Curcumin

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  • Identifiers

    CAS number
    458-37-7

    Molecular formula
    C21H20O6

    SMILES
    COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Spicy 56.55%
    Vanilla 54.39%
    Sweet 53.63%
    Balsamic 45.24%
    Creamy 36.56%
    Powdery 32.05%
    Caramellic 31.42%
    Warm 30.71%
    Milky 27.66%
    Woody 27.63%

     

    Flavor
    Bitter 43.26%
    Odorless 36.8%
    Mild 21.56%
    Bland 21.49%
    Faint 21.22%
    Very mild 20.37%
    Ethyl benzoate 19.95%
    Orange flower 19.69%
    Parsley 19.5%
    Lovage 19.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    10.21 (weak base)

    Molecular weight
    368.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    715°C

    Melting point expt.

    • 356 to 361 °F (NTP, 1992)
    • 183
    • 179 °C-182 °C
    • 183 °C

    Flash point

    • 235.09 ˚C est.

    Solubility expt.

    • Slightly soluble (hot) (NTP, 1992)
    • Insoluble in cold water
    • DARK RED; INSOL IN OIL DILL, VEGETABLE OIL; SOL IN OIL CLOVE; PARTLY SOL IN PROPYLENE GLYCOL, OIL CASSIA /TURMERIC/
    • Insoluble in water
    • Insoluble in ether; soluble in alcohol, glacial acetic acid
    • Very soluble in ethanol, acetic acid

  • Synonyms

    • curcumin
    • 458-37-7
    • Diferuloylmethane
    • Natural yellow 3
    • Kacha haldi
    • Curcumin I
    • Curcuma
    • Haldar
    • Indian saffron
    • Gelbwurz
    • (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
    • Souchet
    • Haidr
    • Halad
    • Halud
    • Yellow Ginger
    • Terra Merita
    • C.I. Natural Yellow 3
    • Safran d'Inde
    • Yo-Kin
    • Yellow puccoon
    • Diferaloylmethane
    • CI Natural Yellow 3
    • C.I. 75300
    • Jianghuangsu
    • Kurkumin
    • NanoCurc
    • Zlut prirodni 3
    • E 100
    • Lipocurc
    • Kurkum
    • Curcumin e100
    • CI 75300
    • NSC32982
    • NSC-32982
    • DTXSID8031077
    • 1,5-Di(vanillyliden)acetylaceton
    • 1,5-Divanillyliden-2,4-pentandion
    • NSC-687842
    • CHEBI:3962
    • IT942ZTH98
    • 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
    • INS NO. 100(I)
    • INS-100(I)
    • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-
    • E-100
    • (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
    • E100
    • DTXCID901421
    • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
    • Tumeric
    • Curcumin phytosome
    • Phytosome, Curcumin
    • Turmeric Essential Oil
    • RefChem:6414
    • Victory 19 Virus Out
    • Turmeric Super Whitening Oil
    • 207-280-5
    • 678-357-2
    • Curcumine
    • Hydrastis
    • Kurkumin [Czech]
    • Tumeric yellow
    • Curcumin (synthetic)
    • 94875-80-6
    • MFCD00008365
    • Zlut prirodni 3 [Czech]
    • Cucurmin
    • (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
    • Tumeric oleoresin
    • 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
    • Curcurmin
    • NSC 32982
    • MLS000069631
    • 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
    • CHEMBL140
    • SMR000058237
    • (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione
    • (E/Z)-Curcumin
    • NSC687842
    • NCGC00017159-05
    • 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
    • CAS-458-37-7
    • trans,trans-Curcumin
    • FEMA No. 3085
    • FEMA No. 3086
    • CCRIS 3257
    • CCRIS 5804
    • HSDB 4334
    • NCI-C61325
    • SR-01000000149
    • EINECS 207-280-5
    • NSC 687842
    • BRN 2306965
    • UNII-IT942ZTH98
    • Curcuma yellow
    • E 100 (Dye)
    • Diferuloylmethane;
    • Curcumin (Standard)
    • starbld0017234
    • CURCUMIN [HSDB]
    • CURCUMIN [USAN]
    • CURCUMIN [MI]
    • Opera_ID_1627
    • CURCUMIN [MART.]
    • CURCUMIN [USP-RS]
    • CURCUMIN [WHO-DD]
    • (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione
    • SCHEMBL8440
    • CUR-0
    • Curcumin, analytical standard
    • 4-08-00-03697 (Beilstein Handbook Reference)
    • MLS001148449
    • BIDD:ER0479
    • CU-01000001305-2
    • CHEMBL116438
    • cid_969516
    • GTPL7000
    • orb1308370
    • SCHEMBL13521974
    • BDBM29532
    • cid_5281767
    • HY-N0005R
    • MSK2436
    • cMAP_000052
    • HMS2233K04
    • HMS3649K06
    • 458-37-7

  • Applications

    Curcumin (CAS 458-37-7) is used as a natural pigment and functional additive across multiple industries: as a colorant in foods and beverages; as a colorant and antioxidant in cosmetics and personal care products; as a pigment in coatings and inks; as an antioxidant and stabilizing additive in polymers and plastics to improve aging resistance; and in pharmaceutical and nutraceutical formulations as a bioactive ingredient or formulation component, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.64
    methanol 3.9
    isopropanol 11.19
    water 0.0
    ethyl acetate 10.99
    n-propanol 12.24
    acetone 84.23
    n-butanol 3.59
    acetonitrile 9.24
    DMF 77.83
    toluene 2.66
    isobutanol 4.92
    1,4-dioxane 54.62
    methyl acetate 24.16
    THF 1275.1
    2-butanone 55.5
    n-pentanol 4.98
    sec-butanol 11.56
    n-hexane 0.71
    ethylene glycol 1.84
    NMP 44.5
    cyclohexane 0.64
    DMSO 1785.98
    n-butyl acetate 4.54
    n-octanol 2.32
    chloroform 22.22
    n-propyl acetate 7.31
    acetic acid 13.46
    dichloromethane 25.7
    cyclohexanone 41.03
    propylene glycol 5.26
    isopropyl acetate 6.11
    DMAc 130.22
    2-ethoxyethanol 22.82
    isopentanol 2.68
    n-heptane 0.58
    ethyl formate 6.45
    1,2-dichloroethane 21.5
    n-hexanol 2.72
    2-methoxyethanol 27.82
    isobutyl acetate 3.15
    tetrachloromethane 1.35
    n-pentyl acetate 3.99
    transcutol 25.71
    n-heptanol 2.06
    ethylbenzene 1.75
    MIBK 6.09
    2-propoxyethanol 16.69
    tert-butanol 13.67
    MTBE 11.49
    2-butoxyethanol 7.69
    propionic acid 10.73
    o-xylene 1.72
    formic acid 3.8
    diethyl ether 13.05
    m-xylene 0.89
    p-xylene 2.43
    chlorobenzene 3.06
    dimethyl carbonate 11.33
    n-octane 0.35
    formamide 13.41
    cyclopentanone 174.53
    2-pentanone 18.28
    anisole 7.95
    cyclopentyl methyl ether 26.91
    gamma-butyrolactone 110.14
    1-methoxy-2-propanol 20.35
    pyridine 27.93
    3-pentanone 17.89
    furfural 25.64
    n-dodecane 0.3
    diethylene glycol 10.69
    diisopropyl ether 1.91
    tert-amyl alcohol 10.39
    acetylacetone 29.29
    n-hexadecane 0.34
    acetophenone 7.91
    methyl propionate 16.65
    isopentyl acetate 4.37
    trichloroethylene 32.48
    n-nonanol 2.87
    cyclohexanol 6.44
    benzyl alcohol 5.82
    2-ethylhexanol 2.25
    isooctanol 2.0
    dipropyl ether 7.36
    1,2-dichlorobenzene 2.99
    ethyl lactate 5.38
    propylene carbonate 12.12
    n-methylformamide 19.05
    2-pentanol 3.33
    n-pentane 0.35
    1-propoxy-2-propanol 11.6
    1-methoxy-2-propyl acetate 10.05
    2-(2-methoxypropoxy) propanol 11.69
    mesitylene 0.6
    ε-caprolactone 20.39
    p-cymene 1.15
    epichlorohydrin 126.78
    1,1,1-trichloroethane 9.39
    2-aminoethanol 4.59
    morpholine-4-carbaldehyde 36.67
    sulfolane 173.3
    2,2,4-trimethylpentane 0.26
    2-methyltetrahydrofuran 96.62
    n-hexyl acetate 5.38
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 13.07
    sec-butyl acetate 4.09
    tert-butyl acetate 7.88
    decalin 0.4
    glycerin 7.55
    diglyme 29.26
    acrylic acid 9.38
    isopropyl myristate 3.05
    n-butyric acid 6.14
    acetyl acetate 6.78
    di(2-ethylhexyl) phthalate 2.95
    ethyl propionate 7.78
    nitromethane 60.73
    1,2-diethoxyethane 12.2
    benzonitrile 4.47
    trioctyl phosphate 2.18
    1-bromopropane 8.85
    gamma-valerolactone 78.31
    n-decanol 2.3
    triethyl phosphate 4.83
    4-methyl-2-pentanol 1.7
    propionitrile 9.73
    vinylene carbonate 8.95
    1,1,2-trichlorotrifluoroethane 29.58
    DMS 7.73
    cumene 1.14
    2-octanol 1.76
    2-hexanone 12.67
    octyl acetate 3.82
    limonene 1.91
    1,2-dimethoxyethane 50.5
    ethyl orthosilicate 4.48
    tributyl phosphate 2.96
    diacetone alcohol 12.85
    N,N-dimethylaniline 5.23
    acrylonitrile 11.86
    aniline 5.35
    1,3-propanediol 6.41
    bromobenzene 2.82
    dibromomethane 14.4
    1,1,2,2-tetrachloroethane 29.47
    2-methyl-cyclohexyl acetate 5.11
    tetrabutyl urea 5.14
    diisobutyl methanol 1.78
    2-phenylethanol 4.26
    styrene 2.31
    dioctyl adipate 5.77
    dimethyl sulfate 28.45
    ethyl butyrate 5.71
    methyl lactate 9.3
    butyl lactate 4.35
    diethyl carbonate 4.31
    propanediol butyl ether 5.85
    triethyl orthoformate 6.27
    p-tert-butyltoluene 1.06
    methyl 4-tert-butylbenzoate 7.6
    morpholine 76.23
    tert-butylamine 4.25
    n-dodecanol 1.83
    dimethoxymethane 51.04
    ethylene carbonate 8.01
    cyrene 14.02
    2-ethoxyethyl acetate 8.23
    2-ethylhexyl acetate 3.34
    1,2,4-trichlorobenzene 4.72
    4-methylpyridine 12.47
    dibutyl ether 5.8
    2,6-dimethyl-4-heptanol 1.78
    DEF 16.41
    dimethyl isosorbide 21.75
    tetrachloroethylene 12.24
    eugenol 7.13
    triacetin 8.6
    span 80 7.05
    1,4-butanediol 3.45
    1,1-dichloroethane 12.52
    2-methyl-1-pentanol 3.54
    methyl formate 15.75
    2-methyl-1-butanol 3.35
    n-decane 0.56
    butyronitrile 5.14
    3,7-dimethyl-1-octanol 2.34
    1-chlorooctane 2.01
    1-chlorotetradecane 0.87
    n-nonane 0.48
    undecane 0.4
    tert-butylcyclohexane 0.3
    cyclooctane 0.22
    cyclopentanol 21.95
    tetrahydropyran 67.39
    tert-amyl methyl ether 8.8
    2,5,8-trioxanonane 22.33
    1-hexene 2.7
    2-isopropoxyethanol 13.45
    2,2,2-trifluoroethanol 6.03
    methyl butyrate 9.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction