Molecular formula
C13H17NO

SMILES
CCN(C1=CC=CC=C1C)C(=O)C=CC

Safety labels

Fragrance
Fruity	49.71%
Grape	41.38%
Floral	35.69%
Citrus	33.65%
Grapefruit	32.96%
Meaty	30.95%
Herbal	30.0%
Sweet	29.01%
Roasted	28.67%
Spicy	27.83%

 

Flavor
Fruity	28.02%
Bitter	27.32%
Odorless	23.29%
Orange flower	20.04%
Roasted	19.97%
Nitrile	19.68%
Heather	19.46%
Genet	19.43%
Bread crust	19.32%
Broom	19.26%

 

Odor impact est.
Medium

XLogP3-AA
2.8

pKa est.
7.06 (neutral)

Molecular weight
203.28 g/mol

Vapor pressure est.

• hPa @ 20°C
• hPa @ 25°C

Evaporation rate
Very slow

Melting point expt.

• < 25 °C

Boiling point

• 154 °C at 1.30E+01 mm Hg

Flash point

• 135.45 ˚C est.

Solubility expt.

• 3.53e-01 g/L

• Crotan
• DTXSID6040664
• CHEBI:31439
• N-ethyl-N-(2-methylphenyl)but-2-enamide
• Crotamiton (Cis/Trans Mixture)
• Crotaglin
• N-ethylcrotono-o-toluidide
• D6S4O4XD0H
• Crotamiton; N-Ethyl-N-(2-methylphenyl)but-2-enamide
• DTXCID4020664
• Prestwick0_000951
• Prestwick1_000951
• Spectrum2_001700
• Spectrum3_001081
• Spectrum4_001234
• CROTAMITON (MART.)
• NCIOpen2_004405
• KBioGR_001728
• SPBio_001660
• SPBio_003091
• CHEMBL3183440
• CROTAMITON (EP IMPURITY)
• KBio3_001942
• CROTAMITON (EP MONOGRAPH)
• CROTAMITON (USP IMPURITY)
• DNTGGZPQPQTDQF-UHFFFAOYSA-N
• CROTAMITON (USP MONOGRAPH)
• HMS3369O11
• HMS3393E10
• AKOS028108434
• DB00265
• NCGC00094571-07
• NCGC00248176-01
• DB-051546
• 207-596-3

Primarily used as a topical antipruritic in dermatology, crotamiton is formulated into creams, lotions, and gels to relieve itching and aid in the management of scabies and other pruritic skin conditions. In cosmetics and personal care, it may be included in skin-care preparations designed to soothe itch-prone or irritated skin. It appears in prescription and over-the-counter topical products as an active ingredient in itch-relief formulations. In formulation development and manufacturing, crotamiton requires attention to quality control and regulatory considerations for dermatology products. Its use is subject to local regulations and formulation limits.

gpt-5-nano

Solvent	Solubility (g/L)
ethanol	472.31
methanol	574.99
isopropanol	392.86
water	1.18
ethyl acetate	479.1
n-propanol	472.19
acetone	698.28
n-butanol	488.0
acetonitrile	548.28
DMF	1242.73
toluene	413.82
isobutanol	416.54
1,4-dioxane	898.4
methyl acetate	488.81
THF	939.05
2-butanone	625.23
n-pentanol	370.05
sec-butanol	413.27
n-hexane	94.42
ethylene glycol	95.85
NMP	1105.92
cyclohexane	172.64
DMSO	661.42
n-butyl acetate	451.56
n-octanol	209.83
chloroform	2960.32
n-propyl acetate	328.16
acetic acid	488.74
dichloromethane	2642.85
cyclohexanone	1091.55
propylene glycol	128.16
isopropyl acetate	291.4
DMAc	912.52
2-ethoxyethanol	342.11
isopentanol	389.35
n-heptane	43.84
ethyl formate	428.06
1,2-dichloroethane	1531.92
n-hexanol	377.49
2-methoxyethanol	539.3
isobutyl acetate	229.31
tetrachloromethane	350.12
n-pentyl acetate	285.16
transcutol	565.83
n-heptanol	190.61
ethylbenzene	253.29
MIBK	284.08
2-propoxyethanol	432.5
tert-butanol	399.73
MTBE	425.04
2-butoxyethanol	260.39
propionic acid	405.99
o-xylene	250.17
formic acid	134.92
diethyl ether	513.52
m-xylene	258.02
p-xylene	310.54
chlorobenzene	691.07
dimethyl carbonate	268.2
n-octane	32.07
formamide	224.99
cyclopentanone	1089.17
2-pentanone	487.17
anisole	393.69
cyclopentyl methyl ether	518.03
gamma-butyrolactone	1068.33
1-methoxy-2-propanol	387.48
pyridine	966.03
3-pentanone	423.69
furfural	892.26
n-dodecane	28.69
diethylene glycol	281.33
diisopropyl ether	139.57
tert-amyl alcohol	390.47
acetylacetone	466.59
n-hexadecane	33.57
acetophenone	368.01
methyl propionate	424.81
isopentyl acetate	363.24
trichloroethylene	2545.83
n-nonanol	179.18
cyclohexanol	499.18
benzyl alcohol	344.53
2-ethylhexanol	219.57
isooctanol	158.93
dipropyl ether	216.85
1,2-dichlorobenzene	603.47
ethyl lactate	174.11
propylene carbonate	647.55
n-methylformamide	513.56
2-pentanol	301.59
n-pentane	79.85
1-propoxy-2-propanol	279.12
1-methoxy-2-propyl acetate	319.54
2-(2-methoxypropoxy) propanol	214.71
mesitylene	166.03
ε-caprolactone	719.18
p-cymene	134.79
epichlorohydrin	1195.32
1,1,1-trichloroethane	1078.95
2-aminoethanol	210.64
morpholine-4-carbaldehyde	759.88
sulfolane	1051.41
2,2,4-trimethylpentane	45.67
2-methyltetrahydrofuran	698.27
n-hexyl acetate	392.17
isooctane	33.08
2-(2-butoxyethoxy)ethanol	282.51
sec-butyl acetate	224.8
tert-butyl acetate	283.26
decalin	84.0
glycerin	160.03
diglyme	483.06
acrylic acid	379.33
isopropyl myristate	149.65
n-butyric acid	551.4
acetyl acetate	327.62
di(2-ethylhexyl) phthalate	154.68
ethyl propionate	295.0
nitromethane	731.91
1,2-diethoxyethane	318.84
benzonitrile	494.7
trioctyl phosphate	118.0
1-bromopropane	830.15
gamma-valerolactone	1008.54
n-decanol	133.43
triethyl phosphate	154.76
4-methyl-2-pentanol	167.64
propionitrile	536.29
vinylene carbonate	646.31
1,1,2-trichlorotrifluoroethane	668.36
DMS	312.68
cumene	163.69
2-octanol	156.69
2-hexanone	367.28
octyl acetate	208.09
limonene	191.89
1,2-dimethoxyethane	631.98
ethyl orthosilicate	148.8
tributyl phosphate	140.32
diacetone alcohol	290.46
N,N-dimethylaniline	259.93
acrylonitrile	629.95
aniline	439.0
1,3-propanediol	310.77
bromobenzene	827.84
dibromomethane	1724.47
1,1,2,2-tetrachloroethane	1850.07
2-methyl-cyclohexyl acetate	242.41
tetrabutyl urea	187.03
diisobutyl methanol	117.57
2-phenylethanol	315.49
styrene	340.21
dioctyl adipate	196.86
dimethyl sulfate	387.71
ethyl butyrate	291.03
methyl lactate	196.53
butyl lactate	201.73
diethyl carbonate	227.07
propanediol butyl ether	220.29
triethyl orthoformate	196.79
p-tert-butyltoluene	124.61
methyl 4-tert-butylbenzoate	259.35
morpholine	900.78
tert-butylamine	287.21
n-dodecanol	103.31
dimethoxymethane	620.48
ethylene carbonate	536.68
cyrene	270.29
2-ethoxyethyl acetate	303.95
2-ethylhexyl acetate	294.55
1,2,4-trichlorobenzene	645.93
4-methylpyridine	835.5
dibutyl ether	235.96
2,6-dimethyl-4-heptanol	117.57
DEF	595.15
dimethyl isosorbide	369.68
tetrachloroethylene	1178.98
eugenol	272.98
triacetin	264.16
span 80	212.22
1,4-butanediol	168.24
1,1-dichloroethane	1311.19
2-methyl-1-pentanol	335.72
methyl formate	443.42
2-methyl-1-butanol	433.55
n-decane	45.02
butyronitrile	572.27
3,7-dimethyl-1-octanol	169.18
1-chlorooctane	188.09
1-chlorotetradecane	77.99
n-nonane	44.66
undecane	35.04
tert-butylcyclohexane	66.45
cyclooctane	47.01
cyclopentanol	463.72
tetrahydropyran	894.56
tert-amyl methyl ether	321.59
2,5,8-trioxanonane	334.1
1-hexene	295.72
2-isopropoxyethanol	252.13
2,2,2-trifluoroethanol	190.82
methyl butyrate	436.75

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