
    cyclohexanol 16.49
    benzyl alcohol 14.71
    2-ethylhexanol 7.56
    isooctanol 6.61
    dipropyl ether 3.84
    1,2-dichlorobenzene 7.29
    ethyl lactate 10.91
    propylene carbonate 30.08
    n-methylformamide 43.93
    2-pentanol 8.81
    n-pentane 0.46
    1-propoxy-2-propanol 23.99
    1-methoxy-2-propyl acetate 17.21
    2-(2-methoxypropoxy) propanol 21.63
    mesitylene 3.33
    ε-caprolactone 33.35
    p-cymene 4.2
    epichlorohydrin 39.14
    1,1,1-trichloroethane 3.89
    2-aminoethanol 38.44
    morpholine-4-carbaldehyde 68.41
    sulfolane 130.02
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 19.06
    n-hexyl acetate 9.24
    isooctane 0.29
    2-(2-butoxyethoxy)ethanol 24.94
    sec-butyl acetate 4.08
    tert-butyl acetate 8.83
    decalin 0.59
    glycerin 56.98
    diglyme 30.44
    acrylic acid 25.28
    isopropyl myristate 4.64
    n-butyric acid 24.3
    acetyl acetate 8.64
    di(2-ethylhexyl) phthalate 10.23
    ethyl propionate 5.51
    nitromethane 36.8
    1,2-diethoxyethane 6.64
    benzonitrile 13.97
    trioctyl phosphate 7.64
    1-bromopropane 2.86
    gamma-valerolactone 83.03
    n-decanol 4.95
    triethyl phosphate 7.21
    4-methyl-2-pentanol 5.72
    propionitrile 7.88
    vinylene carbonate 24.57
    1,1,2-trichlorotrifluoroethane 41.6
    DMS 10.1
    cumene 2.28
    2-octanol 5.26
    2-hexanone 6.93
    octyl acetate 6.86
    limonene 5.12
    1,2-dimethoxyethane 22.0
    ethyl orthosilicate 6.15
    tributyl phosphate 7.46
    diacetone alcohol 27.98
    N,N-dimethylaniline 6.39
    acrylonitrile 15.17
    aniline 10.7
    1,3-propanediol 45.16
    bromobenzene 4.1
    dibromomethane 5.29
    1,1,2,2-tetrachloroethane 15.11
    2-methyl-cyclohexyl acetate 10.68
    tetrabutyl urea 13.52
    diisobutyl methanol 5.2
    2-phenylethanol 18.44
    styrene 2.38
    dioctyl adipate 9.12
    dimethyl sulfate 19.17
    ethyl butyrate 8.29
    methyl lactate 21.69
    butyl lactate 14.66
    diethyl carbonate 6.03
    propanediol butyl ether 22.46
    triethyl orthoformate 6.86
    p-tert-butyltoluene 3.95
    methyl 4-tert-butylbenzoate 19.19
    morpholine 29.48
    tert-butylamine 7.05
    n-dodecanol 3.84
    dimethoxymethane 22.48
    ethylene carbonate 19.16
    cyrene 35.09
    2-ethoxyethyl acetate 11.22
    2-ethylhexyl acetate 8.03
    1,2,4-trichlorobenzene 10.37
    4-methylpyridine 15.72
    dibutyl ether 2.52
    2,6-dimethyl-4-heptanol 5.2
    DEF 19.95
    dimethyl isosorbide 38.62
    tetrachloroethylene 9.65
    eugenol 23.32
    triacetin 12.6
    span 80 23.23
    1,4-butanediol 17.61
    1,1-dichloroethane 4.05
    2-methyl-1-pentanol 7.96
    methyl formate 25.44
    2-methyl-1-butanol 10.36
    n-decane 0.46
    butyronitrile 9.74
    3,7-dimethyl-1-octanol 6.42
    1-chlorooctane 1.79
    1-chlorotetradecane 1.03
    n-nonane 0.39
    undecane 0.39
    tert-butylcyclohexane 0.4
    cyclooctane 0.44
    cyclopentanol 27.95
    tetrahydropyran 12.32
    tert-amyl methyl ether 3.34
    2,5,8-trioxanonane 31.55
    1-hexene 1.18
    2-isopropoxyethanol 13.81
    2,2,2-trifluoroethanol 14.43
    methyl butyrate 8.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction